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Fusion gene ID: 29526 |
FusionGeneSummary for PTPRJ_PPP2CB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTPRJ_PPP2CB | Fusion gene ID: 29526 | Hgene | Tgene | Gene symbol | PTPRJ | PPP2CB | Gene ID | 5795 | 5516 |
| Gene name | protein tyrosine phosphatase, receptor type J | protein phosphatase 2 catalytic subunit beta | |
| Synonyms | CD148|DEP1|HPTPeta|R-PTP-ETA|SCC1 | PP2Abeta|PP2CB | |
| Cytomap | 11p11.2 | 8p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | receptor-type tyrosine-protein phosphatase etaCD148 antigenDEP-1HPTP etaR-PTP-Jdensity-enhanced phosphatase 1human density enhanced phosphatase-1protein tyrosine phosphatase, receptor type, J polypeptideprotein-tyrosine phosphatase etasusceptibil | serine/threonine-protein phosphatase 2A catalytic subunit beta isoformPP2A-betaprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoformprotein phosphatase 2, catalytic subunit, beta isoformprotein phosphatase 2, catalytic subunit, beta iso | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q12913 | P62714 | |
| Ensembl transtripts involved in fusion gene | ENST00000418331, ENST00000440289, ENST00000526550, | ENST00000520500, ENST00000221138, ENST00000518564, | |
| Fusion gene scores | * DoF score | 6 X 6 X 5=180 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PTPRJ [Title/Abstract] AND PPP2CB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PTPRJ | GO:0008285 | negative regulation of cell proliferation | 14709717|16682945|16778204 |
| Hgene | PTPRJ | GO:0010642 | negative regulation of platelet-derived growth factor receptor signaling pathway | 14709717 |
| Hgene | PTPRJ | GO:0030308 | negative regulation of cell growth | 14709717 |
| Hgene | PTPRJ | GO:0030336 | negative regulation of cell migration | 16682945 |
| Hgene | PTPRJ | GO:0035335 | peptidyl-tyrosine dephosphorylation | 9531590|10821867|12913111|16778204|18348712|18936167|19332538 |
| Hgene | PTPRJ | GO:0043116 | negative regulation of vascular permeability | 19332538 |
| Hgene | PTPRJ | GO:0043407 | negative regulation of MAP kinase activity | 19494114 |
| Hgene | PTPRJ | GO:0050860 | negative regulation of T cell receptor signaling pathway | 12913111 |
| Hgene | PTPRJ | GO:0050918 | positive chemotaxis | 14709717 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-XQ-A8TB-01A | PTPRJ | chr11 | 48168515 | + | PPP2CB | chr8 | 30648831 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000418331 | ENST00000520500 | PTPRJ | chr11 | 48168515 | + | PPP2CB | chr8 | 30648831 | - |
| 5CDS-intron | ENST00000418331 | ENST00000221138 | PTPRJ | chr11 | 48168515 | + | PPP2CB | chr8 | 30648831 | - |
| 5CDS-intron | ENST00000418331 | ENST00000518564 | PTPRJ | chr11 | 48168515 | + | PPP2CB | chr8 | 30648831 | - |
| intron-intron | ENST00000440289 | ENST00000520500 | PTPRJ | chr11 | 48168515 | + | PPP2CB | chr8 | 30648831 | - |
| intron-intron | ENST00000440289 | ENST00000221138 | PTPRJ | chr11 | 48168515 | + | PPP2CB | chr8 | 30648831 | - |
| intron-intron | ENST00000440289 | ENST00000518564 | PTPRJ | chr11 | 48168515 | + | PPP2CB | chr8 | 30648831 | - |
| intron-intron | ENST00000526550 | ENST00000520500 | PTPRJ | chr11 | 48168515 | + | PPP2CB | chr8 | 30648831 | - |
| intron-intron | ENST00000526550 | ENST00000221138 | PTPRJ | chr11 | 48168515 | + | PPP2CB | chr8 | 30648831 | - |
| intron-intron | ENST00000526550 | ENST00000518564 | PTPRJ | chr11 | 48168515 | + | PPP2CB | chr8 | 30648831 | - |
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FusionProtFeatures for PTPRJ_PPP2CB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PTPRJ | PPP2CB |
| Tyrosine phosphatase which dephosphorylates orcontributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET,RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1,OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration,proliferation and differentiation. Involved in vasculardevelopment. Regulator of macrophage adhesion and spreading.Positively affects cell-matrix adhesion. Positive regulator ofplatelet activation and thrombosis. Negative regulator of cellproliferation. Negative regulator of PDGF-stimulated cellmigration; through dephosphorylation of PDGFR. Positive regulatorof endothelial cell survival, as well as of VEGF-induced SRC andAKT activation; through KDR dephosphorylation. Negative regulatorof EGFR signaling pathway; through EGFR dephosphorylation.Enhances the barrier function of epithelial junctions duringreassembly. Negatively regulates T-cell receptor (TCR) signaling.Upon T-cell TCR activation, it is up-regulated and excluded fromthe immunological synapses, while upon T-cell-antigen presentingcells (APC) disengagement, it is no longer excluded and candephosphorylate PLCG1 and LAT to down-regulate prolongation ofsignaling. {ECO:0000269|PubMed:10821867,ECO:0000269|PubMed:11259588, ECO:0000269|PubMed:12062403,ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:12475979,ECO:0000269|PubMed:12913111, ECO:0000269|PubMed:14709717,ECO:0000269|PubMed:16682945, ECO:0000269|PubMed:16778204,ECO:0000269|PubMed:18348712, ECO:0000269|PubMed:18936167,ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:19494114,ECO:0000269|PubMed:19836242, ECO:0000269|PubMed:19922411,ECO:0000269|PubMed:21091576, ECO:0000269|PubMed:21262971,ECO:0000269|PubMed:9531590, ECO:0000269|PubMed:9780142}. | PP2A can modulate the activity of phosphorylase B kinasecasein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.{ECO:0000269|PubMed:2555176}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PTPRJ_PPP2CB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PTPRJ_PPP2CB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PTPRJ | CTNND1, CTNNB1, SDCBP, PLCG1, LAT, EGFR, GRB2, PTPRJ, FBXO6, LGALS3, LGALS8, LGALS9, BAP1, CASC3, CYP17A1, EPSTI1, HOXC6, KLK7, KLK9, LYPD3, PRDM14, TRIM25, CDH1, RINT1, C19orf25, NOS1AP, C1orf226, RAB11FIP1 | PPP2CB | STK24, PPP4C, ARL2, TLX1, RELA, PPP2R1A, STRN, STRIP1, STRN4, STRN3, TCP1, CCT2, CCT6A, CTTNBP2NL, MOB4, CCT3, CCT5, IGBP1, PPP2R2A, CCT8, CCT7, CCT4, FGFR1OP, PPP2R5D, CTTNBP2, TIPRL, PPP2R1B, INTS1, INTS6, INTS3, INTS5, TERF1, ACTBL2, PRR14L, SGOL1, MYLPF, SIKE1, PRR14, PPME1, ANKLE2, PFDN6, PPFIA1, SLMAP, VBP1, PPP2R5E, PPP2R5C, PFDN5, PFDN2, PPP2R2B, PPP2R2D, MYH10, ADARB1, HDAC5, MARK4, ZNF775, ZFP28, DOCK7, C22orf39, TCTEX1D2, RPLP1, PLXNA3, ACP5, CBX5, NOTCH1, VCP, ITGA4, MAK, TAB1, GSTA1, HK3, RAF1, TAB2, TRMT61B, CDK17, CDK18, CDK16, AARSD1, ATG7, NIF3L1, NSUN2, ELAC2, WDR12, TTC1, ASB5, STK25, STK26, SNAI2, ZFP36, BHLHE41, CEP350, STRIP2, CCDC6, TBCCD1, NDUFAF1, PPP4R1, PPP2R5A, FECH, PPP2R3C, PPP2R3B, FGFR1OP2, FOXC1, ZNF444, SERTAD4, HMGCS1, PPP2CA, IFI16, MARK3, SET, PPFIA3, MAP7, MAP4K4, PDCD10, CEP131, DECR2, PKN3, PLEKHA5, CPSF3L, CEP72, INTS9, INTS12, SMEK2, INTS2, INTS4, TMEM41B, CCDC61, FOXO3, CRY1, CRY2, ESR1, CDC20, NOSIP, ESRRB, ARHGEF2, CAMSAP3, ENSA, FAM122A, FAM122B, FBXL16, IK, PPP2R4, TBC1D4, TTC33, WDR61, FOXD4, TRIM25, URI1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTPRJ_PPP2CB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PTPRJ_PPP2CB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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