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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29522

FusionGeneSummary for PTPRG_ZNF236

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRG_ZNF236
Fusion gene ID: 29522
HgeneTgene
Gene symbol

PTPRG

ZNF236

Gene ID

5793

7776

Gene nameprotein tyrosine phosphatase, receptor type Gzinc finger protein 236
SynonymsHPTPG|PTPG|R-PTP-GAMMA|RPTPGZNF236A|ZNF236B
Cytomap

3p14.2

18q23

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase gammaH_RG317H01.1protein tyrosine phosphatase gammaprotein tyrosine phosphatase, receptor type, gamma polypeptidereceptor type protein tyrosine phosphatase gammareceptor tyrosine phosphatase gammareceptor-tzinc finger protein 236regulated by glucose
Modification date2018052720180519
UniProtAcc

P23470

Q9UL36

Ensembl transtripts involved in fusion geneENST00000295874, ENST00000474889, 
ENST00000495879, 
ENST00000320610, 
ENST00000253159, ENST00000583095, 
Fusion gene scores* DoF score11 X 6 X 7=4623 X 3 X 1=9
# samples 133
** MAII scorelog2(13/462*10)=-1.8293812283876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PTPRG [Title/Abstract] AND ZNF236 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI052221PTPRGchr3

61756318

-ZNF236chr18

74681364

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000295874ENST00000320610PTPRGchr3

61756318

-ZNF236chr18

74681364

+
intron-3UTRENST00000295874ENST00000253159PTPRGchr3

61756318

-ZNF236chr18

74681364

+
intron-intronENST00000295874ENST00000583095PTPRGchr3

61756318

-ZNF236chr18

74681364

+
intron-3UTRENST00000474889ENST00000320610PTPRGchr3

61756318

-ZNF236chr18

74681364

+
intron-3UTRENST00000474889ENST00000253159PTPRGchr3

61756318

-ZNF236chr18

74681364

+
intron-intronENST00000474889ENST00000583095PTPRGchr3

61756318

-ZNF236chr18

74681364

+
3UTR-3UTRENST00000495879ENST00000320610PTPRGchr3

61756318

-ZNF236chr18

74681364

+
3UTR-3UTRENST00000495879ENST00000253159PTPRGchr3

61756318

-ZNF236chr18

74681364

+
3UTR-intronENST00000495879ENST00000583095PTPRGchr3

61756318

-ZNF236chr18

74681364

+

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FusionProtFeatures for PTPRG_ZNF236


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRG

P23470

ZNF236

Q9UL36

Possesses tyrosine phosphatase activity.{ECO:0000269|PubMed:19167335}. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRG_ZNF236


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRG_ZNF236


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRG_ZNF236


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRG_ZNF236


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRGC0038356Stomach Neoplasms1CTD_human