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Fusion gene ID: 29468 |
FusionGeneSummary for PTPN9_ASH1L |
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Fusion gene information | Fusion gene name: PTPN9_ASH1L | Fusion gene ID: 29468 | Hgene | Tgene | Gene symbol | PTPN9 | ASH1L | Gene ID | 5780 | 55870 |
Gene name | protein tyrosine phosphatase, non-receptor type 9 | ASH1 like histone lysine methyltransferase | |
Synonyms | MEG2|PTPMEG2 | ASH1|ASH1L1|KMT2H|MRD52 | |
Cytomap | 15q24.2 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | tyrosine-protein phosphatase non-receptor type 9PTPase-MEG2protein-tyrosine phosphatase MEG2 | histone-lysine N-methyltransferase ASH1LASH1-like proteinabsent small and homeotic disks protein 1 homologash1 (absent, small, or homeotic)-likelysine N-methyltransferase 2Hprobable histone-lysine N-methyltransferase ASH1L | |
Modification date | 20180520 | 20180519 | |
UniProtAcc | P43378 | Q9NR48 | |
Ensembl transtripts involved in fusion gene | ENST00000306726, ENST00000564970, | ENST00000368346, ENST00000392403, ENST00000548830, | |
Fusion gene scores | * DoF score | 8 X 6 X 7=336 | 9 X 8 X 5=360 |
# samples | 13 | 9 | |
** MAII score | log2(13/336*10)=-1.36994960975031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/360*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PTPN9 [Title/Abstract] AND ASH1L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PTPN9 | GO:0010977 | negative regulation of neuron projection development | 27655914 |
Hgene | PTPN9 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 27655914 |
Hgene | PTPN9 | GO:1903078 | positive regulation of protein localization to plasma membrane | 27655914 |
Tgene | ASH1L | GO:0097676 | histone H3-K36 dimethylation | 26002201 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | GBM | TCGA-06-0141-01A | PTPN9 | chr15 | 75871055 | - | ASH1L | chr1 | 155324421 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000306726 | ENST00000368346 | PTPN9 | chr15 | 75871055 | - | ASH1L | chr1 | 155324421 | - |
Frame-shift | ENST00000306726 | ENST00000392403 | PTPN9 | chr15 | 75871055 | - | ASH1L | chr1 | 155324421 | - |
5CDS-intron | ENST00000306726 | ENST00000548830 | PTPN9 | chr15 | 75871055 | - | ASH1L | chr1 | 155324421 | - |
intron-3CDS | ENST00000564970 | ENST00000368346 | PTPN9 | chr15 | 75871055 | - | ASH1L | chr1 | 155324421 | - |
intron-3CDS | ENST00000564970 | ENST00000392403 | PTPN9 | chr15 | 75871055 | - | ASH1L | chr1 | 155324421 | - |
intron-intron | ENST00000564970 | ENST00000548830 | PTPN9 | chr15 | 75871055 | - | ASH1L | chr1 | 155324421 | - |
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FusionProtFeatures for PTPN9_ASH1L |
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Hgene | Tgene |
PTPN9 | ASH1L |
Protein-tyrosine phosphatase that could participate inthe transfer of hydrophobic ligands or in functions of the Golgiapparatus. {ECO:0000269|PubMed:19167335}. | Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me). {ECO:0000269|PubMed:21239497}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PTPN9_ASH1L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PTPN9_ASH1L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PTPN9 | RTN3, GHR, MYC, TP53BP1, VCP, AGTRAP, REEP6, MAL2, CMTM5, ENO1, MOV10, NXF1, NTRK1, CREB3, LZTR1, PC, EYA1, RAD51C, FAM26D, VSIG8, C5AR2, MDK, PDCD1, PTPN9, GEMIN8, FSIP1, SMN1, DDX20, GEMIN4, PMPCA, SLC39A7, STRAP, TUBA3C, AAR2, SMN2, TUBA3D, LMNA | ASH1L | HIST1H3A, H3F3A, SMAD7, THAP7, MORF4L1, PARD6A, SIKE1, MORF4L2, NXF2, CDX1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTPN9_ASH1L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PTPN9_ASH1L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ASH1L | C0023903 | Liver neoplasms | 1 | CTD_human |