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Fusion gene ID: 29427 |
FusionGeneSummary for PTPN14_PTPN14 |
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Fusion gene information | Fusion gene name: PTPN14_PTPN14 | Fusion gene ID: 29427 | Hgene | Tgene | Gene symbol | PTPN14 | PTPN14 | Gene ID | 5784 | 5784 |
Gene name | protein tyrosine phosphatase, non-receptor type 14 | protein tyrosine phosphatase, non-receptor type 14 | |
Synonyms | CATLPH|PEZ|PTP36 | CATLPH|PEZ|PTP36 | |
Cytomap | 1q32.3-q41 | 1q32.3-q41 | |
Type of gene | protein-coding | protein-coding | |
Description | tyrosine-protein phosphatase non-receptor type 14cytoskeletal-associated protein tyrosine phosphataseprotein-tyrosine phosphatase pez | tyrosine-protein phosphatase non-receptor type 14cytoskeletal-associated protein tyrosine phosphataseprotein-tyrosine phosphatase pez | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q15678 | Q15678 | |
Ensembl transtripts involved in fusion gene | ENST00000366956, ENST00000543945, ENST00000491277, | ENST00000366956, ENST00000543945, ENST00000491277, | |
Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 5 X 6 X 3=90 |
# samples | 5 | 6 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PTPN14 [Title/Abstract] AND PTPN14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PTPN14 | GO:0046825 | regulation of protein export from nucleus | 22948661 |
Tgene | PTPN14 | GO:0046825 | regulation of protein export from nucleus | 22948661 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW276697 | PTPN14 | chr1 | 214527632 | - | PTPN14 | chr1 | 214527378 | + | ||
ChiTaRS3.1 | BF379386 | PTPN14 | chr1 | 214540452 | - | PTPN14 | chr1 | 214540357 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000366956 | ENST00000366956 | PTPN14 | chr1 | 214527632 | - | PTPN14 | chr1 | 214527378 | + |
intron-intron | ENST00000366956 | ENST00000543945 | PTPN14 | chr1 | 214527632 | - | PTPN14 | chr1 | 214527378 | + |
intron-intron | ENST00000366956 | ENST00000491277 | PTPN14 | chr1 | 214527632 | - | PTPN14 | chr1 | 214527378 | + |
intron-3UTR | ENST00000543945 | ENST00000366956 | PTPN14 | chr1 | 214527632 | - | PTPN14 | chr1 | 214527378 | + |
intron-intron | ENST00000543945 | ENST00000543945 | PTPN14 | chr1 | 214527632 | - | PTPN14 | chr1 | 214527378 | + |
intron-intron | ENST00000543945 | ENST00000491277 | PTPN14 | chr1 | 214527632 | - | PTPN14 | chr1 | 214527378 | + |
intron-3UTR | ENST00000491277 | ENST00000366956 | PTPN14 | chr1 | 214527632 | - | PTPN14 | chr1 | 214527378 | + |
intron-intron | ENST00000491277 | ENST00000543945 | PTPN14 | chr1 | 214527632 | - | PTPN14 | chr1 | 214527378 | + |
intron-intron | ENST00000491277 | ENST00000491277 | PTPN14 | chr1 | 214527632 | - | PTPN14 | chr1 | 214527378 | + |
intron-intron | ENST00000366956 | ENST00000366956 | PTPN14 | chr1 | 214540452 | - | PTPN14 | chr1 | 214540357 | + |
intron-intron | ENST00000366956 | ENST00000543945 | PTPN14 | chr1 | 214540452 | - | PTPN14 | chr1 | 214540357 | + |
intron-intron | ENST00000366956 | ENST00000491277 | PTPN14 | chr1 | 214540452 | - | PTPN14 | chr1 | 214540357 | + |
intron-intron | ENST00000543945 | ENST00000366956 | PTPN14 | chr1 | 214540452 | - | PTPN14 | chr1 | 214540357 | + |
intron-intron | ENST00000543945 | ENST00000543945 | PTPN14 | chr1 | 214540452 | - | PTPN14 | chr1 | 214540357 | + |
intron-intron | ENST00000543945 | ENST00000491277 | PTPN14 | chr1 | 214540452 | - | PTPN14 | chr1 | 214540357 | + |
intron-intron | ENST00000491277 | ENST00000366956 | PTPN14 | chr1 | 214540452 | - | PTPN14 | chr1 | 214540357 | + |
intron-intron | ENST00000491277 | ENST00000543945 | PTPN14 | chr1 | 214540452 | - | PTPN14 | chr1 | 214540357 | + |
intron-intron | ENST00000491277 | ENST00000491277 | PTPN14 | chr1 | 214540452 | - | PTPN14 | chr1 | 214540357 | + |
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FusionProtFeatures for PTPN14_PTPN14 |
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Hgene | Tgene |
PTPN14 | PTPN14 |
Protein tyrosine phosphatase which may play a role inthe regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulatesTGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation atadhesion junctions. Acts as a negative regulator of the oncogenicproperty of YAP, a downstream target of the hippo pathway, in acell density-dependent manner. May function as a tumor suppressor.{ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048,ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270,ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271,ECO:0000269|PubMed:22948661}. | Protein tyrosine phosphatase which may play a role inthe regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulatesTGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation atadhesion junctions. Acts as a negative regulator of the oncogenicproperty of YAP, a downstream target of the hippo pathway, in acell density-dependent manner. May function as a tumor suppressor.{ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048,ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270,ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271,ECO:0000269|PubMed:22948661}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PTPN14_PTPN14 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PTPN14_PTPN14 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTPN14_PTPN14 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PTPN14_PTPN14 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PTPN14 | C0007117 | Basal cell carcinoma | 1 | CTD_human |
Hgene | PTPN14 | C0027819 | Neuroblastoma | 1 | CTD_human |
Tgene | PTPN14 | C0007117 | Basal cell carcinoma | 1 | CTD_human |
Tgene | PTPN14 | C0027819 | Neuroblastoma | 1 | CTD_human |