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Fusion gene ID: 29791 |
FusionGeneSummary for QARS_USP19 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: QARS_USP19 | Fusion gene ID: 29791 | Hgene | Tgene | Gene symbol | QARS | USP19 | Gene ID | 5859 | 10869 |
| Gene name | glutaminyl-tRNA synthetase | ubiquitin specific peptidase 19 | |
| Synonyms | GLNRS|MSCCA|PRO2195 | ZMYND9 | |
| Cytomap | 3p21.31 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glutamine--tRNA ligaseglutamine-tRNA synthetase | ubiquitin carboxyl-terminal hydrolase 19deubiquitinating enzyme 19ubiquitin specific protease 19ubiquitin thioesterase 19ubiquitin thiolesterase 19ubiquitin-specific-processing protease 19zinc finger MYND domain-containing protein 9 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P47897 | O94966 | |
| Ensembl transtripts involved in fusion gene | ENST00000306125, ENST00000414533, ENST00000470225, ENST00000420147, | ENST00000398896, ENST00000398898, ENST00000417901, ENST00000453664, ENST00000398892, ENST00000398888, ENST00000434032, ENST00000488993, | |
| Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 3 X 3 X 2=18 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/60*10)=0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: QARS [Title/Abstract] AND USP19 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | QARS | GO:0006425 | glutaminyl-tRNA aminoacylation | 24656866|26869582 |
| Hgene | QARS | GO:0006469 | negative regulation of protein kinase activity | 11096076 |
| Hgene | QARS | GO:0032873 | negative regulation of stress-activated MAPK cascade | 11096076 |
| Hgene | QARS | GO:0045892 | negative regulation of transcription, DNA-templated | 11096076 |
| Hgene | QARS | GO:2001234 | negative regulation of apoptotic signaling pathway | 11096076 |
| Tgene | USP19 | GO:0030433 | ubiquitin-dependent ERAD pathway | 19465887 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AO-A0J2-01A | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000306125 | ENST00000398896 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| In-frame | ENST00000306125 | ENST00000398898 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| In-frame | ENST00000306125 | ENST00000417901 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| In-frame | ENST00000306125 | ENST00000453664 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| In-frame | ENST00000306125 | ENST00000398892 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| In-frame | ENST00000306125 | ENST00000398888 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| In-frame | ENST00000306125 | ENST00000434032 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| 5CDS-intron | ENST00000306125 | ENST00000488993 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| In-frame | ENST00000414533 | ENST00000398896 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| In-frame | ENST00000414533 | ENST00000398898 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| In-frame | ENST00000414533 | ENST00000417901 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| In-frame | ENST00000414533 | ENST00000453664 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| In-frame | ENST00000414533 | ENST00000398892 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| In-frame | ENST00000414533 | ENST00000398888 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| In-frame | ENST00000414533 | ENST00000434032 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| 5CDS-intron | ENST00000414533 | ENST00000488993 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| intron-3CDS | ENST00000470225 | ENST00000398896 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| intron-3CDS | ENST00000470225 | ENST00000398898 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| intron-3CDS | ENST00000470225 | ENST00000417901 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| intron-3CDS | ENST00000470225 | ENST00000453664 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| intron-3CDS | ENST00000470225 | ENST00000398892 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| intron-3CDS | ENST00000470225 | ENST00000398888 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| intron-3CDS | ENST00000470225 | ENST00000434032 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| intron-intron | ENST00000470225 | ENST00000488993 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| intron-3CDS | ENST00000420147 | ENST00000398896 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| intron-3CDS | ENST00000420147 | ENST00000398898 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| intron-3CDS | ENST00000420147 | ENST00000417901 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| intron-3CDS | ENST00000420147 | ENST00000453664 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| intron-3CDS | ENST00000420147 | ENST00000398892 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| intron-3CDS | ENST00000420147 | ENST00000398888 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| intron-3CDS | ENST00000420147 | ENST00000434032 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
| intron-intron | ENST00000420147 | ENST00000488993 | QARS | chr3 | 49135625 | - | USP19 | chr3 | 49150062 | - |
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FusionProtFeatures for QARS_USP19 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| QARS | USP19 |
| Glutamine--tRNA ligase (PubMed:26869582). Plays acritical role in brain development (PubMed:24656866).{ECO:0000269|PubMed:24656866, ECO:0000269|PubMed:26869582}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | QARS | chr3:49135625 | chr3:49150062 | ENST00000306125 | - | 22 | 24 | 270_280 | 717 | 776 | Motif | "HIGH" region |
| Hgene | QARS | chr3:49135625 | chr3:49150062 | ENST00000306125 | - | 22 | 24 | 493_497 | 717 | 776 | Motif | "KMSKS" region |
| Hgene | QARS | chr3:49135625 | chr3:49150062 | ENST00000306125 | - | 22 | 24 | 271_273 | 717 | 776 | Nucleotide binding | ATP |
| Hgene | QARS | chr3:49135625 | chr3:49150062 | ENST00000306125 | - | 22 | 24 | 277_283 | 717 | 776 | Nucleotide binding | ATP |
| Hgene | QARS | chr3:49135625 | chr3:49150062 | ENST00000306125 | - | 22 | 24 | 486_487 | 717 | 776 | Nucleotide binding | ATP |
| Hgene | QARS | chr3:49135625 | chr3:49150062 | ENST00000306125 | - | 22 | 24 | 494_496 | 717 | 776 | Nucleotide binding | ATP |
| Tgene | >USP19 | chr3:49135625 | chr3:49150062 | ENST00000398888 | - | 15 | 26 | 1313_1318 | 732 | 1319 | Topological domain | Lumenal |
| Tgene | >USP19 | chr3:49135625 | chr3:49150062 | ENST00000417901 | - | 16 | 27 | 1313_1318 | 835 | 1385 | Topological domain | Lumenal |
| Tgene | >USP19 | chr3:49135625 | chr3:49150062 | ENST00000434032 | - | 16 | 27 | 1313_1318 | 833 | 1420 | Topological domain | Lumenal |
| Tgene | >USP19 | chr3:49135625 | chr3:49150062 | ENST00000453664 | - | 16 | 27 | 1313_1318 | 823 | 1373 | Topological domain | Lumenal |
| Tgene | >USP19 | chr3:49135625 | chr3:49150062 | ENST00000398888 | - | 15 | 26 | 1292_1312 | 732 | 1319 | Transmembrane | Helical |
| Tgene | >USP19 | chr3:49135625 | chr3:49150062 | ENST00000417901 | - | 16 | 27 | 1292_1312 | 835 | 1385 | Transmembrane | Helical |
| Tgene | >USP19 | chr3:49135625 | chr3:49150062 | ENST00000434032 | - | 16 | 27 | 1292_1312 | 833 | 1420 | Transmembrane | Helical |
| Tgene | >USP19 | chr3:49135625 | chr3:49150062 | ENST00000453664 | - | 16 | 27 | 1292_1312 | 823 | 1373 | Transmembrane | Helical |
| Tgene | >USP19 | chr3:49135625 | chr3:49150062 | ENST00000398888 | - | 15 | 26 | 791_833 | 732 | 1319 | Zinc finger | MYND-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000398888 | - | 15 | 26 | 113_202 | 732 | 1319 | Domain | CS 1 |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000398888 | - | 15 | 26 | 282_384 | 732 | 1319 | Domain | CS 2 |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000398888 | - | 15 | 26 | 497_1214 | 732 | 1319 | Domain | Note=USP |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000417901 | - | 16 | 27 | 113_202 | 835 | 1385 | Domain | CS 1 |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000417901 | - | 16 | 27 | 282_384 | 835 | 1385 | Domain | CS 2 |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000417901 | - | 16 | 27 | 497_1214 | 835 | 1385 | Domain | Note=USP |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000434032 | - | 16 | 27 | 113_202 | 833 | 1420 | Domain | CS 1 |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000434032 | - | 16 | 27 | 282_384 | 833 | 1420 | Domain | CS 2 |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000434032 | - | 16 | 27 | 497_1214 | 833 | 1420 | Domain | Note=USP |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000453664 | - | 16 | 27 | 113_202 | 823 | 1373 | Domain | CS 1 |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000453664 | - | 16 | 27 | 282_384 | 823 | 1373 | Domain | CS 2 |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000453664 | - | 16 | 27 | 497_1214 | 823 | 1373 | Domain | Note=USP |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000398888 | - | 15 | 26 | 1_1291 | 732 | 1319 | Topological domain | Cytoplasmic |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000417901 | - | 16 | 27 | 1_1291 | 835 | 1385 | Topological domain | Cytoplasmic |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000434032 | - | 16 | 27 | 1_1291 | 833 | 1420 | Topological domain | Cytoplasmic |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000453664 | - | 16 | 27 | 1_1291 | 823 | 1373 | Topological domain | Cytoplasmic |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000417901 | - | 16 | 27 | 791_833 | 835 | 1385 | Zinc finger | MYND-type |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000434032 | - | 16 | 27 | 791_833 | 833 | 1420 | Zinc finger | MYND-type |
| Tgene | USP19 | chr3:49135625 | chr3:49150062 | ENST00000453664 | - | 16 | 27 | 791_833 | 823 | 1373 | Zinc finger | MYND-type |
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FusionGeneSequence for QARS_USP19 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for QARS_USP19 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| QARS | PRRC2A, TRAF2, ASL, CPNE3, DUSP11, MAP3K5, RARS, AIMP2, HDAC5, GSK3B, FAM118B, KCNE3, H2AFX, TK1, CDKN1A, CDK4, LAMTOR3, STK3, SMN1, DPPA4, PIN1, PIK3R3, TTR, ANXA7, TSC22D1, GADD45A, CUL3, CDK2, CUL1, APP, AIMP1, EPRS, IARS, KARS, LARS, DARS, MARS, EEF1E1, GARS, UBA1, TRMT1, MRPS18B, MRPS22, TXLNA, VBP1, AARS, ZFR, MRPS23, FN1, SMAD9, RNF11, CLTC, IRF1, SAV1, EIF2S3, HNRNPA1, HNRNPA2B1, IGF2BP3, IQGAP1, CCAR2, MRE11A, NMT1, PSMC6, PTBP1, RTCB, DDX1, DHX9, DNAJA1, EIF2B2, EIF2B3, EIF2S1, EIF4G1, RFC4, RPL10, RPL13, RPL15, RPL19, RPL23A, RPL26L1, RPL27, RPL27A, RPL36, RPL7A, RPLP0, TUBB2A, VARS, STAU1, HUWE1, AES, TCF12, TRIP13, TRAF4, VPS37B, LZTS2, DTX2, KLC3, MOV10, NXF1, CUL7, CCDC8, RNF2, SDCBP, KCMF1, PLEC, ASNS, ATP1B3, CBS, DDX17, TOMM40, TRMT6, NTRK1, KRAS, XRCC3, MAPRE1, FOXB1, FOXM1, MCM2, RNF126, SENP3, NLGN3, C1orf131, PPM1A, OFD1, CYLD, DLD, BRCA1 | USP19 | ACADSB, CAMK2G, CDK1, CSE1L, DMWD, HMOX2, IARS, PDHA1, PYGL, SLC1A5, TRIM21, SUCLG2, HERC2, LRPPRC, USP7, GCN1L1, PARK7, NUP160, TNPO3, FKBP8, LAT, SEC61A1, TMEM33, SEC61A2, UNC45A, SRPRB, NEURL4, ATAD1, DOCK7, SAAL1, MGMT, BIRC2, BIRC3, XIAP, HIF1A, SIAH2, SIAH1, USP4, TLN1, XRN2, HSP90AA1, CFTR, TRA, FLNA, LAMTOR4, CKAP5, ECEL1, RNF2, SNRNP200, HNRNPAB, MLF2, HSPA4, UBC, SEL1L, SYVN1, FAF2, DERL1, AIP, CDC37, CDC37L1, FKBP4, FKBP6, FKBPL, RPAP3, CD2BP2, KPTN, AURKC, NTRK1, CACYBP, STUB1, HDAC1, HDAC2, FERD3L, IRF3, CRYL1, DOCK5, SKP2, DNAJC7, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for QARS_USP19 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for QARS_USP19 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | QARS | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | QARS | C4014239 | MICROCEPHALY, PROGRESSIVE, WITH SEIZURES AND CEREBRAL AND CEREBELLAR ATROPHY | 1 | ORPHANET;UNIPROT |
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