FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 29793

FusionGeneSummary for QDPR_STK40

check button Fusion gene summary
Fusion gene informationFusion gene name: QDPR_STK40
Fusion gene ID: 29793
HgeneTgene
Gene symbol

QDPR

STK40

Gene ID

5860

83931

Gene namequinoid dihydropteridine reductaseserine/threonine kinase 40
SynonymsDHPR|HDHPR|PKU2|SDR33C1SHIK|SgK495
Cytomap

4p15.32

1p34.3

Type of geneprotein-codingprotein-coding
Descriptiondihydropteridine reductase6,7-dihydropteridine reductaseshort chain dehydrogenase/reductase family 33C member 1testis secretory sperm-binding protein Li 236Pserine/threonine-protein kinase 40SINK-homologous serine/threonine-protein kinaseSer/Thr-like kinasesugen kinase 495
Modification date2018052320180519
UniProtAcc

P09417

Q8N2I9

Ensembl transtripts involved in fusion geneENST00000513615, ENST00000281243, 
ENST00000428702, ENST00000508623, 
ENST00000373129, ENST00000373130, 
ENST00000373132, ENST00000482458, 
ENST00000359297, 
Fusion gene scores* DoF score2 X 2 X 1=44 X 4 X 1=16
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/16*10)=1.64385618977472
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: QDPR [Title/Abstract] AND STK40 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF964008QDPRchr4

17488679

-STK40chr1

36831993

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000513615ENST00000373129QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000513615ENST00000373130QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000513615ENST00000373132QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000513615ENST00000482458QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000513615ENST00000359297QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000281243ENST00000373129QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000281243ENST00000373130QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000281243ENST00000373132QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000281243ENST00000482458QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000281243ENST00000359297QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000428702ENST00000373129QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000428702ENST00000373130QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000428702ENST00000373132QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000428702ENST00000482458QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000428702ENST00000359297QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000508623ENST00000373129QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000508623ENST00000373130QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000508623ENST00000373132QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000508623ENST00000482458QDPRchr4

17488679

-STK40chr1

36831993

-
intron-intronENST00000508623ENST00000359297QDPRchr4

17488679

-STK40chr1

36831993

-

Top

FusionProtFeatures for QDPR_STK40


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
QDPR

P09417

STK40

Q8N2I9

The product of this enzyme, tetrahydrobiopterin (BH-4),is an essential cofactor for phenylalanine, tyrosine, andtryptophan hydroxylases.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for QDPR_STK40


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for QDPR_STK40


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for QDPR_STK40


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for QDPR_STK40


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneQDPRC0268465Phenylketonuria II5CTD_human;ORPHANET;UNIPROT
HgeneQDPRC0031485Phenylketonurias1CTD_human