![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 29773 |
FusionGeneSummary for PXT1_FBXL5 |
![]() |
Fusion gene information | Fusion gene name: PXT1_FBXL5 | Fusion gene ID: 29773 | Hgene | Tgene | Gene symbol | PXT1 | FBXL5 | Gene ID | 222659 | 26234 |
Gene name | peroxisomal testis enriched protein 1 | F-box and leucine rich repeat protein 5 | |
Synonyms | STEPP | FBL4|FBL5|FLR1 | |
Cytomap | 6p21.31 | 4p15.32 | |
Type of gene | protein-coding | protein-coding | |
Description | peroxisomal testis-specific protein 1peroxisomal, testis specific 1small testis-specific peroxisomal protein | F-box/LRR-repeat protein 5F-box protein FBL4/FBL5p45SKP2-like protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8NFP0 | Q9UKA1 | |
Ensembl transtripts involved in fusion gene | ENST00000454782, | ENST00000341285, ENST00000412094, ENST00000382358, ENST00000514541, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 1 | 1 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PXT1 [Title/Abstract] AND FBXL5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FBXL5 | GO:0016567 | protein ubiquitination | 17532294|19762596|19762597 |
Tgene | FBXL5 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 17532294|19762596|19762597 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | T18548 | PXT1 | chr6 | 36401851 | - | FBXL5 | chr4 | 15606810 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000454782 | ENST00000341285 | PXT1 | chr6 | 36401851 | - | FBXL5 | chr4 | 15606810 | + |
intron-3UTR | ENST00000454782 | ENST00000412094 | PXT1 | chr6 | 36401851 | - | FBXL5 | chr4 | 15606810 | + |
intron-3UTR | ENST00000454782 | ENST00000382358 | PXT1 | chr6 | 36401851 | - | FBXL5 | chr4 | 15606810 | + |
intron-intron | ENST00000454782 | ENST00000514541 | PXT1 | chr6 | 36401851 | - | FBXL5 | chr4 | 15606810 | + |
Top |
FusionProtFeatures for PXT1_FBXL5 |
![]() |
Hgene | Tgene |
PXT1 | FBXL5 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for PXT1_FBXL5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for PXT1_FBXL5 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PXT1_FBXL5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PXT1_FBXL5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |