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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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RelatedDiseases

Fusion gene ID: 29683

FusionGeneSummary for PUM2_WDR35

check button Fusion gene summary
Fusion gene informationFusion gene name: PUM2_WDR35
Fusion gene ID: 29683
HgeneTgene
Gene symbol

PUM2

WDR35

Gene ID

23369

57539

Gene namepumilio RNA binding family member 2WD repeat domain 35
SynonymsPUMH2|PUML2CED2|IFT121|IFTA1|SRTD7
Cytomap

2p24.1

2p24.1

Type of geneprotein-codingprotein-coding
Descriptionpumilio homolog 2pumilio-2WD repeat-containing protein 35intraflagellar transport protein 121 homolognaofen
Modification date2018052220180523
UniProtAcc

Q8TB72

Q9P2L0

Ensembl transtripts involved in fusion geneENST00000338086, ENST00000319801, 
ENST00000361078, ENST00000536417, 
ENST00000403432, ENST00000420234, 
ENST00000281405, ENST00000345530, 
ENST00000416055, 
Fusion gene scores* DoF score12 X 11 X 8=10563 X 3 X 2=18
# samples 133
** MAII scorelog2(13/1056*10)=-3.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PUM2 [Title/Abstract] AND WDR35 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePUM2

GO:0010608

posttranscriptional regulation of gene expression

25100735

HgenePUM2

GO:0043488

regulation of mRNA stability

26724866

HgenePUM2

GO:0051983

regulation of chromosome segregation

26724866

HgenePUM2

GO:1900246

positive regulation of RIG-I signaling pathway

25340845


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-7901-01APUM2chr2

20527071

-WDR35chr2

20130313

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000338086ENST00000281405PUM2chr2

20527071

-WDR35chr2

20130313

-
In-frameENST00000338086ENST00000345530PUM2chr2

20527071

-WDR35chr2

20130313

-
In-frameENST00000338086ENST00000416055PUM2chr2

20527071

-WDR35chr2

20130313

-
In-frameENST00000319801ENST00000281405PUM2chr2

20527071

-WDR35chr2

20130313

-
In-frameENST00000319801ENST00000345530PUM2chr2

20527071

-WDR35chr2

20130313

-
In-frameENST00000319801ENST00000416055PUM2chr2

20527071

-WDR35chr2

20130313

-
In-frameENST00000361078ENST00000281405PUM2chr2

20527071

-WDR35chr2

20130313

-
In-frameENST00000361078ENST00000345530PUM2chr2

20527071

-WDR35chr2

20130313

-
In-frameENST00000361078ENST00000416055PUM2chr2

20527071

-WDR35chr2

20130313

-
5UTR-3CDSENST00000536417ENST00000281405PUM2chr2

20527071

-WDR35chr2

20130313

-
5UTR-3CDSENST00000536417ENST00000345530PUM2chr2

20527071

-WDR35chr2

20130313

-
5UTR-3CDSENST00000536417ENST00000416055PUM2chr2

20527071

-WDR35chr2

20130313

-
Frame-shiftENST00000403432ENST00000281405PUM2chr2

20527071

-WDR35chr2

20130313

-
Frame-shiftENST00000403432ENST00000345530PUM2chr2

20527071

-WDR35chr2

20130313

-
Frame-shiftENST00000403432ENST00000416055PUM2chr2

20527071

-WDR35chr2

20130313

-
5UTR-3CDSENST00000420234ENST00000281405PUM2chr2

20527071

-WDR35chr2

20130313

-
5UTR-3CDSENST00000420234ENST00000345530PUM2chr2

20527071

-WDR35chr2

20130313

-
5UTR-3CDSENST00000420234ENST00000416055PUM2chr2

20527071

-WDR35chr2

20130313

-

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FusionProtFeatures for PUM2_WDR35


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PUM2

Q8TB72

WDR35

Q9P2L0

Sequence-specific RNA-binding protein that acts as apost-transcriptional repressor by binding the 3'-UTR of mRNAtargets. Binds to an RNA consensus sequence, the Pumilio ResponseElement (PRE), 5'-UGUANAUA-3', that is related to the NanosResponse Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via differentmechanisms: acts via direct recruitment of the CCR4-POP2-NOTdeadenylase leading to translational inhibition and mRNAdegradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs(PubMed:18776931, PubMed:22345517). Acts as a post-transcriptionalrepressor of E2F3 mRNAs by binding to its 3'-UTR and facilitatingmiRNA regulation (PubMed:22345517). Plays a role in cytoplasmicsensing of viral infection (PubMed:25340845). Represses a programof genes necessary to maintain genomic stability such as keymitotic, DNA repair and DNA replication factors. Its ability torepress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its highabundance and multitude of PUMILIO binding sites, is able tosequester a significant fraction of PUM1 and PUM2 in the cytoplasm(PubMed:26724866). May regulate DCUN1D3 mRNA levels(PubMed:25349211). May support proliferation and self-renewal ofstem cells. Binds specifically to miRNA MIR199A precursor, withPUM1, regulates miRNA MIR199A expression at a postranscriptionallevel (PubMed:28431233). {ECO:0000269|PubMed:18776931,ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517,ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845,ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866,ECO:0000269|PubMed:28431233}. Component of the IFT complex A (IFT-A), a complexrequired for retrograde ciliary transport. Required forciliogenesis. May promote CASP3 activation and TNF-stimulatedapoptosis. {ECO:0000269|PubMed:20193664,ECO:0000269|PubMed:21473986}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119278_48817988Compositional biasNote=Ala-rich
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119359_40517988Compositional biasNote=Gln-rich
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119520_68717988Compositional biasNote=Ser-rich
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120278_488171065Compositional biasNote=Ala-rich
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120359_405171065Compositional biasNote=Gln-rich
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120520_687171065Compositional biasNote=Ser-rich
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120278_488171067Compositional biasNote=Ala-rich
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120359_405171067Compositional biasNote=Gln-rich
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120520_687171067Compositional biasNote=Ser-rich
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221278_488171065Compositional biasNote=Ala-rich
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221359_405171065Compositional biasNote=Gln-rich
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221520_687171065Compositional biasNote=Ser-rich
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119706_104817988DomainPUM-HD
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120706_1048171065DomainPUM-HD
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120706_1048171067DomainPUM-HD
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221706_1048171065DomainPUM-HD
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-1191002_100617988RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119741_74517988RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119777_78117988RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119813_81717988RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119851_85517988RegionNon-specific-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119887_89117988RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119923_92717988RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119959_96317988RegionGuanine-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-1201002_1006171065RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120741_745171065RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120777_781171065RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120813_817171065RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120851_855171065RegionNon-specific-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120887_891171065RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120923_927171065RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120959_963171065RegionGuanine-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-1201002_1006171067RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120741_745171067RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120777_781171067RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120813_817171067RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120851_855171067RegionNon-specific-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120887_891171067RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120923_927171067RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120959_963171067RegionGuanine-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-2211002_1006171065RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221741_745171065RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221777_781171065RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221813_817171065RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221851_855171065RegionNon-specific-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221887_891171065RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221923_927171065RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221959_963171065RegionGuanine-nucleotide binding in RNA target
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119726_76117988RepeatPumilio 1
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119762_79717988RepeatPumilio 2
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119798_83517988RepeatPumilio 3
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119836_87117988RepeatPumilio 4
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119872_90717988RepeatPumilio 5
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119908_94317988RepeatPumilio 6
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119944_97917988RepeatPumilio 7
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-119983_102217988RepeatPumilio 8
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120726_761171065RepeatPumilio 1
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120762_797171065RepeatPumilio 2
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120798_835171065RepeatPumilio 3
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120836_871171065RepeatPumilio 4
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120872_907171065RepeatPumilio 5
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120908_943171065RepeatPumilio 6
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120944_979171065RepeatPumilio 7
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-120983_1022171065RepeatPumilio 8
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120726_761171067RepeatPumilio 1
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120762_797171067RepeatPumilio 2
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120798_835171067RepeatPumilio 3
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120836_871171067RepeatPumilio 4
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120872_907171067RepeatPumilio 5
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120908_943171067RepeatPumilio 6
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120944_979171067RepeatPumilio 7
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-120983_1022171067RepeatPumilio 8
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221726_761171065RepeatPumilio 1
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221762_797171065RepeatPumilio 2
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221798_835171065RepeatPumilio 3
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221836_871171065RepeatPumilio 4
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221872_907171065RepeatPumilio 5
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221908_943171065RepeatPumilio 6
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221944_979171065RepeatPumilio 7
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-221983_1022171065RepeatPumilio 8
TgeneWDR35chr2:20527071chr2:20130313ENST00000281405-2327105_1439881171RepeatNote=WD 3
TgeneWDR35chr2:20527071chr2:20130313ENST00000281405-2327147_1859881171RepeatNote=WD 4
TgeneWDR35chr2:20527071chr2:20130313ENST00000281405-2327193_2419881171RepeatNote=WD 5
TgeneWDR35chr2:20527071chr2:20130313ENST00000281405-2327246_2889881171RepeatNote=WD 6
TgeneWDR35chr2:20527071chr2:20130313ENST00000281405-23274_439881171RepeatNote=WD 1
TgeneWDR35chr2:20527071chr2:20130313ENST00000281405-232761_1009881171RepeatNote=WD 2
TgeneWDR35chr2:20527071chr2:20130313ENST00000345530-2428105_1439991182RepeatNote=WD 3
TgeneWDR35chr2:20527071chr2:20130313ENST00000345530-2428147_1859991182RepeatNote=WD 4
TgeneWDR35chr2:20527071chr2:20130313ENST00000345530-2428193_2419991182RepeatNote=WD 5
TgeneWDR35chr2:20527071chr2:20130313ENST00000345530-2428246_2889991182RepeatNote=WD 6
TgeneWDR35chr2:20527071chr2:20130313ENST00000345530-24284_439991182RepeatNote=WD 1
TgeneWDR35chr2:20527071chr2:20130313ENST00000345530-242861_1009991182RepeatNote=WD 2


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FusionGeneSequence for PUM2_WDR35


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PUM2_ENST00000338086_chr2_20527071_-_WDR35_ENST00000281405_chr2_20130313_-_200aa
MNHDFQALALESRGMGEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLA
LCACASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTCVATGSPITEYQFWMCSVCKHGV

>In-frame_PUM2_ENST00000338086_chr2_20527071_-_WDR35_ENST00000345530_chr2_20130313_-_200aa
MNHDFQALALESRGMGEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLA
LCACASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTCVATGSPITEYQFWMCSVCKHGV

>In-frame_PUM2_ENST00000338086_chr2_20527071_-_WDR35_ENST00000416055_chr2_20130313_-_105aa
MNHDFQALALESRGMGEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTVEKGNCQHALPQEAQSLSINS

>In-frame_PUM2_ENST00000319801_chr2_20527071_-_WDR35_ENST00000281405_chr2_20130313_-_200aa
MNHDFQALALESRGMGEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLA
LCACASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTCVATGSPITEYQFWMCSVCKHGV

>In-frame_PUM2_ENST00000319801_chr2_20527071_-_WDR35_ENST00000345530_chr2_20130313_-_200aa
MNHDFQALALESRGMGEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLA
LCACASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTCVATGSPITEYQFWMCSVCKHGV

>In-frame_PUM2_ENST00000319801_chr2_20527071_-_WDR35_ENST00000416055_chr2_20130313_-_105aa
MNHDFQALALESRGMGEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTVEKGNCQHALPQEAQSLSINS

>In-frame_PUM2_ENST00000361078_chr2_20527071_-_WDR35_ENST00000281405_chr2_20130313_-_200aa
MNHDFQALALESRGMGEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLA
LCACASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTCVATGSPITEYQFWMCSVCKHGV

>In-frame_PUM2_ENST00000361078_chr2_20527071_-_WDR35_ENST00000345530_chr2_20130313_-_200aa
MNHDFQALALESRGMGEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLA
LCACASRAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLPTCVATGSPITEYQFWMCSVCKHGV

>In-frame_PUM2_ENST00000361078_chr2_20527071_-_WDR35_ENST00000416055_chr2_20130313_-_105aa
MNHDFQALALESRGMGEATSALAGLLEEEVLSTTDRFTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTVEKGNCQHALPQEAQSLSINS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PUM2_ENST00000338086_chr2_20527071_-_WDR35_ENST00000281405_chr2_20130313_-_600nt
ATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGGCTGGTTTGCTGGAAGAAGAAGTT
CTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATACTTGCACAGAGGCAGCTCTATGAG
GGATGTGTGGACACTGCACTGAAGACAGCTCTTCACCTGAAAGACTATGAAGACATCATCCCTCCTGTGGAGATCTACTCTCTGCTAGCA
CTCTGCGCATGCGCCAGCAGAGCCTTTGGGACTTGTTCAAAAGCTTTCATTAAACTTAAATCTTTAGAGACCCTCAGTTCAGAACAGAAA
CAGCAGTATGAAGACCTTGCTTTAGAAATCTTCACCAAACATACTTCAAAAGATAACAGAAAACCTGAATTGGACAGCCTTATGGAAGGT
GGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAGCCCAATCACTGAGTATCAATTCTGGATGTGCAGTGTATGCAAACACGGTGTC

>In-frame_PUM2_ENST00000338086_chr2_20527071_-_WDR35_ENST00000345530_chr2_20130313_-_600nt
ATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGGCTGGTTTGCTGGAAGAAGAAGTT
CTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATACTTGCACAGAGGCAGCTCTATGAG
GGATGTGTGGACACTGCACTGAAGACAGCTCTTCACCTGAAAGACTATGAAGACATCATCCCTCCTGTGGAGATCTACTCTCTGCTAGCA
CTCTGCGCATGCGCCAGCAGAGCCTTTGGGACTTGTTCAAAAGCTTTCATTAAACTTAAATCTTTAGAGACCCTCAGTTCAGAACAGAAA
CAGCAGTATGAAGACCTTGCTTTAGAAATCTTCACCAAACATACTTCAAAAGATAACAGAAAACCTGAATTGGACAGCCTTATGGAAGGT
GGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAGCCCAATCACTGAGTATCAATTCTGGATGTGCAGTGTATGCAAACACGGTGTC

>In-frame_PUM2_ENST00000338086_chr2_20527071_-_WDR35_ENST00000416055_chr2_20130313_-_315nt
ATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGGCTGGTTTGCTGGAAGAAGAAGTT
CTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATACTTGCACAGAGGCAGCTCTATGAG
GGATGTGTGGACACTGCACTGAAGACAGTGGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAGCCCAATCACTGAGTATCAATTCT

>In-frame_PUM2_ENST00000319801_chr2_20527071_-_WDR35_ENST00000281405_chr2_20130313_-_600nt
ATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGGCTGGTTTGCTGGAAGAAGAAGTT
CTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATACTTGCACAGAGGCAGCTCTATGAG
GGATGTGTGGACACTGCACTGAAGACAGCTCTTCACCTGAAAGACTATGAAGACATCATCCCTCCTGTGGAGATCTACTCTCTGCTAGCA
CTCTGCGCATGCGCCAGCAGAGCCTTTGGGACTTGTTCAAAAGCTTTCATTAAACTTAAATCTTTAGAGACCCTCAGTTCAGAACAGAAA
CAGCAGTATGAAGACCTTGCTTTAGAAATCTTCACCAAACATACTTCAAAAGATAACAGAAAACCTGAATTGGACAGCCTTATGGAAGGT
GGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAGCCCAATCACTGAGTATCAATTCTGGATGTGCAGTGTATGCAAACACGGTGTC

>In-frame_PUM2_ENST00000319801_chr2_20527071_-_WDR35_ENST00000345530_chr2_20130313_-_600nt
ATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGGCTGGTTTGCTGGAAGAAGAAGTT
CTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATACTTGCACAGAGGCAGCTCTATGAG
GGATGTGTGGACACTGCACTGAAGACAGCTCTTCACCTGAAAGACTATGAAGACATCATCCCTCCTGTGGAGATCTACTCTCTGCTAGCA
CTCTGCGCATGCGCCAGCAGAGCCTTTGGGACTTGTTCAAAAGCTTTCATTAAACTTAAATCTTTAGAGACCCTCAGTTCAGAACAGAAA
CAGCAGTATGAAGACCTTGCTTTAGAAATCTTCACCAAACATACTTCAAAAGATAACAGAAAACCTGAATTGGACAGCCTTATGGAAGGT
GGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAGCCCAATCACTGAGTATCAATTCTGGATGTGCAGTGTATGCAAACACGGTGTC

>In-frame_PUM2_ENST00000319801_chr2_20527071_-_WDR35_ENST00000416055_chr2_20130313_-_315nt
ATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGGCTGGTTTGCTGGAAGAAGAAGTT
CTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATACTTGCACAGAGGCAGCTCTATGAG
GGATGTGTGGACACTGCACTGAAGACAGTGGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAGCCCAATCACTGAGTATCAATTCT

>In-frame_PUM2_ENST00000361078_chr2_20527071_-_WDR35_ENST00000281405_chr2_20130313_-_600nt
ATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGGCTGGTTTGCTGGAAGAAGAAGTT
CTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATACTTGCACAGAGGCAGCTCTATGAG
GGATGTGTGGACACTGCACTGAAGACAGCTCTTCACCTGAAAGACTATGAAGACATCATCCCTCCTGTGGAGATCTACTCTCTGCTAGCA
CTCTGCGCATGCGCCAGCAGAGCCTTTGGGACTTGTTCAAAAGCTTTCATTAAACTTAAATCTTTAGAGACCCTCAGTTCAGAACAGAAA
CAGCAGTATGAAGACCTTGCTTTAGAAATCTTCACCAAACATACTTCAAAAGATAACAGAAAACCTGAATTGGACAGCCTTATGGAAGGT
GGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAGCCCAATCACTGAGTATCAATTCTGGATGTGCAGTGTATGCAAACACGGTGTC

>In-frame_PUM2_ENST00000361078_chr2_20527071_-_WDR35_ENST00000345530_chr2_20130313_-_600nt
ATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGGCTGGTTTGCTGGAAGAAGAAGTT
CTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATACTTGCACAGAGGCAGCTCTATGAG
GGATGTGTGGACACTGCACTGAAGACAGCTCTTCACCTGAAAGACTATGAAGACATCATCCCTCCTGTGGAGATCTACTCTCTGCTAGCA
CTCTGCGCATGCGCCAGCAGAGCCTTTGGGACTTGTTCAAAAGCTTTCATTAAACTTAAATCTTTAGAGACCCTCAGTTCAGAACAGAAA
CAGCAGTATGAAGACCTTGCTTTAGAAATCTTCACCAAACATACTTCAAAAGATAACAGAAAACCTGAATTGGACAGCCTTATGGAAGGT
GGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAGCCCAATCACTGAGTATCAATTCTGGATGTGCAGTGTATGCAAACACGGTGTC

>In-frame_PUM2_ENST00000361078_chr2_20527071_-_WDR35_ENST00000416055_chr2_20130313_-_315nt
ATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGGCTGGTTTGCTGGAAGAAGAAGTT
CTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATACTTGCACAGAGGCAGCTCTATGAG
GGATGTGTGGACACTGCACTGAAGACAGTGGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAGCCCAATCACTGAGTATCAATTCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_PUM2_ENST00000338086_chr2_20527071_-_WDR35_ENST00000281405_chr2_20130313_-_3921nt
AACAGGTTTGATCTGTGGATGAAATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGG
CTGGTTTGCTGGAAGAAGAAGTTCTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATAC
TTGCACAGAGGCAGCTCTATGAGGGATGTGTGGACACTGCACTGAAGACAGCTCTTCACCTGAAAGACTATGAAGACATCATCCCTCCTG
TGGAGATCTACTCTCTGCTAGCACTCTGCGCATGCGCCAGCAGAGCCTTTGGGACTTGTTCAAAAGCTTTCATTAAACTTAAATCTTTAG
AGACCCTCAGTTCAGAACAGAAACAGCAGTATGAAGACCTTGCTTTAGAAATCTTCACCAAACATACTTCAAAAGATAACAGAAAACCTG
AATTGGACAGCCTTATGGAAGGTGGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAGCCCAATCACTGAGTATCAATTCTGGATGT
GCAGTGTATGCAAACACGGTGTCCTTGCTCAGGAAATAAGCCACTACAGCTTCTGCCCCTTATGCCATAGTCCAGTGGGATAAAGGAATG
ATAAACTGTATATAACTGTAAAATATATGTAGCATATATACATGGCTATATGCTGTATATGTAATAAGGTTTATTTCTGTGAGTTTTGTA
TGAAAATCAGCCTCATTATTTATAGTTGAATTTTTGCACAAAATATATGTTAATAAAATAATTTTTATGGCAATACAACTGTGAAATAAT
AAGGCCGATTTTCATATAAATGTATGAAAATCAACCATGTTTTCTCTCACCCTCTCTCTTTTGTTTATCTTGTTTTTGGTTACATGATAC
CATGGAAATATTCCAAATAAATTTTTTTCTCACAGTGTCAAGGTAACTGAATTCATTAAAAAATCTTGAAGGGAGTAGGGAGTGGGGGAA
GCATGGGAGTGGGGCAAAGTTGAATTTAGAGAATTTTTATAACCCATGTTACAAGGAAGTTAAACAATTGTAATAATGAAATGAGCTTTC
TCTATAGCCATATTTAATTAAATAAGTGTCGAATGTCTTCTTTATTGTATTTTCAGAAGTGAGGCGATGGCATTTTAAGACATTTTTTAC
AATCTGAATTGTTTCTAATAGCCCTATTCTTCTATTTTAAAACCTGTCCTTTTAGTCTCATTTAAGAGATGGCATTTGGAATTTACACTT
TCATATGATTGTGCAGAAAACTTGCCTCTATTTATAATGAAGATAACTTAAACAGAAATATCCATTTTGTAGTTATAGCTTCTGTTGAAA
CATTGTCACTAAGTTGGACCGTTTATTTACACAAGTATTGTTGAGGGAGTGATTTTTTCTTGATATGCGTCTGTTTTCATTTATTATTAA
TTTGAAAGATAAACAGTTGTGATCCATAATGGATCATTTCTTATGTCTTTTACATAGCTAATAATGTTCTCTGTTTATTTCTCATGAATT
CCCATTTTGTGGCTAAAGACCAGACCTTTGCACTATTTCATCAAGATTATTTTATTGAGGTTTGGCTTACATATAGTAGAGGCAATACAT
AGAGATACGCAACTTTGTTTTTGCAGCTACAATACACTTTCTCAATCTCATATGTTTTTGTCTTGTAGAGACAGAGACAAGTTCAGCATG
TTGCAGATTGGGAATAGTGAGCTATGAGAAGAGATTTAGAGCCTAGATGAGCTTAGGATAGAGAGTGGGCTCATTGGCCTAAATAAAAAG
AGAAGACCAGAAGTCTTTGAGGTCTCTGTCTCTATTCATGCGCCTCGTGGAAAATTACCTTGGTACAATGGTAGCCTCTAAATAGACTGC
CTCGCAAGCTATTCCAGAGGTCATGGAACAGAAAGCCTTATAAACCAAATAAAAATTCTCAAAATACATTGGTTTATTGAACCAATTTGC
AATACACAGTGAGGAACAAGGAGAAAGCAATGATAGATTAACACTGTTAGTGTAACGTGCCAGTGGAGTGGAAAGACCGCAACACCTGAA
TCCTGGGTTTTGTAATGTTTTTATGTCCTGACTCACATTCTGTCACATACGCTTTCCCCTAATAGTCGGGTTACAAAAAGGACCAGAGTG
GCCGCTTGAGCCAGATGACTCAATCAGATGAAATGTGCCTGAGGCCAACGATGTACACTTGCTCTATAGAAGGGTGTCAGGGGCAAGTAC
ACTTCACCACAGCAATAGCTTGCCTATTAGTCTGCTGAGCAGTCATGAATTTTATTGTATTTCTTGGGTAAGGACAGGCCAGAATGAGTG
TCACCAGTGGGTAATTGAATCAACTTCTCACACATACTGAAGGCTTTATATGTCTCATGCATACTTAGTGTATCATGAATATTTGGTATC
TTTGTGGCTTTTCATATTTTTAGTGCTTCATGAATATTTGGTATCTCTTGCTCCTTTCTATCTGTGGTCACACATACACGCTCTATTAAC
TTTGCCTAATAAGTCTCCTAGGTTACTAACTTACTTACCTAAATGTAACACAATGAATTCCAGCTTTCTCATTTGTTCTATACCAGAATG
GGAAATTTCCCCAAATCAGAAAATCACATCCTAACAAAGAAGTCTGTCTAAGACAGTACATCTCCTGTTGAACTTGCATCTTTCCACAGG
ACTTTCTGTTTTTAGGGATGAGACTATTCTCTGCTTCATCAAGGAAAGAGAAATGTTCAGGGTTGTAGGGATGGCACACTTATTAGTTCT
GCCTGTCTGAAAGGTTCCTGCAGGACAGTTTGGTCAGAGCTGCAATTCTTAGTCCATGGTCTAATGCTTGAGTATCTCTTCTTTCCCTTT
CCTGTCTCAGGAATCAGCTGAGAATTCATTCGATTGTCATGCCTCTAGCCCCTTACTGTGATTTGTTGGTTGCACTTTCATTTGCTTTAG
TTCTAGAATCACCTGTTGACTCCTCAGACTTCACCTAACTTTGGAAACTCTCTTTTGGAGGCTTCTCATTTCCCCCTAATTCTGTGCTGC
CTGAGCCCTAGAATTTTCCCACCAACGAATTATTCCAGGTAGATCCTAAGTTGCTGGATCTAGTTGATATTTAAACAATATCTAGTTGAT
ATTTCTCATTCAGTTGGATCCAGAAACCAGTATCTCTAAAAACAACCTCTCATACCTTGTGGACCTAATTTTGTGTGCGTGTGTGTGTGC
GCGCATATGTATATAGACAGGCACATCTTTTTTACTTTTGTAAAAGCTTATGCCTCTTTGGTATCTATATCTGTGAAAGTTTTAATGATC
TGCCATAATGTCTTGGGGACCTTTGTCTTCTGTGTAAATGGTACTAGAGAAAACACCTATATTATGAGTCAATCTAGTTGGTTTTATTCG
ACATGAAGGAAATTTCCAGATAACAACACTAACAAACTCTCCCTTGACTAGGGGGACAAAGAAAAGCAAAACTGACCATAAAAAACAATT
ACCTGGTGAGAAGTTGCATAAACAGAATTAGGTAGTATATTGAAGACAGCATCATTAAACAGTTATGTTGTTCTCCTTGCAAAAAACATG
TACTGACTTCCCGTTGAGTAATGCCAAGTTGTTTTTTTTATTATAAAACTTGCCCTTCATTACATGTTTCAAAGTGGTGTGGTGGGCCAA
AATATTGAAATGATGGAACTGACTGATAAAGCTGTACAAATAAGCAGTGTGCCTAACAAGCAACACAGTAATGTTGACATGCTTAATTCA
CAAATGCTAATTTCATTATAAATTGTTTTGCTAAAATACACTTTGAAACTATTTTTCTGTATTCCAAGAGCTGAGATCTTAGATTTTATG

>In-frame_PUM2_ENST00000338086_chr2_20527071_-_WDR35_ENST00000345530_chr2_20130313_-_3921nt
AACAGGTTTGATCTGTGGATGAAATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGG
CTGGTTTGCTGGAAGAAGAAGTTCTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATAC
TTGCACAGAGGCAGCTCTATGAGGGATGTGTGGACACTGCACTGAAGACAGCTCTTCACCTGAAAGACTATGAAGACATCATCCCTCCTG
TGGAGATCTACTCTCTGCTAGCACTCTGCGCATGCGCCAGCAGAGCCTTTGGGACTTGTTCAAAAGCTTTCATTAAACTTAAATCTTTAG
AGACCCTCAGTTCAGAACAGAAACAGCAGTATGAAGACCTTGCTTTAGAAATCTTCACCAAACATACTTCAAAAGATAACAGAAAACCTG
AATTGGACAGCCTTATGGAAGGTGGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAGCCCAATCACTGAGTATCAATTCTGGATGT
GCAGTGTATGCAAACACGGTGTCCTTGCTCAGGAAATAAGCCACTACAGCTTCTGCCCCTTATGCCATAGTCCAGTGGGATAAAGGAATG
ATAAACTGTATATAACTGTAAAATATATGTAGCATATATACATGGCTATATGCTGTATATGTAATAAGGTTTATTTCTGTGAGTTTTGTA
TGAAAATCAGCCTCATTATTTATAGTTGAATTTTTGCACAAAATATATGTTAATAAAATAATTTTTATGGCAATACAACTGTGAAATAAT
AAGGCCGATTTTCATATAAATGTATGAAAATCAACCATGTTTTCTCTCACCCTCTCTCTTTTGTTTATCTTGTTTTTGGTTACATGATAC
CATGGAAATATTCCAAATAAATTTTTTTCTCACAGTGTCAAGGTAACTGAATTCATTAAAAAATCTTGAAGGGAGTAGGGAGTGGGGGAA
GCATGGGAGTGGGGCAAAGTTGAATTTAGAGAATTTTTATAACCCATGTTACAAGGAAGTTAAACAATTGTAATAATGAAATGAGCTTTC
TCTATAGCCATATTTAATTAAATAAGTGTCGAATGTCTTCTTTATTGTATTTTCAGAAGTGAGGCGATGGCATTTTAAGACATTTTTTAC
AATCTGAATTGTTTCTAATAGCCCTATTCTTCTATTTTAAAACCTGTCCTTTTAGTCTCATTTAAGAGATGGCATTTGGAATTTACACTT
TCATATGATTGTGCAGAAAACTTGCCTCTATTTATAATGAAGATAACTTAAACAGAAATATCCATTTTGTAGTTATAGCTTCTGTTGAAA
CATTGTCACTAAGTTGGACCGTTTATTTACACAAGTATTGTTGAGGGAGTGATTTTTTCTTGATATGCGTCTGTTTTCATTTATTATTAA
TTTGAAAGATAAACAGTTGTGATCCATAATGGATCATTTCTTATGTCTTTTACATAGCTAATAATGTTCTCTGTTTATTTCTCATGAATT
CCCATTTTGTGGCTAAAGACCAGACCTTTGCACTATTTCATCAAGATTATTTTATTGAGGTTTGGCTTACATATAGTAGAGGCAATACAT
AGAGATACGCAACTTTGTTTTTGCAGCTACAATACACTTTCTCAATCTCATATGTTTTTGTCTTGTAGAGACAGAGACAAGTTCAGCATG
TTGCAGATTGGGAATAGTGAGCTATGAGAAGAGATTTAGAGCCTAGATGAGCTTAGGATAGAGAGTGGGCTCATTGGCCTAAATAAAAAG
AGAAGACCAGAAGTCTTTGAGGTCTCTGTCTCTATTCATGCGCCTCGTGGAAAATTACCTTGGTACAATGGTAGCCTCTAAATAGACTGC
CTCGCAAGCTATTCCAGAGGTCATGGAACAGAAAGCCTTATAAACCAAATAAAAATTCTCAAAATACATTGGTTTATTGAACCAATTTGC
AATACACAGTGAGGAACAAGGAGAAAGCAATGATAGATTAACACTGTTAGTGTAACGTGCCAGTGGAGTGGAAAGACCGCAACACCTGAA
TCCTGGGTTTTGTAATGTTTTTATGTCCTGACTCACATTCTGTCACATACGCTTTCCCCTAATAGTCGGGTTACAAAAAGGACCAGAGTG
GCCGCTTGAGCCAGATGACTCAATCAGATGAAATGTGCCTGAGGCCAACGATGTACACTTGCTCTATAGAAGGGTGTCAGGGGCAAGTAC
ACTTCACCACAGCAATAGCTTGCCTATTAGTCTGCTGAGCAGTCATGAATTTTATTGTATTTCTTGGGTAAGGACAGGCCAGAATGAGTG
TCACCAGTGGGTAATTGAATCAACTTCTCACACATACTGAAGGCTTTATATGTCTCATGCATACTTAGTGTATCATGAATATTTGGTATC
TTTGTGGCTTTTCATATTTTTAGTGCTTCATGAATATTTGGTATCTCTTGCTCCTTTCTATCTGTGGTCACACATACACGCTCTATTAAC
TTTGCCTAATAAGTCTCCTAGGTTACTAACTTACTTACCTAAATGTAACACAATGAATTCCAGCTTTCTCATTTGTTCTATACCAGAATG
GGAAATTTCCCCAAATCAGAAAATCACATCCTAACAAAGAAGTCTGTCTAAGACAGTACATCTCCTGTTGAACTTGCATCTTTCCACAGG
ACTTTCTGTTTTTAGGGATGAGACTATTCTCTGCTTCATCAAGGAAAGAGAAATGTTCAGGGTTGTAGGGATGGCACACTTATTAGTTCT
GCCTGTCTGAAAGGTTCCTGCAGGACAGTTTGGTCAGAGCTGCAATTCTTAGTCCATGGTCTAATGCTTGAGTATCTCTTCTTTCCCTTT
CCTGTCTCAGGAATCAGCTGAGAATTCATTCGATTGTCATGCCTCTAGCCCCTTACTGTGATTTGTTGGTTGCACTTTCATTTGCTTTAG
TTCTAGAATCACCTGTTGACTCCTCAGACTTCACCTAACTTTGGAAACTCTCTTTTGGAGGCTTCTCATTTCCCCCTAATTCTGTGCTGC
CTGAGCCCTAGAATTTTCCCACCAACGAATTATTCCAGGTAGATCCTAAGTTGCTGGATCTAGTTGATATTTAAACAATATCTAGTTGAT
ATTTCTCATTCAGTTGGATCCAGAAACCAGTATCTCTAAAAACAACCTCTCATACCTTGTGGACCTAATTTTGTGTGCGTGTGTGTGTGC
GCGCATATGTATATAGACAGGCACATCTTTTTTACTTTTGTAAAAGCTTATGCCTCTTTGGTATCTATATCTGTGAAAGTTTTAATGATC
TGCCATAATGTCTTGGGGACCTTTGTCTTCTGTGTAAATGGTACTAGAGAAAACACCTATATTATGAGTCAATCTAGTTGGTTTTATTCG
ACATGAAGGAAATTTCCAGATAACAACACTAACAAACTCTCCCTTGACTAGGGGGACAAAGAAAAGCAAAACTGACCATAAAAAACAATT
ACCTGGTGAGAAGTTGCATAAACAGAATTAGGTAGTATATTGAAGACAGCATCATTAAACAGTTATGTTGTTCTCCTTGCAAAAAACATG
TACTGACTTCCCGTTGAGTAATGCCAAGTTGTTTTTTTTATTATAAAACTTGCCCTTCATTACATGTTTCAAAGTGGTGTGGTGGGCCAA
AATATTGAAATGATGGAACTGACTGATAAAGCTGTACAAATAAGCAGTGTGCCTAACAAGCAACACAGTAATGTTGACATGCTTAATTCA
CAAATGCTAATTTCATTATAAATTGTTTTGCTAAAATACACTTTGAAACTATTTTTCTGTATTCCAAGAGCTGAGATCTTAGATTTTATG

>In-frame_PUM2_ENST00000338086_chr2_20527071_-_WDR35_ENST00000416055_chr2_20130313_-_698nt
AACAGGTTTGATCTGTGGATGAAATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGG
CTGGTTTGCTGGAAGAAGAAGTTCTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATAC
TTGCACAGAGGCAGCTCTATGAGGGATGTGTGGACACTGCACTGAAGACAGTGGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAG
CCCAATCACTGAGTATCAATTCTGGATGTGCAGTGTATGCAAACACGGTGTCCTTGCTCAGGAAATAAGCCACTACAGCTTCTGCCCCTT
ATGCCATAGTCCAGTGGGATAAAGGAATGATAAACTGTATATAACTGTAAAATATATGTAGCATATATACATGGCTATATGCTGTATATG
TAATAAGGTTTATTTCTGTGAGTTTTGTATGAAAATCAGCCTCATTATTTATAGTTGAATTTTTGCACAAAATATATGTTAATAAAATAA
TTTTTATGGCAATACAACTGTGAAATAATAAGGCCGATTTTCATATAAATGTATGAAAATCAACCATGTTTTCTCTCACCCTCTCTCTTT

>In-frame_PUM2_ENST00000319801_chr2_20527071_-_WDR35_ENST00000281405_chr2_20130313_-_3921nt
AACAGGTTTGATCTGTGGATGAAATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGG
CTGGTTTGCTGGAAGAAGAAGTTCTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATAC
TTGCACAGAGGCAGCTCTATGAGGGATGTGTGGACACTGCACTGAAGACAGCTCTTCACCTGAAAGACTATGAAGACATCATCCCTCCTG
TGGAGATCTACTCTCTGCTAGCACTCTGCGCATGCGCCAGCAGAGCCTTTGGGACTTGTTCAAAAGCTTTCATTAAACTTAAATCTTTAG
AGACCCTCAGTTCAGAACAGAAACAGCAGTATGAAGACCTTGCTTTAGAAATCTTCACCAAACATACTTCAAAAGATAACAGAAAACCTG
AATTGGACAGCCTTATGGAAGGTGGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAGCCCAATCACTGAGTATCAATTCTGGATGT
GCAGTGTATGCAAACACGGTGTCCTTGCTCAGGAAATAAGCCACTACAGCTTCTGCCCCTTATGCCATAGTCCAGTGGGATAAAGGAATG
ATAAACTGTATATAACTGTAAAATATATGTAGCATATATACATGGCTATATGCTGTATATGTAATAAGGTTTATTTCTGTGAGTTTTGTA
TGAAAATCAGCCTCATTATTTATAGTTGAATTTTTGCACAAAATATATGTTAATAAAATAATTTTTATGGCAATACAACTGTGAAATAAT
AAGGCCGATTTTCATATAAATGTATGAAAATCAACCATGTTTTCTCTCACCCTCTCTCTTTTGTTTATCTTGTTTTTGGTTACATGATAC
CATGGAAATATTCCAAATAAATTTTTTTCTCACAGTGTCAAGGTAACTGAATTCATTAAAAAATCTTGAAGGGAGTAGGGAGTGGGGGAA
GCATGGGAGTGGGGCAAAGTTGAATTTAGAGAATTTTTATAACCCATGTTACAAGGAAGTTAAACAATTGTAATAATGAAATGAGCTTTC
TCTATAGCCATATTTAATTAAATAAGTGTCGAATGTCTTCTTTATTGTATTTTCAGAAGTGAGGCGATGGCATTTTAAGACATTTTTTAC
AATCTGAATTGTTTCTAATAGCCCTATTCTTCTATTTTAAAACCTGTCCTTTTAGTCTCATTTAAGAGATGGCATTTGGAATTTACACTT
TCATATGATTGTGCAGAAAACTTGCCTCTATTTATAATGAAGATAACTTAAACAGAAATATCCATTTTGTAGTTATAGCTTCTGTTGAAA
CATTGTCACTAAGTTGGACCGTTTATTTACACAAGTATTGTTGAGGGAGTGATTTTTTCTTGATATGCGTCTGTTTTCATTTATTATTAA
TTTGAAAGATAAACAGTTGTGATCCATAATGGATCATTTCTTATGTCTTTTACATAGCTAATAATGTTCTCTGTTTATTTCTCATGAATT
CCCATTTTGTGGCTAAAGACCAGACCTTTGCACTATTTCATCAAGATTATTTTATTGAGGTTTGGCTTACATATAGTAGAGGCAATACAT
AGAGATACGCAACTTTGTTTTTGCAGCTACAATACACTTTCTCAATCTCATATGTTTTTGTCTTGTAGAGACAGAGACAAGTTCAGCATG
TTGCAGATTGGGAATAGTGAGCTATGAGAAGAGATTTAGAGCCTAGATGAGCTTAGGATAGAGAGTGGGCTCATTGGCCTAAATAAAAAG
AGAAGACCAGAAGTCTTTGAGGTCTCTGTCTCTATTCATGCGCCTCGTGGAAAATTACCTTGGTACAATGGTAGCCTCTAAATAGACTGC
CTCGCAAGCTATTCCAGAGGTCATGGAACAGAAAGCCTTATAAACCAAATAAAAATTCTCAAAATACATTGGTTTATTGAACCAATTTGC
AATACACAGTGAGGAACAAGGAGAAAGCAATGATAGATTAACACTGTTAGTGTAACGTGCCAGTGGAGTGGAAAGACCGCAACACCTGAA
TCCTGGGTTTTGTAATGTTTTTATGTCCTGACTCACATTCTGTCACATACGCTTTCCCCTAATAGTCGGGTTACAAAAAGGACCAGAGTG
GCCGCTTGAGCCAGATGACTCAATCAGATGAAATGTGCCTGAGGCCAACGATGTACACTTGCTCTATAGAAGGGTGTCAGGGGCAAGTAC
ACTTCACCACAGCAATAGCTTGCCTATTAGTCTGCTGAGCAGTCATGAATTTTATTGTATTTCTTGGGTAAGGACAGGCCAGAATGAGTG
TCACCAGTGGGTAATTGAATCAACTTCTCACACATACTGAAGGCTTTATATGTCTCATGCATACTTAGTGTATCATGAATATTTGGTATC
TTTGTGGCTTTTCATATTTTTAGTGCTTCATGAATATTTGGTATCTCTTGCTCCTTTCTATCTGTGGTCACACATACACGCTCTATTAAC
TTTGCCTAATAAGTCTCCTAGGTTACTAACTTACTTACCTAAATGTAACACAATGAATTCCAGCTTTCTCATTTGTTCTATACCAGAATG
GGAAATTTCCCCAAATCAGAAAATCACATCCTAACAAAGAAGTCTGTCTAAGACAGTACATCTCCTGTTGAACTTGCATCTTTCCACAGG
ACTTTCTGTTTTTAGGGATGAGACTATTCTCTGCTTCATCAAGGAAAGAGAAATGTTCAGGGTTGTAGGGATGGCACACTTATTAGTTCT
GCCTGTCTGAAAGGTTCCTGCAGGACAGTTTGGTCAGAGCTGCAATTCTTAGTCCATGGTCTAATGCTTGAGTATCTCTTCTTTCCCTTT
CCTGTCTCAGGAATCAGCTGAGAATTCATTCGATTGTCATGCCTCTAGCCCCTTACTGTGATTTGTTGGTTGCACTTTCATTTGCTTTAG
TTCTAGAATCACCTGTTGACTCCTCAGACTTCACCTAACTTTGGAAACTCTCTTTTGGAGGCTTCTCATTTCCCCCTAATTCTGTGCTGC
CTGAGCCCTAGAATTTTCCCACCAACGAATTATTCCAGGTAGATCCTAAGTTGCTGGATCTAGTTGATATTTAAACAATATCTAGTTGAT
ATTTCTCATTCAGTTGGATCCAGAAACCAGTATCTCTAAAAACAACCTCTCATACCTTGTGGACCTAATTTTGTGTGCGTGTGTGTGTGC
GCGCATATGTATATAGACAGGCACATCTTTTTTACTTTTGTAAAAGCTTATGCCTCTTTGGTATCTATATCTGTGAAAGTTTTAATGATC
TGCCATAATGTCTTGGGGACCTTTGTCTTCTGTGTAAATGGTACTAGAGAAAACACCTATATTATGAGTCAATCTAGTTGGTTTTATTCG
ACATGAAGGAAATTTCCAGATAACAACACTAACAAACTCTCCCTTGACTAGGGGGACAAAGAAAAGCAAAACTGACCATAAAAAACAATT
ACCTGGTGAGAAGTTGCATAAACAGAATTAGGTAGTATATTGAAGACAGCATCATTAAACAGTTATGTTGTTCTCCTTGCAAAAAACATG
TACTGACTTCCCGTTGAGTAATGCCAAGTTGTTTTTTTTATTATAAAACTTGCCCTTCATTACATGTTTCAAAGTGGTGTGGTGGGCCAA
AATATTGAAATGATGGAACTGACTGATAAAGCTGTACAAATAAGCAGTGTGCCTAACAAGCAACACAGTAATGTTGACATGCTTAATTCA
CAAATGCTAATTTCATTATAAATTGTTTTGCTAAAATACACTTTGAAACTATTTTTCTGTATTCCAAGAGCTGAGATCTTAGATTTTATG

>In-frame_PUM2_ENST00000319801_chr2_20527071_-_WDR35_ENST00000345530_chr2_20130313_-_3921nt
AACAGGTTTGATCTGTGGATGAAATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGG
CTGGTTTGCTGGAAGAAGAAGTTCTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATAC
TTGCACAGAGGCAGCTCTATGAGGGATGTGTGGACACTGCACTGAAGACAGCTCTTCACCTGAAAGACTATGAAGACATCATCCCTCCTG
TGGAGATCTACTCTCTGCTAGCACTCTGCGCATGCGCCAGCAGAGCCTTTGGGACTTGTTCAAAAGCTTTCATTAAACTTAAATCTTTAG
AGACCCTCAGTTCAGAACAGAAACAGCAGTATGAAGACCTTGCTTTAGAAATCTTCACCAAACATACTTCAAAAGATAACAGAAAACCTG
AATTGGACAGCCTTATGGAAGGTGGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAGCCCAATCACTGAGTATCAATTCTGGATGT
GCAGTGTATGCAAACACGGTGTCCTTGCTCAGGAAATAAGCCACTACAGCTTCTGCCCCTTATGCCATAGTCCAGTGGGATAAAGGAATG
ATAAACTGTATATAACTGTAAAATATATGTAGCATATATACATGGCTATATGCTGTATATGTAATAAGGTTTATTTCTGTGAGTTTTGTA
TGAAAATCAGCCTCATTATTTATAGTTGAATTTTTGCACAAAATATATGTTAATAAAATAATTTTTATGGCAATACAACTGTGAAATAAT
AAGGCCGATTTTCATATAAATGTATGAAAATCAACCATGTTTTCTCTCACCCTCTCTCTTTTGTTTATCTTGTTTTTGGTTACATGATAC
CATGGAAATATTCCAAATAAATTTTTTTCTCACAGTGTCAAGGTAACTGAATTCATTAAAAAATCTTGAAGGGAGTAGGGAGTGGGGGAA
GCATGGGAGTGGGGCAAAGTTGAATTTAGAGAATTTTTATAACCCATGTTACAAGGAAGTTAAACAATTGTAATAATGAAATGAGCTTTC
TCTATAGCCATATTTAATTAAATAAGTGTCGAATGTCTTCTTTATTGTATTTTCAGAAGTGAGGCGATGGCATTTTAAGACATTTTTTAC
AATCTGAATTGTTTCTAATAGCCCTATTCTTCTATTTTAAAACCTGTCCTTTTAGTCTCATTTAAGAGATGGCATTTGGAATTTACACTT
TCATATGATTGTGCAGAAAACTTGCCTCTATTTATAATGAAGATAACTTAAACAGAAATATCCATTTTGTAGTTATAGCTTCTGTTGAAA
CATTGTCACTAAGTTGGACCGTTTATTTACACAAGTATTGTTGAGGGAGTGATTTTTTCTTGATATGCGTCTGTTTTCATTTATTATTAA
TTTGAAAGATAAACAGTTGTGATCCATAATGGATCATTTCTTATGTCTTTTACATAGCTAATAATGTTCTCTGTTTATTTCTCATGAATT
CCCATTTTGTGGCTAAAGACCAGACCTTTGCACTATTTCATCAAGATTATTTTATTGAGGTTTGGCTTACATATAGTAGAGGCAATACAT
AGAGATACGCAACTTTGTTTTTGCAGCTACAATACACTTTCTCAATCTCATATGTTTTTGTCTTGTAGAGACAGAGACAAGTTCAGCATG
TTGCAGATTGGGAATAGTGAGCTATGAGAAGAGATTTAGAGCCTAGATGAGCTTAGGATAGAGAGTGGGCTCATTGGCCTAAATAAAAAG
AGAAGACCAGAAGTCTTTGAGGTCTCTGTCTCTATTCATGCGCCTCGTGGAAAATTACCTTGGTACAATGGTAGCCTCTAAATAGACTGC
CTCGCAAGCTATTCCAGAGGTCATGGAACAGAAAGCCTTATAAACCAAATAAAAATTCTCAAAATACATTGGTTTATTGAACCAATTTGC
AATACACAGTGAGGAACAAGGAGAAAGCAATGATAGATTAACACTGTTAGTGTAACGTGCCAGTGGAGTGGAAAGACCGCAACACCTGAA
TCCTGGGTTTTGTAATGTTTTTATGTCCTGACTCACATTCTGTCACATACGCTTTCCCCTAATAGTCGGGTTACAAAAAGGACCAGAGTG
GCCGCTTGAGCCAGATGACTCAATCAGATGAAATGTGCCTGAGGCCAACGATGTACACTTGCTCTATAGAAGGGTGTCAGGGGCAAGTAC
ACTTCACCACAGCAATAGCTTGCCTATTAGTCTGCTGAGCAGTCATGAATTTTATTGTATTTCTTGGGTAAGGACAGGCCAGAATGAGTG
TCACCAGTGGGTAATTGAATCAACTTCTCACACATACTGAAGGCTTTATATGTCTCATGCATACTTAGTGTATCATGAATATTTGGTATC
TTTGTGGCTTTTCATATTTTTAGTGCTTCATGAATATTTGGTATCTCTTGCTCCTTTCTATCTGTGGTCACACATACACGCTCTATTAAC
TTTGCCTAATAAGTCTCCTAGGTTACTAACTTACTTACCTAAATGTAACACAATGAATTCCAGCTTTCTCATTTGTTCTATACCAGAATG
GGAAATTTCCCCAAATCAGAAAATCACATCCTAACAAAGAAGTCTGTCTAAGACAGTACATCTCCTGTTGAACTTGCATCTTTCCACAGG
ACTTTCTGTTTTTAGGGATGAGACTATTCTCTGCTTCATCAAGGAAAGAGAAATGTTCAGGGTTGTAGGGATGGCACACTTATTAGTTCT
GCCTGTCTGAAAGGTTCCTGCAGGACAGTTTGGTCAGAGCTGCAATTCTTAGTCCATGGTCTAATGCTTGAGTATCTCTTCTTTCCCTTT
CCTGTCTCAGGAATCAGCTGAGAATTCATTCGATTGTCATGCCTCTAGCCCCTTACTGTGATTTGTTGGTTGCACTTTCATTTGCTTTAG
TTCTAGAATCACCTGTTGACTCCTCAGACTTCACCTAACTTTGGAAACTCTCTTTTGGAGGCTTCTCATTTCCCCCTAATTCTGTGCTGC
CTGAGCCCTAGAATTTTCCCACCAACGAATTATTCCAGGTAGATCCTAAGTTGCTGGATCTAGTTGATATTTAAACAATATCTAGTTGAT
ATTTCTCATTCAGTTGGATCCAGAAACCAGTATCTCTAAAAACAACCTCTCATACCTTGTGGACCTAATTTTGTGTGCGTGTGTGTGTGC
GCGCATATGTATATAGACAGGCACATCTTTTTTACTTTTGTAAAAGCTTATGCCTCTTTGGTATCTATATCTGTGAAAGTTTTAATGATC
TGCCATAATGTCTTGGGGACCTTTGTCTTCTGTGTAAATGGTACTAGAGAAAACACCTATATTATGAGTCAATCTAGTTGGTTTTATTCG
ACATGAAGGAAATTTCCAGATAACAACACTAACAAACTCTCCCTTGACTAGGGGGACAAAGAAAAGCAAAACTGACCATAAAAAACAATT
ACCTGGTGAGAAGTTGCATAAACAGAATTAGGTAGTATATTGAAGACAGCATCATTAAACAGTTATGTTGTTCTCCTTGCAAAAAACATG
TACTGACTTCCCGTTGAGTAATGCCAAGTTGTTTTTTTTATTATAAAACTTGCCCTTCATTACATGTTTCAAAGTGGTGTGGTGGGCCAA
AATATTGAAATGATGGAACTGACTGATAAAGCTGTACAAATAAGCAGTGTGCCTAACAAGCAACACAGTAATGTTGACATGCTTAATTCA
CAAATGCTAATTTCATTATAAATTGTTTTGCTAAAATACACTTTGAAACTATTTTTCTGTATTCCAAGAGCTGAGATCTTAGATTTTATG

>In-frame_PUM2_ENST00000319801_chr2_20527071_-_WDR35_ENST00000416055_chr2_20130313_-_698nt
AACAGGTTTGATCTGTGGATGAAATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGG
CTGGTTTGCTGGAAGAAGAAGTTCTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATAC
TTGCACAGAGGCAGCTCTATGAGGGATGTGTGGACACTGCACTGAAGACAGTGGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAG
CCCAATCACTGAGTATCAATTCTGGATGTGCAGTGTATGCAAACACGGTGTCCTTGCTCAGGAAATAAGCCACTACAGCTTCTGCCCCTT
ATGCCATAGTCCAGTGGGATAAAGGAATGATAAACTGTATATAACTGTAAAATATATGTAGCATATATACATGGCTATATGCTGTATATG
TAATAAGGTTTATTTCTGTGAGTTTTGTATGAAAATCAGCCTCATTATTTATAGTTGAATTTTTGCACAAAATATATGTTAATAAAATAA
TTTTTATGGCAATACAACTGTGAAATAATAAGGCCGATTTTCATATAAATGTATGAAAATCAACCATGTTTTCTCTCACCCTCTCTCTTT

>In-frame_PUM2_ENST00000361078_chr2_20527071_-_WDR35_ENST00000281405_chr2_20130313_-_3921nt
AACAGGTTTGATCTGTGGATGAAATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGG
CTGGTTTGCTGGAAGAAGAAGTTCTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATAC
TTGCACAGAGGCAGCTCTATGAGGGATGTGTGGACACTGCACTGAAGACAGCTCTTCACCTGAAAGACTATGAAGACATCATCCCTCCTG
TGGAGATCTACTCTCTGCTAGCACTCTGCGCATGCGCCAGCAGAGCCTTTGGGACTTGTTCAAAAGCTTTCATTAAACTTAAATCTTTAG
AGACCCTCAGTTCAGAACAGAAACAGCAGTATGAAGACCTTGCTTTAGAAATCTTCACCAAACATACTTCAAAAGATAACAGAAAACCTG
AATTGGACAGCCTTATGGAAGGTGGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAGCCCAATCACTGAGTATCAATTCTGGATGT
GCAGTGTATGCAAACACGGTGTCCTTGCTCAGGAAATAAGCCACTACAGCTTCTGCCCCTTATGCCATAGTCCAGTGGGATAAAGGAATG
ATAAACTGTATATAACTGTAAAATATATGTAGCATATATACATGGCTATATGCTGTATATGTAATAAGGTTTATTTCTGTGAGTTTTGTA
TGAAAATCAGCCTCATTATTTATAGTTGAATTTTTGCACAAAATATATGTTAATAAAATAATTTTTATGGCAATACAACTGTGAAATAAT
AAGGCCGATTTTCATATAAATGTATGAAAATCAACCATGTTTTCTCTCACCCTCTCTCTTTTGTTTATCTTGTTTTTGGTTACATGATAC
CATGGAAATATTCCAAATAAATTTTTTTCTCACAGTGTCAAGGTAACTGAATTCATTAAAAAATCTTGAAGGGAGTAGGGAGTGGGGGAA
GCATGGGAGTGGGGCAAAGTTGAATTTAGAGAATTTTTATAACCCATGTTACAAGGAAGTTAAACAATTGTAATAATGAAATGAGCTTTC
TCTATAGCCATATTTAATTAAATAAGTGTCGAATGTCTTCTTTATTGTATTTTCAGAAGTGAGGCGATGGCATTTTAAGACATTTTTTAC
AATCTGAATTGTTTCTAATAGCCCTATTCTTCTATTTTAAAACCTGTCCTTTTAGTCTCATTTAAGAGATGGCATTTGGAATTTACACTT
TCATATGATTGTGCAGAAAACTTGCCTCTATTTATAATGAAGATAACTTAAACAGAAATATCCATTTTGTAGTTATAGCTTCTGTTGAAA
CATTGTCACTAAGTTGGACCGTTTATTTACACAAGTATTGTTGAGGGAGTGATTTTTTCTTGATATGCGTCTGTTTTCATTTATTATTAA
TTTGAAAGATAAACAGTTGTGATCCATAATGGATCATTTCTTATGTCTTTTACATAGCTAATAATGTTCTCTGTTTATTTCTCATGAATT
CCCATTTTGTGGCTAAAGACCAGACCTTTGCACTATTTCATCAAGATTATTTTATTGAGGTTTGGCTTACATATAGTAGAGGCAATACAT
AGAGATACGCAACTTTGTTTTTGCAGCTACAATACACTTTCTCAATCTCATATGTTTTTGTCTTGTAGAGACAGAGACAAGTTCAGCATG
TTGCAGATTGGGAATAGTGAGCTATGAGAAGAGATTTAGAGCCTAGATGAGCTTAGGATAGAGAGTGGGCTCATTGGCCTAAATAAAAAG
AGAAGACCAGAAGTCTTTGAGGTCTCTGTCTCTATTCATGCGCCTCGTGGAAAATTACCTTGGTACAATGGTAGCCTCTAAATAGACTGC
CTCGCAAGCTATTCCAGAGGTCATGGAACAGAAAGCCTTATAAACCAAATAAAAATTCTCAAAATACATTGGTTTATTGAACCAATTTGC
AATACACAGTGAGGAACAAGGAGAAAGCAATGATAGATTAACACTGTTAGTGTAACGTGCCAGTGGAGTGGAAAGACCGCAACACCTGAA
TCCTGGGTTTTGTAATGTTTTTATGTCCTGACTCACATTCTGTCACATACGCTTTCCCCTAATAGTCGGGTTACAAAAAGGACCAGAGTG
GCCGCTTGAGCCAGATGACTCAATCAGATGAAATGTGCCTGAGGCCAACGATGTACACTTGCTCTATAGAAGGGTGTCAGGGGCAAGTAC
ACTTCACCACAGCAATAGCTTGCCTATTAGTCTGCTGAGCAGTCATGAATTTTATTGTATTTCTTGGGTAAGGACAGGCCAGAATGAGTG
TCACCAGTGGGTAATTGAATCAACTTCTCACACATACTGAAGGCTTTATATGTCTCATGCATACTTAGTGTATCATGAATATTTGGTATC
TTTGTGGCTTTTCATATTTTTAGTGCTTCATGAATATTTGGTATCTCTTGCTCCTTTCTATCTGTGGTCACACATACACGCTCTATTAAC
TTTGCCTAATAAGTCTCCTAGGTTACTAACTTACTTACCTAAATGTAACACAATGAATTCCAGCTTTCTCATTTGTTCTATACCAGAATG
GGAAATTTCCCCAAATCAGAAAATCACATCCTAACAAAGAAGTCTGTCTAAGACAGTACATCTCCTGTTGAACTTGCATCTTTCCACAGG
ACTTTCTGTTTTTAGGGATGAGACTATTCTCTGCTTCATCAAGGAAAGAGAAATGTTCAGGGTTGTAGGGATGGCACACTTATTAGTTCT
GCCTGTCTGAAAGGTTCCTGCAGGACAGTTTGGTCAGAGCTGCAATTCTTAGTCCATGGTCTAATGCTTGAGTATCTCTTCTTTCCCTTT
CCTGTCTCAGGAATCAGCTGAGAATTCATTCGATTGTCATGCCTCTAGCCCCTTACTGTGATTTGTTGGTTGCACTTTCATTTGCTTTAG
TTCTAGAATCACCTGTTGACTCCTCAGACTTCACCTAACTTTGGAAACTCTCTTTTGGAGGCTTCTCATTTCCCCCTAATTCTGTGCTGC
CTGAGCCCTAGAATTTTCCCACCAACGAATTATTCCAGGTAGATCCTAAGTTGCTGGATCTAGTTGATATTTAAACAATATCTAGTTGAT
ATTTCTCATTCAGTTGGATCCAGAAACCAGTATCTCTAAAAACAACCTCTCATACCTTGTGGACCTAATTTTGTGTGCGTGTGTGTGTGC
GCGCATATGTATATAGACAGGCACATCTTTTTTACTTTTGTAAAAGCTTATGCCTCTTTGGTATCTATATCTGTGAAAGTTTTAATGATC
TGCCATAATGTCTTGGGGACCTTTGTCTTCTGTGTAAATGGTACTAGAGAAAACACCTATATTATGAGTCAATCTAGTTGGTTTTATTCG
ACATGAAGGAAATTTCCAGATAACAACACTAACAAACTCTCCCTTGACTAGGGGGACAAAGAAAAGCAAAACTGACCATAAAAAACAATT
ACCTGGTGAGAAGTTGCATAAACAGAATTAGGTAGTATATTGAAGACAGCATCATTAAACAGTTATGTTGTTCTCCTTGCAAAAAACATG
TACTGACTTCCCGTTGAGTAATGCCAAGTTGTTTTTTTTATTATAAAACTTGCCCTTCATTACATGTTTCAAAGTGGTGTGGTGGGCCAA
AATATTGAAATGATGGAACTGACTGATAAAGCTGTACAAATAAGCAGTGTGCCTAACAAGCAACACAGTAATGTTGACATGCTTAATTCA
CAAATGCTAATTTCATTATAAATTGTTTTGCTAAAATACACTTTGAAACTATTTTTCTGTATTCCAAGAGCTGAGATCTTAGATTTTATG

>In-frame_PUM2_ENST00000361078_chr2_20527071_-_WDR35_ENST00000345530_chr2_20130313_-_3921nt
AACAGGTTTGATCTGTGGATGAAATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGG
CTGGTTTGCTGGAAGAAGAAGTTCTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATAC
TTGCACAGAGGCAGCTCTATGAGGGATGTGTGGACACTGCACTGAAGACAGCTCTTCACCTGAAAGACTATGAAGACATCATCCCTCCTG
TGGAGATCTACTCTCTGCTAGCACTCTGCGCATGCGCCAGCAGAGCCTTTGGGACTTGTTCAAAAGCTTTCATTAAACTTAAATCTTTAG
AGACCCTCAGTTCAGAACAGAAACAGCAGTATGAAGACCTTGCTTTAGAAATCTTCACCAAACATACTTCAAAAGATAACAGAAAACCTG
AATTGGACAGCCTTATGGAAGGTGGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAGCCCAATCACTGAGTATCAATTCTGGATGT
GCAGTGTATGCAAACACGGTGTCCTTGCTCAGGAAATAAGCCACTACAGCTTCTGCCCCTTATGCCATAGTCCAGTGGGATAAAGGAATG
ATAAACTGTATATAACTGTAAAATATATGTAGCATATATACATGGCTATATGCTGTATATGTAATAAGGTTTATTTCTGTGAGTTTTGTA
TGAAAATCAGCCTCATTATTTATAGTTGAATTTTTGCACAAAATATATGTTAATAAAATAATTTTTATGGCAATACAACTGTGAAATAAT
AAGGCCGATTTTCATATAAATGTATGAAAATCAACCATGTTTTCTCTCACCCTCTCTCTTTTGTTTATCTTGTTTTTGGTTACATGATAC
CATGGAAATATTCCAAATAAATTTTTTTCTCACAGTGTCAAGGTAACTGAATTCATTAAAAAATCTTGAAGGGAGTAGGGAGTGGGGGAA
GCATGGGAGTGGGGCAAAGTTGAATTTAGAGAATTTTTATAACCCATGTTACAAGGAAGTTAAACAATTGTAATAATGAAATGAGCTTTC
TCTATAGCCATATTTAATTAAATAAGTGTCGAATGTCTTCTTTATTGTATTTTCAGAAGTGAGGCGATGGCATTTTAAGACATTTTTTAC
AATCTGAATTGTTTCTAATAGCCCTATTCTTCTATTTTAAAACCTGTCCTTTTAGTCTCATTTAAGAGATGGCATTTGGAATTTACACTT
TCATATGATTGTGCAGAAAACTTGCCTCTATTTATAATGAAGATAACTTAAACAGAAATATCCATTTTGTAGTTATAGCTTCTGTTGAAA
CATTGTCACTAAGTTGGACCGTTTATTTACACAAGTATTGTTGAGGGAGTGATTTTTTCTTGATATGCGTCTGTTTTCATTTATTATTAA
TTTGAAAGATAAACAGTTGTGATCCATAATGGATCATTTCTTATGTCTTTTACATAGCTAATAATGTTCTCTGTTTATTTCTCATGAATT
CCCATTTTGTGGCTAAAGACCAGACCTTTGCACTATTTCATCAAGATTATTTTATTGAGGTTTGGCTTACATATAGTAGAGGCAATACAT
AGAGATACGCAACTTTGTTTTTGCAGCTACAATACACTTTCTCAATCTCATATGTTTTTGTCTTGTAGAGACAGAGACAAGTTCAGCATG
TTGCAGATTGGGAATAGTGAGCTATGAGAAGAGATTTAGAGCCTAGATGAGCTTAGGATAGAGAGTGGGCTCATTGGCCTAAATAAAAAG
AGAAGACCAGAAGTCTTTGAGGTCTCTGTCTCTATTCATGCGCCTCGTGGAAAATTACCTTGGTACAATGGTAGCCTCTAAATAGACTGC
CTCGCAAGCTATTCCAGAGGTCATGGAACAGAAAGCCTTATAAACCAAATAAAAATTCTCAAAATACATTGGTTTATTGAACCAATTTGC
AATACACAGTGAGGAACAAGGAGAAAGCAATGATAGATTAACACTGTTAGTGTAACGTGCCAGTGGAGTGGAAAGACCGCAACACCTGAA
TCCTGGGTTTTGTAATGTTTTTATGTCCTGACTCACATTCTGTCACATACGCTTTCCCCTAATAGTCGGGTTACAAAAAGGACCAGAGTG
GCCGCTTGAGCCAGATGACTCAATCAGATGAAATGTGCCTGAGGCCAACGATGTACACTTGCTCTATAGAAGGGTGTCAGGGGCAAGTAC
ACTTCACCACAGCAATAGCTTGCCTATTAGTCTGCTGAGCAGTCATGAATTTTATTGTATTTCTTGGGTAAGGACAGGCCAGAATGAGTG
TCACCAGTGGGTAATTGAATCAACTTCTCACACATACTGAAGGCTTTATATGTCTCATGCATACTTAGTGTATCATGAATATTTGGTATC
TTTGTGGCTTTTCATATTTTTAGTGCTTCATGAATATTTGGTATCTCTTGCTCCTTTCTATCTGTGGTCACACATACACGCTCTATTAAC
TTTGCCTAATAAGTCTCCTAGGTTACTAACTTACTTACCTAAATGTAACACAATGAATTCCAGCTTTCTCATTTGTTCTATACCAGAATG
GGAAATTTCCCCAAATCAGAAAATCACATCCTAACAAAGAAGTCTGTCTAAGACAGTACATCTCCTGTTGAACTTGCATCTTTCCACAGG
ACTTTCTGTTTTTAGGGATGAGACTATTCTCTGCTTCATCAAGGAAAGAGAAATGTTCAGGGTTGTAGGGATGGCACACTTATTAGTTCT
GCCTGTCTGAAAGGTTCCTGCAGGACAGTTTGGTCAGAGCTGCAATTCTTAGTCCATGGTCTAATGCTTGAGTATCTCTTCTTTCCCTTT
CCTGTCTCAGGAATCAGCTGAGAATTCATTCGATTGTCATGCCTCTAGCCCCTTACTGTGATTTGTTGGTTGCACTTTCATTTGCTTTAG
TTCTAGAATCACCTGTTGACTCCTCAGACTTCACCTAACTTTGGAAACTCTCTTTTGGAGGCTTCTCATTTCCCCCTAATTCTGTGCTGC
CTGAGCCCTAGAATTTTCCCACCAACGAATTATTCCAGGTAGATCCTAAGTTGCTGGATCTAGTTGATATTTAAACAATATCTAGTTGAT
ATTTCTCATTCAGTTGGATCCAGAAACCAGTATCTCTAAAAACAACCTCTCATACCTTGTGGACCTAATTTTGTGTGCGTGTGTGTGTGC
GCGCATATGTATATAGACAGGCACATCTTTTTTACTTTTGTAAAAGCTTATGCCTCTTTGGTATCTATATCTGTGAAAGTTTTAATGATC
TGCCATAATGTCTTGGGGACCTTTGTCTTCTGTGTAAATGGTACTAGAGAAAACACCTATATTATGAGTCAATCTAGTTGGTTTTATTCG
ACATGAAGGAAATTTCCAGATAACAACACTAACAAACTCTCCCTTGACTAGGGGGACAAAGAAAAGCAAAACTGACCATAAAAAACAATT
ACCTGGTGAGAAGTTGCATAAACAGAATTAGGTAGTATATTGAAGACAGCATCATTAAACAGTTATGTTGTTCTCCTTGCAAAAAACATG
TACTGACTTCCCGTTGAGTAATGCCAAGTTGTTTTTTTTATTATAAAACTTGCCCTTCATTACATGTTTCAAAGTGGTGTGGTGGGCCAA
AATATTGAAATGATGGAACTGACTGATAAAGCTGTACAAATAAGCAGTGTGCCTAACAAGCAACACAGTAATGTTGACATGCTTAATTCA
CAAATGCTAATTTCATTATAAATTGTTTTGCTAAAATACACTTTGAAACTATTTTTCTGTATTCCAAGAGCTGAGATCTTAGATTTTATG

>In-frame_PUM2_ENST00000361078_chr2_20527071_-_WDR35_ENST00000416055_chr2_20130313_-_698nt
AACAGGTTTGATCTGTGGATGAAATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGGCCACTTCTGCCTTGG
CTGGTTTGCTGGAAGAAGAAGTTCTGTCTACAACAGATCGTTTCACAGATAATGCATGGAGAGGGGCAGAGGCTTACCACTTCTTTATAC
TTGCACAGAGGCAGCTCTATGAGGGATGTGTGGACACTGCACTGAAGACAGTGGAGAAGGGAAACTGCCAACATGCGTTGCCACAGGAAG
CCCAATCACTGAGTATCAATTCTGGATGTGCAGTGTATGCAAACACGGTGTCCTTGCTCAGGAAATAAGCCACTACAGCTTCTGCCCCTT
ATGCCATAGTCCAGTGGGATAAAGGAATGATAAACTGTATATAACTGTAAAATATATGTAGCATATATACATGGCTATATGCTGTATATG
TAATAAGGTTTATTTCTGTGAGTTTTGTATGAAAATCAGCCTCATTATTTATAGTTGAATTTTTGCACAAAATATATGTTAATAAAATAA
TTTTTATGGCAATACAACTGTGAAATAATAAGGCCGATTTTCATATAAATGTATGAAAATCAACCATGTTTTCTCTCACCCTCTCTCTTT


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FusionGenePPI for PUM2_WDR35


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PUM2PUM2, NANOS1, AURKA, MED4, ELAVL1, DAZ1, DAZL, NANOS3, BMI1, RBFOX2, ILF2, NTRK1, SAMD1, RBM45, CLASRP, ELAVL2, CELF5, STRBP, CDX1, LITAF, TRIM25, G3BP1WDR35BCL6, ALYREF, CUL3, C11orf74, IFT122, NTRK1, KIF2A, MAD2L1, PCNT, AURKA, RNPS1, SGTB, ZSCAN26, IFT43, TULP3, TULP2, DNAJC7, WDR19, IFT140, TTC21B, NTPCR, NUDC, NEK7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePUM2chr2:20527071chr2:20130313ENST00000319801-1191_26017988SNAPIN
HgenePUM2chr2:20527071chr2:20130313ENST00000338086-1201_260171065SNAPIN
HgenePUM2chr2:20527071chr2:20130313ENST00000361078-1201_260171067SNAPIN
HgenePUM2chr2:20527071chr2:20130313ENST00000403432-2211_260171065SNAPIN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PUM2_WDR35


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PUM2_WDR35


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWDR35C0010278Craniosynostosis1CTD_human
TgeneWDR35C3150874CRANIOECTODERMAL DYSPLASIA 21CTD_human;UNIPROT
TgeneWDR35C3279792SHORT-RIB THORACIC DYSPLASIA 7 WITH OR WITHOUT POLYDACTYLY1UNIPROT