FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 29554

FusionGeneSummary for PTPRK_UACA

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRK_UACA
Fusion gene ID: 29554
HgeneTgene
Gene symbol

PTPRK

UACA

Gene ID

5796

55075

Gene nameprotein tyrosine phosphatase, receptor type Kuveal autoantigen with coiled-coil domains and ankyrin repeats
SynonymsR-PTP-kappaNUCLING
Cytomap

6q22.33

15q23

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase kappadJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappaprotein-tyrosine phosphatase kappaprotein-tyrosine phosphauveal autoantigen with coiled-coil domains and ankyrin repeatsnuclear membrane binding protein
Modification date2018051920180519
UniProtAcc

Q15262

Q9BZF9

Ensembl transtripts involved in fusion geneENST00000368226, ENST00000368227, 
ENST00000532331, ENST00000368213, 
ENST00000368210, ENST00000368215, 
ENST00000368207, ENST00000524481, 
ENST00000525459, 		ENST00000322954, 
ENST00000539319, ENST00000379983, 
ENST00000560441, ENST00000559183, 
Fusion gene scores* DoF score26 X 12 X 13=40564 X 4 X 3=48
# samples 344
** MAII scorelog2(34/4056*10)=-3.57645100086564
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRK [Title/Abstract] AND UACA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRK

GO:0006470

protein dephosphorylation

16263724

HgenePTPRK

GO:0007165

signal transduction

16849327

HgenePTPRK

GO:0007179

transforming growth factor beta receptor signaling pathway

15899872

HgenePTPRK

GO:0008285

negative regulation of cell proliferation

15899872|18276111

HgenePTPRK

GO:0010839

negative regulation of keratinocyte proliferation

16263724

HgenePTPRK

GO:0030336

negative regulation of cell migration

18276111

HgenePTPRK

GO:0034394

protein localization to cell surface

18276111

HgenePTPRK

GO:0034614

cellular response to reactive oxygen species

16849327

HgenePTPRK

GO:0034644

cellular response to UV

16849327

HgenePTPRK

GO:0045786

negative regulation of cell cycle

15899872

HgenePTPRK

GO:0045892

negative regulation of transcription, DNA-templated

18276111


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG959344PTPRKchr6

128418923

-UACAchr15

70961256

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000368226ENST00000322954PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368226ENST00000539319PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368226ENST00000379983PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368226ENST00000560441PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-intronENST00000368226ENST00000559183PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368227ENST00000322954PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368227ENST00000539319PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368227ENST00000379983PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368227ENST00000560441PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-intronENST00000368227ENST00000559183PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000532331ENST00000322954PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000532331ENST00000539319PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000532331ENST00000379983PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000532331ENST00000560441PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-intronENST00000532331ENST00000559183PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368213ENST00000322954PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368213ENST00000539319PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368213ENST00000379983PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368213ENST00000560441PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-intronENST00000368213ENST00000559183PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368210ENST00000322954PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368210ENST00000539319PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368210ENST00000379983PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368210ENST00000560441PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-intronENST00000368210ENST00000559183PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368215ENST00000322954PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368215ENST00000539319PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368215ENST00000379983PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368215ENST00000560441PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-intronENST00000368215ENST00000559183PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368207ENST00000322954PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368207ENST00000539319PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368207ENST00000379983PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000368207ENST00000560441PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-intronENST00000368207ENST00000559183PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000524481ENST00000322954PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000524481ENST00000539319PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000524481ENST00000379983PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000524481ENST00000560441PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-intronENST00000524481ENST00000559183PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000525459ENST00000322954PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000525459ENST00000539319PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000525459ENST00000379983PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-3CDSENST00000525459ENST00000560441PTPRKchr6

128418923

-UACAchr15

70961256

+
intron-intronENST00000525459ENST00000559183PTPRKchr6

128418923

-UACAchr15

70961256

+

Top

FusionProtFeatures for PTPRK_UACA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRK

Q15262

UACA

Q9BZF9

Regulation of processes involving cell contact andadhesion such as growth control, tumor invasion, and metastasis.Negative regulator of EGFR signaling pathway. Forms complexes withbeta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be asubstrate for the catalytic activity of PTPRK/PTP-kappa.{ECO:0000269|PubMed:19836242}. Regulates APAF1 expression and plays an important rolein the regulation of stress-induced apoptosis. Promotes apoptosisby regulating three pathways, apoptosome up-regulation,LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation.Regulates the redistribution of APAF1 into the nucleus afterproapoptotic stress. Down-regulates the expression of LGALS3 byinhibiting NFKB1 (By similarity). {ECO:0000250}. Modulates isoactin dynamics to regulate themorphological alterations required for cell growth and motility.Interaction with ARF6 may modulate cell shape and motility afterinjury. May be involved in multiple neurite formation (Bysimilarity). {ECO:0000250|UniProtKB:Q8CGB3,ECO:0000250|UniProtKB:Q8HYY4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PTPRK_UACA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PTPRK_UACA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PTPRK_UACA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PTPRK_UACA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRKC0025202melanoma2CTD_human
HgenePTPRKC0033578Prostatic Neoplasms1CTD_human