FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 29431

FusionGeneSummary for PTPN1_BCAS4

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPN1_BCAS4
Fusion gene ID: 29431
HgeneTgene
Gene symbol

PTPN1

BCAS4

Gene ID

5770

55653

Gene nameprotein tyrosine phosphatase, non-receptor type 1breast carcinoma amplified sequence 4
SynonymsPTP1BCNOL
Cytomap

20q13.13

20q13.13

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein phosphatase non-receptor type 1protein tyrosine phosphatase, placentalprotein-tyrosine phosphatase 1Bbreast carcinoma-amplified sequence 4BCAS4/BCAS3 fusionbreast carcinoma amplified sequence 4/3 fusion protein
Modification date2018052220180523
UniProtAcc

P18031

Q8TDM0

Ensembl transtripts involved in fusion geneENST00000371621, ENST00000541713, 
ENST00000358791, ENST00000262591, 
ENST00000371608, ENST00000609336, 
ENST00000485049, 
Fusion gene scores* DoF score7 X 4 X 5=1406 X 3 X 6=108
# samples 86
** MAII scorelog2(8/140*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPN1 [Title/Abstract] AND BCAS4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPN1

GO:0030100

regulation of endocytosis

21135139

HgenePTPN1

GO:0030968

endoplasmic reticulum unfolded protein response

22169477

HgenePTPN1

GO:0035335

peptidyl-tyrosine dephosphorylation

21135139

HgenePTPN1

GO:0061098

positive regulation of protein tyrosine kinase activity

21216966

HgenePTPN1

GO:1903898

negative regulation of PERK-mediated unfolded protein response

21216966


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-HC-A6HY-01APTPN1chr20

49127127

+BCAS4chr20

49434748

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000371621ENST00000358791PTPN1chr20

49127127

+BCAS4chr20

49434748

+
In-frameENST00000371621ENST00000262591PTPN1chr20

49127127

+BCAS4chr20

49434748

+
In-frameENST00000371621ENST00000371608PTPN1chr20

49127127

+BCAS4chr20

49434748

+
In-frameENST00000371621ENST00000609336PTPN1chr20

49127127

+BCAS4chr20

49434748

+
5CDS-3UTRENST00000371621ENST00000485049PTPN1chr20

49127127

+BCAS4chr20

49434748

+
5UTR-3CDSENST00000541713ENST00000358791PTPN1chr20

49127127

+BCAS4chr20

49434748

+
5UTR-3CDSENST00000541713ENST00000262591PTPN1chr20

49127127

+BCAS4chr20

49434748

+
5UTR-3CDSENST00000541713ENST00000371608PTPN1chr20

49127127

+BCAS4chr20

49434748

+
5UTR-3CDSENST00000541713ENST00000609336PTPN1chr20

49127127

+BCAS4chr20

49434748

+
5UTR-3UTRENST00000541713ENST00000485049PTPN1chr20

49127127

+BCAS4chr20

49434748

+

Top

FusionProtFeatures for PTPN1_BCAS4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPN1

P18031

BCAS4

Q8TDM0

Tyrosine-protein phosphatase which acts as a regulatorof endoplasmic reticulum unfolded protein response. Mediatesdephosphorylation of EIF2AK3/PERK; inactivating the protein kinaseactivity of EIF2AK3/PERK. May play an important role in CKII- andp60c-src-induced signal transduction cascades. May regulate theEFNA5-EPHA3 signaling pathway which modulates cell reorganizationand cell-cell repulsion. May also regulate the hepatocyte growthfactor receptor signaling pathway through dephosphorylation ofMET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139,ECO:0000269|PubMed:22169477}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN1chr20:49127127chr20:49434748ENST00000371621+1103_27721436DomainTyrosine-protein phosphatase
HgenePTPN1chr20:49127127chr20:49434748ENST00000371621+110215_22121436RegionSubstrate binding


Top

FusionGeneSequence for PTPN1_BCAS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PTPN1_ENST00000371621_chr20_49127127_+_BCAS4_ENST00000358791_chr20_49434748_+_173aa
MEMEKEFEQIDKSGSWAAIYQAKEVEETIEGMLLRLEEFCSLADLIRSDTSQILEENIPVLKAKLTEMRGITAKVDRLEAFVKMVGHHVA

>In-frame_PTPN1_ENST00000371621_chr20_49127127_+_BCAS4_ENST00000262591_chr20_49434748_+_120aa
MEMEKEFEQIDKSGSWAAIYQAKEVEETIEGMLLRLEEFCSLADLIRSDTSQILEENIPVLKAKLTEMRGITAKVDRLEKSPAPVPVTYE

>In-frame_PTPN1_ENST00000371621_chr20_49127127_+_BCAS4_ENST00000371608_chr20_49434748_+_165aa
MEMEKEFEQIDKSGSWAAIYQAKEVEETIEGMLLRLEEFCSLADLIRSDTSQILEENIPVLKAKLTEMRGITAKVDRLEAFVKMVGHHVA

>In-frame_PTPN1_ENST00000371621_chr20_49127127_+_BCAS4_ENST00000609336_chr20_49434748_+_173aa
MEMEKEFEQIDKSGSWAAIYQAKEVEETIEGMLLRLEEFCSLADLIRSDTSQILEENIPVLKAKLTEMRGITAKVDRLEAFVKMVGHHVA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PTPN1_ENST00000371621_chr20_49127127_+_BCAS4_ENST00000358791_chr20_49434748_+_519nt
ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGCGAAGGAGGTGGAGGAGACCATCGAG
GGCATGCTCCTCAGGCTGGAAGAGTTTTGCAGCCTGGCTGACCTGATCAGGAGTGATACTTCACAGATCCTGGAGGAAAACATCCCAGTC
CTTAAGGCCAAACTGACAGAAATGCGTGGCATCTATGCCAAAGTGGACCGGCTAGAGGCCTTCGTCAAGATGGTTGGACACCACGTCGCC
TTCCTGGAAGCAGACGTGCTTCAGGCTGAGCGGGACCATGGGGCCTTCCCTCAGGCCCTGCGGAGGTGGCTGGGATCCGCAGGGCTCCCC
TCCTTCAGGAACGTGGAGTGCAGTGGCACAATCCCAGCTCGCTGCAACCTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCCGCCTCC

>In-frame_PTPN1_ENST00000371621_chr20_49127127_+_BCAS4_ENST00000262591_chr20_49434748_+_360nt
ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGCGAAGGAGGTGGAGGAGACCATCGAG
GGCATGCTCCTCAGGCTGGAAGAGTTTTGCAGCCTGGCTGACCTGATCAGGAGTGATACTTCACAGATCCTGGAGGAAAACATCCCAGTC
CTTAAGGCCAAACTGACAGAAATGCGTGGCATCTATGCCAAAGTGGACCGGCTAGAGAAGTCACCTGCACCGGTGCCCGTGACGTACGAG
CTGCCCACACTGTATAGGACGGAGGACTATTTTCCTGTGGACGCCGGGGAAGCACAGCACCACCCCCGCACCTGCCCTCGGCCTTTGTGA

>In-frame_PTPN1_ENST00000371621_chr20_49127127_+_BCAS4_ENST00000371608_chr20_49434748_+_495nt
ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGCGAAGGAGGTGGAGGAGACCATCGAG
GGCATGCTCCTCAGGCTGGAAGAGTTTTGCAGCCTGGCTGACCTGATCAGGAGTGATACTTCACAGATCCTGGAGGAAAACATCCCAGTC
CTTAAGGCCAAACTGACAGAAATGCGTGGCATCTATGCCAAAGTGGACCGGCTAGAGGCCTTCGTCAAGATGGTTGGACACCACGTCGCC
TTCCTGGAAGCAGACGTGCTTCAGGCTGAGCGGGACCATGGGGCCTTCCCTCAGGCCCTGCGGAGGTGGCTGGGATCCGCAGGGCTCCCC
TCCTTCAGGAACAAGTCACCTGCACCGGTGCCCGTGACGTACGAGCTGCCCACACTGTATAGGACGGAGGACTATTTTCCTGTGGACGCC

>In-frame_PTPN1_ENST00000371621_chr20_49127127_+_BCAS4_ENST00000609336_chr20_49434748_+_519nt
ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGCGAAGGAGGTGGAGGAGACCATCGAG
GGCATGCTCCTCAGGCTGGAAGAGTTTTGCAGCCTGGCTGACCTGATCAGGAGTGATACTTCACAGATCCTGGAGGAAAACATCCCAGTC
CTTAAGGCCAAACTGACAGAAATGCGTGGCATCTATGCCAAAGTGGACCGGCTAGAGGCCTTCGTCAAGATGGTTGGACACCACGTCGCC
TTCCTGGAAGCAGACGTGCTTCAGGCTGAGCGGGACCATGGGGCCTTCCCTCAGGCCCTGCGGAGGTGGCTGGGATCCGCAGGGCTCCCC
TCCTTCAGGAACGTGGAGTGCAGTGGCACAATCCCAGCTCGCTGCAACCTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCCGCCTCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_PTPN1_ENST00000371621_chr20_49127127_+_BCAS4_ENST00000358791_chr20_49434748_+_1335nt
GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC
TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG
ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGCGAAGGAGGTGGAGGAGACCATCGAGGGCATG
CTCCTCAGGCTGGAAGAGTTTTGCAGCCTGGCTGACCTGATCAGGAGTGATACTTCACAGATCCTGGAGGAAAACATCCCAGTCCTTAAG
GCCAAACTGACAGAAATGCGTGGCATCTATGCCAAAGTGGACCGGCTAGAGGCCTTCGTCAAGATGGTTGGACACCACGTCGCCTTCCTG
GAAGCAGACGTGCTTCAGGCTGAGCGGGACCATGGGGCCTTCCCTCAGGCCCTGCGGAGGTGGCTGGGATCCGCAGGGCTCCCCTCCTTC
AGGAACGTGGAGTGCAGTGGCACAATCCCAGCTCGCTGCAACCTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCCGCCTCCCAAGTA
GCTGGGATTACAGAAGTCACCTGCACCGGTGCCCGTGACGTACGAGCTGCCCACACTGTATAGGACGGAGGACTATTTTCCTGTGGACGC
CGGGGAAGCACAGCACCACCCCCGCACCTGCCCTCGGCCTTTGTGAGCTTTGTGGTCTTCCCATCAGGAACGCTGGAAAGTGACATTGTG
TACACACTGCAGCTTGGGGGTTTTTTCTTTGTATTGCTGTTTATTTTATATTTTAAAAATATTTAAAAAAATGTCGAGATGGGGTCTCAC
TATGTTGTCCAGACTGATCTCAAACTCCTGGGCTCAAGTGATCCACCCACCTTGGCCTTCCAAAGTGGTGGGATTATGGGCAGGAGCCTC
CGTGCCCAGGCTGCTGCCATTTTCAAATTTCCTCCCTGCCTCATGTGAGACCACAGGGTTTGGAGAAGCAGTTGGAACCCACGTGTGGTG
ATGCCTCCCACATCGGCCTGCTTGGGGTTCTACAGGGGTTGAGGGACCAGGCCTGGCCGGGGCTGATGGACAGTGGGGACTTTCCTTCTC
TCCATGATGGCTTTGCAGGGGCTCCATGGTCCTTCTCTCTGTGATGGGTTTTTGCACGGGGTGTGCTCTGCCACTGTGGTGGGTGGGTGG

>In-frame_PTPN1_ENST00000371621_chr20_49127127_+_BCAS4_ENST00000262591_chr20_49434748_+_1102nt
GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC
TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG
ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGCGAAGGAGGTGGAGGAGACCATCGAGGGCATG
CTCCTCAGGCTGGAAGAGTTTTGCAGCCTGGCTGACCTGATCAGGAGTGATACTTCACAGATCCTGGAGGAAAACATCCCAGTCCTTAAG
GCCAAACTGACAGAAATGCGTGGCATCTATGCCAAAGTGGACCGGCTAGAGAAGTCACCTGCACCGGTGCCCGTGACGTACGAGCTGCCC
ACACTGTATAGGACGGAGGACTATTTTCCTGTGGACGCCGGGGAAGCACAGCACCACCCCCGCACCTGCCCTCGGCCTTTGTGAGCTTTG
TGGTCTTCCCATCAGGAACGCTGGAAAGTGACATTGTGTACACACTGCAGCTTGGGGGTTTTTTCTTTGTATTGCTGTTTATTTTATATT
TTAAAAATATTTAAAAAAATGTCGAGATGGGGTCTCACTATGTTGTCCAGACTGATCTCAAACTCCTGGGCTCAAGTGATCCACCCACCT
TGGCCTTCCAAAGTGGTGGGATTATGGGCAGGAGCCTCCGTGCCCAGGCTGCTGCCATTTTCAAATTTCCTCCCTGCCTCATGTGAGACC
ACAGGGTTTGGAGAAGCAGTTGGAACCCACGTGTGGTGATGCCTCCCACATCGGCCTGCTTGGGGTTCTACAGGGGTTGAGGGACCAGGC
CTGGCCGGGGCTGATGGACAGTGGGGACTTTCCTTCTCTCCATGATGGCTTTGCAGGGGCTCCATGGTCCTTCTCTCTGTGATGGGTTTT
TGCACGGGGTGTGCTCTGCCACTGTGGTGGGTGGGTGGATGCTGCTTCTGTTGCCTCCAGACCTCGGTGCCCACAGCCTTGAGGATCCTT

>In-frame_PTPN1_ENST00000371621_chr20_49127127_+_BCAS4_ENST00000371608_chr20_49434748_+_1238nt
GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC
TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG
ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGCGAAGGAGGTGGAGGAGACCATCGAGGGCATG
CTCCTCAGGCTGGAAGAGTTTTGCAGCCTGGCTGACCTGATCAGGAGTGATACTTCACAGATCCTGGAGGAAAACATCCCAGTCCTTAAG
GCCAAACTGACAGAAATGCGTGGCATCTATGCCAAAGTGGACCGGCTAGAGGCCTTCGTCAAGATGGTTGGACACCACGTCGCCTTCCTG
GAAGCAGACGTGCTTCAGGCTGAGCGGGACCATGGGGCCTTCCCTCAGGCCCTGCGGAGGTGGCTGGGATCCGCAGGGCTCCCCTCCTTC
AGGAACAAGTCACCTGCACCGGTGCCCGTGACGTACGAGCTGCCCACACTGTATAGGACGGAGGACTATTTTCCTGTGGACGCCGGGGAA
GCACAGCACCACCCCCGCACCTGCCCTCGGCCTTTGTGAGCTTTGTGGTCTTCCCATCAGGAACGCTGGAAAGTGACATTGTGTACACAC
TGCAGCTTGGGGGTTTTTTCTTTGTATTGCTGTTTATTTTATATTTTAAAAATATTTAAAAAAATGTCGAGATGGGGTCTCACTATGTTG
TCCAGACTGATCTCAAACTCCTGGGCTCAAGTGATCCACCCACCTTGGCCTTCCAAAGTGGTGGGATTATGGGCAGGAGCCTCCGTGCCC
AGGCTGCTGCCATTTTCAAATTTCCTCCCTGCCTCATGTGAGACCACAGGGTTTGGAGAAGCAGTTGGAACCCACGTGTGGTGATGCCTC
CCACATCGGCCTGCTTGGGGTTCTACAGGGGTTGAGGGACCAGGCCTGGCCGGGGCTGATGGACAGTGGGGACTTTCCTTCTCTCCATGA
TGGCTTTGCAGGGGCTCCATGGTCCTTCTCTCTGTGATGGGTTTTTGCACGGGGTGTGCTCTGCCACTGTGGTGGGTGGGTGGATGCTGC

>In-frame_PTPN1_ENST00000371621_chr20_49127127_+_BCAS4_ENST00000609336_chr20_49434748_+_881nt
GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCC
TCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAG
ATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGCGAAGGAGGTGGAGGAGACCATCGAGGGCATG
CTCCTCAGGCTGGAAGAGTTTTGCAGCCTGGCTGACCTGATCAGGAGTGATACTTCACAGATCCTGGAGGAAAACATCCCAGTCCTTAAG
GCCAAACTGACAGAAATGCGTGGCATCTATGCCAAAGTGGACCGGCTAGAGGCCTTCGTCAAGATGGTTGGACACCACGTCGCCTTCCTG
GAAGCAGACGTGCTTCAGGCTGAGCGGGACCATGGGGCCTTCCCTCAGGCCCTGCGGAGGTGGCTGGGATCCGCAGGGCTCCCCTCCTTC
AGGAACGTGGAGTGCAGTGGCACAATCCCAGCTCGCTGCAACCTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCCGCCTCCCAAGTA
GCTGGGATTACAGAAGTCACCTGCACCGGTGCCCGTGACGTACGAGCTGCCCACACTGTATAGGACGGAGGACTATTTTCCTGTGGACGC
CGGGGAAGCACAGCACCACCCCCGCACCTGCCCTCGGCCTTTGTGAGCTTTGTGGTCTTCCCATCAGGAACGCTGGAAAGTGACATTGTG


Top

FusionGenePPI for PTPN1_BCAS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPN1GSK3B, GRB2, IRS1, CAV1, EGFR, CRK, BCAR1, CTNNB1, STAT5A, STAT5B, NTRK1, NTRK2, NTRK3, LTK, TYK2, JAK2, INSR, IGF1R, GHR, STAM2, ILF3, SLC25A3, MCAT, MARCKSL1, LAMTOR3, HNRNPU, ZMPSTE24, STAT3, ATF2, CSNK2A1, SRC, ATP4A, ASS1, RFWD2, IL1B, ASGR2, HMOX2, SLC39A4, LYPD3, ENPP6, ZACN, PLTP, LYPD6, KRAS, AGR3, BCAS3, CASC3, CASZ1, CCL5, CDH13, DIRAS3, FAM84B, KLK7, MRC2, RHOBTB2, SNAI1, THRSP, VPS45, HERC2, TCTN2, TCTN3, EVC2, TMEM17, TMEM216, ATP6V1B2, ATP6V0A1, COL5A1, STOM, FLOT2, GALNT2, MSN, PHB, ABCD3, SMARCD2, ATP6V0D1, GOSR1, MVP, FLOT1, PHB2, LTN1, GOLIM4, BCOR, WRAP53, MREG, PCNP, KIDINS220, RNF213, ARHGAP39, PTRF, CDH1, ACTB, APLP2, CASC4, SNRPD2, TOMM70A, CTDNEP1, C5AR2, TMEM63A, C3AR1, GPR21, GHITM, SLCO6A1, TMPRSS3, AMTN, MRAP2, GPR114, KIAA1467, SLC39A12, APLNR, DUSP1, DCUN1D5, PISD, COX11, NDUFAF4, NARS, PTRH2, TBC1D15, NPPC, PFN2, ARL1, DHCR24, AIP, RAB5C, PGRMC1, SEC61A1, CDIPT, SLC27A4, ILVBL, DHCR7, TRIP13, ARF4, HEATR3, PCMT1, ARF1, CCDC47, CDK4, FLAD1, RMDN3, CLK2, LATBCAS4DTNBP1, PKD2, BLOC1S6, BLOC1S2, BLOC1S5, BLOC1S1, LOH12CR1, ATG4A, SNAPIN, BLOC1S3, SRCIN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PTPN1_BCAS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePTPN1P18031DB01133Tiludronic acidTyrosine-protein phosphatase non-receptor type 1small moleculeapproved|investigational|vet_approved

Top

RelatedDiseases for PTPN1_BCAS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPN1C0019829Hodgkin Disease1CTD_human
HgenePTPN1C0021655Insulin Resistance1CTD_human
HgenePTPN1C0023893Liver Cirrhosis, Experimental1CTD_human
HgenePTPN1C0025063Mediastinal Neoplasms1CTD_human
HgenePTPN1C0028754Obesity1CTD_human
HgenePTPN1C0035372Rett Syndrome1CTD_human
HgenePTPN1C0036341Schizophrenia1PSYGENET
HgenePTPN1C0079731B-Cell Lymphomas1CTD_human