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Fusion gene ID: 29397 |
FusionGeneSummary for PTP4A1_PTP4A1 |
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Fusion gene information | Fusion gene name: PTP4A1_PTP4A1 | Fusion gene ID: 29397 | Hgene | Tgene | Gene symbol | PTP4A1 | PTP4A1 | Gene ID | 7803 | 7803 |
Gene name | protein tyrosine phosphatase type IVA, member 1 | protein tyrosine phosphatase type IVA, member 1 | |
Synonyms | HH72|PRL-1|PRL1|PTP(CAAX1)|PTPCAAX1 | HH72|PRL-1|PRL1|PTP(CAAX1)|PTPCAAX1 | |
Cytomap | 6q12 | 6q12 | |
Type of gene | protein-coding | protein-coding | |
Description | protein tyrosine phosphatase type IVA 1PVT1/PTP4A1 fusionphosphatase of regenerating liver 1protein tyrosine phosphatase type IVA protein 1protein-tyrosine phosphatase 4a1protein-tyrosine phosphatase of regenerating liver 1 | protein tyrosine phosphatase type IVA 1PVT1/PTP4A1 fusionphosphatase of regenerating liver 1protein tyrosine phosphatase type IVA protein 1protein-tyrosine phosphatase 4a1protein-tyrosine phosphatase of regenerating liver 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q93096 | Q93096 | |
Ensembl transtripts involved in fusion gene | ENST00000370651, ENST00000370650, ENST00000578299, ENST00000473334, | ENST00000370651, ENST00000370650, ENST00000578299, ENST00000473334, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 2 X 3=24 |
# samples | 3 | 4 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PTP4A1 [Title/Abstract] AND PTP4A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE069169 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000370651 | ENST00000370651 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
5CDS-3UTR | ENST00000370651 | ENST00000370650 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
5CDS-intron | ENST00000370651 | ENST00000578299 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
5CDS-intron | ENST00000370651 | ENST00000473334 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
5CDS-3UTR | ENST00000370650 | ENST00000370651 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
5CDS-3UTR | ENST00000370650 | ENST00000370650 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
5CDS-intron | ENST00000370650 | ENST00000578299 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
5CDS-intron | ENST00000370650 | ENST00000473334 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
intron-3UTR | ENST00000578299 | ENST00000370651 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
intron-3UTR | ENST00000578299 | ENST00000370650 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
intron-intron | ENST00000578299 | ENST00000578299 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
intron-intron | ENST00000578299 | ENST00000473334 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
intron-3UTR | ENST00000473334 | ENST00000370651 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
intron-3UTR | ENST00000473334 | ENST00000370650 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
intron-intron | ENST00000473334 | ENST00000578299 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
intron-intron | ENST00000473334 | ENST00000473334 | PTP4A1 | chr6 | 64289988 | - | PTP4A1 | chr6 | 64290442 | - |
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FusionProtFeatures for PTP4A1_PTP4A1 |
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Hgene | Tgene |
PTP4A1 | PTP4A1 |
Protein tyrosine phosphatase which stimulatesprogression from G1 into S phase during mitosis. May play a rolein the development and maintenance of differentiating epithelialtissues. Enhances cell proliferation, cell motility and invasiveactivity, and promotes cancer metastasis.{ECO:0000269|PubMed:12235145, ECO:0000269|PubMed:12782572,ECO:0000269|PubMed:14643450}. | Protein tyrosine phosphatase which stimulatesprogression from G1 into S phase during mitosis. May play a rolein the development and maintenance of differentiating epithelialtissues. Enhances cell proliferation, cell motility and invasiveactivity, and promotes cancer metastasis.{ECO:0000269|PubMed:12235145, ECO:0000269|PubMed:12782572,ECO:0000269|PubMed:14643450}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PTP4A1_PTP4A1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PTP4A1_PTP4A1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTP4A1_PTP4A1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PTP4A1_PTP4A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PTP4A1 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
Tgene | PTP4A1 | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |