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Fusion gene ID: 29436 |
FusionGeneSummary for PTPN1_ROMO1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTPN1_ROMO1 | Fusion gene ID: 29436 | Hgene | Tgene | Gene symbol | PTPN1 | ROMO1 | Gene ID | 5770 | 140823 |
| Gene name | protein tyrosine phosphatase, non-receptor type 1 | reactive oxygen species modulator 1 | |
| Synonyms | PTP1B | C20orf52|MTGM|MTGMP|bA353C18.2 | |
| Cytomap | 20q13.13 | 20q11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein phosphatase non-receptor type 1protein tyrosine phosphatase, placentalprotein-tyrosine phosphatase 1B | reactive oxygen species modulator 1PCM19ROS modulator 1epididymis tissue protein Li 175glyrichinmitochondrial targeting GXXXG proteinmitochondrial targeting GxxxG motif proteinprotein MGR2 homolog | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P18031 | P60602 | |
| Ensembl transtripts involved in fusion gene | ENST00000371621, ENST00000541713, | ENST00000374078, ENST00000374077, ENST00000374072, ENST00000397416, ENST00000336695, | |
| Fusion gene scores | * DoF score | 7 X 4 X 5=140 | 5 X 5 X 3=75 |
| # samples | 8 | 5 | |
| ** MAII score | log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PTPN1 [Title/Abstract] AND ROMO1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PTPN1 | GO:0030100 | regulation of endocytosis | 21135139 |
| Hgene | PTPN1 | GO:0030968 | endoplasmic reticulum unfolded protein response | 22169477 |
| Hgene | PTPN1 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 21135139 |
| Hgene | PTPN1 | GO:0061098 | positive regulation of protein tyrosine kinase activity | 21216966 |
| Hgene | PTPN1 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response | 21216966 |
| Tgene | ROMO1 | GO:0008284 | positive regulation of cell proliferation | 18313394 |
| Tgene | ROMO1 | GO:0031640 | killing of cells of other organism | 22083756 |
| Tgene | ROMO1 | GO:0042742 | defense response to bacterium | 22083756 |
| Tgene | ROMO1 | GO:0050829 | defense response to Gram-negative bacterium | 22083756 |
| Tgene | ROMO1 | GO:0050830 | defense response to Gram-positive bacterium | 22083756 |
| Tgene | ROMO1 | GO:0051715 | cytolysis in other organism | 22083756 |
| Tgene | ROMO1 | GO:2000379 | positive regulation of reactive oxygen species metabolic process | 16842742 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-EW-A2FW-01A | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000371621 | ENST00000374078 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
| In-frame | ENST00000371621 | ENST00000374077 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
| In-frame | ENST00000371621 | ENST00000374072 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
| In-frame | ENST00000371621 | ENST00000397416 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
| Frame-shit | ENST00000371621 | ENST00000336695 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
| In-frame | ENST00000541713 | ENST00000374078 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
| In-frame | ENST00000541713 | ENST00000374077 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
| In-frame | ENST00000541713 | ENST00000374072 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
| In-frame | ENST00000541713 | ENST00000397416 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
| Frame-shit | ENST00000541713 | ENST00000336695 | PTPN1 | chr20 | 49191191 | + | ROMO1 | chr20 | 34287555 | + |
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FusionProtFeatures for PTPN1_ROMO1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PTPN1 | ROMO1 |
| Tyrosine-protein phosphatase which acts as a regulatorof endoplasmic reticulum unfolded protein response. Mediatesdephosphorylation of EIF2AK3/PERK; inactivating the protein kinaseactivity of EIF2AK3/PERK. May play an important role in CKII- andp60c-src-induced signal transduction cascades. May regulate theEFNA5-EPHA3 signaling pathway which modulates cell reorganizationand cell-cell repulsion. May also regulate the hepatocyte growthfactor receptor signaling pathway through dephosphorylation ofMET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139,ECO:0000269|PubMed:22169477}. | Induces production of reactive oxygen species (ROS)which are necessary for cell proliferation. May play a role ininducing oxidative DNA damage and replicative senescence. May playa role in the coordination of mitochondrial morphology and cellproliferation. Has antibacterial activity against a variety of bacteriaincluding S.aureus, P.aeruginosa and M.tuberculosis. Acts byinducing bacterial membrane breakage. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000336695 | + | 0 | 2 | 42_60 | -61 | 80 | Region | Note=Sufficient for antibacterial activity |
| Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000374072 | + | 0 | 3 | 42_60 | 0 | 60 | Region | Note=Sufficient for antibacterial activity |
| Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000374077 | + | 0 | 3 | 42_60 | 0 | 80 | Region | Note=Sufficient for antibacterial activity |
| Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000374078 | + | 0 | 3 | 42_60 | 0 | 80 | Region | Note=Sufficient for antibacterial activity |
| Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000397416 | + | 0 | 3 | 42_60 | 0 | 80 | Region | Note=Sufficient for antibacterial activity |
| Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000336695 | + | 0 | 2 | 22_44 | -61 | 80 | Transmembrane | Helical |
| Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000374072 | + | 0 | 3 | 22_44 | 0 | 60 | Transmembrane | Helical |
| Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000374077 | + | 0 | 3 | 22_44 | 0 | 80 | Transmembrane | Helical |
| Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000374078 | + | 0 | 3 | 22_44 | 0 | 80 | Transmembrane | Helical |
| Tgene | >ROMO1 | chr20:49191191 | chr20:34287555 | ENST00000397416 | + | 0 | 3 | 22_44 | 0 | 80 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PTPN1 | chr20:49191191 | chr20:34287555 | ENST00000371621 | + | 5 | 10 | 3_277 | 164 | 436 | Domain | Tyrosine-protein phosphatase |
| Hgene | >PTPN1 | chr20:49191191 | chr20:34287555 | ENST00000371621 | + | 5 | 10 | 215_221 | 164 | 436 | Region | Substrate binding |
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FusionGeneSequence for PTPN1_ROMO1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_244aa MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDTINASLIKMEEAQRSYILTQGPLPN TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSTTTVRQLELENLTMPVAVGPYGQSQPSCF >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_244aa MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDTINASLIKMEEAQRSYILTQGPLPN TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSTTTVRQLELENLTMPVAVGPYGQSQPSCF >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_224aa MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDTINASLIKMEEAQRSYILTQGPLPN TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSTTTVRQLELENLTMPVAVGPYGQSQPSCF >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_244aa MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDTINASLIKMEEAQRSYILTQGPLPN TCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSTTTVRQLELENLTMPVAVGPYGQSQPSCF >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_171aa MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSTTTVRQLELENL >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_171aa MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSTTTVRQLELENL >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_151aa MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSTTTVRQLELENL >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_171aa MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSTTTVRQLELENL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_732nt ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTC CCATGTAGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACAT CAAGAAGATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAAC ACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAA TGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAG TCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTC GACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGA ATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGC >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_732nt ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTC CCATGTAGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACAT CAAGAAGATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAAC ACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAA TGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAG TCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTC GACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGA ATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGC >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_672nt ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTC CCATGTAGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACAT CAAGAAGATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAAC ACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAA TGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAG TCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTC GACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGCTCCATC >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_732nt ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTC CCATGTAGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACAT CAAGAAGATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAAC ACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAA TGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAG TCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTC GACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGA ATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGC >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_513nt ATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAA AGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATG ATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTT ACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTG GGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACC >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_513nt ATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAA AGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATG ATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTT ACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTG GGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACC >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_453nt ATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAA AGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATG ATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTT ACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTG GGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGCTCCATCTTGGTTTCCTCCTCAGGATCGGAATGCGGGGTCGAGAGC >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_513nt ATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAGAAA AGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATG ATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTT ACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCCGTG GGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_984nt GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTCCCATGT AGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACATCAAGAA GATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGC GGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCA CAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATAT TATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGT GTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGG GGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGA >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_984nt GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTCCCATGT AGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACATCAAGAA GATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGC GGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCA CAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATAT TATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGT GTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGG GGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGA >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_1001nt GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTCCCATGT AGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACATCAAGAA GATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGC GGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCA CAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATAT TATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGT GTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGCTCCATCTTGGTT TCCTCCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCA TGGCCATTGGGATGGGCATCCGATGCTAACCATGGTTGCCAACTACATCTGTCCCTTCCCATCAATCCCAGCCCATGTACTAATAAAAGA >In-frame_PTPN1_ENST00000371621_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_910nt GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAGTGACTTCCCATGT AGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACATCAAGAA GATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGC GGTCACTTTTGGGAGATGGTGTGGGAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCA CAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATAT TATACAGTGCGACAGCTAGAATTGGAAAACCTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGT GTCAAAATGGGCTTCGTGATGGGTTGCGCCGTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGG GGTCGAGAGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGA >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374078_chr20_34287555_+_864nt ATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCCTCGGGGCTAAGAGCGCGACGCGGCCTAGA GCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAA GTCCGGGAGCTGGGCGGCCATTTACCAGTTGACCATAGTCGGATTAAACTACATCAAGAAGATAATGACTATATCAACGCTAGTTTGATA AAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAG AAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAG ATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAAC CTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCC GTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAA ACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGATGCTAACCATGGTTGCCAACTACATCTGTC >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374077_chr20_34287555_+_864nt ATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCCTCGGGGCTAAGAGCGCGACGCGGCCTAGA GCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAA GTCCGGGAGCTGGGCGGCCATTTACCAGTTGACCATAGTCGGATTAAACTACATCAAGAAGATAATGACTATATCAACGCTAGTTTGATA AAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAG AAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAG ATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAAC CTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCC GTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAA ACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGATGCTAACCATGGTTGCCAACTACATCTGTC >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000374072_chr20_34287555_+_881nt ATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCCTCGGGGCTAAGAGCGCGACGCGGCCTAGA GCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAA GTCCGGGAGCTGGGCGGCCATTTACCAGTTGACCATAGTCGGATTAAACTACATCAAGAAGATAATGACTATATCAACGCTAGTTTGATA AAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAG AAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAG ATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAAC CTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCC GTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGCTCCATCTTGGTTTCCTCCTCAGGATCGGAATGCGGGGTCGAG AGCTGATGGGCGGCATTGGGAAAACCATGATGCAGAGTGGCGGCACCTTTGGCACATTCATGGCCATTGGGATGGGCATCCGATGCTAAC >In-frame_PTPN1_ENST00000541713_chr20_49191191_+_ROMO1_ENST00000397416_chr20_34287555_+_790nt ATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCCTCGGGGCTAAGAGCGCGACGCGGCCTAGA GCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAA GTCCGGGAGCTGGGCGGCCATTTACCAGTTGACCATAGTCGGATTAAACTACATCAAGAAGATAATGACTATATCAACGCTAGTTTGATA AAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGGGAGCAG AAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAATGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAG ATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAAC CTTACAATGCCGGTGGCCGTGGGTCCCTACGGACAGTCCCAGCCAAGCTGCTTCGACCGTGTCAAAATGGGCTTCGTGATGGGTTGCGCC GTGGGCATGGCGGCCGGGGCGCTCTTCGGCACCTTTTCCTGTCTCAGGATCGGAATGCGGGGTCGAGAGCTGATGGGCGGCATTGGGAAA |
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FusionGenePPI for PTPN1_ROMO1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PTPN1 | GSK3B, GRB2, IRS1, CAV1, EGFR, CRK, BCAR1, CTNNB1, STAT5A, STAT5B, NTRK1, NTRK2, NTRK3, LTK, TYK2, JAK2, INSR, IGF1R, GHR, STAM2, ILF3, SLC25A3, MCAT, MARCKSL1, LAMTOR3, HNRNPU, ZMPSTE24, STAT3, ATF2, CSNK2A1, SRC, ATP4A, ASS1, RFWD2, IL1B, ASGR2, HMOX2, SLC39A4, LYPD3, ENPP6, ZACN, PLTP, LYPD6, KRAS, AGR3, BCAS3, CASC3, CASZ1, CCL5, CDH13, DIRAS3, FAM84B, KLK7, MRC2, RHOBTB2, SNAI1, THRSP, VPS45, HERC2, TCTN2, TCTN3, EVC2, TMEM17, TMEM216, ATP6V1B2, ATP6V0A1, COL5A1, STOM, FLOT2, GALNT2, MSN, PHB, ABCD3, SMARCD2, ATP6V0D1, GOSR1, MVP, FLOT1, PHB2, LTN1, GOLIM4, BCOR, WRAP53, MREG, PCNP, KIDINS220, RNF213, ARHGAP39, PTRF, CDH1, ACTB, APLP2, CASC4, SNRPD2, TOMM70A, CTDNEP1, C5AR2, TMEM63A, C3AR1, GPR21, GHITM, SLCO6A1, TMPRSS3, AMTN, MRAP2, GPR114, KIAA1467, SLC39A12, APLNR, DUSP1, DCUN1D5, PISD, COX11, NDUFAF4, NARS, PTRH2, TBC1D15, NPPC, PFN2, ARL1, DHCR24, AIP, RAB5C, PGRMC1, SEC61A1, CDIPT, SLC27A4, ILVBL, DHCR7, TRIP13, ARF4, HEATR3, PCMT1, ARF1, CCDC47, CDK4, FLAD1, RMDN3, CLK2, LAT | ROMO1 | COQ9, NDUFA4, C15orf48, ERAP1, TIMM17A, ELOVL5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTPN1_ROMO1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PTPN1 | P18031 | DB01133 | Tiludronic acid | Tyrosine-protein phosphatase non-receptor type 1 | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for PTPN1_ROMO1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PTPN1 | C0019829 | Hodgkin Disease | 1 | CTD_human |
| Hgene | PTPN1 | C0021655 | Insulin Resistance | 1 | CTD_human |
| Hgene | PTPN1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | PTPN1 | C0025063 | Mediastinal Neoplasms | 1 | CTD_human |
| Hgene | PTPN1 | C0028754 | Obesity | 1 | CTD_human |
| Hgene | PTPN1 | C0035372 | Rett Syndrome | 1 | CTD_human |
| Hgene | PTPN1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | PTPN1 | C0079731 | B-Cell Lymphomas | 1 | CTD_human |
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