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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29397

FusionGeneSummary for PTP4A1_PTP4A1

check button Fusion gene summary
Fusion gene informationFusion gene name: PTP4A1_PTP4A1
Fusion gene ID: 29397
HgeneTgene
Gene symbol

PTP4A1

PTP4A1

Gene ID

7803

7803

Gene nameprotein tyrosine phosphatase type IVA, member 1protein tyrosine phosphatase type IVA, member 1
SynonymsHH72|PRL-1|PRL1|PTP(CAAX1)|PTPCAAX1HH72|PRL-1|PRL1|PTP(CAAX1)|PTPCAAX1
Cytomap

6q12

6q12

Type of geneprotein-codingprotein-coding
Descriptionprotein tyrosine phosphatase type IVA 1PVT1/PTP4A1 fusionphosphatase of regenerating liver 1protein tyrosine phosphatase type IVA protein 1protein-tyrosine phosphatase 4a1protein-tyrosine phosphatase of regenerating liver 1protein tyrosine phosphatase type IVA 1PVT1/PTP4A1 fusionphosphatase of regenerating liver 1protein tyrosine phosphatase type IVA protein 1protein-tyrosine phosphatase 4a1protein-tyrosine phosphatase of regenerating liver 1
Modification date2018052320180523
UniProtAcc

Q93096

Q93096

Ensembl transtripts involved in fusion geneENST00000370651, ENST00000370650, 
ENST00000578299, ENST00000473334, 
ENST00000370651, ENST00000370650, 
ENST00000578299, ENST00000473334, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 2 X 3=24
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PTP4A1 [Title/Abstract] AND PTP4A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE069169PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000370651ENST00000370651PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-
5CDS-3UTRENST00000370651ENST00000370650PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-
5CDS-intronENST00000370651ENST00000578299PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-
5CDS-intronENST00000370651ENST00000473334PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-
5CDS-3UTRENST00000370650ENST00000370651PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-
5CDS-3UTRENST00000370650ENST00000370650PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-
5CDS-intronENST00000370650ENST00000578299PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-
5CDS-intronENST00000370650ENST00000473334PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-
intron-3UTRENST00000578299ENST00000370651PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-
intron-3UTRENST00000578299ENST00000370650PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-
intron-intronENST00000578299ENST00000578299PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-
intron-intronENST00000578299ENST00000473334PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-
intron-3UTRENST00000473334ENST00000370651PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-
intron-3UTRENST00000473334ENST00000370650PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-
intron-intronENST00000473334ENST00000578299PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-
intron-intronENST00000473334ENST00000473334PTP4A1chr6

64289988

-PTP4A1chr6

64290442

-

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FusionProtFeatures for PTP4A1_PTP4A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTP4A1

Q93096

PTP4A1

Q93096

Protein tyrosine phosphatase which stimulatesprogression from G1 into S phase during mitosis. May play a rolein the development and maintenance of differentiating epithelialtissues. Enhances cell proliferation, cell motility and invasiveactivity, and promotes cancer metastasis.{ECO:0000269|PubMed:12235145, ECO:0000269|PubMed:12782572,ECO:0000269|PubMed:14643450}. Protein tyrosine phosphatase which stimulatesprogression from G1 into S phase during mitosis. May play a rolein the development and maintenance of differentiating epithelialtissues. Enhances cell proliferation, cell motility and invasiveactivity, and promotes cancer metastasis.{ECO:0000269|PubMed:12235145, ECO:0000269|PubMed:12782572,ECO:0000269|PubMed:14643450}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTP4A1_PTP4A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTP4A1_PTP4A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTP4A1_PTP4A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTP4A1_PTP4A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTP4A1C0001973Alcoholic Intoxication, Chronic2PSYGENET
TgenePTP4A1C0001973Alcoholic Intoxication, Chronic2PSYGENET