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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29563

FusionGeneSummary for PTPRM_ZNF595

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRM_ZNF595
Fusion gene ID: 29563
HgeneTgene
Gene symbol

PTPRM

ZNF595

Gene ID

5797

152687

Gene nameprotein tyrosine phosphatase, receptor type Mzinc finger protein 595
SynonymsPTPRL1|R-PTP-MU|RPTPM|RPTPU|hR-PTPu-
Cytomap

18p11.23

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase muprotein tyrosine phosphatase muprotein tyrosine phosphatase, receptor type, mu polypeptidezinc finger protein 595
Modification date2018052220180522
UniProtAcc

P28827

Ensembl transtripts involved in fusion geneENST00000580170, ENST00000332175, 
ENST00000400060, ENST00000400053, 
ENST00000444013, ENST00000578571, 
ENST00000339368, ENST00000509152, 
ENST00000526473, 
Fusion gene scores* DoF score9 X 8 X 7=5047 X 1 X 7=49
# samples 97
** MAII scorelog2(9/504*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/49*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PTPRM [Title/Abstract] AND ZNF595 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRM

GO:0006470

protein dephosphorylation

8393854|10809770

HgenePTPRM

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

8393854

HgenePTPRM

GO:0007165

signal transduction

15080886

HgenePTPRM

GO:0031175

neuron projection development

16380380

HgenePTPRM

GO:0031290

retinal ganglion cell axon guidance

15080886

HgenePTPRM

GO:0042493

response to drug

18566238


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-EY-A54A-01APTPRMchr18

8069992

+ZNF595chr4

59323

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000580170ENST00000339368PTPRMchr18

8069992

+ZNF595chr4

59323

+
5CDS-3UTRENST00000580170ENST00000509152PTPRMchr18

8069992

+ZNF595chr4

59323

+
5CDS-3UTRENST00000580170ENST00000526473PTPRMchr18

8069992

+ZNF595chr4

59323

+
5CDS-3UTRENST00000332175ENST00000339368PTPRMchr18

8069992

+ZNF595chr4

59323

+
5CDS-3UTRENST00000332175ENST00000509152PTPRMchr18

8069992

+ZNF595chr4

59323

+
5CDS-3UTRENST00000332175ENST00000526473PTPRMchr18

8069992

+ZNF595chr4

59323

+
5CDS-3UTRENST00000400060ENST00000339368PTPRMchr18

8069992

+ZNF595chr4

59323

+
5CDS-3UTRENST00000400060ENST00000509152PTPRMchr18

8069992

+ZNF595chr4

59323

+
5CDS-3UTRENST00000400060ENST00000526473PTPRMchr18

8069992

+ZNF595chr4

59323

+
5CDS-3UTRENST00000400053ENST00000339368PTPRMchr18

8069992

+ZNF595chr4

59323

+
5CDS-3UTRENST00000400053ENST00000509152PTPRMchr18

8069992

+ZNF595chr4

59323

+
5CDS-3UTRENST00000400053ENST00000526473PTPRMchr18

8069992

+ZNF595chr4

59323

+
5CDS-3UTRENST00000444013ENST00000339368PTPRMchr18

8069992

+ZNF595chr4

59323

+
5CDS-3UTRENST00000444013ENST00000509152PTPRMchr18

8069992

+ZNF595chr4

59323

+
5CDS-3UTRENST00000444013ENST00000526473PTPRMchr18

8069992

+ZNF595chr4

59323

+
3UTR-3UTRENST00000578571ENST00000339368PTPRMchr18

8069992

+ZNF595chr4

59323

+
3UTR-3UTRENST00000578571ENST00000509152PTPRMchr18

8069992

+ZNF595chr4

59323

+
3UTR-3UTRENST00000578571ENST00000526473PTPRMchr18

8069992

+ZNF595chr4

59323

+

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FusionProtFeatures for PTPRM_ZNF595


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRM

P28827

ZNF595

Involved in cell-cell adhesion through homophilicinteractions. May play a key role in signal transduction andgrowth control. {ECO:0000269|PubMed:16456543}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRM_ZNF595


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRM_ZNF595


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRMGNB2L1, CTNND1, DTNBP1, LMTK2, EHD4, CDC42BPA, NHSL1, TRIM25ZNF595JUNB, TRIM28


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRM_ZNF595


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRM_ZNF595


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource