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Fusion gene ID: 29424 |
FusionGeneSummary for PTPN14_ANKRD44 |
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Fusion gene information | Fusion gene name: PTPN14_ANKRD44 | Fusion gene ID: 29424 | Hgene | Tgene | Gene symbol | PTPN14 | ANKRD44 | Gene ID | 5784 | 91526 |
Gene name | protein tyrosine phosphatase, non-receptor type 14 | ankyrin repeat domain 44 | |
Synonyms | CATLPH|PEZ|PTP36 | PP6-ARS-B | |
Cytomap | 1q32.3-q41 | 2q33.1 | |
Type of gene | protein-coding | protein-coding | |
Description | tyrosine-protein phosphatase non-receptor type 14cytoskeletal-associated protein tyrosine phosphataseprotein-tyrosine phosphatase pez | serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit Bankyrin repeat domain-containing protein 44protein phosphatase 6 ankyrin repeat subunit Bserine/threonine-protein phosphatase 6 regulatory subunit ARS-B | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q15678 | Q8N8A2 | |
Ensembl transtripts involved in fusion gene | ENST00000366956, ENST00000543945, ENST00000491277, | ENST00000282272, ENST00000337207, ENST00000450567, ENST00000328737, ENST00000409153, ENST00000539527, ENST00000409919, ENST00000477852, | |
Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 3 X 3 X 2=18 |
# samples | 5 | 3 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PTPN14 [Title/Abstract] AND ANKRD44 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PTPN14 | GO:0046825 | regulation of protein export from nucleus | 22948661 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | OV | TCGA-23-1122-01A | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000366956 | ENST00000282272 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
5CDS-intron | ENST00000366956 | ENST00000337207 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
5CDS-intron | ENST00000366956 | ENST00000450567 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
5CDS-intron | ENST00000366956 | ENST00000328737 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
5CDS-intron | ENST00000366956 | ENST00000409153 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
5CDS-intron | ENST00000366956 | ENST00000539527 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
5CDS-intron | ENST00000366956 | ENST00000409919 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
5CDS-intron | ENST00000366956 | ENST00000477852 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
3UTR-intron | ENST00000543945 | ENST00000282272 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
3UTR-intron | ENST00000543945 | ENST00000337207 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
3UTR-intron | ENST00000543945 | ENST00000450567 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
3UTR-intron | ENST00000543945 | ENST00000328737 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
3UTR-intron | ENST00000543945 | ENST00000409153 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
3UTR-intron | ENST00000543945 | ENST00000539527 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
3UTR-intron | ENST00000543945 | ENST00000409919 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
3UTR-intron | ENST00000543945 | ENST00000477852 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
intron-intron | ENST00000491277 | ENST00000282272 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
intron-intron | ENST00000491277 | ENST00000337207 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
intron-intron | ENST00000491277 | ENST00000450567 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
intron-intron | ENST00000491277 | ENST00000328737 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
intron-intron | ENST00000491277 | ENST00000409153 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
intron-intron | ENST00000491277 | ENST00000539527 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
intron-intron | ENST00000491277 | ENST00000409919 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
intron-intron | ENST00000491277 | ENST00000477852 | PTPN14 | chr1 | 214537855 | - | ANKRD44 | chr2 | 197832170 | - |
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FusionProtFeatures for PTPN14_ANKRD44 |
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Hgene | Tgene |
PTPN14 | ANKRD44 |
Protein tyrosine phosphatase which may play a role inthe regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulatesTGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation atadhesion junctions. Acts as a negative regulator of the oncogenicproperty of YAP, a downstream target of the hippo pathway, in acell density-dependent manner. May function as a tumor suppressor.{ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048,ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270,ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271,ECO:0000269|PubMed:22948661}. | Putative regulatory subunit of protein phosphatase 6(PP6) that may be involved in the recognition of phosphoproteinsubstrates. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PTPN14_ANKRD44 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PTPN14_ANKRD44 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PTPN14 | CTNNB1, CTNNA1, TJP1, JUP, MYC, PTEN, AMOT, YWHAE, CUL2, YAP1, PLK1, DDB1, PPP2R1A, PPP2R2A, WWC1, YWHAZ, YWHAB, WWC2, UBC, COPS4, STK3, LRR1, WWP1, WWP2, CSNK1D, VHL, NPM1, LATS1, LATS2, MOB1A, MOB1B, SAV1, WWOX, PARD6B, CRLF3, PDLIM7, CTDSPL, MAGI1, RHPN1, MAGI3, STXBP4, PHF20, JPH4, ACAD11, PTPN14, ANKRD50, RMND5A, BAG3, HECW2, MAEA, WDR26, ARMC8, YWHAH, GPS1, AMMECR1L, NDEL1, ACAD8, BPIFB1, ATE1, RANBP10, CCT8L1P, YWHAG, USP9X, KIF2A, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, CGN, LRFN1, DENND1A, SH3PXD2A, RTKN, SRGAP2, MAST3, EIF4E2, SIPA1L1, PPM1H, LIMA1, TESK2, DCLK1, ZNF638, DENND4C, HDAC4, NF1, CBY1, SRSF12, SYDE1, INPP5E | ANKRD44 | PLK1, PPP6C, USP6, BRCA1, ANKRD28, MOB1A, PPP6R1, PPP6R2, PPP6R3, WWP2, NXF1, NOTCH1, NOTCH2, NOTCH3, ANKFY1, HIF1AN, MTCL1, CDKN2C, PLK2, NTRK1, USP10, TRMT2A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTPN14_ANKRD44 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PTPN14_ANKRD44 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PTPN14 | C0007117 | Basal cell carcinoma | 1 | CTD_human |
Hgene | PTPN14 | C0027819 | Neuroblastoma | 1 | CTD_human |