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Fusion gene ID: 29602 |
FusionGeneSummary for PTPRT_ZCCHC8 |
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Fusion gene information | Fusion gene name: PTPRT_ZCCHC8 | Fusion gene ID: 29602 | Hgene | Tgene | Gene symbol | PTPRT | ZCCHC8 | Gene ID | 11122 | 55596 |
Gene name | protein tyrosine phosphatase, receptor type T | zinc finger CCHC-type containing 8 | |
Synonyms | RPTPrho | - | |
Cytomap | 20q12-q13.11 | 12q24.31 | |
Type of gene | protein-coding | protein-coding | |
Description | receptor-type tyrosine-protein phosphatase TR-PTP-TRPTP-rhoreceptor protein tyrosine phosphatasereceptor-type tyrosine-protein phosphatase rho | zinc finger CCHC domain-containing protein 8TRAMP-like complex RNA-binding factor ZCCHC8zinc finger, CCHC domain containing 8 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O14522 | Q6NZY4 | |
Ensembl transtripts involved in fusion gene | ENST00000373184, ENST00000373187, ENST00000356100, ENST00000373190, ENST00000373193, ENST00000373198, ENST00000373201, ENST00000485499, | ENST00000536306, ENST00000543897, ENST00000336229, ENST00000538116, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 4 X 5 X 5=100 |
# samples | 6 | 7 | |
** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PTPRT [Title/Abstract] AND ZCCHC8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PTPRT | GO:0006470 | protein dephosphorylation | 16973135 |
Hgene | PTPRT | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 18644975 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AL157434 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000373184 | ENST00000536306 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-5UTR | ENST00000373184 | ENST00000543897 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-intron | ENST00000373184 | ENST00000336229 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-intron | ENST00000373184 | ENST00000538116 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-3CDS | ENST00000373187 | ENST00000536306 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-5UTR | ENST00000373187 | ENST00000543897 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-intron | ENST00000373187 | ENST00000336229 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-intron | ENST00000373187 | ENST00000538116 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-3CDS | ENST00000356100 | ENST00000536306 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-5UTR | ENST00000356100 | ENST00000543897 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-intron | ENST00000356100 | ENST00000336229 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-intron | ENST00000356100 | ENST00000538116 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-3CDS | ENST00000373190 | ENST00000536306 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-5UTR | ENST00000373190 | ENST00000543897 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-intron | ENST00000373190 | ENST00000336229 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-intron | ENST00000373190 | ENST00000538116 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-3CDS | ENST00000373193 | ENST00000536306 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-5UTR | ENST00000373193 | ENST00000543897 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-intron | ENST00000373193 | ENST00000336229 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-intron | ENST00000373193 | ENST00000538116 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-3CDS | ENST00000373198 | ENST00000536306 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-5UTR | ENST00000373198 | ENST00000543897 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-intron | ENST00000373198 | ENST00000336229 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-intron | ENST00000373198 | ENST00000538116 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-3CDS | ENST00000373201 | ENST00000536306 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-5UTR | ENST00000373201 | ENST00000543897 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-intron | ENST00000373201 | ENST00000336229 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-intron | ENST00000373201 | ENST00000538116 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-3CDS | ENST00000485499 | ENST00000536306 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-5UTR | ENST00000485499 | ENST00000543897 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-intron | ENST00000485499 | ENST00000336229 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
intron-intron | ENST00000485499 | ENST00000538116 | PTPRT | chr20 | 41089951 | - | ZCCHC8 | chr12 | 122983869 | - |
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FusionProtFeatures for PTPRT_ZCCHC8 |
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Hgene | Tgene |
PTPRT | ZCCHC8 |
Scaffolding subunit of the trimeric nuclear exosometargeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosomeis fundamental for the degradation of RNA in eukaryotic nuclei.Substrate targeting is facilitated by its cofactor MTREX, whichlinks to RNA-binding protein adapters (PubMed:27871484). May beinvolved in pre-mRNA splicing (Probable).{ECO:0000269|PubMed:27871484, ECO:0000305|PubMed:16263084}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PTPRT_ZCCHC8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PTPRT_ZCCHC8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTPRT_ZCCHC8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PTPRT_ZCCHC8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ZCCHC8 | C3714756 | Intellectual Disability | 1 | CTD_human |