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Fusion gene ID: 29436 |
FusionGeneSummary for PTPN1_ROMO1 |
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Fusion gene information | Fusion gene name: PTPN1_ROMO1 | Fusion gene ID: 29436 | Hgene | Tgene | Gene symbol | PTPN1 | ROMO1 | Gene ID | 5770 | 140823 |
Gene name | protein tyrosine phosphatase, non-receptor type 1 | reactive oxygen species modulator 1 | |
Synonyms | PTP1B | C20orf52|MTGM|MTGMP|bA353C18.2 | |
Cytomap | 20q13.13 | 20q11.22 | |
Type of gene | protein-coding | protein-coding | |
Description | tyrosine-protein phosphatase non-receptor type 1protein tyrosine phosphatase, placentalprotein-tyrosine phosphatase 1B | reactive oxygen species modulator 1PCM19ROS modulator 1epididymis tissue protein Li 175glyrichinmitochondrial targeting GXXXG proteinmitochondrial targeting GxxxG motif proteinprotein MGR2 homolog | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P18031 | P60602 | |
Ensembl transtripts involved in fusion gene | ENST00000371621, ENST00000541713, | ENST00000374078, ENST00000374077, ENST00000374072, ENST00000397416, ENST00000336695, | |
Fusion gene scores | * DoF score | 7 X 4 X 5=140 | 5 X 5 X 3=75 |
# samples | 8 | 5 | |
** MAII score | log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PTPN1 [Title/Abstract] AND ROMO1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PTPN1 | GO:0030100 | regulation of endocytosis | 21135139 |
Hgene | PTPN1 | GO:0030968 | endoplasmic reticulum unfolded protein response | 22169477 |
Hgene | PTPN1 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 21135139 |
Hgene | PTPN1 | GO:0061098 | positive regulation of protein tyrosine kinase activity | 21216966 |
Hgene | PTPN1 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response | 21216966 |
Tgene | ROMO1 | GO:0008284 | positive regulation of cell proliferation | 18313394 |
Tgene | ROMO1 | GO:0031640 | killing of cells of other organism | 22083756 |
Tgene | ROMO1 | GO:0042742 | defense response to bacterium | 22083756 |
Tgene | ROMO1 | GO:0050829 | defense response to Gram-negative bacterium | 22083756 |
Tgene | ROMO1 | GO:0050830 | defense response to Gram-positive bacterium | 22083756 |
Tgene | ROMO1 | GO:0051715 | cytolysis in other organism | 22083756 |
Tgene | ROMO1 | GO:2000379 | positive regulation of reactive oxygen species metabolic process | 16842742 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-EW-A2FW-01A | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000371621 | ENST00000374078 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
In-frame | ENST00000371621 | ENST00000374077 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
In-frame | ENST00000371621 | ENST00000374072 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
In-frame | ENST00000371621 | ENST00000397416 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
Frame-shift | ENST00000371621 | ENST00000336695 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
In-frame | ENST00000541713 | ENST00000374078 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
In-frame | ENST00000541713 | ENST00000374077 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
In-frame | ENST00000541713 | ENST00000374072 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
In-frame | ENST00000541713 | ENST00000397416 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
Frame-shift | ENST00000541713 | ENST00000336695 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
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FusionProtFeatures for PTPN1_ROMO1 |
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Hgene | Tgene |
PTPN1 | ROMO1 |
Tyrosine-protein phosphatase which acts as a regulatorof endoplasmic reticulum unfolded protein response. Mediatesdephosphorylation of EIF2AK3/PERK; inactivating the protein kinaseactivity of EIF2AK3/PERK. May play an important role in CKII- andp60c-src-induced signal transduction cascades. May regulate theEFNA5-EPHA3 signaling pathway which modulates cell reorganizationand cell-cell repulsion. May also regulate the hepatocyte growthfactor receptor signaling pathway through dephosphorylation ofMET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139,ECO:0000269|PubMed:22169477}. | Induces production of reactive oxygen species (ROS)which are necessary for cell proliferation. May play a role ininducing oxidative DNA damage and replicative senescence. May playa role in the coordination of mitochondrial morphology and cellproliferation. Has antibacterial activity against a variety of bacteriaincluding S.aureus, P.aeruginosa and M.tuberculosis. Acts byinducing bacterial membrane breakage. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000336695 | + | 0 | 2 | 42_60 | -61 | 80 | Region | Note=Sufficient for antibacterial activity |
Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000374072 | + | 0 | 3 | 42_60 | 0 | 60 | Region | Note=Sufficient for antibacterial activity |
Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000374077 | + | 0 | 3 | 42_60 | 0 | 80 | Region | Note=Sufficient for antibacterial activity |
Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000374078 | + | 0 | 3 | 42_60 | 0 | 80 | Region | Note=Sufficient for antibacterial activity |
Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000397416 | + | 0 | 3 | 42_60 | 0 | 80 | Region | Note=Sufficient for antibacterial activity |
Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000336695 | + | 0 | 2 | 22_44 | -61 | 80 | Transmembrane | Helical |
Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000374072 | + | 0 | 3 | 22_44 | 0 | 60 | Transmembrane | Helical |
Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000374077 | + | 0 | 3 | 22_44 | 0 | 80 | Transmembrane | Helical |
Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000374078 | + | 0 | 3 | 22_44 | 0 | 80 | Transmembrane | Helical |
Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000397416 | + | 0 | 3 | 22_44 | 0 | 80 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >PTPN1 | chr20:49191191 | chr20:34287555 | ENST00000371621 | + | 5 | 10 | 3_277 | 164 | 436 | Domain | Tyrosine-protein phosphatase |
Hgene | >PTPN1 | chr20:49191191 | chr20:34287555 | ENST00000371621 | + | 5 | 10 | 215_221 | 164 | 436 | Region | Substrate binding |
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FusionGeneSequence for PTPN1_ROMO1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_244aa MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPN TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTMPVAVGPYGQSQPSCF >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_244aa MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPN TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTMPVAVGPYGQSQPSCF >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_224aa MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPN TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTMPVAVGPYGQSQPSCF >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_244aa MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPN TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTMPVAVGPYGQSQPSCF >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_171aa MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENL >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_171aa MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENL >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_151aa MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENL >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_171aa MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENL |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_732nt ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTC CCATGTAGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACAT CAAGAAGATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAAC ACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAA TGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAG TCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTC GACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGA ATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGC >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_732nt ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTC CCATGTAGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACAT CAAGAAGATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAAC ACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAA TGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAG TCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTC GACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGA ATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGC >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_672nt ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTC CCATGTAGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACAT CAAGAAGATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAAC ACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAA TGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAG TCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTC GACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGCTCCATC >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_732nt ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTC CCATGTAGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACAT CAAGAAGATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAAC ACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAA TGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAG TCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTC GACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGA ATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGC >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_513nt ATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAA AGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATG ATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTT ACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTG GGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACC >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_513nt ATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAA AGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATG ATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTT ACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTG GGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACC >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_453nt ATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAA AGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATG ATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTT ACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTG GGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGCTCCATCTTGGTTTCCTCCTCAGGATCGGAATGCGGGGTCGAGAGC >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_513nt ATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAA AGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATG ATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTT ACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTG GGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_984nt GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTCCCATGT AGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACATCAAGAA GATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGC GGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCA CAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATAT TATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGT GTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGG GGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGA >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_984nt GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTCCCATGT AGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACATCAAGAA GATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGC GGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCA CAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATAT TATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGT GTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGG GGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGA >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_1001nt GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTCCCATGT AGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACATCAAGAA GATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGC GGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCA CAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATAT TATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGT GTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGCTCCATCTTGGTT TCCTCCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCA TGGCCATTGGGATGGGCATCCGATGCTAACCATGGTTGCCAACTACATCTGTCCCTTCCCATCAATCCCAGCCCATGTACTAATAAAAGA >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_910nt GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTCCCATGT AGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACATCAAGAA GATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGC GGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCA CAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATAT TATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGT GTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGG GGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGA >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_864nt ATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCCTCGGGGCTAAGAGCGCGACGCGGCCTAGA GCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAA GTCCGGGAGCTGGGCGGCCATTTACCAGTTGACCATAGTCGGATTAAACTACATCAAGAAGATAATGACTATATCAACGCTAGTTTGATA AAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAG AAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAG ATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAAC CTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCC GTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAA ACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGATGCTAACCATGGTTGCCAACTACATCTGTC >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_864nt ATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCCTCGGGGCTAAGAGCGCGACGCGGCCTAGA GCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAA GTCCGGGAGCTGGGCGGCCATTTACCAGTTGACCATAGTCGGATTAAACTACATCAAGAAGATAATGACTATATCAACGCTAGTTTGATA AAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAG AAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAG ATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAAC CTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCC GTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAA ACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGATGCTAACCATGGTTGCCAACTACATCTGTC >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_881nt ATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCCTCGGGGCTAAGAGCGCGACGCGGCCTAGA GCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAA GTCCGGGAGCTGGGCGGCCATTTACCAGTTGACCATAGTCGGATTAAACTACATCAAGAAGATAATGACTATATCAACGCTAGTTTGATA AAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAG AAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAG ATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAAC CTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCC GTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGCTCCATCTTGGTTTCCTCCTCAGGATCGGAATGCGGGGTCGAG AGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGATGCTAAC >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_790nt ATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCCTCGGGGCTAAGAGCGCGACGCGGCCTAGA GCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAA GTCCGGGAGCTGGGCGGCCATTTACCAGTTGACCATAGTCGGATTAAACTACATCAAGAAGATAATGACTATATCAACGCTAGTTTGATA AAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAG AAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAG ATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAAC CTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCC GTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAA |
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FusionGenePPI for PTPN1_ROMO1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PTPN1 | GSK3B, GRB2, IRS1, CAV1, EGFR, CRK, BCAR1, CTNNB1, STAT5A, STAT5B, NTRK1, NTRK2, NTRK3, LTK, TYK2, JAK2, INSR, IGF1R, GHR, STAM2, ILF3, SLC25A3, MCAT, MARCKSL1, LAMTOR3, HNRNPU, ZMPSTE24, STAT3, ATF2, CSNK2A1, SRC, ATP4A, ASS1, RFWD2, IL1B, ASGR2, HMOX2, SLC39A4, LYPD3, ENPP6, ZACN, PLTP, LYPD6, KRAS, AGR3, BCAS3, CASC3, CASZ1, CCL5, CDH13, DIRAS3, FAM84B, KLK7, MRC2, RHOBTB2, SNAI1, THRSP, VPS45, HERC2, TCTN2, TCTN3, EVC2, TMEM17, TMEM216, ATP6V1B2, ATP6V0A1, COL5A1, STOM, FLOT2, GALNT2, MSN, PHB, ABCD3, SMARCD2, ATP6V0D1, GOSR1, MVP, FLOT1, PHB2, LTN1, GOLIM4, BCOR, WRAP53, MREG, PCNP, KIDINS220, RNF213, ARHGAP39, PTRF, CDH1, ACTB, APLP2, CASC4, SNRPD2, TOMM70A, CTDNEP1, C5AR2, TMEM63A, C3AR1, GPR21, GHITM, SLCO6A1, TMPRSS3, AMTN, MRAP2, GPR114, KIAA1467, SLC39A12, APLNR, DUSP1, DCUN1D5, PISD, COX11, NDUFAF4, NARS, PTRH2, TBC1D15, NPPC, PFN2, ARL1, DHCR24, AIP, RAB5C, PGRMC1, SEC61A1, CDIPT, SLC27A4, ILVBL, DHCR7, TRIP13, ARF4, HEATR3, PCMT1, ARF1, CCDC47, CDK4, FLAD1, RMDN3, CLK2, LAT | ROMO1 | COQ9, NDUFA4, C15orf48, ERAP1, TIMM17A, ELOVL5 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTPN1_ROMO1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PTPN1 | P18031 | DB01133 | Tiludronic acid | Tyrosine-protein phosphatase non-receptor type 1 | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for PTPN1_ROMO1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PTPN1 | C0019829 | Hodgkin Disease | 1 | CTD_human |
Hgene | PTPN1 | C0021655 | Insulin Resistance | 1 | CTD_human |
Hgene | PTPN1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | PTPN1 | C0025063 | Mediastinal Neoplasms | 1 | CTD_human |
Hgene | PTPN1 | C0028754 | Obesity | 1 | CTD_human |
Hgene | PTPN1 | C0035372 | Rett Syndrome | 1 | CTD_human |
Hgene | PTPN1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | PTPN1 | C0079731 | B-Cell Lymphomas | 1 | CTD_human |