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Fusion gene ID: 29603 |
FusionGeneSummary for PTPRU_GAB1 |
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Fusion gene information | Fusion gene name: PTPRU_GAB1 | Fusion gene ID: 29603 | Hgene | Tgene | Gene symbol | PTPRU | GAB1 | Gene ID | 10076 | 128869 |
Gene name | protein tyrosine phosphatase, receptor type U | phosphatidylinositol glycan anchor biosynthesis class U | |
Synonyms | FMI|PCP-2|PTP|PTP-J|PTP-PI|PTP-RO|PTPPSI|PTPRO|PTPU2|R-PTP-PSI|R-PTP-U|hPTP-J | CDC91L1|GAB1 | |
Cytomap | 1p35.3 | 20q11.22 | |
Type of gene | protein-coding | protein-coding | |
Description | receptor-type tyrosine-protein phosphatase UPTP piReceptor protein tyrosine phosphatase hPTP-Jpancreatic carcinoma phosphatase 2pi R-PTP-Psiprotein-tyrosine phosphatase Jprotein-tyrosine phosphatase piprotein-tyrosine phosphatase receptor omicronr | phosphatidylinositol glycan anchor biosynthesis class U proteinCDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1GPI transamidase component PIG-UGPI transamidase subunitcell division cycle 91-like 1 proteincell division cycle protein 91-li | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q92729 | Q13480 | |
Ensembl transtripts involved in fusion gene | ENST00000345512, ENST00000373779, ENST00000356870, ENST00000323874, ENST00000428026, ENST00000460170, ENST00000415600, | ENST00000262995, ENST00000262994, ENST00000505913, ENST00000515388, | |
Fusion gene scores | * DoF score | 6 X 5 X 6=180 | 6 X 4 X 4=96 |
# samples | 6 | 6 | |
** MAII score | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PTPRU [Title/Abstract] AND GAB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PTPRU | GO:0006470 | protein dephosphorylation | 12501215 |
Hgene | PTPRU | GO:0008285 | negative regulation of cell proliferation | 16574648 |
Hgene | PTPRU | GO:0030336 | negative regulation of cell migration | 12501215|16574648 |
Hgene | PTPRU | GO:0034394 | protein localization to cell surface | 16574648 |
Hgene | PTPRU | GO:0060070 | canonical Wnt signaling pathway | 16574648 |
Hgene | PTPRU | GO:0098609 | cell-cell adhesion | 16574648 |
Tgene | GAB1 | GO:0006506 | GPI anchor biosynthetic process | 15034568 |
Tgene | GAB1 | GO:0046425 | regulation of JAK-STAT cascade | 15034568 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA907583 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000345512 | ENST00000262995 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
intron-intron | ENST00000345512 | ENST00000262994 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
intron-intron | ENST00000345512 | ENST00000505913 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
intron-intron | ENST00000345512 | ENST00000515388 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-3UTR | ENST00000373779 | ENST00000262995 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-intron | ENST00000373779 | ENST00000262994 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-intron | ENST00000373779 | ENST00000505913 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-intron | ENST00000373779 | ENST00000515388 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-3UTR | ENST00000356870 | ENST00000262995 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-intron | ENST00000356870 | ENST00000262994 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-intron | ENST00000356870 | ENST00000505913 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-intron | ENST00000356870 | ENST00000515388 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-3UTR | ENST00000323874 | ENST00000262995 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-intron | ENST00000323874 | ENST00000262994 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-intron | ENST00000323874 | ENST00000505913 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-intron | ENST00000323874 | ENST00000515388 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-3UTR | ENST00000428026 | ENST00000262995 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-intron | ENST00000428026 | ENST00000262994 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-intron | ENST00000428026 | ENST00000505913 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-intron | ENST00000428026 | ENST00000515388 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-3UTR | ENST00000460170 | ENST00000262995 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-intron | ENST00000460170 | ENST00000262994 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-intron | ENST00000460170 | ENST00000505913 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
3UTR-intron | ENST00000460170 | ENST00000515388 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
intron-3UTR | ENST00000415600 | ENST00000262995 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
intron-intron | ENST00000415600 | ENST00000262994 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
intron-intron | ENST00000415600 | ENST00000505913 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
intron-intron | ENST00000415600 | ENST00000515388 | PTPRU | chr1 | 29652910 | - | GAB1 | chr4 | 144391895 | - |
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FusionProtFeatures for PTPRU_GAB1 |
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Hgene | Tgene |
PTPRU | GAB1 |
Adapter protein that plays a role in intracellularsignaling cascades triggered by activated receptor-type kinases.Plays a role in FGFR1 signaling. Probably involved in signaling bythe epidermal growth factor receptor (EGFR) and the insulinreceptor (INSR). |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PTPRU_GAB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PTPRU_GAB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTPRU_GAB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PTPRU_GAB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GAB1 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |