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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29459

FusionGeneSummary for PTPN4_GRID1

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPN4_GRID1
Fusion gene ID: 29459
HgeneTgene
Gene symbol

PTPN4

GRID1

Gene ID

5775

2894

Gene nameprotein tyrosine phosphatase, non-receptor type 4glutamate ionotropic receptor delta type subunit 1
SynonymsMEG|PTPMEG|PTPMEG1GluD1
Cytomap

2q14.2

10q23.1-q23.2

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein phosphatase non-receptor type 4PTPase-MEG1megakaryocyte phosphatasemegakaryocyte protein-tyrosine phosphataseprotein tyrosine phosphatase MEG1protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)glutamate receptor ionotropic, delta-1gluR delta-1 subunitglutamate receptor delta-1 subunit
Modification date2018051920180523
UniProtAcc

P29074

Q9ULK0

Ensembl transtripts involved in fusion geneENST00000263708, ENST00000544261, 
ENST00000460162, 		ENST00000327946, 
ENST00000536331, ENST00000552278, 
Fusion gene scores* DoF score4 X 3 X 3=369 X 6 X 8=432
# samples 49
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPN4 [Title/Abstract] AND GRID1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-NC-A5HM-01APTPN4chr2

120567567

+GRID1chr10

87489371

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000263708ENST00000327946PTPN4chr2

120567567

+GRID1chr10

87489371

-
5CDS-5UTRENST00000263708ENST00000536331PTPN4chr2

120567567

+GRID1chr10

87489371

-
5CDS-intronENST00000263708ENST00000552278PTPN4chr2

120567567

+GRID1chr10

87489371

-
intron-3CDSENST00000544261ENST00000327946PTPN4chr2

120567567

+GRID1chr10

87489371

-
intron-5UTRENST00000544261ENST00000536331PTPN4chr2

120567567

+GRID1chr10

87489371

-
intron-intronENST00000544261ENST00000552278PTPN4chr2

120567567

+GRID1chr10

87489371

-
intron-3CDSENST00000460162ENST00000327946PTPN4chr2

120567567

+GRID1chr10

87489371

-
intron-5UTRENST00000460162ENST00000536331PTPN4chr2

120567567

+GRID1chr10

87489371

-
intron-intronENST00000460162ENST00000552278PTPN4chr2

120567567

+GRID1chr10

87489371

-

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FusionProtFeatures for PTPN4_GRID1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPN4

P29074

GRID1

Q9ULK0

May act at junctions between the membrane and thecytoskeleton. Receptor for glutamate. L-glutamate acts as anexcitatory neurotransmitter at many synapses in the centralnervous system. The postsynaptic actions of Glu are mediated by avariety of receptors that are named according to their selectiveagonists.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGRID1chr2:120567567chr10:87489371ENST00000327946-716584_6374111010Topological domainCytoplasmic
TgeneGRID1chr2:120567567chr10:87489371ENST00000327946-716659_8304111010Topological domainExtracellular
TgeneGRID1chr2:120567567chr10:87489371ENST00000327946-716852_10094111010Topological domainCytoplasmic
TgeneGRID1chr2:120567567chr10:87489371ENST00000327946-716563_5834111010TransmembraneHelical
TgeneGRID1chr2:120567567chr10:87489371ENST00000327946-716638_6584111010TransmembraneHelical
TgeneGRID1chr2:120567567chr10:87489371ENST00000327946-716831_8514111010TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN4chr2:120567567chr10:87489371ENST00000263708+22729_31246927DomainFERM
HgenePTPN4chr2:120567567chr10:87489371ENST00000263708+227517_58946927DomainPDZ
HgenePTPN4chr2:120567567chr10:87489371ENST00000263708+227655_91146927DomainTyrosine-protein phosphatase
HgenePTPN4chr2:120567567chr10:87489371ENST00000263708+227852_85846927RegionSubstrate binding
TgeneGRID1chr2:120567567chr10:87489371ENST00000327946-71621_5624111010Topological domainExtracellular


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FusionGeneSequence for PTPN4_GRID1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PTPN4_ENST00000263708_chr2_120567567_+_GRID1_ENST00000327946_chr10_87489371_-_645aa
MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAEN
ILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILI
KKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMG
SWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSP
SEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTS
HASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISPASIELSALEM
GGLAPTQTLEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPLPLSSSATMPSMQCKHRSPNGGLFRQSPVKTPIPMSFQPVPGG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PTPN4_ENST00000263708_chr2_120567567_+_GRID1_ENST00000327946_chr10_87489371_-_1935nt
ATGACCTCACGTTTCCGATTGCCTGCTGGCAGAACCTACAATGTACGAGCATCAGAGTTGGCCCGAGACAGACAGCATACTGAAGTGGTT
TGCAACATCCTTCTTCTGGATAACACTGTACAAGCTTTCAAAGTCAATTTGGCGACATGGGACTCAGAGAAGGGCTTGAATGGCAGCTTG
CAAGAGAGGCCCATGGGCAGCCGCCTCCAAGGATTGACTCTTAAAGTGGTGACTGTCTTGGAAGAGCCTTTCGTGATGGTGGCTGAGAAC
ATCCTAGGACAGCCCAAGCGCTACAAAGGGTTCTCCATAGATGTCCTGGATGCACTGGCCAAGGCTCTGGGCTTTAAATATGAGATTTAC
CAAGCCCCTGATGGCAGGTACGGTCACCAGCTCCATAACACCTCCTGGAACGGGATGATCGGGGAGCTCATCAGCAAGAGAGCAGACTTG
GCCATCTCTGCCATCACCATCACCCCAGAGAGGGAGAGCGTTGTGGACTTCAGCAAGCGGTACATGGACTATTCAGTGGGGATTCTAATT
AAGAAGCCCGAGGAGAAAATCAGCATCTTCTCCCTCTTTGCTCCATTTGATTTCGCTGTGTGGGCCTGCATTGCAGCAGCCATCCCTGTG
GTTGGTGTGCTGATATTTGTGTTGAACAGGATACAGGCTGTGAGGGCTCAGAGTGCTGCCCAGCCCAGGCCGTCAGCTTCTGCCACTCTG
CACAGCGCCATCTGGATTGTCTATGGAGCCTTCGTACAGCAAGGTGGCGAATCTTCCGTGAACTCCATGGCCATGCGCATCGTGATGGGC
AGCTGGTGGCTCTTCACGCTCATTGTGTGCTCCTCCTACACAGCCAACCTTGCTGCCTTCCTCACAGTGTCCAGGATGGACAACCCCATA
AGGACTTTCCAGGACCTGTCCAAACAAGTGGAAATGTCTTATGGCACTGTCCGGGATTCTGCTGTATATGAGTACTTCCGAGCCAAGGGC
ACCAACCCCCTGGAGCAGGACAGCACGTTTGCTGAACTCTGGCGGACCATCAGCAAGAACGGAGGGGCTGACAACTGCGTGTCCAGTCCT
TCAGAAGGCATCAGGAAGGCAAAGAAGGGGAACTACGCCTTCCTGTGGGATGTGGCCGTGGTGGAATACGCAGCCCTGACGGATGACGAC
TGCTCGGTGACTGTCATCGGCAACAGCATCAGCAGCAAGGGTTACGGGATTGCCCTGCAGCATGGCAGCCCCTACAGGGACCTCTTCTCC
CAGAGGATCCTGGAGCTGCAGGACACAGGGGACCTGGATGTGCTGAAGCAGAAGTGGTGGCCGCACATGGGCCGCTGTGACCTCACCAGC
CATGCCAGCGCCCAGGCCGACGGCAAATCCCTCAAGCTGCACAGCTTCGCCGGGGTCTTCTGCATCCTGGCCATTGGCCTGCTCCTGGCC
TGCCTGGTGGCTGCCCTGGAGTTGTGGTGGAACAGCAACCGGTGCCACCAGGAGACCCCCAAGGAGGACAAAGAAGTGAACTTGGAGCAG
GTCCACCGGCGCATGAACAGCCTCATGGATGAAGACATTGCTCACAAGCAGATTTCCCCAGCGTCGATTGAGCTCTCGGCCCTGGAGATG
GGGGGCCTGGCTCCCACCCAGACCTTGGAGCCGACACGGGAGTACCAGAACACCCAGCTCTCGGTCAGCACCTTTCTGCCAGAGCAGAGC
AGCCATGGCACCAGCCGGACACTCTCATCAGGGCCCAGCAGCAACCTGCCGCTGCCGCTGAGCAGCTCGGCGACCATGCCCTCCATGCAG
TGCAAACACAGGTCACCCAACGGGGGGCTGTTCCGGCAGAGCCCGGTGAAGACCCCCATCCCCATGTCCTTCCAGCCCGTGCCTGGAGGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_PTPN4_ENST00000263708_chr2_120567567_+_GRID1_ENST00000327946_chr10_87489371_-_5424nt
CCTGCGTGTCCCTCTGCGCTCCGACTGGTGCGACTTCTCCCTGCGCTAGCGAGGCAGGGTTTTGGCCTCGCCTCTCGCGAGATCGCCTCC
TGTTGCTGCCGCCGCCGCTCCTGGCCACTGACTGGCGGCGCCTGCGCAGCCGCCATGTTCGGTTGCTATGCTGCGGCCTAGGAGAGGGGG
TGTGCTTGAGGGAGGAGGAAGAGATAGAGGAGGAGGAGGGGGAGGAAGAGGAGGTGGAGAAGGAGGGGGGTGACTGAGCTCCTCTTGCAC
TCTCACACACAAACGCTGCCCAGGATTACCCGCCAGCTCACGCCGCGCAGTGCGCTTTTCCGCTCCTCGCGCCCCACCACCAACATTGTT
CTCTCAGGACTCCTGGGTCCCAGGGGCCGGAATTGGGCCTGAGCGGGAGAGGAAAGAGACTTGGCTTTGGCCGCGGGGTCGGAGGATTGG
GGCCAGGCCCCCTCCCCCACGCACTTTTGGGGGTGTGGATTATCTCATCCCTGCAGGGAGGTAGGAGAGGTCGCCGGCTGCCCGCCTCCC
TGCCACCTCCCCAGCGGCGCCGGCCCGCGGCTGCCCAGCAGCATGAGGTGGTGCTGGCGGCTCCGGGTCGTGGCGCGACCGCTGCGGCGG
CGGCTGCTCGGGGGGCGCTGAGGTAGCCCCCCGGAGCGGCACGGAGGACGCGCTTCTCCTCTGCGCGCCGGGGCCTCGAGGCTTTTTTTC
TCCAGCCGAGAGGACGCGGCTGTGATATACGAAGACTTTGTGTGGACAGTAATGACCTCACGTTTCCGATTGCCTGCTGGCAGAACCTAC
AATGTACGAGCATCAGAGTTGGCCCGAGACAGACAGCATACTGAAGTGGTTTGCAACATCCTTCTTCTGGATAACACTGTACAAGCTTTC
AAAGTCAATTTGGCGACATGGGACTCAGAGAAGGGCTTGAATGGCAGCTTGCAAGAGAGGCCCATGGGCAGCCGCCTCCAAGGATTGACT
CTTAAAGTGGTGACTGTCTTGGAAGAGCCTTTCGTGATGGTGGCTGAGAACATCCTAGGACAGCCCAAGCGCTACAAAGGGTTCTCCATA
GATGTCCTGGATGCACTGGCCAAGGCTCTGGGCTTTAAATATGAGATTTACCAAGCCCCTGATGGCAGGTACGGTCACCAGCTCCATAAC
ACCTCCTGGAACGGGATGATCGGGGAGCTCATCAGCAAGAGAGCAGACTTGGCCATCTCTGCCATCACCATCACCCCAGAGAGGGAGAGC
GTTGTGGACTTCAGCAAGCGGTACATGGACTATTCAGTGGGGATTCTAATTAAGAAGCCCGAGGAGAAAATCAGCATCTTCTCCCTCTTT
GCTCCATTTGATTTCGCTGTGTGGGCCTGCATTGCAGCAGCCATCCCTGTGGTTGGTGTGCTGATATTTGTGTTGAACAGGATACAGGCT
GTGAGGGCTCAGAGTGCTGCCCAGCCCAGGCCGTCAGCTTCTGCCACTCTGCACAGCGCCATCTGGATTGTCTATGGAGCCTTCGTACAG
CAAGGTGGCGAATCTTCCGTGAACTCCATGGCCATGCGCATCGTGATGGGCAGCTGGTGGCTCTTCACGCTCATTGTGTGCTCCTCCTAC
ACAGCCAACCTTGCTGCCTTCCTCACAGTGTCCAGGATGGACAACCCCATAAGGACTTTCCAGGACCTGTCCAAACAAGTGGAAATGTCT
TATGGCACTGTCCGGGATTCTGCTGTATATGAGTACTTCCGAGCCAAGGGCACCAACCCCCTGGAGCAGGACAGCACGTTTGCTGAACTC
TGGCGGACCATCAGCAAGAACGGAGGGGCTGACAACTGCGTGTCCAGTCCTTCAGAAGGCATCAGGAAGGCAAAGAAGGGGAACTACGCC
TTCCTGTGGGATGTGGCCGTGGTGGAATACGCAGCCCTGACGGATGACGACTGCTCGGTGACTGTCATCGGCAACAGCATCAGCAGCAAG
GGTTACGGGATTGCCCTGCAGCATGGCAGCCCCTACAGGGACCTCTTCTCCCAGAGGATCCTGGAGCTGCAGGACACAGGGGACCTGGAT
GTGCTGAAGCAGAAGTGGTGGCCGCACATGGGCCGCTGTGACCTCACCAGCCATGCCAGCGCCCAGGCCGACGGCAAATCCCTCAAGCTG
CACAGCTTCGCCGGGGTCTTCTGCATCCTGGCCATTGGCCTGCTCCTGGCCTGCCTGGTGGCTGCCCTGGAGTTGTGGTGGAACAGCAAC
CGGTGCCACCAGGAGACCCCCAAGGAGGACAAAGAAGTGAACTTGGAGCAGGTCCACCGGCGCATGAACAGCCTCATGGATGAAGACATT
GCTCACAAGCAGATTTCCCCAGCGTCGATTGAGCTCTCGGCCCTGGAGATGGGGGGCCTGGCTCCCACCCAGACCTTGGAGCCGACACGG
GAGTACCAGAACACCCAGCTCTCGGTCAGCACCTTTCTGCCAGAGCAGAGCAGCCATGGCACCAGCCGGACACTCTCATCAGGGCCCAGC
AGCAACCTGCCGCTGCCGCTGAGCAGCTCGGCGACCATGCCCTCCATGCAGTGCAAACACAGGTCACCCAACGGGGGGCTGTTCCGGCAG
AGCCCGGTGAAGACCCCCATCCCCATGTCCTTCCAGCCCGTGCCTGGAGGCGTCCTTCCAGAGGCTCTGGACACCTCCCACGGGACCTCC
ATCTGACTGCGCCGCCTGCCCTCCTGCCCACCCTCCCACCCACCCGACCAGCAGAGCTTTTTAATACAAGAAAACAACAACACAAACCAC
ACACACTCGCACACACACACATACACAGAGACTCTTTCATTTTTCTTGTACATATGTGTAAATAATGACAGAATGGAGTGGGGTAAAAGT
GTATTTTGAATATTCCCAATTTTCGAAGTCAGTAAAAAAACACAAAAACTGTATGAATGACTTTGTAAATTTTGTTCTATATGAATAAAA
AGGCAAATTACTTGTGATCATTCTGAAGTGCCAAAGGAGCCCCCCCATTCCTGGGCCTTTCTGAGGGCAGGAGGGGCGACCAGATAAGGA
GCCCCTCTCTGCTGGGGGAGAAGGGAAGACGAGGAACCCCACATGCCACTCGCTGCCTTGTCCCACAGCTTGCTGCCCCATTTCTTTGCT
CCTGGCACCTCGTCCCTTTTAGTCCCTCAGCTTGATAAAGAGTGAGTTTGGAGCCCGCATTGGGCTGGCCCACTGGGTTGCTGTGCTGTA
GGGTGATCGGCTGTTCTGGGTAGCCTGGGGCTGAGGAGGTGCCCTGGACTCAGGGCTATCCTGTCCTGTCTTGGATCTTGCGGGACGAGT
TAGTCACCGCTGTGTGTGTTGCAGTGTGCCTCTGCCCCATGGGCCCGAGAGAAGCTGACAATTACCCATAGTGAGGTAATTGAGGGCTTT
GATACTGAGCTGTTCTCATATCATACTGTTGGCCTTGTTTTTCATTTTCTTTTCAAAATTAGAAGAATCAAAAAGTGATAGAATATTGGG
GGAAGGAGGGCAGACTCCATCGTTTCCTCAGGGAGACTGGGCGGAGGTGGGGTTGGTCTGGAAGAAGGTCCATGGGGGCAGGGAGTTGCG
AGGTGGGGTTAGTTGCATGGACCAGGTGAGGTGGTGGAACAAAAGGCCAGGTAGAGGAAGAATATTCCCTTGGGTTTGGACCCATGGTCC
CAGGTGAGAGAAGGAAGTGAGGCCATAGATGCAGGGAGTAGAAGCTTTGTGGTGTCAGGCAAACGGACTCTGTTAGTAAGAGTTGGGGGA
GGTGCCCAGGTGGGTGGACCAGTACTCCAGGTGATGGGGCATGCTGAGAAATAGAGAAAAGAGACCATGTTTATTTGGGTAGGAGGAAGC
CTTGCCTTGCGCCTTAGGTGAGAAGCATAAGTGTAACTCCCATCCACCAGGGAAGTTGCTTGTAGCCCCAAAAGTAAAGGCCTATCTCTG
GGTCATAAATCCTGCAGGCAGTCCAACAAACAGGGCTGGCTCCAGCACAAACTCTCCCTTCCACCTTTACGACCCTCTCCAGACCAGACC
TGGAGTCCTCTTCAAGCAGCAATCCAACCCAGAGCAGGGGCCCTCCCCACTCAGGCATCTGATAACCTCTGAGATTTCCAGGCCTATCCC
TGTGCAGGTACAGCTGCAGGGAAGCCCAGTTTTCTAAGCCTAGGACCACCTAACAGCGCCCCCTCCTTCAGTTGCCCTTTCTGAGGCAAC
TAAACTACAGAATCAGGGAAAGAACCATTAGGAGTGGAACTGGGGGAATCTGAGTTGTGTCACTTCAGTTCCTCTCCTAAAGACAAAGGT
TAGTCTGATCTCCAGACCCGTCAGAATGGAATACACAGCCCACATCTGTCACTGAAGGAGGTGGAGCTCCCACAGCCAGCAGTAATCAGG
GAGCTGAGAGCCTGGTTCTGTGATCATGGAGAAATACAAAGTCCTATTGATTGCTTCTTCTATAGCCTTGTAGAGTTTCTAGAGAGATGT
ATTTATGAGGGTGATAACTAGCCCAGGATTGATTTCTTTCCTAAAGTCCCTAGTGACATGATTGAGCAGTAAAGAACGGCCAAATCACAC
AGTCAGCTAAAAGCACTGTGGGGAAGAGAGTGTTTATAATTATGTTATTTATTGCTGGATGCTGAGAATGGTCTGATATTCGTGCTACCT
AGGCAATCCATTGACATTTCTCCAATCAGAGCATGTGGACCTTGGAGCCAGGCATGCTCAGAGAAGCCTAGGTGGGCTACCATGACCCCG
AGGAAGAGCAGGCTTTGTTTTCCATCAGCACGTTGGGGGCCCTGCCCTGAATGGTCAATTTTTCACATATATATCTCTCTATTTTTTTAA
TCAAACTCTGGTCTCACTGCCTTATCTCACACCAACTCTGTTTCCTCATTGCCCCCTGAGATGGCCTGTCTTCTGGGGTATAGCTTGGAT
GTCTTCTTGGATGGTTCTGCTTAGAATGAGTGTCAAGGAGGAAAGAGAGGGAGATGGAGGATGTGTTTGTGCGCCTGTGTGTGTGTGTTT
GTGTGTGTGTGTGTGTGTGAGAGAGAGAGAGAGAGAGAGAGAGACCAGCATCTTCAAGAGAAGTATTCTGCTTATACAAAATCCTTAACA
CCTCATGGTGTTATTCTTCACCATGTTTATATATATATATATATATTTTTTTTTTTTTTTAGAATTTTCTACCCTTGGCATGAGGGGAAA
TGATTGATATTCAAGCAAGTTCTCTAGGAAAAAAAAAAACTTCCCAACTCAGATTTCTGTGTCAGCTCAGAATGTATCTTTTTTTCATGC
TTTGCTCTTTGGATTTATAACTCTGTTTAGACTATTCCATACATTTTAGGTATATTTTGTGCCTTCAGACACTGCAAATAATAATCAGCA


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FusionGenePPI for PTPN4_GRID1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPN4ZZEF1, ATRX, LPL, KAT5, EEF1A1, EEF1G, GRID2, GRIN2A, MGMT, TK1, CRK, KCTD17, ADH5, CADM1, GOLIM4, LTBP1, MPP7, PAK4, PEX19, SHKBP1, SNRPD1, YWHAG, YWHAH, YWHAQ, YWHAZ, PTPN4, CRKL, C18orf25, UNC13B, CSNK2A1, CSNK2A2, SIRT1, YWHABGRID1DEF6, EGFR, TCTN2, HTR3A, HBB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneGRID1chr2:120567567chr10:87489371ENST00000327946-71621_4364111010CBLN1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPN4_GRID1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePTPN4P29074DB00630Alendronic acidTyrosine-protein phosphatase non-receptor type 4small moleculeapproved
TgeneGRID1Q9ULK0DB00142Glutamic AcidGlutamate receptor ionotropic, delta-1small moleculeapproved|nutraceutical

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RelatedDiseases for PTPN4_GRID1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGRID1C0036341Schizophrenia5PSYGENET
TgeneGRID1C0011570Mental Depression3PSYGENET
TgeneGRID1C0011581Depressive disorder3PSYGENET
TgeneGRID1C0005586Bipolar Disorder1PSYGENET
TgeneGRID1C0009404Colorectal Neoplasms1CTD_human