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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29551

FusionGeneSummary for PTPRK_SPARCL1

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRK_SPARCL1
Fusion gene ID: 29551
HgeneTgene
Gene symbol

PTPRK

SPARCL1

Gene ID

5796

8404

Gene nameprotein tyrosine phosphatase, receptor type KSPARC like 1
SynonymsR-PTP-kappaMAST 9|MAST9|PIG33|SC1
Cytomap

6q22.33

4q22.1

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase kappadJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappaprotein-tyrosine phosphatase kappaprotein-tyrosine phosphaSPARC-like protein 1SPARC-like 1 (hevin)high endothelial venule proteinproliferation-inducing protein 33
Modification date2018051920180523
UniProtAcc

Q15262

Q14515

Ensembl transtripts involved in fusion geneENST00000368226, ENST00000368227, 
ENST00000532331, ENST00000368213, 
ENST00000368210, ENST00000368215, 
ENST00000368207, ENST00000524481, 
ENST00000525459, 
ENST00000282470, 
ENST00000418378, ENST00000503414, 
Fusion gene scores* DoF score26 X 12 X 13=405610 X 8 X 5=400
# samples 3411
** MAII scorelog2(34/4056*10)=-3.57645100086564
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/400*10)=-1.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRK [Title/Abstract] AND SPARCL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRK

GO:0006470

protein dephosphorylation

16263724

HgenePTPRK

GO:0007165

signal transduction

16849327

HgenePTPRK

GO:0007179

transforming growth factor beta receptor signaling pathway

15899872

HgenePTPRK

GO:0008285

negative regulation of cell proliferation

15899872|18276111

HgenePTPRK

GO:0010839

negative regulation of keratinocyte proliferation

16263724

HgenePTPRK

GO:0030336

negative regulation of cell migration

18276111

HgenePTPRK

GO:0034394

protein localization to cell surface

18276111

HgenePTPRK

GO:0034614

cellular response to reactive oxygen species

16849327

HgenePTPRK

GO:0034644

cellular response to UV

16849327

HgenePTPRK

GO:0045786

negative regulation of cell cycle

15899872

HgenePTPRK

GO:0045892

negative regulation of transcription, DNA-templated

18276111


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A2-A0CY-01APTPRKchr6

128505577

-SPARCL1chr4

88420737

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000368226ENST00000282470PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368226ENST00000418378PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368226ENST00000503414PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368227ENST00000282470PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368227ENST00000418378PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368227ENST00000503414PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000532331ENST00000282470PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000532331ENST00000418378PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000532331ENST00000503414PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368213ENST00000282470PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368213ENST00000418378PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368213ENST00000503414PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368210ENST00000282470PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368210ENST00000418378PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368210ENST00000503414PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368215ENST00000282470PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368215ENST00000418378PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368215ENST00000503414PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368207ENST00000282470PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368207ENST00000418378PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5CDS-5UTRENST00000368207ENST00000503414PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5UTR-5UTRENST00000524481ENST00000282470PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5UTR-5UTRENST00000524481ENST00000418378PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
5UTR-5UTRENST00000524481ENST00000503414PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
intron-5UTRENST00000525459ENST00000282470PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
intron-5UTRENST00000525459ENST00000418378PTPRKchr6

128505577

-SPARCL1chr4

88420737

-
intron-5UTRENST00000525459ENST00000503414PTPRKchr6

128505577

-SPARCL1chr4

88420737

-

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FusionProtFeatures for PTPRK_SPARCL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRK

Q15262

SPARCL1

Q14515

Regulation of processes involving cell contact andadhesion such as growth control, tumor invasion, and metastasis.Negative regulator of EGFR signaling pathway. Forms complexes withbeta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be asubstrate for the catalytic activity of PTPRK/PTP-kappa.{ECO:0000269|PubMed:19836242}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRK_SPARCL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRK_SPARCL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRKPSMD11, TK1, CTNNB1, JUP, CSNK2B, FKBP8, GADD45G, GADD45A, LGALS3, LGALS8, LGALS9, LAMB2, ATRN, CACNA2D2, ECE1, CES3, TCTN2, LRP1B, INSR, PXDN, FRAS1, CACNA2D1, LAMA5, CD109, POGLUT1, ARSK, MEGF8, UBR3, ARSA, GALNS, ARSG, LAMB1, LRIG3, LRIG1, B3GALTL, SCARB1, ADAM9, NPC1, SUSD1, COL6A2, EOGT, PLXNA2, PLXNA3, PLXNA1, EGFR, MOXD1, CCDC102A, CHST10, COL6A1, DNAJB9, MAN2A1, CNTNAP3, PLXNB2, MANBA, ITGA8, MGRN1, ARSB, COL4A2, TMEM67, FBLN1, CLN5, SCARB2, FUT11, GLG1, CERCAM, ERO1LB, DCBLD2, CHST12, AMIGO1, PCSK5, LAMA3, SIAE, GNPTG, CTSF, PLAT, BCHE, ITGA4, GALNT18, MICA, LEPREL2, WNT5A, DGCR2, MAN2A2, BTD, SP3, AMIGO3, ANKRD46, HYAL2, TMEM132A, RIPK3, ATP2A2, SIPA1L3, ARHGAP32, TANC1, MINK1, PKP4, NCKAP5L, PEAK1, PIK3R1, SEC24B, RPL28, PTPRU, DEFA5, PCDHGB1, TUFM, MMP26, NID2, PCDHGB4, LYPD1, ZNF3, TMPRSS11B, BMP7SPARCL1EGFR, DISC1, SKIL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRK_SPARCL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRK_SPARCL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRKC0025202melanoma2CTD_human
HgenePTPRKC0033578Prostatic Neoplasms1CTD_human
TgeneSPARCL1C0014175Endometriosis1CTD_human
TgeneSPARCL1C0014544Epilepsy1CTD_human