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Fusion gene ID: 29563 |
FusionGeneSummary for PTPRM_ZNF595 |
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Fusion gene information | Fusion gene name: PTPRM_ZNF595 | Fusion gene ID: 29563 | Hgene | Tgene | Gene symbol | PTPRM | ZNF595 | Gene ID | 5797 | 152687 |
Gene name | protein tyrosine phosphatase, receptor type M | zinc finger protein 595 | |
Synonyms | PTPRL1|R-PTP-MU|RPTPM|RPTPU|hR-PTPu | - | |
Cytomap | 18p11.23 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | receptor-type tyrosine-protein phosphatase muprotein tyrosine phosphatase muprotein tyrosine phosphatase, receptor type, mu polypeptide | zinc finger protein 595 | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | P28827 | ||
Ensembl transtripts involved in fusion gene | ENST00000580170, ENST00000332175, ENST00000400060, ENST00000400053, ENST00000444013, ENST00000578571, | ENST00000339368, ENST00000509152, ENST00000526473, | |
Fusion gene scores | * DoF score | 9 X 8 X 7=504 | 7 X 1 X 7=49 |
# samples | 9 | 7 | |
** MAII score | log2(9/504*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/49*10)=0.514573172829758 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PTPRM [Title/Abstract] AND ZNF595 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PTPRM | GO:0006470 | protein dephosphorylation | 8393854|10809770 |
Hgene | PTPRM | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 8393854 |
Hgene | PTPRM | GO:0007165 | signal transduction | 15080886 |
Hgene | PTPRM | GO:0031175 | neuron projection development | 16380380 |
Hgene | PTPRM | GO:0031290 | retinal ganglion cell axon guidance | 15080886 |
Hgene | PTPRM | GO:0042493 | response to drug | 18566238 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | UCEC | TCGA-EY-A54A-01A | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000580170 | ENST00000339368 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
5CDS-3UTR | ENST00000580170 | ENST00000509152 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
5CDS-3UTR | ENST00000580170 | ENST00000526473 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
5CDS-3UTR | ENST00000332175 | ENST00000339368 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
5CDS-3UTR | ENST00000332175 | ENST00000509152 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
5CDS-3UTR | ENST00000332175 | ENST00000526473 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
5CDS-3UTR | ENST00000400060 | ENST00000339368 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
5CDS-3UTR | ENST00000400060 | ENST00000509152 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
5CDS-3UTR | ENST00000400060 | ENST00000526473 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
5CDS-3UTR | ENST00000400053 | ENST00000339368 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
5CDS-3UTR | ENST00000400053 | ENST00000509152 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
5CDS-3UTR | ENST00000400053 | ENST00000526473 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
5CDS-3UTR | ENST00000444013 | ENST00000339368 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
5CDS-3UTR | ENST00000444013 | ENST00000509152 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
5CDS-3UTR | ENST00000444013 | ENST00000526473 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
3UTR-3UTR | ENST00000578571 | ENST00000339368 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
3UTR-3UTR | ENST00000578571 | ENST00000509152 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
3UTR-3UTR | ENST00000578571 | ENST00000526473 | PTPRM | chr18 | 8069992 | + | ZNF595 | chr4 | 59323 | + |
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FusionProtFeatures for PTPRM_ZNF595 |
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Hgene | Tgene |
PTPRM | ZNF595 |
Involved in cell-cell adhesion through homophilicinteractions. May play a key role in signal transduction andgrowth control. {ECO:0000269|PubMed:16456543}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PTPRM_ZNF595 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PTPRM_ZNF595 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PTPRM | GNB2L1, CTNND1, DTNBP1, LMTK2, EHD4, CDC42BPA, NHSL1, TRIM25 | ZNF595 | JUNB, TRIM28 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTPRM_ZNF595 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PTPRM_ZNF595 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |