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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29424

FusionGeneSummary for PTPN14_ANKRD44

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPN14_ANKRD44
Fusion gene ID: 29424
HgeneTgene
Gene symbol

PTPN14

ANKRD44

Gene ID

5784

91526

Gene nameprotein tyrosine phosphatase, non-receptor type 14ankyrin repeat domain 44
SynonymsCATLPH|PEZ|PTP36PP6-ARS-B
Cytomap

1q32.3-q41

2q33.1

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein phosphatase non-receptor type 14cytoskeletal-associated protein tyrosine phosphataseprotein-tyrosine phosphatase pezserine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit Bankyrin repeat domain-containing protein 44protein phosphatase 6 ankyrin repeat subunit Bserine/threonine-protein phosphatase 6 regulatory subunit ARS-B
Modification date2018051920180519
UniProtAcc

Q15678

Q8N8A2

Ensembl transtripts involved in fusion geneENST00000366956, ENST00000543945, 
ENST00000491277, 
ENST00000282272, 
ENST00000337207, ENST00000450567, 
ENST00000328737, ENST00000409153, 
ENST00000539527, ENST00000409919, 
ENST00000477852, 
Fusion gene scores* DoF score4 X 5 X 3=603 X 3 X 2=18
# samples 53
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PTPN14 [Title/Abstract] AND ANKRD44 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPN14

GO:0046825

regulation of protein export from nucleus

22948661


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-23-1122-01APTPN14chr1

214537855

-ANKRD44chr2

197832170

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000366956ENST00000282272PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
5CDS-intronENST00000366956ENST00000337207PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
5CDS-intronENST00000366956ENST00000450567PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
5CDS-intronENST00000366956ENST00000328737PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
5CDS-intronENST00000366956ENST00000409153PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
5CDS-intronENST00000366956ENST00000539527PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
5CDS-intronENST00000366956ENST00000409919PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
5CDS-intronENST00000366956ENST00000477852PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
3UTR-intronENST00000543945ENST00000282272PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
3UTR-intronENST00000543945ENST00000337207PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
3UTR-intronENST00000543945ENST00000450567PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
3UTR-intronENST00000543945ENST00000328737PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
3UTR-intronENST00000543945ENST00000409153PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
3UTR-intronENST00000543945ENST00000539527PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
3UTR-intronENST00000543945ENST00000409919PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
3UTR-intronENST00000543945ENST00000477852PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
intron-intronENST00000491277ENST00000282272PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
intron-intronENST00000491277ENST00000337207PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
intron-intronENST00000491277ENST00000450567PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
intron-intronENST00000491277ENST00000328737PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
intron-intronENST00000491277ENST00000409153PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
intron-intronENST00000491277ENST00000539527PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
intron-intronENST00000491277ENST00000409919PTPN14chr1

214537855

-ANKRD44chr2

197832170

-
intron-intronENST00000491277ENST00000477852PTPN14chr1

214537855

-ANKRD44chr2

197832170

-

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FusionProtFeatures for PTPN14_ANKRD44


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPN14

Q15678

ANKRD44

Q8N8A2

Protein tyrosine phosphatase which may play a role inthe regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulatesTGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation atadhesion junctions. Acts as a negative regulator of the oncogenicproperty of YAP, a downstream target of the hippo pathway, in acell density-dependent manner. May function as a tumor suppressor.{ECO:0000269|PubMed:10934049, ECO:0000269|PubMed:12808048,ECO:0000269|PubMed:17893246, ECO:0000269|PubMed:20826270,ECO:0000269|PubMed:22233626, ECO:0000269|PubMed:22525271,ECO:0000269|PubMed:22948661}. Putative regulatory subunit of protein phosphatase 6(PP6) that may be involved in the recognition of phosphoproteinsubstrates.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPN14_ANKRD44


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPN14_ANKRD44


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPN14CTNNB1, CTNNA1, TJP1, JUP, MYC, PTEN, AMOT, YWHAE, CUL2, YAP1, PLK1, DDB1, PPP2R1A, PPP2R2A, WWC1, YWHAZ, YWHAB, WWC2, UBC, COPS4, STK3, LRR1, WWP1, WWP2, CSNK1D, VHL, NPM1, LATS1, LATS2, MOB1A, MOB1B, SAV1, WWOX, PARD6B, CRLF3, PDLIM7, CTDSPL, MAGI1, RHPN1, MAGI3, STXBP4, PHF20, JPH4, ACAD11, PTPN14, ANKRD50, RMND5A, BAG3, HECW2, MAEA, WDR26, ARMC8, YWHAH, GPS1, AMMECR1L, NDEL1, ACAD8, BPIFB1, ATE1, RANBP10, CCT8L1P, YWHAG, USP9X, KIF2A, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, CGN, LRFN1, DENND1A, SH3PXD2A, RTKN, SRGAP2, MAST3, EIF4E2, SIPA1L1, PPM1H, LIMA1, TESK2, DCLK1, ZNF638, DENND4C, HDAC4, NF1, CBY1, SRSF12, SYDE1, INPP5EANKRD44PLK1, PPP6C, USP6, BRCA1, ANKRD28, MOB1A, PPP6R1, PPP6R2, PPP6R3, WWP2, NXF1, NOTCH1, NOTCH2, NOTCH3, ANKFY1, HIF1AN, MTCL1, CDKN2C, PLK2, NTRK1, USP10, TRMT2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPN14_ANKRD44


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPN14_ANKRD44


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPN14C0007117Basal cell carcinoma1CTD_human
HgenePTPN14C0027819Neuroblastoma1CTD_human