![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 2960 |
FusionGeneSummary for ASH1L_CUL9 |
![]() |
Fusion gene information | Fusion gene name: ASH1L_CUL9 | Fusion gene ID: 2960 | Hgene | Tgene | Gene symbol | ASH1L | CUL9 | Gene ID | 55870 | 23113 |
Gene name | ASH1 like histone lysine methyltransferase | cullin 9 | |
Synonyms | ASH1|ASH1L1|KMT2H|MRD52 | H7AP1|PARC | |
Cytomap | 1q22 | 6p21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | histone-lysine N-methyltransferase ASH1LASH1-like proteinabsent small and homeotic disks protein 1 homologash1 (absent, small, or homeotic)-likelysine N-methyltransferase 2Hprobable histone-lysine N-methyltransferase ASH1L | cullin-9CUL-9UbcH7-associated protein 1p53-associated parkin-like cytoplasmic proteinparkin-like cytoplasmic p53 binding protein | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q9NR48 | Q8IWT3 | |
Ensembl transtripts involved in fusion gene | ENST00000368346, ENST00000392403, ENST00000548830, | ENST00000252050, ENST00000354495, ENST00000372647, ENST00000502937, | |
Fusion gene scores | * DoF score | 27 X 14 X 13=4914 | 4 X 4 X 2=32 |
# samples | 30 | 4 | |
** MAII score | log2(30/4914*10)=-4.03386345186628 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ASH1L [Title/Abstract] AND CUL9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ASH1L | GO:0097676 | histone H3-K36 dimethylation | 26002201 |
Tgene | CUL9 | GO:0016567 | protein ubiquitination | 24793696 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF334880 | ASH1L | chr1 | 155327202 | + | CUL9 | chr6 | 43187904 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000368346 | ENST00000252050 | ASH1L | chr1 | 155327202 | + | CUL9 | chr6 | 43187904 | + |
intron-intron | ENST00000368346 | ENST00000354495 | ASH1L | chr1 | 155327202 | + | CUL9 | chr6 | 43187904 | + |
intron-intron | ENST00000368346 | ENST00000372647 | ASH1L | chr1 | 155327202 | + | CUL9 | chr6 | 43187904 | + |
intron-intron | ENST00000368346 | ENST00000502937 | ASH1L | chr1 | 155327202 | + | CUL9 | chr6 | 43187904 | + |
intron-intron | ENST00000392403 | ENST00000252050 | ASH1L | chr1 | 155327202 | + | CUL9 | chr6 | 43187904 | + |
intron-intron | ENST00000392403 | ENST00000354495 | ASH1L | chr1 | 155327202 | + | CUL9 | chr6 | 43187904 | + |
intron-intron | ENST00000392403 | ENST00000372647 | ASH1L | chr1 | 155327202 | + | CUL9 | chr6 | 43187904 | + |
intron-intron | ENST00000392403 | ENST00000502937 | ASH1L | chr1 | 155327202 | + | CUL9 | chr6 | 43187904 | + |
intron-intron | ENST00000548830 | ENST00000252050 | ASH1L | chr1 | 155327202 | + | CUL9 | chr6 | 43187904 | + |
intron-intron | ENST00000548830 | ENST00000354495 | ASH1L | chr1 | 155327202 | + | CUL9 | chr6 | 43187904 | + |
intron-intron | ENST00000548830 | ENST00000372647 | ASH1L | chr1 | 155327202 | + | CUL9 | chr6 | 43187904 | + |
intron-intron | ENST00000548830 | ENST00000502937 | ASH1L | chr1 | 155327202 | + | CUL9 | chr6 | 43187904 | + |
Top |
FusionProtFeatures for ASH1L_CUL9 |
![]() |
Hgene | Tgene |
ASH1L | CUL9 |
Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me). {ECO:0000269|PubMed:21239497}. | Core component of a Cul9-RING ubiquitin-protein ligasecomplex, a complex that mediates ubiquitination and subsequentdegradation of BIRC5 and is required to maintain microtubuledynamics and genome integrity. Acts downstream of the 3M complex,which inhibits CUL9 activity, leading to prevent ubiquitination ofBIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localizationof p53/TP53 and subsequent function (PubMed:12526791,PubMed:17332328). {ECO:0000269|PubMed:12526791,ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:24793696}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ASH1L_CUL9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ASH1L_CUL9 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ASH1L_CUL9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ASH1L_CUL9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ASH1L | C0023903 | Liver neoplasms | 1 | CTD_human |