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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29436

FusionGeneSummary for PTPN1_ROMO1

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPN1_ROMO1
Fusion gene ID: 29436
HgeneTgene
Gene symbol

PTPN1

ROMO1

Gene ID

5770

140823

Gene nameprotein tyrosine phosphatase, non-receptor type 1reactive oxygen species modulator 1
SynonymsPTP1BC20orf52|MTGM|MTGMP|bA353C18.2
Cytomap

20q13.13

20q11.22

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein phosphatase non-receptor type 1protein tyrosine phosphatase, placentalprotein-tyrosine phosphatase 1Breactive oxygen species modulator 1PCM19ROS modulator 1epididymis tissue protein Li 175glyrichinmitochondrial targeting GXXXG proteinmitochondrial targeting GxxxG motif proteinprotein MGR2 homolog
Modification date2018052220180523
UniProtAcc

P18031

P60602

Ensembl transtripts involved in fusion geneENST00000371621, ENST00000541713, 
ENST00000374078, ENST00000374077, 
ENST00000374072, ENST00000397416, 
ENST00000336695, 
Fusion gene scores* DoF score7 X 4 X 5=1405 X 5 X 3=75
# samples 85
** MAII scorelog2(8/140*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPN1 [Title/Abstract] AND ROMO1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPN1

GO:0030100

regulation of endocytosis

21135139

HgenePTPN1

GO:0030968

endoplasmic reticulum unfolded protein response

22169477

HgenePTPN1

GO:0035335

peptidyl-tyrosine dephosphorylation

21135139

HgenePTPN1

GO:0061098

positive regulation of protein tyrosine kinase activity

21216966

HgenePTPN1

GO:1903898

negative regulation of PERK-mediated unfolded protein response

21216966

TgeneROMO1

GO:0008284

positive regulation of cell proliferation

18313394

TgeneROMO1

GO:0031640

killing of cells of other organism

22083756

TgeneROMO1

GO:0042742

defense response to bacterium

22083756

TgeneROMO1

GO:0050829

defense response to Gram-negative bacterium

22083756

TgeneROMO1

GO:0050830

defense response to Gram-positive bacterium

22083756

TgeneROMO1

GO:0051715

cytolysis in other organism

22083756

TgeneROMO1

GO:2000379

positive regulation of reactive oxygen species metabolic process

16842742


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-EW-A2FW-01APTPN1chr20

49191191

+ROMO1chr20

34287555

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000371621ENST00000374078PTPN1chr20

49191191

+ROMO1chr20

34287555

+
In-frameENST00000371621ENST00000374077PTPN1chr20

49191191

+ROMO1chr20

34287555

+
In-frameENST00000371621ENST00000374072PTPN1chr20

49191191

+ROMO1chr20

34287555

+
In-frameENST00000371621ENST00000397416PTPN1chr20

49191191

+ROMO1chr20

34287555

+
Frame-shitENST00000371621ENST00000336695PTPN1chr20

49191191

+ROMO1chr20

34287555

+
In-frameENST00000541713ENST00000374078PTPN1chr20

49191191

+ROMO1chr20

34287555

+
In-frameENST00000541713ENST00000374077PTPN1chr20

49191191

+ROMO1chr20

34287555

+
In-frameENST00000541713ENST00000374072PTPN1chr20

49191191

+ROMO1chr20

34287555

+
In-frameENST00000541713ENST00000397416PTPN1chr20

49191191

+ROMO1chr20

34287555

+
Frame-shitENST00000541713ENST00000336695PTPN1chr20

49191191

+ROMO1chr20

34287555

+

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FusionProtFeatures for PTPN1_ROMO1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPN1

P18031

ROMO1

P60602

Tyrosine-protein phosphatase which acts as a regulatorof endoplasmic reticulum unfolded protein response. Mediatesdephosphorylation of EIF2AK3/PERK; inactivating the protein kinaseactivity of EIF2AK3/PERK. May play an important role in CKII- andp60c-src-induced signal transduction cascades. May regulate theEFNA5-EPHA3 signaling pathway which modulates cell reorganizationand cell-cell repulsion. May also regulate the hepatocyte growthfactor receptor signaling pathway through dephosphorylation ofMET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139,ECO:0000269|PubMed:22169477}. Induces production of reactive oxygen species (ROS)which are necessary for cell proliferation. May play a role ininducing oxidative DNA damage and replicative senescence. May playa role in the coordination of mitochondrial morphology and cellproliferation. Has antibacterial activity against a variety of bacteriaincluding S.aureus, P.aeruginosa and M.tuberculosis. Acts byinducing bacterial membrane breakage.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneROMO1chr20:49191191chr20:34287555ENST00000336695+0242_60-6180RegionNote=Sufficient for antibacterial activity
TgeneROMO1chr20:49191191chr20:34287555ENST00000374072+0342_60060RegionNote=Sufficient for antibacterial activity
TgeneROMO1chr20:49191191chr20:34287555ENST00000374077+0342_60080RegionNote=Sufficient for antibacterial activity
TgeneROMO1chr20:49191191chr20:34287555ENST00000374078+0342_60080RegionNote=Sufficient for antibacterial activity
TgeneROMO1chr20:49191191chr20:34287555ENST00000397416+0342_60080RegionNote=Sufficient for antibacterial activity
TgeneROMO1chr20:49191191chr20:34287555ENST00000336695+0222_44-6180TransmembraneHelical
TgeneROMO1chr20:49191191chr20:34287555ENST00000374072+0322_44060TransmembraneHelical
TgeneROMO1chr20:49191191chr20:34287555ENST00000374077+0322_44080TransmembraneHelical
TgeneROMO1chr20:49191191chr20:34287555ENST00000374078+0322_44080TransmembraneHelical
TgeneROMO1chr20:49191191chr20:34287555ENST00000397416+0322_44080TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN1chr20:49191191chr20:34287555ENST00000371621+5103_277164436DomainTyrosine-protein phosphatase
HgenePTPN1chr20:49191191chr20:34287555ENST00000371621+510215_221164436RegionSubstrate binding


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FusionGeneSequence for PTPN1_ROMO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_244aa
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDTINASLIKMEEAQRSYILTQGPLPN
TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSTTTVRQLELENLTMPVAVGPYGQSQPSCF

>In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_244aa
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDTINASLIKMEEAQRSYILTQGPLPN
TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSTTTVRQLELENLTMPVAVGPYGQSQPSCF

>In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_224aa
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDTINASLIKMEEAQRSYILTQGPLPN
TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSTTTVRQLELENLTMPVAVGPYGQSQPSCF

>In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_244aa
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDTINASLIKMEEAQRSYILTQGPLPN
TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSTTTVRQLELENLTMPVAVGPYGQSQPSCF

>In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_171aa
MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSTTTVRQLELENL

>In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_171aa
MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSTTTVRQLELENL

>In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_151aa
MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSTTTVRQLELENL

>In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_171aa
MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSTTTVRQLELENL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_732nt
ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTC
CCATGTAGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACAT
CAAGAAGATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAAC
ACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAA
TGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAG
TCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTC
GACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGA
ATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGC

>In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_732nt
ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTC
CCATGTAGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACAT
CAAGAAGATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAAC
ACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAA
TGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAG
TCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTC
GACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGA
ATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGC

>In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_672nt
ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTC
CCATGTAGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACAT
CAAGAAGATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAAC
ACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAA
TGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAG
TCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTC
GACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGCTCCATC

>In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_732nt
ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTC
CCATGTAGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACAT
CAAGAAGATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAAC
ACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAA
TGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAG
TCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTC
GACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGA
ATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGC

>In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_513nt
ATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAA
AGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATG
ATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTT
ACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTG
GGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACC

>In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_513nt
ATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAA
AGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATG
ATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTT
ACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTG
GGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACC

>In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_453nt
ATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAA
AGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATG
ATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTT
ACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTG
GGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGCTCCATCTTGGTTTCCTCCTCAGGATCGGAATGCGGGGTCGAGAGC

>In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_513nt
ATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAA
AGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATG
ATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTT
ACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTG
GGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACC


* Fusion transcript sequences (Full-length transcript).
>In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_984nt
GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC
TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG
ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTCCCATGT
AGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACATCAAGAA
GATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGC
GGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCA
CAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATAT
TATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGT
GTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGG
GGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGA

>In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_984nt
GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC
TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG
ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTCCCATGT
AGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACATCAAGAA
GATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGC
GGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCA
CAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATAT
TATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGT
GTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGG
GGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGA

>In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_1001nt
GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC
TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG
ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTCCCATGT
AGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACATCAAGAA
GATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGC
GGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCA
CAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATAT
TATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGT
GTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGCTCCATCTTGGTT
TCCTCCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCA
TGGCCATTGGGATGGGCATCCGATGCTAACCATGGTTGCCAACTACATCTGTCCCTTCCCATCAATCCCAGCCCATGTACTAATAAAAGA

>In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_910nt
GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC
TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG
ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTCCCATGT
AGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACATCAAGAA
GATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGC
GGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCA
CAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATAT
TATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGT
GTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGG
GGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGA

>In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_864nt
ATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCCTCGGGGCTAAGAGCGCGACGCGGCCTAGA
GCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAA
GTCCGGGAGCTGGGCGGCCATTTACCAGTTGACCATAGTCGGATTAAACTACATCAAGAAGATAATGACTATATCAACGCTAGTTTGATA
AAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAG
AAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAG
ATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAAC
CTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCC
GTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAA
ACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGATGCTAACCATGGTTGCCAACTACATCTGTC

>In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_864nt
ATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCCTCGGGGCTAAGAGCGCGACGCGGCCTAGA
GCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAA
GTCCGGGAGCTGGGCGGCCATTTACCAGTTGACCATAGTCGGATTAAACTACATCAAGAAGATAATGACTATATCAACGCTAGTTTGATA
AAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAG
AAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAG
ATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAAC
CTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCC
GTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAA
ACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGATGCTAACCATGGTTGCCAACTACATCTGTC

>In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_881nt
ATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCCTCGGGGCTAAGAGCGCGACGCGGCCTAGA
GCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAA
GTCCGGGAGCTGGGCGGCCATTTACCAGTTGACCATAGTCGGATTAAACTACATCAAGAAGATAATGACTATATCAACGCTAGTTTGATA
AAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAG
AAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAG
ATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAAC
CTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCC
GTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGCTCCATCTTGGTTTCCTCCTCAGGATCGGAATGCGGGGTCGAG
AGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGATGCTAAC

>In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_790nt
ATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCCTCGGGGCTAAGAGCGCGACGCGGCCTAGA
GCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAA
GTCCGGGAGCTGGGCGGCCATTTACCAGTTGACCATAGTCGGATTAAACTACATCAAGAAGATAATGACTATATCAACGCTAGTTTGATA
AAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAG
AAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAG
ATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAAC
CTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCC
GTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAA


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FusionGenePPI for PTPN1_ROMO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPN1GSK3B, GRB2, IRS1, CAV1, EGFR, CRK, BCAR1, CTNNB1, STAT5A, STAT5B, NTRK1, NTRK2, NTRK3, LTK, TYK2, JAK2, INSR, IGF1R, GHR, STAM2, ILF3, SLC25A3, MCAT, MARCKSL1, LAMTOR3, HNRNPU, ZMPSTE24, STAT3, ATF2, CSNK2A1, SRC, ATP4A, ASS1, RFWD2, IL1B, ASGR2, HMOX2, SLC39A4, LYPD3, ENPP6, ZACN, PLTP, LYPD6, KRAS, AGR3, BCAS3, CASC3, CASZ1, CCL5, CDH13, DIRAS3, FAM84B, KLK7, MRC2, RHOBTB2, SNAI1, THRSP, VPS45, HERC2, TCTN2, TCTN3, EVC2, TMEM17, TMEM216, ATP6V1B2, ATP6V0A1, COL5A1, STOM, FLOT2, GALNT2, MSN, PHB, ABCD3, SMARCD2, ATP6V0D1, GOSR1, MVP, FLOT1, PHB2, LTN1, GOLIM4, BCOR, WRAP53, MREG, PCNP, KIDINS220, RNF213, ARHGAP39, PTRF, CDH1, ACTB, APLP2, CASC4, SNRPD2, TOMM70A, CTDNEP1, C5AR2, TMEM63A, C3AR1, GPR21, GHITM, SLCO6A1, TMPRSS3, AMTN, MRAP2, GPR114, KIAA1467, SLC39A12, APLNR, DUSP1, DCUN1D5, PISD, COX11, NDUFAF4, NARS, PTRH2, TBC1D15, NPPC, PFN2, ARL1, DHCR24, AIP, RAB5C, PGRMC1, SEC61A1, CDIPT, SLC27A4, ILVBL, DHCR7, TRIP13, ARF4, HEATR3, PCMT1, ARF1, CCDC47, CDK4, FLAD1, RMDN3, CLK2, LATROMO1COQ9, NDUFA4, C15orf48, ERAP1, TIMM17A, ELOVL5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPN1_ROMO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePTPN1P18031DB01133Tiludronic acidTyrosine-protein phosphatase non-receptor type 1small moleculeapproved|investigational|vet_approved

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RelatedDiseases for PTPN1_ROMO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPN1C0019829Hodgkin Disease1CTD_human
HgenePTPN1C0021655Insulin Resistance1CTD_human
HgenePTPN1C0023893Liver Cirrhosis, Experimental1CTD_human
HgenePTPN1C0025063Mediastinal Neoplasms1CTD_human
HgenePTPN1C0028754Obesity1CTD_human
HgenePTPN1C0035372Rett Syndrome1CTD_human
HgenePTPN1C0036341Schizophrenia1PSYGENET
HgenePTPN1C0079731B-Cell Lymphomas1CTD_human