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Fusion gene ID: 2958 |
FusionGeneSummary for ASH1L_CAPRIN1 |
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Fusion gene information | Fusion gene name: ASH1L_CAPRIN1 | Fusion gene ID: 2958 | Hgene | Tgene | Gene symbol | ASH1L | CAPRIN1 | Gene ID | 55870 | 4076 |
Gene name | ASH1 like histone lysine methyltransferase | cell cycle associated protein 1 | |
Synonyms | ASH1|ASH1L1|KMT2H|MRD52 | GPIAP1|GPIP137|GRIP137|M11S1|RNG105|p137GPI | |
Cytomap | 1q22 | 11p13 | |
Type of gene | protein-coding | protein-coding | |
Description | histone-lysine N-methyltransferase ASH1LASH1-like proteinabsent small and homeotic disks protein 1 homologash1 (absent, small, or homeotic)-likelysine N-methyltransferase 2Hprobable histone-lysine N-methyltransferase ASH1L | caprin-1GPI-anchored membrane protein 1GPI-anchored protein p137GPI-p137RNA granule protein 105activation/proliferation-associated protein 1caprin 1cytoplasmic activation- and proliferation-associated protein 1cytoplasmic activation/proliferation- | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9NR48 | Q14444 | |
Ensembl transtripts involved in fusion gene | ENST00000368346, ENST00000392403, ENST00000548830, | ENST00000341394, ENST00000389645, ENST00000532820, ENST00000530820, ENST00000529307, ENST00000533657, | |
Fusion gene scores | * DoF score | 27 X 14 X 13=4914 | 6 X 5 X 4=120 |
# samples | 30 | 8 | |
** MAII score | log2(30/4914*10)=-4.03386345186628 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ASH1L [Title/Abstract] AND CAPRIN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ASH1L | GO:0097676 | histone H3-K36 dimethylation | 26002201 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM150614 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000368346 | ENST00000341394 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000368346 | ENST00000389645 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000368346 | ENST00000532820 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000368346 | ENST00000530820 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000368346 | ENST00000529307 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000368346 | ENST00000533657 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000392403 | ENST00000341394 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000392403 | ENST00000389645 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000392403 | ENST00000532820 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000392403 | ENST00000530820 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000392403 | ENST00000529307 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000392403 | ENST00000533657 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000548830 | ENST00000341394 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000548830 | ENST00000389645 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000548830 | ENST00000532820 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000548830 | ENST00000530820 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000548830 | ENST00000529307 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
intron-intron | ENST00000548830 | ENST00000533657 | ASH1L | chr1 | 155369436 | - | CAPRIN1 | chr11 | 34197541 | - |
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FusionProtFeatures for ASH1L_CAPRIN1 |
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Hgene | Tgene |
ASH1L | CAPRIN1 |
Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me). {ECO:0000269|PubMed:21239497}. | May regulate the transport and translation of mRNAs ofproteins involved in synaptic plasticity in neurons and cellproliferation and migration in multiple cell types. Binds directlyand selectively to MYC and CCND2 RNAs. In neuronal cells, directlybinds to several mRNAs associated with RNA granules, includingBDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 andKPNB1 mRNAs, but not to rRNAs. {ECO:0000269|PubMed:17210633}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ASH1L_CAPRIN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ASH1L_CAPRIN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ASH1L_CAPRIN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ASH1L_CAPRIN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ASH1L | C0023903 | Liver neoplasms | 1 | CTD_human |