	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 29413

FusionGeneSummary for PTPN12_DYNC1I1

Fusion gene summary

Fusion gene information	Fusion gene name: PTPN12_DYNC1I1
	Fusion gene ID: 29413
		Hgene	Tgene
	Gene symbol	PTPN12	DYNC1I1
	Gene ID	5782	1780
	Gene name	protein tyrosine phosphatase, non-receptor type 12	dynein cytoplasmic 1 intermediate chain 1
	Synonyms	PTP-PEST\|PTPG1	DNCI1\|DNCIC1
	Cytomap	7q11.23	7q21.3
	Type of gene	protein-coding	protein-coding
	Description	tyrosine-protein phosphatase non-receptor type 12protein-tyrosine phosphatase G1	cytoplasmic dynein 1 intermediate chain 1DH IC-1cytoplasmic dynein intermediate chain 1dynein intermediate chain 1, cytosolicdynein, cytoplasmic, intermediate polypeptide 1
	Modification date	20180522	20180523
	UniProtAcc	Q05209	O14576
	Ensembl transtripts involved in fusion gene	ENST00000248594, ENST00000415482, ENST00000435495,	ENST00000447467, ENST00000324972, ENST00000537881, ENST00000437599, ENST00000359388, ENST00000413338, ENST00000457059, ENST00000497626,
Fusion gene scores	* DoF score	9 X 8 X 5=360	6 X 5 X 6=180
	# samples	11	7
	** MAII score	log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PTPN12 [Title/Abstract] AND DYNC1I1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PTPN12	GO:0006470	protein dephosphorylation	27134172
Hgene	PTPN12	GO:0035335	peptidyl-tyrosine dephosphorylation	27134172

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LGG	TCGA-DU-5855-01A	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000248594	ENST00000447467	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
In-frame	ENST00000248594	ENST00000324972	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
In-frame	ENST00000248594	ENST00000537881	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
In-frame	ENST00000248594	ENST00000437599	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
In-frame	ENST00000248594	ENST00000359388	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
5CDS-intron	ENST00000248594	ENST00000413338	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
5CDS-intron	ENST00000248594	ENST00000457059	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
5CDS-intron	ENST00000248594	ENST00000497626	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
intron-3CDS	ENST00000415482	ENST00000447467	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
intron-3CDS	ENST00000415482	ENST00000324972	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
intron-3CDS	ENST00000415482	ENST00000537881	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
intron-3CDS	ENST00000415482	ENST00000437599	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
intron-3CDS	ENST00000415482	ENST00000359388	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
intron-intron	ENST00000415482	ENST00000413338	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
intron-intron	ENST00000415482	ENST00000457059	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
intron-intron	ENST00000415482	ENST00000497626	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
intron-3CDS	ENST00000435495	ENST00000447467	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
intron-3CDS	ENST00000435495	ENST00000324972	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
intron-3CDS	ENST00000435495	ENST00000537881	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
intron-3CDS	ENST00000435495	ENST00000437599	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
intron-3CDS	ENST00000435495	ENST00000359388	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
intron-intron	ENST00000435495	ENST00000413338	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
intron-intron	ENST00000435495	ENST00000457059	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
intron-intron	ENST00000435495	ENST00000497626	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+

Top

FusionProtFeatures for PTPN12_DYNC1I1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PTPN12 Q05209	DYNC1I1 O14576
	Acts as one of several non-catalytic accessorycomponents of the cytoplasmic dynein 1 complex that are thought tobe involved in linking dynein to cargos and to adapter proteinsthat regulate dynein function. Cytoplasmic dynein 1 acts as amotor for the intracellular retrograde motility of vesicles andorganelles along microtubules. The intermediate chains mediate thebinding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction ofcytoplasmic dynein with membranous organelles and kinetochores.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

>>>>>>>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000324972

530_570

520

646

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000324972

576_615

520

646

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000359388

482_527

483

609

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000359388

530_570

483

609

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000359388

576_615

483

609

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000447467

530_570

503

629

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000447467

576_615

503

629

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000457059

530_570

503

629

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000457059

576_615

503

629

Repeat

Note=WD 7

- In-frame and not-retained protein feature among the 13 regional features.

>>>>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PTPN12

chr7:77166962

chr7:95705369

ENST00000248594

28_293

781

Domain

Tyrosine-protein phosphatase

Hgene

PTPN12

chr7:77166962

chr7:95705369

ENST00000435495

28_293

-78

651

Domain

Tyrosine-protein phosphatase

Hgene

PTPN12

chr7:77166962

chr7:95705369

ENST00000248594

231_237

781

Region

Substrate binding

Hgene

PTPN12

chr7:77166962

chr7:95705369

ENST00000248594

63_67

781

Region

Substrate binding

Hgene

PTPN12

chr7:77166962

chr7:95705369

ENST00000435495

231_237

-78

651

Region

Substrate binding

Hgene

PTPN12

chr7:77166962

chr7:95705369

ENST00000435495

63_67

-78

651

Region

Substrate binding

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000324972

285_334

520

646

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000324972

338_378

520

646

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000324972

387_428

520

646

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000324972

437_477

520

646

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000324972

482_527

520

646

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000359388

285_334

483

609

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000359388

338_378

483

609

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000359388

387_428

483

609

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000359388

437_477

483

609

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000447467

285_334

503

629

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000447467

338_378

503

629

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000447467

387_428

503

629

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000447467

437_477

503

629

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000447467

482_527

503

629

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000457059

285_334

503

629

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000457059

338_378

503

629

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000457059

387_428

503

629

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000457059

437_477

503

629

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000457059

482_527

503

629

Repeat

Note=WD 5

Top

FusionGeneSequence for PTPN12_DYNC1I1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

>In-frame_PTPN12_ENST00000248594_chr7_77166962_+_DYNC1I1_ENST00000447467_chr7_95705369_+_159aa
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

>In-frame_PTPN12_ENST00000248594_chr7_77166962_+_DYNC1I1_ENST00000324972_chr7_95705369_+_159aa
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

>In-frame_PTPN12_ENST00000248594_chr7_77166962_+_DYNC1I1_ENST00000537881_chr7_95705369_+_153aa
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

>In-frame_PTPN12_ENST00000248594_chr7_77166962_+_DYNC1I1_ENST00000437599_chr7_95705369_+_159aa
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

>In-frame_PTPN12_ENST00000248594_chr7_77166962_+_DYNC1I1_ENST00000359388_chr7_95705369_+_159aa
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

* Fusion transcript sequences (only coding sequence (CDS) region).

>In-frame_PTPN12_ENST00000248594_chr7_77166962_+_DYNC1I1_ENST00000447467_chr7_95705369_+_477nt
ATGGAGCAAGTGGAGATCCTGAGGAAATTCATCCAGAGGGTCCAGGCCATGAAGAGTCCTGACCACAATGGGGAGGACAACTTCGCCCGG
GACTTCATGCACAACAAGCCGCTCTACTCCTTTGAAGACAATGCAGACTATGTGTACGATGTCATGTGGTCCCCCGTGCATCCTGCGCTT
TTTGCCTGCGTGGACGGGATGGGGCGCTTGGACCTCTGGAACCTCAACAATGACACCGAGGTTCCAACAGCAAGTGTGGCCATTGAGGGG
GCATCCGCCCTAAACCGTGTTCGTTGGGCCCAAGCTGGCAAAGAAGTTGCTGTTGGGGACTCGGAAGGCCGTATTTGGGTCTATGACGTT
GGAGAGCTTGCAGTTCCCCACAATGATGAATGGACCCGATTTGCCAGGACCCTTGTGGAAATTCGTGCTAACAGAGCTGATAGCGAGGAG

>In-frame_PTPN12_ENST00000248594_chr7_77166962_+_DYNC1I1_ENST00000324972_chr7_95705369_+_477nt
ATGGAGCAAGTGGAGATCCTGAGGAAATTCATCCAGAGGGTCCAGGCCATGAAGAGTCCTGACCACAATGGGGAGGACAACTTCGCCCGG
GACTTCATGCACAACAAGCCGCTCTACTCCTTTGAAGACAATGCAGACTATGTGTACGATGTCATGTGGTCCCCCGTGCATCCTGCGCTT
TTTGCCTGCGTGGACGGGATGGGGCGCTTGGACCTCTGGAACCTCAACAATGACACCGAGGTTCCAACAGCAAGTGTGGCCATTGAGGGG
GCATCCGCCCTAAACCGTGTTCGTTGGGCCCAAGCTGGCAAAGAAGTTGCTGTTGGGGACTCGGAAGGCCGTATTTGGGTCTATGACGTT
GGAGAGCTTGCAGTTCCCCACAATGATGAATGGACCCGATTTGCCAGGACCCTTGTGGAAATTCGTGCTAACAGAGCTGATAGCGAGGAG

>In-frame_PTPN12_ENST00000248594_chr7_77166962_+_DYNC1I1_ENST00000537881_chr7_95705369_+_459nt
ATGGAGCAAGTGGAGATCCTGAGGAAATTCATCCAGAGGGTCCAGGCCATGAAGAGTCCTGACCACAATGGGGAGGACAACTTCGCCCGG
GACTTCATGCACAACAAGCCGCTCTACTCCTTTGAAGACAATGCAGACTATGTGTACGATGTCATGTGGTCCCCCGTGCATCCTGCGCTT
TTTGCCTGCGTGGACGGGATGGGGCGCTTGGACCTCTGGAACCTCAACAATGACACCGAGGTTCCAACAGCAAGTGTGGCCATTGAGGGG
GCATCCGCCCTAAACCGTGTTCGTTGGGCCCAAGCTGGCAAAGAAGTTGCTGTTGGGGACTCGGAAGGCCGTATTTGGGTCTATGACGTT
GGAGAGGGTCTTGCTATGTTGCCAGGCTGGTCTCAAAATTCCTGGACTCAAGCAATCCTCCTATGTTGGCCTCCCAAAGTGCTGGGATTA

>In-frame_PTPN12_ENST00000248594_chr7_77166962_+_DYNC1I1_ENST00000437599_chr7_95705369_+_477nt
ATGGAGCAAGTGGAGATCCTGAGGAAATTCATCCAGAGGGTCCAGGCCATGAAGAGTCCTGACCACAATGGGGAGGACAACTTCGCCCGG
GACTTCATGCACAACAAGCCGCTCTACTCCTTTGAAGACAATGCAGACTATGTGTACGATGTCATGTGGTCCCCCGTGCATCCTGCGCTT
TTTGCCTGCGTGGACGGGATGGGGCGCTTGGACCTCTGGAACCTCAACAATGACACCGAGGTTCCAACAGCAAGTGTGGCCATTGAGGGG
GCATCCGCCCTAAACCGTGTTCGTTGGGCCCAAGCTGGCAAAGAAGTTGCTGTTGGGGACTCGGAAGGCCGTATTTGGGTCTATGACGTT
GGAGAGCTTGCAGTTCCCCACAATGATGAATGGACCCGATTTGCCAGGACCCTTGTGGAAATTCGTGCTAACAGAGCTGATAGCGAGGAG

>In-frame_PTPN12_ENST00000248594_chr7_77166962_+_DYNC1I1_ENST00000359388_chr7_95705369_+_477nt
ATGGAGCAAGTGGAGATCCTGAGGAAATTCATCCAGAGGGTCCAGGCCATGAAGAGTCCTGACCACAATGGGGAGGACAACTTCGCCCGG
GACTTCATGCACAACAAGCCGCTCTACTCCTTTGAAGACAATGCAGACTATGTGTACGATGTCATGTGGTCCCCCGTGCATCCTGCGCTT
TTTGCCTGCGTGGACGGGATGGGGCGCTTGGACCTCTGGAACCTCAACAATGACACCGAGGTTCCAACAGCAAGTGTGGCCATTGAGGGG
GCATCCGCCCTAAACCGTGTTCGTTGGGCCCAAGCTGGCAAAGAAGTTGCTGTTGGGGACTCGGAAGGCCGTATTTGGGTCTATGACGTT
GGAGAGCTTGCAGTTCCCCACAATGATGAATGGACCCGATTTGCCAGGACCCTTGTGGAAATTCGTGCTAACAGAGCTGATAGCGAGGAG

* Fusion transcript sequences (Full-length transcript).

>In-frame_PTPN12_ENST00000248594_chr7_77166962_+_DYNC1I1_ENST00000447467_chr7_95705369_+_1580nt
AGCTGGGGGTTGGGGTTGGCGCTAGCGCAGCGGCTCGCCTGGTACTGTGGGAGAGCGGCGGCTGCTCCTGGAAGTTGTGGTGTCGGGAGC
CCAGCCGGTGCCGCCGCAGCCGCCGCCTAGGGCGGTGGGGAGGAGGAGGGAGCCGCGGGGCTTGGCGGGGTCGGGAGGGAGGGACGTGCT
GGGGGAACGAGCTGGGGAAGACGGAGCGGGCTCTGTGCCGGGCGGGCGGGCGGCGGGGGGGCCAGCGACCGCAGCCGGGGGGACGCGGGA
GGATGGAGCAAGTGGAGATCCTGAGGAAATTCATCCAGAGGGTCCAGGCCATGAAGAGTCCTGACCACAATGGGGAGGACAACTTCGCCC
GGGACTTCATGCACAACAAGCCGCTCTACTCCTTTGAAGACAATGCAGACTATGTGTACGATGTCATGTGGTCCCCCGTGCATCCTGCGC
TTTTTGCCTGCGTGGACGGGATGGGGCGCTTGGACCTCTGGAACCTCAACAATGACACCGAGGTTCCAACAGCAAGTGTGGCCATTGAGG
GGGCATCCGCCCTAAACCGTGTTCGTTGGGCCCAAGCTGGCAAAGAAGTTGCTGTTGGGGACTCGGAAGGCCGTATTTGGGTCTATGACG
TTGGAGAGCTTGCAGTTCCCCACAATGATGAATGGACCCGATTTGCCAGGACCCTTGTGGAAATTCGTGCTAACAGAGCTGATAGCGAGG
AGGAAGGCACTGTTGAGTTATCTGCCTAGTGGAAATGAGCCACCCCCACTGCAGCCCCCACCTTTGTGTCCTAGAGCTCAGCGTCTGCAG
TCAAGTCTCTTGTATTCGGTGTCCATTCAGTATCAGTATTGCTGTGATATTTTGGGTGCCATATTGTGCCAGCTTTGCTCCAAGTATTCT
AAATGTGTCCCATCATGCTTTCCACTGACCCAAAATTCACCACAGCATTTCTATCTTTATATTTCTGTCTCAAAAATGAAGAGAAGGGGG
TTATGGGTTAAGTTGCTGCCTTTTAACTACTTTGTAGCTGTATTTAATAGCTGGAAACCTCTGGTTAAATTTGTGCTTACATGCACTCCT
GGCATAGTCCTATTAAATCCATATGAAGCCAGATATGATTGGGTGCAGATGTGGTGTTCCTCATATTATGGTACAGGGCCAAAGACTTGA
GACGTGGTGTTTTACATGGTGACTCACATTATGAATGGATTTACTAGAAGAACATTGCTGCTCCTTATTTATTGTAGTGTGCTGCATGGA
ACGTATTTATTTGAAAGCATTAAAATAAATGATCCTAGAGCATGTGCATAATGAGAGGACTGTATTCTCTCTGCTGCTGTTGAGGTTATA
TTAAGTTCCACATAGCAATTACAGTATGCCAGTTCCACTGAAGACATGAAATCTTTAGAGGTTTCTTGCAGTGAACGAAATGAATTTTAA
TGCCTATTATTTCTGGGTACTTTAACAATATTTCAAATATCATTGACCACTAATACTTCTCACTGAAGCTAACACAGTCTGACAAAAGTC

>In-frame_PTPN12_ENST00000248594_chr7_77166962_+_DYNC1I1_ENST00000324972_chr7_95705369_+_1568nt
AGCTGGGGGTTGGGGTTGGCGCTAGCGCAGCGGCTCGCCTGGTACTGTGGGAGAGCGGCGGCTGCTCCTGGAAGTTGTGGTGTCGGGAGC
CCAGCCGGTGCCGCCGCAGCCGCCGCCTAGGGCGGTGGGGAGGAGGAGGGAGCCGCGGGGCTTGGCGGGGTCGGGAGGGAGGGACGTGCT
GGGGGAACGAGCTGGGGAAGACGGAGCGGGCTCTGTGCCGGGCGGGCGGGCGGCGGGGGGGCCAGCGACCGCAGCCGGGGGGACGCGGGA
GGATGGAGCAAGTGGAGATCCTGAGGAAATTCATCCAGAGGGTCCAGGCCATGAAGAGTCCTGACCACAATGGGGAGGACAACTTCGCCC
GGGACTTCATGCACAACAAGCCGCTCTACTCCTTTGAAGACAATGCAGACTATGTGTACGATGTCATGTGGTCCCCCGTGCATCCTGCGC
TTTTTGCCTGCGTGGACGGGATGGGGCGCTTGGACCTCTGGAACCTCAACAATGACACCGAGGTTCCAACAGCAAGTGTGGCCATTGAGG
GGGCATCCGCCCTAAACCGTGTTCGTTGGGCCCAAGCTGGCAAAGAAGTTGCTGTTGGGGACTCGGAAGGCCGTATTTGGGTCTATGACG
TTGGAGAGCTTGCAGTTCCCCACAATGATGAATGGACCCGATTTGCCAGGACCCTTGTGGAAATTCGTGCTAACAGAGCTGATAGCGAGG
AGGAAGGCACTGTTGAGTTATCTGCCTAGTGGAAATGAGCCACCCCCACTGCAGCCCCCACCTTTGTGTCCTAGAGCTCAGCGTCTGCAG
TCAAGTCTCTTGTATTCGGTGTCCATTCAGTATCAGTATTGCTGTGATATTTTGGGTGCCATATTGTGCCAGCTTTGCTCCAAGTATTCT
AAATGTGTCCCATCATGCTTTCCACTGACCCAAAATTCACCACAGCATTTCTATCTTTATATTTCTGTCTCAAAAATGAAGAGAAGGGGG
TTATGGGTTAAGTTGCTGCCTTTTAACTACTTTGTAGCTGTATTTAATAGCTGGAAACCTCTGGTTAAATTTGTGCTTACATGCACTCCT
GGCATAGTCCTATTAAATCCATATGAAGCCAGATATGATTGGGTGCAGATGTGGTGTTCCTCATATTATGGTACAGGGCCAAAGACTTGA
GACGTGGTGTTTTACATGGTGACTCACATTATGAATGGATTTACTAGAAGAACATTGCTGCTCCTTATTTATTGTAGTGTGCTGCATGGA
ACGTATTTATTTGAAAGCATTAAAATAAATGATCCTAGAGCATGTGCATAATGAGAGGACTGTATTCTCTCTGCTGCTGTTGAGGTTATA
TTAAGTTCCACATAGCAATTACAGTATGCCAGTTCCACTGAAGACATGAAATCTTTAGAGGTTTCTTGCAGTGAACGAAATGAATTTTAA
TGCCTATTATTTCTGGGTACTTTAACAATATTTCAAATATCATTGACCACTAATACTTCTCACTGAAGCTAACACAGTCTGACAAAAGTC

>In-frame_PTPN12_ENST00000248594_chr7_77166962_+_DYNC1I1_ENST00000537881_chr7_95705369_+_982nt
AGCTGGGGGTTGGGGTTGGCGCTAGCGCAGCGGCTCGCCTGGTACTGTGGGAGAGCGGCGGCTGCTCCTGGAAGTTGTGGTGTCGGGAGC
CCAGCCGGTGCCGCCGCAGCCGCCGCCTAGGGCGGTGGGGAGGAGGAGGGAGCCGCGGGGCTTGGCGGGGTCGGGAGGGAGGGACGTGCT
GGGGGAACGAGCTGGGGAAGACGGAGCGGGCTCTGTGCCGGGCGGGCGGGCGGCGGGGGGGCCAGCGACCGCAGCCGGGGGGACGCGGGA
GGATGGAGCAAGTGGAGATCCTGAGGAAATTCATCCAGAGGGTCCAGGCCATGAAGAGTCCTGACCACAATGGGGAGGACAACTTCGCCC
GGGACTTCATGCACAACAAGCCGCTCTACTCCTTTGAAGACAATGCAGACTATGTGTACGATGTCATGTGGTCCCCCGTGCATCCTGCGC
TTTTTGCCTGCGTGGACGGGATGGGGCGCTTGGACCTCTGGAACCTCAACAATGACACCGAGGTTCCAACAGCAAGTGTGGCCATTGAGG
GGGCATCCGCCCTAAACCGTGTTCGTTGGGCCCAAGCTGGCAAAGAAGTTGCTGTTGGGGACTCGGAAGGCCGTATTTGGGTCTATGACG
TTGGAGAGGGTCTTGCTATGTTGCCAGGCTGGTCTCAAAATTCCTGGACTCAAGCAATCCTCCTATGTTGGCCTCCCAAAGTGCTGGGAT
TACAGACATGAGCCACTGTGCCCAGCTATGCCTGCTTGTTATATCAGCTACTGAGAGATGAGTACCAAAATCTGGAAGTATAATTGTGGA
TATCTTTTAGTTCTTTCAGTTCTATCAGCTTTTGTTTTCTGTATCCAAAGCTTTGTTATTAGGTGCCTACATATTGAGGATTTCATGTGT

>In-frame_PTPN12_ENST00000248594_chr7_77166962_+_DYNC1I1_ENST00000437599_chr7_95705369_+_1580nt
AGCTGGGGGTTGGGGTTGGCGCTAGCGCAGCGGCTCGCCTGGTACTGTGGGAGAGCGGCGGCTGCTCCTGGAAGTTGTGGTGTCGGGAGC
CCAGCCGGTGCCGCCGCAGCCGCCGCCTAGGGCGGTGGGGAGGAGGAGGGAGCCGCGGGGCTTGGCGGGGTCGGGAGGGAGGGACGTGCT
GGGGGAACGAGCTGGGGAAGACGGAGCGGGCTCTGTGCCGGGCGGGCGGGCGGCGGGGGGGCCAGCGACCGCAGCCGGGGGGACGCGGGA
GGATGGAGCAAGTGGAGATCCTGAGGAAATTCATCCAGAGGGTCCAGGCCATGAAGAGTCCTGACCACAATGGGGAGGACAACTTCGCCC
GGGACTTCATGCACAACAAGCCGCTCTACTCCTTTGAAGACAATGCAGACTATGTGTACGATGTCATGTGGTCCCCCGTGCATCCTGCGC
TTTTTGCCTGCGTGGACGGGATGGGGCGCTTGGACCTCTGGAACCTCAACAATGACACCGAGGTTCCAACAGCAAGTGTGGCCATTGAGG
GGGCATCCGCCCTAAACCGTGTTCGTTGGGCCCAAGCTGGCAAAGAAGTTGCTGTTGGGGACTCGGAAGGCCGTATTTGGGTCTATGACG
TTGGAGAGCTTGCAGTTCCCCACAATGATGAATGGACCCGATTTGCCAGGACCCTTGTGGAAATTCGTGCTAACAGAGCTGATAGCGAGG
AGGAAGGCACTGTTGAGTTATCTGCCTAGTGGAAATGAGCCACCCCCACTGCAGCCCCCACCTTTGTGTCCTAGAGCTCAGCGTCTGCAG
TCAAGTCTCTTGTATTCGGTGTCCATTCAGTATCAGTATTGCTGTGATATTTTGGGTGCCATATTGTGCCAGCTTTGCTCCAAGTATTCT
AAATGTGTCCCATCATGCTTTCCACTGACCCAAAATTCACCACAGCATTTCTATCTTTATATTTCTGTCTCAAAAATGAAGAGAAGGGGG
TTATGGGTTAAGTTGCTGCCTTTTAACTACTTTGTAGCTGTATTTAATAGCTGGAAACCTCTGGTTAAATTTGTGCTTACATGCACTCCT
GGCATAGTCCTATTAAATCCATATGAAGCCAGATATGATTGGGTGCAGATGTGGTGTTCCTCATATTATGGTACAGGGCCAAAGACTTGA
GACGTGGTGTTTTACATGGTGACTCACATTATGAATGGATTTACTAGAAGAACATTGCTGCTCCTTATTTATTGTAGTGTGCTGCATGGA
ACGTATTTATTTGAAAGCATTAAAATAAATGATCCTAGAGCATGTGCATAATGAGAGGACTGTATTCTCTCTGCTGCTGTTGAGGTTATA
TTAAGTTCCACATAGCAATTACAGTATGCCAGTTCCACTGAAGACATGAAATCTTTAGAGGTTTCTTGCAGTGAACGAAATGAATTTTAA
TGCCTATTATTTCTGGGTACTTTAACAATATTTCAAATATCATTGACCACTAATACTTCTCACTGAAGCTAACACAGTCTGACAAAAGTC

>In-frame_PTPN12_ENST00000248594_chr7_77166962_+_DYNC1I1_ENST00000359388_chr7_95705369_+_1580nt
AGCTGGGGGTTGGGGTTGGCGCTAGCGCAGCGGCTCGCCTGGTACTGTGGGAGAGCGGCGGCTGCTCCTGGAAGTTGTGGTGTCGGGAGC
CCAGCCGGTGCCGCCGCAGCCGCCGCCTAGGGCGGTGGGGAGGAGGAGGGAGCCGCGGGGCTTGGCGGGGTCGGGAGGGAGGGACGTGCT
GGGGGAACGAGCTGGGGAAGACGGAGCGGGCTCTGTGCCGGGCGGGCGGGCGGCGGGGGGGCCAGCGACCGCAGCCGGGGGGACGCGGGA
GGATGGAGCAAGTGGAGATCCTGAGGAAATTCATCCAGAGGGTCCAGGCCATGAAGAGTCCTGACCACAATGGGGAGGACAACTTCGCCC
GGGACTTCATGCACAACAAGCCGCTCTACTCCTTTGAAGACAATGCAGACTATGTGTACGATGTCATGTGGTCCCCCGTGCATCCTGCGC
TTTTTGCCTGCGTGGACGGGATGGGGCGCTTGGACCTCTGGAACCTCAACAATGACACCGAGGTTCCAACAGCAAGTGTGGCCATTGAGG
GGGCATCCGCCCTAAACCGTGTTCGTTGGGCCCAAGCTGGCAAAGAAGTTGCTGTTGGGGACTCGGAAGGCCGTATTTGGGTCTATGACG
TTGGAGAGCTTGCAGTTCCCCACAATGATGAATGGACCCGATTTGCCAGGACCCTTGTGGAAATTCGTGCTAACAGAGCTGATAGCGAGG
AGGAAGGCACTGTTGAGTTATCTGCCTAGTGGAAATGAGCCACCCCCACTGCAGCCCCCACCTTTGTGTCCTAGAGCTCAGCGTCTGCAG
TCAAGTCTCTTGTATTCGGTGTCCATTCAGTATCAGTATTGCTGTGATATTTTGGGTGCCATATTGTGCCAGCTTTGCTCCAAGTATTCT
AAATGTGTCCCATCATGCTTTCCACTGACCCAAAATTCACCACAGCATTTCTATCTTTATATTTCTGTCTCAAAAATGAAGAGAAGGGGG
TTATGGGTTAAGTTGCTGCCTTTTAACTACTTTGTAGCTGTATTTAATAGCTGGAAACCTCTGGTTAAATTTGTGCTTACATGCACTCCT
GGCATAGTCCTATTAAATCCATATGAAGCCAGATATGATTGGGTGCAGATGTGGTGTTCCTCATATTATGGTACAGGGCCAAAGACTTGA
GACGTGGTGTTTTACATGGTGACTCACATTATGAATGGATTTACTAGAAGAACATTGCTGCTCCTTATTTATTGTAGTGTGCTGCATGGA
ACGTATTTATTTGAAAGCATTAAAATAAATGATCCTAGAGCATGTGCATAATGAGAGGACTGTATTCTCTCTGCTGCTGTTGAGGTTATA
TTAAGTTCCACATAGCAATTACAGTATGCCAGTTCCACTGAAGACATGAAATCTTTAGAGGTTTCTTGCAGTGAACGAAATGAATTTTAA
TGCCTATTATTTCTGGGTACTTTAACAATATTTCAAATATCATTGACCACTAATACTTCTCACTGAAGCTAACACAGTCTGACAAAAGTC

Top

FusionGenePPI for PTPN12_DYNC1I1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
PTPN12	PSTPIP1, SHC1, PXN, BCAR1, JAK2, NEDD9, EFS, TGFB1I1, GSN, GRB2, PTK2B, EGFR, SORBS2, WASF1, APP, STX16, CGA, CSH1, CSH2, BAG6, UTRN, PSG9, ZFP2, IFT20, THAP2, TEX10, RBM19, SMAD5, ANKS1A, EPN1, NUSAP1, PACSIN2, PLOD2, DEK, DNPEP, GANAB, TNS3, TRIM47, UGP2, VASN, NTRK1, CENPJ, NANOG, ERBB4, FGFR2, FGFR4, IGF1R, KDR, PSTPIP2, ARHGAP10, ASAP1, NCK2, CSK, LPXN, PTPN6, AIFM1, VAPA, LMTK2, AATK, ERBB3, ROR2, PTK7, TRIM25	DYNC1I1	DYNLL2, DYNLRB1, DYNLL1, DYNLT1, DYNLT3, STAU1, DNM2, NUDT21, CADM4, C2orf44, FAM110A, KAT7, FBP1, TAOK1, RUNDC3B, MCC, FAM83D, RAP1GAP, DCTN1, GRB7, TK1, CDKN1A, NAGK, SMN1, RCC1, PIN1, ANXA7, KIAA0368, CUL3, EMILIN1, PAFAH1B1, KLC3, TUBB3, KCNA5, BICD2, DYNC1H1, DYNC1LI1, DCTN2, TRIM58, AMBRA1, BECN1, EP300, NDEL1, DCDC5, DYNC1LI2, WDR34, DISC1, DYNC1I2, RPL23, C15orf39, SAMD1, MGA

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	PTPN12	chr7:77166962	chr7:95705369	ENST00000248594	+	1	18	345_438	33	781	TGFB1I1
Hgene	PTPN12	chr7:77166962	chr7:95705369	ENST00000435495	+	1	17	345_438	-78	651	TGFB1I1
Tgene	DYNC1I1	chr7:77166962	chr7:95705369	ENST00000324972	+	13	17	2_123	520	646	DCTN1
Tgene	DYNC1I1	chr7:77166962	chr7:95705369	ENST00000359388	+	12	16	2_123	483	609	DCTN1
Tgene	DYNC1I1	chr7:77166962	chr7:95705369	ENST00000447467	+	13	17	2_123	503	629	DCTN1
Tgene	DYNC1I1	chr7:77166962	chr7:95705369	ENST00000457059	+	13	17	2_123	503	629	DCTN1
Tgene	DYNC1I1	chr7:77166962	chr7:95705369	ENST00000324972	+	13	17	147_163	520	646	DYNLT1
Tgene	DYNC1I1	chr7:77166962	chr7:95705369	ENST00000359388	+	12	16	147_163	483	609	DYNLT1
Tgene	DYNC1I1	chr7:77166962	chr7:95705369	ENST00000447467	+	13	17	147_163	503	629	DYNLT1
Tgene	DYNC1I1	chr7:77166962	chr7:95705369	ENST00000457059	+	13	17	147_163	503	629	DYNLT1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for PTPN12_DYNC1I1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for PTPN12_DYNC1I1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	DYNC1I1	C0031117	Peripheral Neuropathy	1	CTD_human

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 29413

FusionGeneSummary for PTPN12_DYNC1I1

FusionProtFeatures for PTPN12_DYNC1I1

FusionGeneSequence for PTPN12_DYNC1I1

FusionGenePPI for PTPN12_DYNC1I1

RelatedDrugs for PTPN12_DYNC1I1

RelatedDiseases for PTPN12_DYNC1I1