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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29673

FusionGeneSummary for PUM2_ATF5

check button Fusion gene summary
Fusion gene informationFusion gene name: PUM2_ATF5
Fusion gene ID: 29673
HgeneTgene
Gene symbol

PUM2

ATF5

Gene ID

23369

22809

Gene namepumilio RNA binding family member 2activating transcription factor 5
SynonymsPUMH2|PUML2ATFX|HMFN0395
Cytomap

2p24.1

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionpumilio homolog 2pumilio-2cyclic AMP-dependent transcription factor ATF-5cAMP-dependent transcription factor ATF-5transcription factor ATFx
Modification date2018052220180523
UniProtAcc

Q8TB72

Q9Y2D1

Ensembl transtripts involved in fusion geneENST00000338086, ENST00000319801, 
ENST00000361078, ENST00000536417, 
ENST00000403432, ENST00000420234, 
ENST00000595125, ENST00000423777, 
ENST00000600336, 
Fusion gene scores* DoF score12 X 11 X 8=10565 X 5 X 2=50
# samples 135
** MAII scorelog2(13/1056*10)=-3.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: PUM2 [Title/Abstract] AND ATF5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePUM2

GO:0010608

posttranscriptional regulation of gene expression

25100735

HgenePUM2

GO:0043488

regulation of mRNA stability

26724866

HgenePUM2

GO:0051983

regulation of chromosome segregation

26724866

HgenePUM2

GO:1900246

positive regulation of RIG-I signaling pathway

25340845

TgeneATF5

GO:0006355

regulation of transcription, DNA-templated

20654631

TgeneATF5

GO:0008285

negative regulation of cell proliferation

22528486

TgeneATF5

GO:0045892

negative regulation of transcription, DNA-templated

22528486

TgeneATF5

GO:0045893

positive regulation of transcription, DNA-templated

21212266|25512613

TgeneATF5

GO:0045944

positive regulation of transcription by RNA polymerase II

16300731

TgeneATF5

GO:0046605

regulation of centrosome cycle

26213385

TgeneATF5

GO:1902750

negative regulation of cell cycle G2/M phase transition

22528486


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE708509PUM2chr2

20450480

-ATF5chr19

50436873

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000338086ENST00000595125PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-3UTRENST00000338086ENST00000423777PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-intronENST00000338086ENST00000600336PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-intronENST00000319801ENST00000595125PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-3UTRENST00000319801ENST00000423777PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-intronENST00000319801ENST00000600336PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-intronENST00000361078ENST00000595125PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-3UTRENST00000361078ENST00000423777PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-intronENST00000361078ENST00000600336PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-intronENST00000536417ENST00000595125PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-3UTRENST00000536417ENST00000423777PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-intronENST00000536417ENST00000600336PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-intronENST00000403432ENST00000595125PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-3UTRENST00000403432ENST00000423777PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-intronENST00000403432ENST00000600336PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-intronENST00000420234ENST00000595125PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-3UTRENST00000420234ENST00000423777PUM2chr2

20450480

-ATF5chr19

50436873

+
intron-intronENST00000420234ENST00000600336PUM2chr2

20450480

-ATF5chr19

50436873

+

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FusionProtFeatures for PUM2_ATF5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PUM2

Q8TB72

ATF5

Q9Y2D1

Sequence-specific RNA-binding protein that acts as apost-transcriptional repressor by binding the 3'-UTR of mRNAtargets. Binds to an RNA consensus sequence, the Pumilio ResponseElement (PRE), 5'-UGUANAUA-3', that is related to the NanosResponse Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via differentmechanisms: acts via direct recruitment of the CCR4-POP2-NOTdeadenylase leading to translational inhibition and mRNAdegradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs(PubMed:18776931, PubMed:22345517). Acts as a post-transcriptionalrepressor of E2F3 mRNAs by binding to its 3'-UTR and facilitatingmiRNA regulation (PubMed:22345517). Plays a role in cytoplasmicsensing of viral infection (PubMed:25340845). Represses a programof genes necessary to maintain genomic stability such as keymitotic, DNA repair and DNA replication factors. Its ability torepress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its highabundance and multitude of PUMILIO binding sites, is able tosequester a significant fraction of PUM1 and PUM2 in the cytoplasm(PubMed:26724866). May regulate DCUN1D3 mRNA levels(PubMed:25349211). May support proliferation and self-renewal ofstem cells. Binds specifically to miRNA MIR199A precursor, withPUM1, regulates miRNA MIR199A expression at a postranscriptionallevel (PubMed:28431233). {ECO:0000269|PubMed:18776931,ECO:0000269|PubMed:21397187, ECO:0000269|PubMed:22345517,ECO:0000269|PubMed:22955276, ECO:0000269|PubMed:25340845,ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26724866,ECO:0000269|PubMed:28431233}. Transcription factor that either stimulates or repressesgene transcription through binding of different DNA regulatoryelements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE)(consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acidresponse element (AARE), present in many viral and cellularpromoters. Critically involved, often in a cell type-dependentmanner, in cell survival, proliferation, and differentiation(PubMed:10373550, PubMed:15358120, PubMed:21212266,PubMed:20654631). Its transcriptional activity is enhanced byCCND3 and slightly inhibited by CDK4 (PubMed:15358120). Importantregulator of the cerebral cortex formation, functions in cerebralcortical neuroprogenitor cells to maintain proliferation and toblock differentiation into neurons. Must be down-regulated inorder for such cells to exit the cycle and differentiate (Bysimilarity). Participates in the pathways by which SHH promotescerebellar granule neuron progenitor cells proliferation (Bysimilarity). Critical for survival of mature olfactory sensoryneurons (OSN), directs expression of OSN-specific genes (Bysimilarity). May be involved in osteogenic differentiation(PubMed:22442021). Promotes cell proliferation and survival byinducing the expression of EGR1 sinergistically with ELK1. Onceacetylated by EP300, binds to ARE sequences on target genespromoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2,this function seems to be cell type-dependent (By similarity).Cooperates with NR1I3/CAR in the transcriptional activation ofCYP2B6 in liver (PubMed:18332083). In hepatic cells, repressesCRE-dependent transcription and inhibits proliferation by blockingat G2/M phase (PubMed:22528486, PubMed:18701499). May act as anegative regulator of IL1B transduction pathway in liver(PubMed:24379400). Upon IL1B stimulus, cooperates with NLK toactivate the transactivation activity of C/EBP subfamily members(PubMed:25512613). Besides its function of transcription factor,acts as a cofactor of CEBPB to activate CEBPA and promoteadipocyte differentiation (PubMed:24216764). Regulates centrosomedynamics in a cell-cycle- and centriole-age-dependent manner.Forms 9-foci symmetrical ring scaffold around the mother centrioleto control centrosome function and the interaction betweencentrioles and pericentriolar material (PubMed:26213385).{ECO:0000250|UniProtKB:O70191, ECO:0000250|UniProtKB:Q6P788,ECO:0000269|PubMed:10373550, ECO:0000269|PubMed:15358120,ECO:0000269|PubMed:18332083, ECO:0000269|PubMed:18701499,ECO:0000269|PubMed:20654631, ECO:0000269|PubMed:21212266,ECO:0000269|PubMed:21791614, ECO:0000269|PubMed:22442021,ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:24216764,ECO:0000269|PubMed:24379400, ECO:0000269|PubMed:25512613,ECO:0000269|PubMed:26213385}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PUM2_ATF5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PUM2_ATF5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PUM2_ATF5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PUM2_ATF5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneATF5C0005586Bipolar Disorder1PSYGENET