FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 29602

FusionGeneSummary for PTPRT_ZCCHC8

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRT_ZCCHC8
Fusion gene ID: 29602
HgeneTgene
Gene symbol

PTPRT

ZCCHC8

Gene ID

11122

55596

Gene nameprotein tyrosine phosphatase, receptor type Tzinc finger CCHC-type containing 8
SynonymsRPTPrho-
Cytomap

20q12-q13.11

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase TR-PTP-TRPTP-rhoreceptor protein tyrosine phosphatasereceptor-type tyrosine-protein phosphatase rhozinc finger CCHC domain-containing protein 8TRAMP-like complex RNA-binding factor ZCCHC8zinc finger, CCHC domain containing 8
Modification date2018051920180519
UniProtAcc

O14522

Q6NZY4

Ensembl transtripts involved in fusion geneENST00000373184, ENST00000373187, 
ENST00000356100, ENST00000373190, 
ENST00000373193, ENST00000373198, 
ENST00000373201, ENST00000485499, 
ENST00000536306, ENST00000543897, 
ENST00000336229, ENST00000538116, 
Fusion gene scores* DoF score5 X 5 X 4=1004 X 5 X 5=100
# samples 67
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRT [Title/Abstract] AND ZCCHC8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRT

GO:0006470

protein dephosphorylation

16973135

HgenePTPRT

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

18644975


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AL157434PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000373184ENST00000536306PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-5UTRENST00000373184ENST00000543897PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-intronENST00000373184ENST00000336229PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-intronENST00000373184ENST00000538116PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-3CDSENST00000373187ENST00000536306PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-5UTRENST00000373187ENST00000543897PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-intronENST00000373187ENST00000336229PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-intronENST00000373187ENST00000538116PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-3CDSENST00000356100ENST00000536306PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-5UTRENST00000356100ENST00000543897PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-intronENST00000356100ENST00000336229PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-intronENST00000356100ENST00000538116PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-3CDSENST00000373190ENST00000536306PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-5UTRENST00000373190ENST00000543897PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-intronENST00000373190ENST00000336229PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-intronENST00000373190ENST00000538116PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-3CDSENST00000373193ENST00000536306PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-5UTRENST00000373193ENST00000543897PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-intronENST00000373193ENST00000336229PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-intronENST00000373193ENST00000538116PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-3CDSENST00000373198ENST00000536306PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-5UTRENST00000373198ENST00000543897PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-intronENST00000373198ENST00000336229PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-intronENST00000373198ENST00000538116PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-3CDSENST00000373201ENST00000536306PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-5UTRENST00000373201ENST00000543897PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-intronENST00000373201ENST00000336229PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-intronENST00000373201ENST00000538116PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-3CDSENST00000485499ENST00000536306PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-5UTRENST00000485499ENST00000543897PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-intronENST00000485499ENST00000336229PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-
intron-intronENST00000485499ENST00000538116PTPRTchr20

41089951

-ZCCHC8chr12

122983869

-

Top

FusionProtFeatures for PTPRT_ZCCHC8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRT

O14522

ZCCHC8

Q6NZY4

Scaffolding subunit of the trimeric nuclear exosometargeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosomeis fundamental for the degradation of RNA in eukaryotic nuclei.Substrate targeting is facilitated by its cofactor MTREX, whichlinks to RNA-binding protein adapters (PubMed:27871484). May beinvolved in pre-mRNA splicing (Probable).{ECO:0000269|PubMed:27871484, ECO:0000305|PubMed:16263084}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PTPRT_ZCCHC8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PTPRT_ZCCHC8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PTPRT_ZCCHC8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PTPRT_ZCCHC8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZCCHC8C3714756Intellectual Disability1CTD_human