FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 29764

FusionGeneSummary for PXK_USP4

check button Fusion gene summary
Fusion gene informationFusion gene name: PXK_USP4
Fusion gene ID: 29764
HgeneTgene
Gene symbol

PXK

USP4

Gene ID

54899

7375

Gene namePX domain containing serine/threonine kinase likeubiquitin specific peptidase 4
SynonymsMONAKA|SLOBUNP|Unph
Cytomap

3p14.3

3p21.31

Type of geneprotein-codingprotein-coding
DescriptionPX domain-containing protein kinase-like proteinPX ser/thr kinase v2PX serine/threonine kinasemodulator of Na,K-ATPase long formubiquitin carboxyl-terminal hydrolase 4deubiquitinating enzyme 4ubiquitin carboxyl-terminal esterase 4ubiquitin specific peptidase 4 (proto-oncogene)ubiquitin specific protease 4 (proto-oncogene)ubiquitin thioesterase 4ubiquitin thiolesterase 4ubiq
Modification date2018052320180522
UniProtAcc

Q7Z7A4

Q13107

Ensembl transtripts involved in fusion geneENST00000356151, ENST00000302779, 
ENST00000383716, ENST00000463280, 
ENST00000383715, ENST00000484288, 
ENST00000479241, ENST00000536660, 
ENST00000351842, ENST00000265560, 
ENST00000488520, ENST00000416417, 
ENST00000415188, 
Fusion gene scores* DoF score4 X 2 X 5=404 X 4 X 3=48
# samples 53
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/48*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PXK [Title/Abstract] AND USP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUSP4

GO:0016579

protein deubiquitination

16316627|16339847|16472766

TgeneUSP4

GO:0031647

regulation of protein stability

16472766

TgeneUSP4

GO:0034394

protein localization to cell surface

16339847


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDTHYMTCGA-ZB-A96L-01APXKchr3

58318817

+USP4chr3

49332031

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000356151ENST00000351842PXKchr3

58318817

+USP4chr3

49332031

-
Frame-shiftENST00000356151ENST00000265560PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000356151ENST00000488520PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000356151ENST00000416417PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000356151ENST00000415188PXKchr3

58318817

+USP4chr3

49332031

-
Frame-shiftENST00000302779ENST00000351842PXKchr3

58318817

+USP4chr3

49332031

-
Frame-shiftENST00000302779ENST00000265560PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000302779ENST00000488520PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000302779ENST00000416417PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000302779ENST00000415188PXKchr3

58318817

+USP4chr3

49332031

-
Frame-shiftENST00000383716ENST00000351842PXKchr3

58318817

+USP4chr3

49332031

-
Frame-shiftENST00000383716ENST00000265560PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000383716ENST00000488520PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000383716ENST00000416417PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000383716ENST00000415188PXKchr3

58318817

+USP4chr3

49332031

-
Frame-shiftENST00000463280ENST00000351842PXKchr3

58318817

+USP4chr3

49332031

-
Frame-shiftENST00000463280ENST00000265560PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000463280ENST00000488520PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000463280ENST00000416417PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000463280ENST00000415188PXKchr3

58318817

+USP4chr3

49332031

-
Frame-shiftENST00000383715ENST00000351842PXKchr3

58318817

+USP4chr3

49332031

-
Frame-shiftENST00000383715ENST00000265560PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000383715ENST00000488520PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000383715ENST00000416417PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000383715ENST00000415188PXKchr3

58318817

+USP4chr3

49332031

-
Frame-shiftENST00000484288ENST00000351842PXKchr3

58318817

+USP4chr3

49332031

-
Frame-shiftENST00000484288ENST00000265560PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000484288ENST00000488520PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000484288ENST00000416417PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000484288ENST00000415188PXKchr3

58318817

+USP4chr3

49332031

-
Frame-shiftENST00000479241ENST00000351842PXKchr3

58318817

+USP4chr3

49332031

-
Frame-shiftENST00000479241ENST00000265560PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000479241ENST00000488520PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000479241ENST00000416417PXKchr3

58318817

+USP4chr3

49332031

-
5CDS-intronENST00000479241ENST00000415188PXKchr3

58318817

+USP4chr3

49332031

-
5UTR-3CDSENST00000536660ENST00000351842PXKchr3

58318817

+USP4chr3

49332031

-
5UTR-3CDSENST00000536660ENST00000265560PXKchr3

58318817

+USP4chr3

49332031

-
5UTR-intronENST00000536660ENST00000488520PXKchr3

58318817

+USP4chr3

49332031

-
5UTR-intronENST00000536660ENST00000416417PXKchr3

58318817

+USP4chr3

49332031

-
5UTR-intronENST00000536660ENST00000415188PXKchr3

58318817

+USP4chr3

49332031

-

Top

FusionProtFeatures for PXK_USP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PXK

Q7Z7A4

USP4

Q13107

Hydrolase that deubiquitinates target proteins such asthe receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination ofADORA2A increases the amount of functional receptor at the cellsurface. May regulate mRNA splicing through deubiquitination ofthe U4 spliceosomal protein PRPF3. This may prevent itsrecognition by the U5 component PRPF8 thereby destabilizinginteractions within the U4/U6.U5 snRNP. May also play a role inthe regulation of quality control in the ER.{ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:16339847,ECO:0000269|PubMed:16472766, ECO:0000269|PubMed:20595234,ECO:0000269|PubMed:7784062}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PXK_USP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PXK_USP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PXKPIK3R1, EEA1, TFRC, LAMP2, ACTBL2, YBX3, FBL, HNRNPA0, ALYREF, CCKBR, TMC6, USP48, CLEC14A, EDNRB, GPRC5CUSP4TP53BP2, RB1, RBL1, RBL2, TRIM21, ADSL, USP11, USP1, PRPF4, PRPF3, AKAP7, EIF4E2, PPIH, LSM6, LSM4, PRPF31, LSM7, LSM8, DCP1A, MEPCE, LSM2, TUT1, EDC3, USP32, DCP1B, SART3, IGKV2D-29, UBC, USP4, TRAF2, TRAF6, TK1, CDKN1A, SMN1, RCC1, ANXA7, HUWE1, PDK1, MAP3K7, IKBKB, RIPK1, TNFRSF1A, TGFBR1, AKT1, YWHAH, SFN, USP15, USP19, CUL4B, NLK, LGALS1, PSMD11, FAM96B, PSAP, ATP1B3, LAMA5, NPC2, PSMA6, ATP1B1, PLOD1, PPIA, ASS1, PGM1, PSMC5, TRIM63, TRIM55, TRIM54, USP21, USP28, BRAP, DDX58, PTEN, PLA2G2A, PRPF19, PCNA, CT55, OBFC1, TCEAL1, ELMO1, NTRK1, TCF7L2, RORC, HDAC2, RAD50, MRE11A, RBBP8, PTP4A3, CTNNB1, RNPS1, TCP10L, CABP1, JUNB, RNF19B, RAB30, FAM196A, MAP3K6, BSPRY, LGALS7, TRMT1, ENSA, RIPPLY2, ATP6V0D1, EXOC1, C6orf141, SLX1A, FAM46A, SRP9, IRF8, SMAD4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PXK_USP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PXK_USP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePXKC0003873Rheumatoid Arthritis1CTD_human
HgenePXKC0024141Lupus Erythematosus, Systemic1CTD_human