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Fusion gene ID: 29422 |
FusionGeneSummary for PTPN13_PTPN13 |
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Fusion gene information | Fusion gene name: PTPN13_PTPN13 | Fusion gene ID: 29422 | Hgene | Tgene | Gene symbol | PTPN13 | PTPN13 | Gene ID | 5783 | 5783 |
Gene name | protein tyrosine phosphatase, non-receptor type 13 | protein tyrosine phosphatase, non-receptor type 13 | |
Synonyms | FAP-1|PNP1|PTP-BAS|PTP-BL|PTP1E|PTPL1|PTPLE|hPTP1E | FAP-1|PNP1|PTP-BAS|PTP-BL|PTP1E|PTPL1|PTPLE|hPTP1E | |
Cytomap | 4q21.3 | 4q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | tyrosine-protein phosphatase non-receptor type 13fas-associated protein-tyrosine phosphatase 1hPTPE1protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)protein-tyrosine phosphatase 1Eprotein-tyrosine phosphatas | tyrosine-protein phosphatase non-receptor type 13fas-associated protein-tyrosine phosphatase 1hPTPE1protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)protein-tyrosine phosphatase 1Eprotein-tyrosine phosphatas | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q12923 | Q12923 | |
Ensembl transtripts involved in fusion gene | ENST00000427191, ENST00000436978, ENST00000502971, ENST00000411767, ENST00000316707, ENST00000511467, | ENST00000427191, ENST00000436978, ENST00000502971, ENST00000411767, ENST00000316707, ENST00000511467, | |
Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 5 X 8 X 6=240 |
# samples | 6 | 11 | |
** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/240*10)=-1.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PTPN13 [Title/Abstract] AND PTPN13 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PTPN13 | GO:0006470 | protein dephosphorylation | 17657516 |
Hgene | PTPN13 | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | 23604317 |
Tgene | PTPN13 | GO:0006470 | protein dephosphorylation | 17657516 |
Tgene | PTPN13 | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | 23604317 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | U12128 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000427191 | ENST00000427191 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000427191 | ENST00000436978 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000427191 | ENST00000502971 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000427191 | ENST00000411767 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000427191 | ENST00000316707 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000427191 | ENST00000511467 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000436978 | ENST00000427191 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000436978 | ENST00000436978 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000436978 | ENST00000502971 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000436978 | ENST00000411767 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000436978 | ENST00000316707 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000436978 | ENST00000511467 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000502971 | ENST00000427191 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000502971 | ENST00000436978 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000502971 | ENST00000502971 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000502971 | ENST00000411767 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000502971 | ENST00000316707 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000502971 | ENST00000511467 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000411767 | ENST00000427191 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000411767 | ENST00000436978 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000411767 | ENST00000502971 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000411767 | ENST00000411767 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000411767 | ENST00000316707 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000411767 | ENST00000511467 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000316707 | ENST00000427191 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000316707 | ENST00000436978 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000316707 | ENST00000502971 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000316707 | ENST00000411767 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000316707 | ENST00000316707 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000316707 | ENST00000511467 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000511467 | ENST00000427191 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000511467 | ENST00000436978 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000511467 | ENST00000502971 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000511467 | ENST00000411767 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000511467 | ENST00000316707 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
5CDS-5UTR | ENST00000511467 | ENST00000511467 | PTPN13 | chr4 | 87610347 | + | PTPN13 | chr4 | 87556404 | + |
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FusionProtFeatures for PTPN13_PTPN13 |
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Hgene | Tgene |
PTPN13 | PTPN13 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PTPN13_PTPN13 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PTPN13_PTPN13 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PTPN13 | PKN2, NFKBIA, EFNB1, ARHGAP29, FASLG, CTNNB1, GHR, FBXL2, LATS1, LATS2, YWHAB, RAPGEF2, RASSF10, WHSC1, FBXW11, DNM2, NINL, TMEM17, PLEKHA1, STXBP4, PTEN, RGS2, DFFB, KCTD3, KIF13B, CGN, ZBTB21, KSR1, GIGYF1, LPIN3, LRFN1, RTKN, DENND4C, MAST3, SH3RF3, DENND1A, SH3PXD2A, SRGAP2, PPM1H, TANC2, RALGPS2, EIF4E2, SIPA1L1, NF1, CDC25C, CBY1, GIGYF2, INPP5E, MTNR1A, HEY1 | PTPN13 | PKN2, NFKBIA, EFNB1, ARHGAP29, FASLG, CTNNB1, GHR, FBXL2, LATS1, LATS2, YWHAB, RAPGEF2, RASSF10, WHSC1, FBXW11, DNM2, NINL, TMEM17, PLEKHA1, STXBP4, PTEN, RGS2, DFFB, KCTD3, KIF13B, CGN, ZBTB21, KSR1, GIGYF1, LPIN3, LRFN1, RTKN, DENND4C, MAST3, SH3RF3, DENND1A, SH3PXD2A, SRGAP2, PPM1H, TANC2, RALGPS2, EIF4E2, SIPA1L1, NF1, CDC25C, CBY1, GIGYF2, INPP5E, MTNR1A, HEY1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTPN13_PTPN13 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PTPN13_PTPN13 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |