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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29395

FusionGeneSummary for PTP4A1_EYS

check button Fusion gene summary
Fusion gene informationFusion gene name: PTP4A1_EYS
Fusion gene ID: 29395
HgeneTgene
Gene symbol

PTP4A1

EYS

Gene ID

7803

346007

Gene nameprotein tyrosine phosphatase type IVA, member 1eyes shut homolog (Drosophila)
SynonymsHH72|PRL-1|PRL1|PTP(CAAX1)|PTPCAAX1C6orf178|C6orf179|C6orf180|EGFL10|EGFL11|RP25|SPAM|bA166P24.2|bA307F22.3|bA74E24.1|dJ1018A4.2|dJ22I17.2|dJ303F19.1
Cytomap

6q12

6q12

Type of geneprotein-codingprotein-coding
Descriptionprotein tyrosine phosphatase type IVA 1PVT1/PTP4A1 fusionphosphatase of regenerating liver 1protein tyrosine phosphatase type IVA protein 1protein-tyrosine phosphatase 4a1protein-tyrosine phosphatase of regenerating liver 1protein eyes shut homologEGF-like-domain, multiple 10EGF-like-domain, multiple 11epidermal growth factor-like protein 10epidermal growth factor-like protein 11protein spacemaker homolog
Modification date2018052320180519
UniProtAcc

Q93096

Q5T1H1

Ensembl transtripts involved in fusion geneENST00000370651, ENST00000370650, 
ENST00000578299, ENST00000473334, 
ENST00000503581, ENST00000370621, 
ENST00000370616, ENST00000393380, 
ENST00000342421, ENST00000370618, 
ENST00000486069, 
Fusion gene scores* DoF score3 X 3 X 3=2726 X 15 X 12=4680
# samples 327
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(27/4680*10)=-4.11547721741994
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTP4A1 [Title/Abstract] AND EYS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E9-A2JS-01APTP4A1chr6

64286890

+EYSchr6

65532715

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000370651ENST00000503581PTP4A1chr6

64286890

+EYSchr6

65532715

-
Frame-shiftENST00000370651ENST00000370621PTP4A1chr6

64286890

+EYSchr6

65532715

-
Frame-shiftENST00000370651ENST00000370616PTP4A1chr6

64286890

+EYSchr6

65532715

-
5CDS-intronENST00000370651ENST00000393380PTP4A1chr6

64286890

+EYSchr6

65532715

-
5CDS-intronENST00000370651ENST00000342421PTP4A1chr6

64286890

+EYSchr6

65532715

-
5CDS-intronENST00000370651ENST00000370618PTP4A1chr6

64286890

+EYSchr6

65532715

-
5CDS-intronENST00000370651ENST00000486069PTP4A1chr6

64286890

+EYSchr6

65532715

-
Frame-shiftENST00000370650ENST00000503581PTP4A1chr6

64286890

+EYSchr6

65532715

-
Frame-shiftENST00000370650ENST00000370621PTP4A1chr6

64286890

+EYSchr6

65532715

-
Frame-shiftENST00000370650ENST00000370616PTP4A1chr6

64286890

+EYSchr6

65532715

-
5CDS-intronENST00000370650ENST00000393380PTP4A1chr6

64286890

+EYSchr6

65532715

-
5CDS-intronENST00000370650ENST00000342421PTP4A1chr6

64286890

+EYSchr6

65532715

-
5CDS-intronENST00000370650ENST00000370618PTP4A1chr6

64286890

+EYSchr6

65532715

-
5CDS-intronENST00000370650ENST00000486069PTP4A1chr6

64286890

+EYSchr6

65532715

-
intron-3CDSENST00000578299ENST00000503581PTP4A1chr6

64286890

+EYSchr6

65532715

-
intron-3CDSENST00000578299ENST00000370621PTP4A1chr6

64286890

+EYSchr6

65532715

-
intron-3CDSENST00000578299ENST00000370616PTP4A1chr6

64286890

+EYSchr6

65532715

-
intron-intronENST00000578299ENST00000393380PTP4A1chr6

64286890

+EYSchr6

65532715

-
intron-intronENST00000578299ENST00000342421PTP4A1chr6

64286890

+EYSchr6

65532715

-
intron-intronENST00000578299ENST00000370618PTP4A1chr6

64286890

+EYSchr6

65532715

-
intron-intronENST00000578299ENST00000486069PTP4A1chr6

64286890

+EYSchr6

65532715

-
intron-3CDSENST00000473334ENST00000503581PTP4A1chr6

64286890

+EYSchr6

65532715

-
intron-3CDSENST00000473334ENST00000370621PTP4A1chr6

64286890

+EYSchr6

65532715

-
intron-3CDSENST00000473334ENST00000370616PTP4A1chr6

64286890

+EYSchr6

65532715

-
intron-intronENST00000473334ENST00000393380PTP4A1chr6

64286890

+EYSchr6

65532715

-
intron-intronENST00000473334ENST00000342421PTP4A1chr6

64286890

+EYSchr6

65532715

-
intron-intronENST00000473334ENST00000370618PTP4A1chr6

64286890

+EYSchr6

65532715

-
intron-intronENST00000473334ENST00000486069PTP4A1chr6

64286890

+EYSchr6

65532715

-

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FusionProtFeatures for PTP4A1_EYS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTP4A1

Q93096

EYS

Q5T1H1

Protein tyrosine phosphatase which stimulatesprogression from G1 into S phase during mitosis. May play a rolein the development and maintenance of differentiating epithelialtissues. Enhances cell proliferation, cell motility and invasiveactivity, and promotes cancer metastasis.{ECO:0000269|PubMed:12235145, ECO:0000269|PubMed:12782572,ECO:0000269|PubMed:14643450}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTP4A1_EYS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTP4A1_EYS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTP4A1TNFAIP8, PTP4A2, ATF7, ELAVL1, APP, LAMP1, GNL1, CREB3L2, ZNF212, RABGGTB, LRRC39, PDHB, AUP1, ISLR, FNTB, BLMH, CNNM1, CNNM3, CNNM4, FDFT1, NUDT12, CDC25A, PTP4A1, MACROD1, RPS12, POLDIP2, CMSS1, EIF3M, MRTO4, RPS19BP1, SSB, RPS10P5, PA2G4, NUDT16, RPL36AL, GRSF1, GADD45GIP1, ACOT8, MRPS28, NIFK, RPL3L, SND1, MBLAC2, EIF3L, PTPREEYSEGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTP4A1_EYS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTP4A1_EYS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTP4A1C0001973Alcoholic Intoxication, Chronic2PSYGENET
TgeneEYSC1864446Retinitis Pigmentosa 252CTD_human;UNIPROT
TgeneEYSC0035334Retinitis Pigmentosa1CTD_human;ORPHANET