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Fusion gene ID: 2950 |
FusionGeneSummary for ASF1B_KLF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ASF1B_KLF1 | Fusion gene ID: 2950 | Hgene | Tgene | Gene symbol | ASF1B | KLF1 | Gene ID | 55723 | 10661 |
| Gene name | anti-silencing function 1B histone chaperone | Kruppel like factor 1 | |
| Synonyms | CIA-II | EKLF | |
| Cytomap | 19p13.12 | 19p13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone chaperone ASF1BASF1 anti-silencing function 1 homolog BCCG1-interacting factor A-IIanti-silencing function protein 1 homolog BhAsf1hAsf1bhCIA-II | Krueppel-like factor 1erythroid Kruppel-like factorerythroid krueppel-like transcription factorerythroid-specific transcription factor EKLF | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9NVP2 | Q13351 | |
| Ensembl transtripts involved in fusion gene | ENST00000263382, ENST00000592798, ENST00000474890, | ENST00000264834, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ASF1B [Title/Abstract] AND KLF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ASF1B | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
| Hgene | ASF1B | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
| Tgene | KLF1 | GO:0045893 | positive regulation of transcription, DNA-templated | 15084587|20676099|21055716 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | DLBC | TCGA-RQ-A6JB-01A | ASF1B | chr19 | 14236933 | - | KLF1 | chr19 | 12996626 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000263382 | ENST00000264834 | ASF1B | chr19 | 14236933 | - | KLF1 | chr19 | 12996626 | - |
| In-frame | ENST00000592798 | ENST00000264834 | ASF1B | chr19 | 14236933 | - | KLF1 | chr19 | 12996626 | - |
| In-frame | ENST00000474890 | ENST00000264834 | ASF1B | chr19 | 14236933 | - | KLF1 | chr19 | 12996626 | - |
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FusionProtFeatures for ASF1B_KLF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ASF1B | KLF1 |
| Histone chaperone that facilitates histone depositionand histone exchange and removal during nucleosome assembly anddisassembly. Cooperates with chromatin assembly factor 1 (CAF-1)to promote replication-dependent chromatin assembly. Does notparticipate in replication-independent nucleosome deposition whichis mediated by ASF1A and HIRA. Required for spermatogenesis.{ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904,ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15664198,ECO:0000269|PubMed:16151251}. | Transcription regulator of erythrocyte development thatprobably serves as a general switch factor during erythropoiesis.Is a dual regulator of fetal-to-adult globin switching. Binds tothe CACCC box in the beta-globin gene promoter and acts as apreferential activator of this gene. Furthermore, it binds to theBCL11A promoter and activates expression of BCL11A, which in turnrepresses the HBG1 and HBG2 genes. This dual activity ensuresthat, in most adults, fetal hemoglobin levels are low. Able toactivate CD44 and AQP1 promoters. When sumoylated, acts as atranscriptional repressor by promoting interaction withCDH2/MI2beta and also represses megakaryocytic differentiation.{ECO:0000250|UniProtKB:P46099, ECO:0000269|PubMed:25585695}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >KLF1 | chr19:14236933 | chr19:12996626 | ENST00000264834 | - | 0 | 3 | 1_263 | -14 | 363 | Compositional bias | Note=Pro-rich |
| Tgene | >KLF1 | chr19:14236933 | chr19:12996626 | ENST00000264834 | - | 0 | 3 | 61_76 | -14 | 363 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Tgene | >KLF1 | chr19:14236933 | chr19:12996626 | ENST00000264834 | - | 0 | 3 | 279_303 | -14 | 363 | Zinc finger | C2H2-type 1 |
| Tgene | >KLF1 | chr19:14236933 | chr19:12996626 | ENST00000264834 | - | 0 | 3 | 309_333 | -14 | 363 | Zinc finger | C2H2-type 2 |
| Tgene | >KLF1 | chr19:14236933 | chr19:12996626 | ENST00000264834 | - | 0 | 3 | 339_361 | -14 | 363 | Zinc finger | C2H2-type 3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ASF1B_KLF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ASF1B_ENST00000263382_chr19_14236933_-_KLF1_ENST00000264834_chr19_12996626_-_75aa >In-frame_ASF1B_ENST00000592798_chr19_14236933_-_KLF1_ENST00000264834_chr19_12996626_-_75aa >In-frame_ASF1B_ENST00000474890_chr19_14236933_-_KLF1_ENST00000264834_chr19_12996626_-_75aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ASF1B_ENST00000263382_chr19_14236933_-_KLF1_ENST00000264834_chr19_12996626_-_225nt ATGGCCAAGGTGTCGGTGCTGAACGTGGCGGTCCTGGAGAACCCGAGCCCTTTCCACAGCCCCTTCCGGTTCGAGATCAGCTTCGAGTGC AGTGAAGCCCTGGCGGACGACCTGGAGTGGAAGATCATTTATGTTGGCTCGGCTGAGAGTGAGGAATTTGATCAGATCCTAGACTCGGTG >In-frame_ASF1B_ENST00000592798_chr19_14236933_-_KLF1_ENST00000264834_chr19_12996626_-_225nt ATGGCCAAGGTGTCGGTGCTGAACGTGGCGGTCCTGGAGAACCCGAGCCCTTTCCACAGCCCCTTCCGGTTCGAGATCAGCTTCGAGTGC AGTGAAGCCCTGGCGGACGACCTGGAGTGGAAGATCATTTATGTTGGCTCGGCTGAGAGTGAGGAATTTGATCAGATCCTAGACTCGGTG >In-frame_ASF1B_ENST00000474890_chr19_14236933_-_KLF1_ENST00000264834_chr19_12996626_-_225nt ATGGCCAAGGTGTCGGTGCTGAACGTGGCGGTCCTGGAGAACCCGAGCCCTTTCCACAGCCCCTTCCGGTTCGAGATCAGCTTCGAGTGC AGTGAAGCCCTGGCGGACGACCTGGAGTGGAAGATCATTTATGTTGGCTCGGCTGAGAGTGAGGAATTTGATCAGATCCTAGACTCGGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ASF1B_ENST00000263382_chr19_14236933_-_KLF1_ENST00000264834_chr19_12996626_-_1881nt CGCTGCGCGCTGCGGGATGCATCTCCCGGAAAAGCGAGGCGAGGGGCGGGCCACGCCGGTGCGGGAACCCTCAGGATTGGCCAGAAGGAG GCCGGCGCTGTGACTCCGTCCATTCCCGCCGTTGACATCCAAGTCGGAGACGCTGGGGATTGGTTTCCAGCGGACACGCTAAGAAGCTTG GAGATAGTTTCGCCCTCCTCACACGCTGCGGAGAGGGAGCTCCGCTGATTGGTCCGAGGAGTCTGGGCGCGCGCCGATCGGCGCTCCAGG ACTGGCTGAGGGGGTGCGCGCGCCGCCAGGGAGCGTTGGCGGTGATTGGCCAGAGGGCGGAGGCCGGCTATTTGAAGGCGGCGCGCGGAC TAGGTGCGCACTTCAGTTCTCGGAGAGAAGAGGCGGGAGTGGACCTGGTCAGCCCTACCCCACTGACCCCACCGGACCCAGGCGCGGCCT CCGCCACAGCCACAGCCCCTGCCCCTGCTGCGGCGCGGCGAGGCGAGGCGATGGCCAAGGTGTCGGTGCTGAACGTGGCGGTCCTGGAGA ACCCGAGCCCTTTCCACAGCCCCTTCCGGTTCGAGATCAGCTTCGAGTGCAGTGAAGCCCTGGCGGACGACCTGGAGTGGAAGATCATTT ATGTTGGCTCGGCTGAGAGTGAGGAATTTGATCAGATCCTAGACTCGGTGCTGGTGGGCCCTGTGCCAGCAGGGAGACACATGTTTGTCT TTCAGTGGTGGCGCTCCGAAGAGGCGCAGGACATGGGCCCGGGTCCTCCTGACCCCACGGAGCCGCCCCTCCACGTGAAGTCTGAGGACC AGCCCGGGGAGGAAGAGGACGATGAGAGGGGCGCGGACGCCACCTGGGACCTGGATCTCCTCCTCACCAACTTCTCGGGCCCGGAGCCCG GTGGCGCGCCCCAGACCTGCGCTCTGGCGCCCAGCGAGGCCTCCGGGGCGCAATATCCGCCGCCGCCCGAGACTCTGGGCGCATATGCTG GCGGCCCGGGGCTGGTGGCTGGGCTTTTGGGTTCGGAGGATCACTCGGGTTGGGTGCGCCCTGCCCTGCGAGCCCGGGCTCCCGACGCCT TCGTGGGCCCAGCCCTGGCTCCAGCCCCGGCCCCCGAGCCCAAGGCGCTGGCGCTGCAACCGGTGTACCCGGGGCCCGGCGCCGGCTCCT CGGGTGGCTACTTCCCGCGGACCGGGCTTTCAGTGCCTGCGGCGTCGGGCGCCCCCTACGGGCTACTGTCCGGGTACCCCGCGATGTACC CGGCGCCTCAGTACCAAGGGCACTTCCAGCTCTTCCGCGGGCTCCAGGGACCCGCGCCCGGTCCCGCCACGTCCCCCTCCTTCCTGAGTT GTTTGGGACCCGGGACGGTGGGCACTGGACTCGGGGGGACTGCAGAGGATCCAGGTGTGATAGCCGAGACCGCGCCATCCAAGCGAGGCC GACGTTCGTGGGCGCGCAAGAGGCAGGCAGCGCACACGTGCGCGCACCCGGGTTGCGGCAAGAGCTACACCAAGAGCTCCCACCTGAAGG CGCATCTGCGCACGCACACAGTGGTGGCGCTCCGAAGAGGCGCAGGACATGGGCCCGGGTCCTCCTGACCCCACGGAGCCGCCCCTCCAC GTGAAGTCTGAGGACCAGCCCGGGGAGGAAGAGGACGATGAGAGGGGCGCGGACGCCACCTGGGACCTGGATCTCCTCCTCACCAACTTC TCGGGCCCGGAGCCCGGTGGCGCGCCCCAGACCTGCGCTCTGGCGCCCAGCGAGGCCTCCGGGGCGCAATATCCGCCGCCGCCCGAGACT >In-frame_ASF1B_ENST00000592798_chr19_14236933_-_KLF1_ENST00000264834_chr19_12996626_-_1478nt CCTGGTCAGCCCTACCCCACTGACCCCACCGGACCCAGGCGCGGCCTCCGCCACAGCCACAGCCCCTGCCCCTGCTGCGGCGCGGCGAGG CGAGGCGATGGCCAAGGTGTCGGTGCTGAACGTGGCGGTCCTGGAGAACCCGAGCCCTTTCCACAGCCCCTTCCGGTTCGAGATCAGCTT CGAGTGCAGTGAAGCCCTGGCGGACGACCTGGAGTGGAAGATCATTTATGTTGGCTCGGCTGAGAGTGAGGAATTTGATCAGATCCTAGA CTCGGTGCTGGTGGGCCCTGTGCCAGCAGGGAGACACATGTTTGTCTTTCAGTGGTGGCGCTCCGAAGAGGCGCAGGACATGGGCCCGGG TCCTCCTGACCCCACGGAGCCGCCCCTCCACGTGAAGTCTGAGGACCAGCCCGGGGAGGAAGAGGACGATGAGAGGGGCGCGGACGCCAC CTGGGACCTGGATCTCCTCCTCACCAACTTCTCGGGCCCGGAGCCCGGTGGCGCGCCCCAGACCTGCGCTCTGGCGCCCAGCGAGGCCTC CGGGGCGCAATATCCGCCGCCGCCCGAGACTCTGGGCGCATATGCTGGCGGCCCGGGGCTGGTGGCTGGGCTTTTGGGTTCGGAGGATCA CTCGGGTTGGGTGCGCCCTGCCCTGCGAGCCCGGGCTCCCGACGCCTTCGTGGGCCCAGCCCTGGCTCCAGCCCCGGCCCCCGAGCCCAA GGCGCTGGCGCTGCAACCGGTGTACCCGGGGCCCGGCGCCGGCTCCTCGGGTGGCTACTTCCCGCGGACCGGGCTTTCAGTGCCTGCGGC GTCGGGCGCCCCCTACGGGCTACTGTCCGGGTACCCCGCGATGTACCCGGCGCCTCAGTACCAAGGGCACTTCCAGCTCTTCCGCGGGCT CCAGGGACCCGCGCCCGGTCCCGCCACGTCCCCCTCCTTCCTGAGTTGTTTGGGACCCGGGACGGTGGGCACTGGACTCGGGGGGACTGC AGAGGATCCAGGTGTGATAGCCGAGACCGCGCCATCCAAGCGAGGCCGACGTTCGTGGGCGCGCAAGAGGCAGGCAGCGCACACGTGCGC GCACCCGGGTTGCGGCAAGAGCTACACCAAGAGCTCCCACCTGAAGGCGCATCTGCGCACGCACACAGTGGTGGCGCTCCGAAGAGGCGC AGGACATGGGCCCGGGTCCTCCTGACCCCACGGAGCCGCCCCTCCACGTGAAGTCTGAGGACCAGCCCGGGGAGGAAGAGGACGATGAGA GGGGCGCGGACGCCACCTGGGACCTGGATCTCCTCCTCACCAACTTCTCGGGCCCGGAGCCCGGTGGCGCGCCCCAGACCTGCGCTCTGG CGCCCAGCGAGGCCTCCGGGGCGCAATATCCGCCGCCGCCCGAGACTCTGGGCGCATATGCTGGCGGCCCGGGGCTGGTGGCTGGGCTTT >In-frame_ASF1B_ENST00000474890_chr19_14236933_-_KLF1_ENST00000264834_chr19_12996626_-_1499nt GAGAGAAGAGGCGGGAGTGGACCTGGTCAGCCCTACCCCACTGACCCCACCGGACCCAGGCGCGGCCTCCGCCACAGCCACAGCCCCTGC CCCTGCTGCGGCGCGGCGAGGCGAGGCGATGGCCAAGGTGTCGGTGCTGAACGTGGCGGTCCTGGAGAACCCGAGCCCTTTCCACAGCCC CTTCCGGTTCGAGATCAGCTTCGAGTGCAGTGAAGCCCTGGCGGACGACCTGGAGTGGAAGATCATTTATGTTGGCTCGGCTGAGAGTGA GGAATTTGATCAGATCCTAGACTCGGTGCTGGTGGGCCCTGTGCCAGCAGGGAGACACATGTTTGTCTTTCAGTGGTGGCGCTCCGAAGA GGCGCAGGACATGGGCCCGGGTCCTCCTGACCCCACGGAGCCGCCCCTCCACGTGAAGTCTGAGGACCAGCCCGGGGAGGAAGAGGACGA TGAGAGGGGCGCGGACGCCACCTGGGACCTGGATCTCCTCCTCACCAACTTCTCGGGCCCGGAGCCCGGTGGCGCGCCCCAGACCTGCGC TCTGGCGCCCAGCGAGGCCTCCGGGGCGCAATATCCGCCGCCGCCCGAGACTCTGGGCGCATATGCTGGCGGCCCGGGGCTGGTGGCTGG GCTTTTGGGTTCGGAGGATCACTCGGGTTGGGTGCGCCCTGCCCTGCGAGCCCGGGCTCCCGACGCCTTCGTGGGCCCAGCCCTGGCTCC AGCCCCGGCCCCCGAGCCCAAGGCGCTGGCGCTGCAACCGGTGTACCCGGGGCCCGGCGCCGGCTCCTCGGGTGGCTACTTCCCGCGGAC CGGGCTTTCAGTGCCTGCGGCGTCGGGCGCCCCCTACGGGCTACTGTCCGGGTACCCCGCGATGTACCCGGCGCCTCAGTACCAAGGGCA CTTCCAGCTCTTCCGCGGGCTCCAGGGACCCGCGCCCGGTCCCGCCACGTCCCCCTCCTTCCTGAGTTGTTTGGGACCCGGGACGGTGGG CACTGGACTCGGGGGGACTGCAGAGGATCCAGGTGTGATAGCCGAGACCGCGCCATCCAAGCGAGGCCGACGTTCGTGGGCGCGCAAGAG GCAGGCAGCGCACACGTGCGCGCACCCGGGTTGCGGCAAGAGCTACACCAAGAGCTCCCACCTGAAGGCGCATCTGCGCACGCACACAGT GGTGGCGCTCCGAAGAGGCGCAGGACATGGGCCCGGGTCCTCCTGACCCCACGGAGCCGCCCCTCCACGTGAAGTCTGAGGACCAGCCCG GGGAGGAAGAGGACGATGAGAGGGGCGCGGACGCCACCTGGGACCTGGATCTCCTCCTCACCAACTTCTCGGGCCCGGAGCCCGGTGGCG CGCCCCAGACCTGCGCTCTGGCGCCCAGCGAGGCCTCCGGGGCGCAATATCCGCCGCCGCCCGAGACTCTGGGCGCATATGCTGGCGGCC |
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FusionGenePPI for ASF1B_KLF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ASF1B | TLK1, IPO4, CDAN1, TLK2, CHAF1B, RPS3A, DOK2, C15orf41, MMS22L, RBBP4, CHAF1A, TTN, TONSL, HIST1H3F, UBXN1, DYNLL1, PSPH, RPL31, MRPS7, HCFC1, HIRA, HIST3H3, HIST4H4, HAT1, RBBP7, HIST1H3A, H3F3A, MCM2, MCM6, HIST1H3E, ASF1A, HIST1H3C, KHSRP, IDH1, MOV10, NXF1, MCM3, MCM4, MCM5, MCM7, NASP, STAT5B, CABIN1, UBN1, UBN2, PAN3, PAN2, PPTC7, RIF1, HIST1H4A, HIST2H4A, RCVRN | KLF1 | ARID1A, SMARCA4, SMARCC2, SMARCC1, SMARCD1, SMARCE1, SMARCB1, CREBBP, CSNK2A2, CSNK2A1, FLI1, HDAC1, SIN3A, GTF2H1, EP300, UBC |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | ASF1B | chr19:14236933 | chr19:12996626 | ENST00000263382 | - | 2 | 4 | 1_155 | 75 | 203 | CHAF1B |
| Hgene | ASF1B | chr19:14236933 | chr19:12996626 | ENST00000263382 | - | 2 | 4 | 1_156 | 75 | 203 | histone H3 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ASF1B_KLF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ASF1B_KLF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | KLF1 | C0018939 | Hematological Disease | 1 | CTD_human |
| Tgene | KLF1 | C3150926 | ANEMIA, CONGENITAL DYSERYTHROPOIETIC, TYPE IV | 1 | ORPHANET;UNIPROT |
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