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Fusion gene ID: 29475 |
FusionGeneSummary for PTPRA_ANAPC10 |
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Fusion gene information | Fusion gene name: PTPRA_ANAPC10 | Fusion gene ID: 29475 | Hgene | Tgene | Gene symbol | PTPRA | ANAPC10 | Gene ID | 5786 | 10393 |
Gene name | protein tyrosine phosphatase, receptor type A | anaphase promoting complex subunit 10 | |
Synonyms | HEPTP|HLPR|HPTPA|HPTPalpha|LRP|PTPA|PTPRL2|R-PTP-alpha|RPTPA | APC10|DOC1 | |
Cytomap | 20p13 | 4q31.21 | |
Type of gene | protein-coding | protein-coding | |
Description | receptor-type tyrosine-protein phosphatase alphaLeukocyte common antigen-related peptide (protein tyrosine phosphate)PTPLCA-related phosphatasePTPase-alphaprotein tyrosine phosphatase, receptor type, alpha polypeptideprotein-tyrosine phosphatase alph | anaphase-promoting complex subunit 10cyclosome subunit 10 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P18433 | Q9UM13 | |
Ensembl transtripts involved in fusion gene | ENST00000380393, ENST00000216877, ENST00000358719, ENST00000399903, ENST00000425918, ENST00000318266, ENST00000356147, | ENST00000507656, ENST00000451299, ENST00000309439, ENST00000510270, ENST00000512680, | |
Fusion gene scores | * DoF score | 13 X 10 X 8=1040 | 2 X 2 X 2=8 |
# samples | 14 | 2 | |
** MAII score | log2(14/1040*10)=-2.89308479608349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: PTPRA [Title/Abstract] AND ANAPC10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ANAPC10 | GO:0070979 | protein K11-linked ubiquitination | 18485873 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-D8-A13Z-01A | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000380393 | ENST00000507656 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000380393 | ENST00000451299 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000380393 | ENST00000309439 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
5CDS-5UTR | ENST00000380393 | ENST00000510270 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
5CDS-intron | ENST00000380393 | ENST00000512680 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000216877 | ENST00000507656 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000216877 | ENST00000451299 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000216877 | ENST00000309439 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
5CDS-5UTR | ENST00000216877 | ENST00000510270 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
5CDS-intron | ENST00000216877 | ENST00000512680 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000358719 | ENST00000507656 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000358719 | ENST00000451299 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000358719 | ENST00000309439 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
5CDS-5UTR | ENST00000358719 | ENST00000510270 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
5CDS-intron | ENST00000358719 | ENST00000512680 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000399903 | ENST00000507656 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000399903 | ENST00000451299 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000399903 | ENST00000309439 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
5CDS-5UTR | ENST00000399903 | ENST00000510270 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
5CDS-intron | ENST00000399903 | ENST00000512680 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000425918 | ENST00000507656 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000425918 | ENST00000451299 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000425918 | ENST00000309439 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
5CDS-5UTR | ENST00000425918 | ENST00000510270 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
5CDS-intron | ENST00000425918 | ENST00000512680 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000318266 | ENST00000507656 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000318266 | ENST00000451299 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000318266 | ENST00000309439 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
5CDS-5UTR | ENST00000318266 | ENST00000510270 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
5CDS-intron | ENST00000318266 | ENST00000512680 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000356147 | ENST00000507656 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000356147 | ENST00000451299 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
Frame-shift | ENST00000356147 | ENST00000309439 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
5CDS-5UTR | ENST00000356147 | ENST00000510270 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
5CDS-intron | ENST00000356147 | ENST00000512680 | PTPRA | chr20 | 3018775 | + | ANAPC10 | chr4 | 145916755 | - |
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FusionProtFeatures for PTPRA_ANAPC10 |
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Hgene | Tgene |
PTPRA | ANAPC10 |
Component of the anaphase promoting complex/cyclosome(APC/C), a cell cycle-regulated E3 ubiquitin ligase that controlsprogression through mitosis and the G1 phase of the cell cycle.The APC/C complex acts by mediating ubiquitination and subsequentdegradation of target proteins: it mainly mediates the formationof 'Lys-11'-linked polyubiquitin chains and, to a lower extent,the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitinchains. {ECO:0000269|PubMed:18485873}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PTPRA_ANAPC10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PTPRA_ANAPC10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PTPRA | GRB2, KCNA2, SRC, FYN, UVRAG, GABARAPL2, CALM1, LGALS8, FCN1, HSPB1, YWHAZ, SMEK1, EGFR, ERBB2, ARL2, ATXN2, KCNMA1, NCBP1, PSAT1, PTPRE, VPS25, TMEM51, CCDC88A, EPB41L1, PSD3, BASP1, GPRIN3, EXOC3, BAIAP2, RAPH1, NF2, GAB1, ASNSD1, DENND4A, TPCN2, SP4, CYB561, GALNT12, LGALS1, PTPRA, TXNDC5, XPO5, TNPO3, SAAL1, XPO4, B4GAT1, XPO6, PDIA6, NCDN, CSE1L, TNPO1, XPOT, CANX, MBP, PTPRG | ANAPC10 | CDC27, SMAD2, SMAD3, LRP2, LRP1, LRP8, ANAPC11, CDC20, PPP2R1A, CDC16, CDC23, ANAPC1, ANAPC4, ANAPC7, ANAPC2, LIG4, MDC1, TP53BP1, ANAPC15, FZR1, CBWD1, SMPD2, LPPR2, TAF5, CDC26, NAP1L4, TAF3, UTP15, KRAS, MAPK8IP2, XPO1, CFAP97, CCNB1, BUB1B, TSC22D2, ANAPC13, NUP98, HOXD13, LNP1, HHEX |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTPRA_ANAPC10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PTPRA_ANAPC10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PTPRA | C0036341 | Schizophrenia | 2 | PSYGENET |
Hgene | PTPRA | C0151744 | Myocardial Ischemia | 1 | CTD_human |