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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29475

FusionGeneSummary for PTPRA_ANAPC10

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRA_ANAPC10
Fusion gene ID: 29475
HgeneTgene
Gene symbol

PTPRA

ANAPC10

Gene ID

5786

10393

Gene nameprotein tyrosine phosphatase, receptor type Aanaphase promoting complex subunit 10
SynonymsHEPTP|HLPR|HPTPA|HPTPalpha|LRP|PTPA|PTPRL2|R-PTP-alpha|RPTPAAPC10|DOC1
Cytomap

20p13

4q31.21

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase alphaLeukocyte common antigen-related peptide (protein tyrosine phosphate)PTPLCA-related phosphatasePTPase-alphaprotein tyrosine phosphatase, receptor type, alpha polypeptideprotein-tyrosine phosphatase alphanaphase-promoting complex subunit 10cyclosome subunit 10
Modification date2018052720180523
UniProtAcc

P18433

Q9UM13

Ensembl transtripts involved in fusion geneENST00000380393, ENST00000216877, 
ENST00000358719, ENST00000399903, 
ENST00000425918, ENST00000318266, 
ENST00000356147, 		ENST00000507656, 
ENST00000451299, ENST00000309439, 
ENST00000510270, ENST00000512680, 
Fusion gene scores* DoF score13 X 10 X 8=10402 X 2 X 2=8
# samples 142
** MAII scorelog2(14/1040*10)=-2.89308479608349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: PTPRA [Title/Abstract] AND ANAPC10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneANAPC10

GO:0070979

protein K11-linked ubiquitination

18485873


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A13Z-01APTPRAchr20

3018775

+ANAPC10chr4

145916755

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000380393ENST00000507656PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000380393ENST00000451299PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000380393ENST00000309439PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
5CDS-5UTRENST00000380393ENST00000510270PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
5CDS-intronENST00000380393ENST00000512680PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000216877ENST00000507656PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000216877ENST00000451299PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000216877ENST00000309439PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
5CDS-5UTRENST00000216877ENST00000510270PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
5CDS-intronENST00000216877ENST00000512680PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000358719ENST00000507656PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000358719ENST00000451299PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000358719ENST00000309439PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
5CDS-5UTRENST00000358719ENST00000510270PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
5CDS-intronENST00000358719ENST00000512680PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000399903ENST00000507656PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000399903ENST00000451299PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000399903ENST00000309439PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
5CDS-5UTRENST00000399903ENST00000510270PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
5CDS-intronENST00000399903ENST00000512680PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000425918ENST00000507656PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000425918ENST00000451299PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000425918ENST00000309439PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
5CDS-5UTRENST00000425918ENST00000510270PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
5CDS-intronENST00000425918ENST00000512680PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000318266ENST00000507656PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000318266ENST00000451299PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000318266ENST00000309439PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
5CDS-5UTRENST00000318266ENST00000510270PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
5CDS-intronENST00000318266ENST00000512680PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000356147ENST00000507656PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000356147ENST00000451299PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
Frame-shitENST00000356147ENST00000309439PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
5CDS-5UTRENST00000356147ENST00000510270PTPRAchr20

3018775

+ANAPC10chr4

145916755

-
5CDS-intronENST00000356147ENST00000512680PTPRAchr20

3018775

+ANAPC10chr4

145916755

-

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FusionProtFeatures for PTPRA_ANAPC10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRA

P18433

ANAPC10

Q9UM13

Component of the anaphase promoting complex/cyclosome(APC/C), a cell cycle-regulated E3 ubiquitin ligase that controlsprogression through mitosis and the G1 phase of the cell cycle.The APC/C complex acts by mediating ubiquitination and subsequentdegradation of target proteins: it mainly mediates the formationof 'Lys-11'-linked polyubiquitin chains and, to a lower extent,the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitinchains. {ECO:0000269|PubMed:18485873}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRA_ANAPC10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRA_ANAPC10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRAGRB2, KCNA2, SRC, FYN, UVRAG, GABARAPL2, CALM1, LGALS8, FCN1, HSPB1, YWHAZ, SMEK1, EGFR, ERBB2, ARL2, ATXN2, KCNMA1, NCBP1, PSAT1, PTPRE, VPS25, TMEM51, CCDC88A, EPB41L1, PSD3, BASP1, GPRIN3, EXOC3, BAIAP2, RAPH1, NF2, GAB1, ASNSD1, DENND4A, TPCN2, SP4, CYB561, GALNT12, LGALS1, PTPRA, TXNDC5, XPO5, TNPO3, SAAL1, XPO4, B4GAT1, XPO6, PDIA6, NCDN, CSE1L, TNPO1, XPOT, CANX, MBP, PTPRGANAPC10CDC27, SMAD2, SMAD3, LRP2, LRP1, LRP8, ANAPC11, CDC20, PPP2R1A, CDC16, CDC23, ANAPC1, ANAPC4, ANAPC7, ANAPC2, LIG4, MDC1, TP53BP1, ANAPC15, FZR1, CBWD1, SMPD2, LPPR2, TAF5, CDC26, NAP1L4, TAF3, UTP15, KRAS, MAPK8IP2, XPO1, CFAP97, CCNB1, BUB1B, TSC22D2, ANAPC13, NUP98, HOXD13, LNP1, HHEX


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRA_ANAPC10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRA_ANAPC10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRAC0036341Schizophrenia2PSYGENET
HgenePTPRAC0151744Myocardial Ischemia1CTD_human