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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29794

FusionGeneSummary for QKI_AKAP7

check button Fusion gene summary
Fusion gene informationFusion gene name: QKI_AKAP7
Fusion gene ID: 29794
HgeneTgene
Gene symbol

QKI

AKAP7

Gene ID

9444

9465

Gene nameQKI, KH domain containing RNA bindingA-kinase anchoring protein 7
SynonymsHqk|QK|QK1|QK3|hqkIAKAP15|AKAP18
Cytomap

6q26

6q23.2

Type of geneprotein-codingprotein-coding
Descriptionprotein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA bindingA-kinase anchoring protein 7A kinase (PRKA) anchor protein 7A-kinase anchor protein 18 kDaA-kinase anchor protein 9 kDaAKAP 18
Modification date2018052220180523
UniProtAcc

Q96PU8

Q9P0M2

Ensembl transtripts involved in fusion geneENST00000275262, ENST00000392127, 
ENST00000453779, ENST00000361752, 
ENST00000361195, ENST00000424802, 
ENST00000431975, ENST00000541650, 
ENST00000366358, ENST00000368123, 
ENST00000537868, ENST00000263050, 
ENST00000342266, ENST00000474850, 
Fusion gene scores* DoF score7 X 6 X 7=2943 X 3 X 3=27
# samples 133
** MAII scorelog2(13/294*10)=-1.17730453180791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: QKI [Title/Abstract] AND AKAP7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-HT-7689-01AQKIchr6

163983101

+AKAP7chr6

131603539

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000275262ENST00000431975QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000275262ENST00000541650QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-intronENST00000275262ENST00000366358QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000275262ENST00000368123QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000275262ENST00000537868QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000275262ENST00000263050QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000275262ENST00000342266QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-intronENST00000275262ENST00000474850QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000392127ENST00000431975QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000392127ENST00000541650QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-intronENST00000392127ENST00000366358QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000392127ENST00000368123QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000392127ENST00000537868QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000392127ENST00000263050QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000392127ENST00000342266QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-intronENST00000392127ENST00000474850QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000453779ENST00000431975QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000453779ENST00000541650QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-intronENST00000453779ENST00000366358QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000453779ENST00000368123QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000453779ENST00000537868QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000453779ENST00000263050QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000453779ENST00000342266QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-intronENST00000453779ENST00000474850QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000361752ENST00000431975QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000361752ENST00000541650QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-intronENST00000361752ENST00000366358QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000361752ENST00000368123QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000361752ENST00000537868QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000361752ENST00000263050QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000361752ENST00000342266QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-intronENST00000361752ENST00000474850QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000361195ENST00000431975QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000361195ENST00000541650QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-intronENST00000361195ENST00000366358QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000361195ENST00000368123QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000361195ENST00000537868QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000361195ENST00000263050QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000361195ENST00000342266QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-intronENST00000361195ENST00000474850QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000424802ENST00000431975QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000424802ENST00000541650QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-intronENST00000424802ENST00000366358QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000424802ENST00000368123QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000424802ENST00000537868QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000424802ENST00000263050QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-3UTRENST00000424802ENST00000342266QKIchr6

163983101

+AKAP7chr6

131603539

+
5CDS-intronENST00000424802ENST00000474850QKIchr6

163983101

+AKAP7chr6

131603539

+

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FusionProtFeatures for QKI_AKAP7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
QKI

Q96PU8

AKAP7

Q9P0M2

Probably targets cAMP-dependent protein kinase (PKA) tothe cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity,whereas the free cytoplasmic form may negatively regulate ENaCchannel feedback inhibition by intracellular sodium.{ECO:0000269|PubMed:10613906, ECO:0000269|PubMed:17244820}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for QKI_AKAP7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for QKI_AKAP7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
QKIHNRNPK, USP30, MED12, MED13, MED25, MED16, MED17, MED1, MED24, MED23, MED4, MED29, MED31, MED15, MED14, MED26, MED10, POLR2A, MED27, ELAVL1, PSMF1, C10orf10, FUBP3, HCLS1, PCBP2, PTBP1, PTBP2, RBM14, RBFOX2, RBPMS, RNF138, SERF2, THAP1, USH1C, RBFOX1, PCBP1, PCBP4, APP, NDUFA7, CDV3, ATXN1, FN1, U2AF2, RBM23, RALY, WDR77, HNRNPH2, QKI, DAZ1, IL7R, CARM1, SNRPA, RBM11, NABP1, HNRNPLL, OIP5, RBMX, ZACN, CYP1A1, NTRK1, EWSR1, HYPK, DUSP22, DUSP4, ATE1, RBM42, FBXW11, SLC39A12, VAC14, TRIM11, SYNCRIP, SNRNP27AKAP7PRKAR2A, USP4, MEPCE, PRKACA, PRKACB, PRKAR2B, SPA17, ROPN1, CEP76, LSM5, LSM6, PRPF3, SNRPE, PRKACG, SNRPG, SNRPF, SNRPN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for QKI_AKAP7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for QKI_AKAP7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneQKIC0036341Schizophrenia5PSYGENET
HgeneQKIC0017638Glioma1CTD_human
HgeneQKIC0041696Unipolar Depression1PSYGENET
HgeneQKIC1269683Major Depressive Disorder1PSYGENET
TgeneAKAP7C0236969Substance-Related Disorders1CTD_human