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Fusion gene ID: 29792 |
FusionGeneSummary for QDPR_DHX34 |
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Fusion gene information | Fusion gene name: QDPR_DHX34 | Fusion gene ID: 29792 | Hgene | Tgene | Gene symbol | QDPR | DHX34 | Gene ID | 5860 | 9704 |
Gene name | quinoid dihydropteridine reductase | DExH-box helicase 34 | |
Synonyms | DHPR|HDHPR|PKU2|SDR33C1 | DDX34|HRH1 | |
Cytomap | 4p15.32 | 19q13.32 | |
Type of gene | protein-coding | protein-coding | |
Description | dihydropteridine reductase6,7-dihydropteridine reductaseshort chain dehydrogenase/reductase family 33C member 1testis secretory sperm-binding protein Li 236P | probable ATP-dependent RNA helicase DHX34DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 34DEAH (Asp-Glu-Ala-His) box polypeptide 34DEAH box protein 34DEAH-box helicase 34probable ATP-dependent helicase DHX34 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P09417 | Q14147 | |
Ensembl transtripts involved in fusion gene | ENST00000513615, ENST00000281243, ENST00000428702, ENST00000508623, | ENST00000328771, ENST00000471451, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 4 X 4 X 1=16 |
# samples | 2 | 5 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(5/16*10)=1.64385618977472 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: QDPR [Title/Abstract] AND DHX34 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF375181 | QDPR | chr4 | 17492289 | - | DHX34 | chr19 | 47865909 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000513615 | ENST00000328771 | QDPR | chr4 | 17492289 | - | DHX34 | chr19 | 47865909 | - |
3UTR-intron | ENST00000513615 | ENST00000471451 | QDPR | chr4 | 17492289 | - | DHX34 | chr19 | 47865909 | - |
Frame-shift | ENST00000281243 | ENST00000328771 | QDPR | chr4 | 17492289 | - | DHX34 | chr19 | 47865909 | - |
5CDS-intron | ENST00000281243 | ENST00000471451 | QDPR | chr4 | 17492289 | - | DHX34 | chr19 | 47865909 | - |
Frame-shift | ENST00000428702 | ENST00000328771 | QDPR | chr4 | 17492289 | - | DHX34 | chr19 | 47865909 | - |
5CDS-intron | ENST00000428702 | ENST00000471451 | QDPR | chr4 | 17492289 | - | DHX34 | chr19 | 47865909 | - |
intron-3CDS | ENST00000508623 | ENST00000328771 | QDPR | chr4 | 17492289 | - | DHX34 | chr19 | 47865909 | - |
intron-intron | ENST00000508623 | ENST00000471451 | QDPR | chr4 | 17492289 | - | DHX34 | chr19 | 47865909 | - |
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FusionProtFeatures for QDPR_DHX34 |
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Hgene | Tgene |
QDPR | DHX34 |
The product of this enzyme, tetrahydrobiopterin (BH-4),is an essential cofactor for phenylalanine, tyrosine, andtryptophan hydroxylases. | Probable ATP-binding RNA helicase. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for QDPR_DHX34 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for QDPR_DHX34 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for QDPR_DHX34 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for QDPR_DHX34 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | QDPR | C0268465 | Phenylketonuria II | 5 | CTD_human;ORPHANET;UNIPROT |
Hgene | QDPR | C0031485 | Phenylketonurias | 1 | CTD_human |