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Fusion gene ID: 2959 |
FusionGeneSummary for ASH1L_CCT3 |
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Fusion gene information | Fusion gene name: ASH1L_CCT3 | Fusion gene ID: 2959 | Hgene | Tgene | Gene symbol | ASH1L | CCT3 | Gene ID | 55870 | 7203 |
Gene name | ASH1 like histone lysine methyltransferase | chaperonin containing TCP1 subunit 3 | |
Synonyms | ASH1|ASH1L1|KMT2H|MRD52 | CCT-gamma|CCTG|PIG48|TCP-1-gamma|TRIC5 | |
Cytomap | 1q22 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | histone-lysine N-methyltransferase ASH1LASH1-like proteinabsent small and homeotic disks protein 1 homologash1 (absent, small, or homeotic)-likelysine N-methyltransferase 2Hprobable histone-lysine N-methyltransferase ASH1L | T-complex protein 1 subunit gammaT-complex protein 1, gamma subunitTCP1 (t-complex-1) ring complex, polypeptide 5chaperonin containing TCP1, subunit 3 (gamma)hTRiC5 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9NR48 | P49368 | |
Ensembl transtripts involved in fusion gene | ENST00000368346, ENST00000392403, ENST00000548830, | ENST00000295688, ENST00000368259, ENST00000368261, ENST00000472765, ENST00000368256, | |
Fusion gene scores | * DoF score | 27 X 14 X 13=4914 | 12 X 8 X 9=864 |
# samples | 30 | 12 | |
** MAII score | log2(30/4914*10)=-4.03386345186628 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/864*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ASH1L [Title/Abstract] AND CCT3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ASH1L | GO:0097676 | histone H3-K36 dimethylation | 26002201 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-05-4427-01A | ASH1L | chr1 | 155447677 | - | CCT3 | chr1 | 156282012 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000368346 | ENST00000295688 | ASH1L | chr1 | 155447677 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000368346 | ENST00000368259 | ASH1L | chr1 | 155447677 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000368346 | ENST00000368261 | ASH1L | chr1 | 155447677 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000368346 | ENST00000472765 | ASH1L | chr1 | 155447677 | - | CCT3 | chr1 | 156282012 | - |
5CDS-intron | ENST00000368346 | ENST00000368256 | ASH1L | chr1 | 155447677 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000392403 | ENST00000295688 | ASH1L | chr1 | 155447677 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000392403 | ENST00000368259 | ASH1L | chr1 | 155447677 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000392403 | ENST00000368261 | ASH1L | chr1 | 155447677 | - | CCT3 | chr1 | 156282012 | - |
Frame-shift | ENST00000392403 | ENST00000472765 | ASH1L | chr1 | 155447677 | - | CCT3 | chr1 | 156282012 | - |
5CDS-intron | ENST00000392403 | ENST00000368256 | ASH1L | chr1 | 155447677 | - | CCT3 | chr1 | 156282012 | - |
intron-3CDS | ENST00000548830 | ENST00000295688 | ASH1L | chr1 | 155447677 | - | CCT3 | chr1 | 156282012 | - |
intron-3CDS | ENST00000548830 | ENST00000368259 | ASH1L | chr1 | 155447677 | - | CCT3 | chr1 | 156282012 | - |
intron-3CDS | ENST00000548830 | ENST00000368261 | ASH1L | chr1 | 155447677 | - | CCT3 | chr1 | 156282012 | - |
intron-3CDS | ENST00000548830 | ENST00000472765 | ASH1L | chr1 | 155447677 | - | CCT3 | chr1 | 156282012 | - |
intron-intron | ENST00000548830 | ENST00000368256 | ASH1L | chr1 | 155447677 | - | CCT3 | chr1 | 156282012 | - |
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FusionProtFeatures for ASH1L_CCT3 |
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Hgene | Tgene |
ASH1L | CCT3 |
Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me). {ECO:0000269|PubMed:21239497}. | Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ASH1L_CCT3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ASH1L_CCT3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ASH1L | HIST1H3A, H3F3A, SMAD7, THAP7, MORF4L1, PARD6A, SIKE1, MORF4L2, NXF2, CDX1 | CCT3 | SSSCA1, FANCA, RAF1, EIF2B2, PAFAH1B2, PPP4C, CTTNBP2, MOB4, PPP2CA, STK24, STRN, STRN3, PPP2CB, PPP2R2C, IGBP1, TCP1, CDK9, RFWD2, ATG16L1, MAPK6, VHL, WDR82, UBC, MYC, PPP2R2A, PPP2R2B, PPP2R2D, PPP2R4, AGO3, HDAC5, PSMA3, FBXW8, RAD21, SH3BP4, VAV2, SIRT7, ISG15, PSMA2, CUL3, CDK2, XRCC6, INPPL1, UBASH3B, GRB2, EPS15, FBXO6, PACRG, CCT2, CCT5, CCT7, CCT8, CCT6A, CCT4, CCT6B, MARS, PSMA6, PSMA5, NOTCH1, VCP, FN1, VCAM1, ATF2, PEX14, NOS2, CAMKMT, FAM86B2, METTL18, METTL20, METTL21B, METTL21C, METTL23, ITGA4, CFTR, PAN2, CD81, IGSF8, ICAM1, HDAC3, HDAC11, HDAC6, FBXW4, PARK2, ACACA, COPA, EEF1G, LRRC47, PPP4R2, VARS, TRIM28, CDK5, ILK, CDC20, LGALS3BP, NEDD1, TP53, TUBG1, HUWE1, FUS, MIPOL1, CUL7, OBSL1, CCDC8, SUZ12, RNF2, BMI1, CDK13, IKBKE, IRAK1, JAK3, MAPK8, PRKY, PTK6, SGK2, TSSK6, TYK2, WDR76, POC1A, NXF5, TXNDC9, FYCO1, WDR37, WDR83, DCAF5, WDR92, PEX7, GNB5, TSSC1, DDB2, TUBB2B, ACTR1B, SEC31B, TUBAL3, ACTL6A, PNPLA1, TTLL3, TUBA3C, TUBA3E, C17orf102, RPS6KB2, LGALS3, DCAF7, AMBRA1, ARF1, CAD, CANX, CLTC, DNAJA1, DNAJA4, EHD2, ETFA, GTF2I, HSPE1, LDHA, LDHB, PDCL3, PSMC2, SLC25A3, SUCLG2, WARS, CYP27A1, HSP90B1, KPNA4, MCM7, PC, RPN1, STOM, UQCRC2, NTRK1, BTRC, B9D1, MKS1, CETN2, AHSA1, GBA, HDAC1, PDK3, DNAJC7, XRCC3, NSMAF, NIPSNAP1, PRPF4, ACTR2, WRAP53, RFWD3, KIF21A, SEH1L, TUBA1C, ARMC6, GAN, SKI, FBXW7, MCM2, SNW1, CDC5L, ERRFI1, TTC27, CDC73, ZNF746, PPM1J, TUBD1, DCAF12, DTL, WDR70, DCAF13, JMJD4, KLHL33, KDM4B, DCAF10, KLHDC8A, KLHL8, WDR77, WDR46, RAP2C, DCAF4, DNAI2, BUB3, WDR86, ODF1, KLHDC8B, DCAF11, WDTC1, TUBG2, GNB1L, METAP2, DCAF8, ACTR3B, TBL1Y, THOC3, PDCL, WDR34, UTP18, GNB2, GANAB, SMOX, HCFC2, WDR5B, C4orf26, C1orf127, ACTR3, NOL10, MLST8, POC1B, ACTBL2, MAPK15, P4HA2, C11orf70, KLHDC2, CDK11A, TTLL9, STRADB, RPE65, PNPLA5, TUBA1B, DCAF12L2, C11orf54, RBM3, CYLD, TRIM25, G3BP1, BRCA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ASH1L_CCT3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | CCT3 | P49368 | DB11638 | Artenimol | T-complex protein 1 subunit gamma | small molecule | approved|investigational |
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RelatedDiseases for ASH1L_CCT3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ASH1L | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | CCT3 | C0019693 | HIV Infections | 1 | CTD_human |