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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29371

FusionGeneSummary for PTK7_SRF

check button Fusion gene summary
Fusion gene informationFusion gene name: PTK7_SRF
Fusion gene ID: 29371
HgeneTgene
Gene symbol

PTK7

SRF

Gene ID

5754

6722

Gene nameprotein tyrosine kinase 7 (inactive)serum response factor
SynonymsCCK-4|CCK4MCM1
Cytomap

6p21.1

6p21.1

Type of geneprotein-codingprotein-coding
Descriptioninactive tyrosine-protein kinase 7PTK7 protein tyrosine kinase 7colon carcinoma kinase 4pseudo tyrosine kinase receptor 7tyrosine-protein kinase-like 7serum response factorc-fos serum response element-binding transcription factorminichromosome maintenance 1 homolog
Modification date2018052320180523
UniProtAcc

Q13308

P11831

Ensembl transtripts involved in fusion geneENST00000230419, ENST00000349241, 
ENST00000345201, ENST00000352931, 
ENST00000481273, ENST00000476760, 
ENST00000471863, 		ENST00000265354, 
ENST00000457278, 
Fusion gene scores* DoF score10 X 3 X 10=3001 X 1 X 1=1
# samples 101
** MAII scorelog2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: PTK7 [Title/Abstract] AND SRF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSRF

GO:0001829

trophectodermal cell differentiation

17576768

TgeneSRF

GO:0006366

transcription by RNA polymerase II

3203386

TgeneSRF

GO:0009725

response to hormone

17975004

TgeneSRF

GO:0010735

positive regulation of transcription via serum response element binding

3203386|8887666

TgeneSRF

GO:0045597

positive regulation of cell differentiation

17576768

TgeneSRF

GO:0045944

positive regulation of transcription by RNA polymerase II

17576768|19578358

TgeneSRF

GO:0045987

positive regulation of smooth muscle contraction

17215356

TgeneSRF

GO:0051091

positive regulation of DNA binding transcription factor activity

19098903

TgeneSRF

GO:0060261

positive regulation of transcription initiation from RNA polymerase II promoter

8887666


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDTGCTTCGA-2G-AAGZ-01APTK7chr6

43044305

+SRFchr6

43146544

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000230419ENST00000265354PTK7chr6

43044305

+SRFchr6

43146544

+
In-frameENST00000230419ENST00000457278PTK7chr6

43044305

+SRFchr6

43146544

+
In-frameENST00000349241ENST00000265354PTK7chr6

43044305

+SRFchr6

43146544

+
In-frameENST00000349241ENST00000457278PTK7chr6

43044305

+SRFchr6

43146544

+
In-frameENST00000345201ENST00000265354PTK7chr6

43044305

+SRFchr6

43146544

+
In-frameENST00000345201ENST00000457278PTK7chr6

43044305

+SRFchr6

43146544

+
In-frameENST00000352931ENST00000265354PTK7chr6

43044305

+SRFchr6

43146544

+
In-frameENST00000352931ENST00000457278PTK7chr6

43044305

+SRFchr6

43146544

+
intron-3CDSENST00000481273ENST00000265354PTK7chr6

43044305

+SRFchr6

43146544

+
intron-3CDSENST00000481273ENST00000457278PTK7chr6

43044305

+SRFchr6

43146544

+
In-frameENST00000476760ENST00000265354PTK7chr6

43044305

+SRFchr6

43146544

+
In-frameENST00000476760ENST00000457278PTK7chr6

43044305

+SRFchr6

43146544

+
In-frameENST00000471863ENST00000265354PTK7chr6

43044305

+SRFchr6

43146544

+
In-frameENST00000471863ENST00000457278PTK7chr6

43044305

+SRFchr6

43146544

+

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FusionProtFeatures for PTK7_SRF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTK7

Q13308

SRF

P11831

SRF is a transcription factor that binds to the serumresponse element (SRE), a short sequence of dyad symmetry located300 bp to the 5' of the site of transcription initiation of somegenes (such as FOS). Required for cardiac differentiation andmaturation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTK7chr6:43044305chr6:43146544ENST00000230419+120128_218261071DomainNote=Ig-like C2-type 2
HgenePTK7chr6:43044305chr6:43146544ENST00000230419+120225_317261071DomainNote=Ig-like C2-type 3
HgenePTK7chr6:43044305chr6:43146544ENST00000230419+120309_407261071DomainNote=Ig-like C2-type 4
HgenePTK7chr6:43044305chr6:43146544ENST00000230419+12031_120261071DomainNote=Ig-like C2-type 1
HgenePTK7chr6:43044305chr6:43146544ENST00000230419+120412_497261071DomainNote=Ig-like C2-type 5
HgenePTK7chr6:43044305chr6:43146544ENST00000230419+120503_586261071DomainNote=Ig-like C2-type 6
HgenePTK7chr6:43044305chr6:43146544ENST00000230419+120578_680261071DomainNote=Ig-like C2-type 7
HgenePTK7chr6:43044305chr6:43146544ENST00000230419+120796_1066261071DomainProtein kinase%3B inactive
HgenePTK7chr6:43044305chr6:43146544ENST00000345201+119128_218261031DomainNote=Ig-like C2-type 2
HgenePTK7chr6:43044305chr6:43146544ENST00000345201+119225_317261031DomainNote=Ig-like C2-type 3
HgenePTK7chr6:43044305chr6:43146544ENST00000345201+119309_407261031DomainNote=Ig-like C2-type 4
HgenePTK7chr6:43044305chr6:43146544ENST00000345201+11931_120261031DomainNote=Ig-like C2-type 1
HgenePTK7chr6:43044305chr6:43146544ENST00000345201+119412_497261031DomainNote=Ig-like C2-type 5
HgenePTK7chr6:43044305chr6:43146544ENST00000345201+119503_586261031DomainNote=Ig-like C2-type 6
HgenePTK7chr6:43044305chr6:43146544ENST00000345201+119578_680261031DomainNote=Ig-like C2-type 7
HgenePTK7chr6:43044305chr6:43146544ENST00000345201+119796_1066261031DomainProtein kinase%3B inactive
HgenePTK7chr6:43044305chr6:43146544ENST00000349241+117128_21826941DomainNote=Ig-like C2-type 2
HgenePTK7chr6:43044305chr6:43146544ENST00000349241+117225_31726941DomainNote=Ig-like C2-type 3
HgenePTK7chr6:43044305chr6:43146544ENST00000349241+117309_40726941DomainNote=Ig-like C2-type 4
HgenePTK7chr6:43044305chr6:43146544ENST00000349241+11731_12026941DomainNote=Ig-like C2-type 1
HgenePTK7chr6:43044305chr6:43146544ENST00000349241+117412_49726941DomainNote=Ig-like C2-type 5
HgenePTK7chr6:43044305chr6:43146544ENST00000349241+117503_58626941DomainNote=Ig-like C2-type 6
HgenePTK7chr6:43044305chr6:43146544ENST00000349241+117578_68026941DomainNote=Ig-like C2-type 7
HgenePTK7chr6:43044305chr6:43146544ENST00000349241+117796_106626941DomainProtein kinase%3B inactive
HgenePTK7chr6:43044305chr6:43146544ENST00000352931+119128_218261015DomainNote=Ig-like C2-type 2
HgenePTK7chr6:43044305chr6:43146544ENST00000352931+119225_317261015DomainNote=Ig-like C2-type 3
HgenePTK7chr6:43044305chr6:43146544ENST00000352931+119309_407261015DomainNote=Ig-like C2-type 4
HgenePTK7chr6:43044305chr6:43146544ENST00000352931+11931_120261015DomainNote=Ig-like C2-type 1
HgenePTK7chr6:43044305chr6:43146544ENST00000352931+119412_497261015DomainNote=Ig-like C2-type 5
HgenePTK7chr6:43044305chr6:43146544ENST00000352931+119503_586261015DomainNote=Ig-like C2-type 6
HgenePTK7chr6:43044305chr6:43146544ENST00000352931+119578_680261015DomainNote=Ig-like C2-type 7
HgenePTK7chr6:43044305chr6:43146544ENST00000352931+119796_1066261015DomainProtein kinase%3B inactive
HgenePTK7chr6:43044305chr6:43146544ENST00000481273+120128_218-241079DomainNote=Ig-like C2-type 2
HgenePTK7chr6:43044305chr6:43146544ENST00000481273+120225_317-241079DomainNote=Ig-like C2-type 3
HgenePTK7chr6:43044305chr6:43146544ENST00000481273+120309_407-241079DomainNote=Ig-like C2-type 4
HgenePTK7chr6:43044305chr6:43146544ENST00000481273+12031_120-241079DomainNote=Ig-like C2-type 1
HgenePTK7chr6:43044305chr6:43146544ENST00000481273+120412_497-241079DomainNote=Ig-like C2-type 5
HgenePTK7chr6:43044305chr6:43146544ENST00000481273+120503_586-241079DomainNote=Ig-like C2-type 6
HgenePTK7chr6:43044305chr6:43146544ENST00000481273+120578_680-241079DomainNote=Ig-like C2-type 7
HgenePTK7chr6:43044305chr6:43146544ENST00000481273+120796_1066-241079DomainProtein kinase%3B inactive
HgenePTK7chr6:43044305chr6:43146544ENST00000230419+12031_704261071Topological domainExtracellular
HgenePTK7chr6:43044305chr6:43146544ENST00000230419+120726_1070261071Topological domainCytoplasmic
HgenePTK7chr6:43044305chr6:43146544ENST00000345201+11931_704261031Topological domainExtracellular
HgenePTK7chr6:43044305chr6:43146544ENST00000345201+119726_1070261031Topological domainCytoplasmic
HgenePTK7chr6:43044305chr6:43146544ENST00000349241+11731_70426941Topological domainExtracellular
HgenePTK7chr6:43044305chr6:43146544ENST00000349241+117726_107026941Topological domainCytoplasmic
HgenePTK7chr6:43044305chr6:43146544ENST00000352931+11931_704261015Topological domainExtracellular
HgenePTK7chr6:43044305chr6:43146544ENST00000352931+119726_1070261015Topological domainCytoplasmic
HgenePTK7chr6:43044305chr6:43146544ENST00000481273+12031_704-241079Topological domainExtracellular
HgenePTK7chr6:43044305chr6:43146544ENST00000481273+120726_1070-241079Topological domainCytoplasmic
HgenePTK7chr6:43044305chr6:43146544ENST00000230419+120705_725261071TransmembraneHelical
HgenePTK7chr6:43044305chr6:43146544ENST00000345201+119705_725261031TransmembraneHelical
HgenePTK7chr6:43044305chr6:43146544ENST00000349241+117705_72526941TransmembraneHelical
HgenePTK7chr6:43044305chr6:43146544ENST00000352931+119705_725261015TransmembraneHelical
HgenePTK7chr6:43044305chr6:43146544ENST00000481273+120705_725-241079TransmembraneHelical
TgeneSRFchr6:43044305chr6:43146544ENST00000265354+4713_142451509Compositional biasNote=Gly-rich
TgeneSRFchr6:43044305chr6:43146544ENST00000265354+47242_258451509Compositional biasNote=Asp/Glu-rich (acidic)
TgeneSRFchr6:43044305chr6:43146544ENST00000265354+4780_90451509Compositional biasNote=Asp/Glu-rich (acidic)
TgeneSRFchr6:43044305chr6:43146544ENST00000265354+47133_222451509DNA binding.
TgeneSRFchr6:43044305chr6:43146544ENST00000265354+47141_201451509DomainMADS-box
TgeneSRFchr6:43044305chr6:43146544ENST00000265354+47168_222451509RegionNote=Involved in dimerization


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FusionGeneSequence for PTK7_SRF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PTK7_ENST00000230419_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_84aa

>In-frame_PTK7_ENST00000230419_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_84aa

>In-frame_PTK7_ENST00000349241_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_84aa

>In-frame_PTK7_ENST00000349241_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_84aa

>In-frame_PTK7_ENST00000345201_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_84aa

>In-frame_PTK7_ENST00000345201_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_84aa

>In-frame_PTK7_ENST00000352931_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_84aa

>In-frame_PTK7_ENST00000352931_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_84aa

>In-frame_PTK7_ENST00000476760_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_84aa

>In-frame_PTK7_ENST00000476760_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_84aa

>In-frame_PTK7_ENST00000471863_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_84aa

>In-frame_PTK7_ENST00000471863_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_84aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PTK7_ENST00000230419_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_252nt
ATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCC
CAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCC

>In-frame_PTK7_ENST00000230419_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_252nt
ATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCC
CAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCC

>In-frame_PTK7_ENST00000349241_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_252nt
ATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCC
CAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCC

>In-frame_PTK7_ENST00000349241_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_252nt
ATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCC
CAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCC

>In-frame_PTK7_ENST00000345201_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_252nt
ATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCC
CAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCC

>In-frame_PTK7_ENST00000345201_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_252nt
ATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCC
CAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCC

>In-frame_PTK7_ENST00000352931_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_252nt
ATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCC
CAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCC

>In-frame_PTK7_ENST00000352931_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_252nt
ATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCC
CAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCC

>In-frame_PTK7_ENST00000476760_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_252nt
ATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCC
CAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCC

>In-frame_PTK7_ENST00000476760_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_252nt
ATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCC
CAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCC

>In-frame_PTK7_ENST00000471863_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_252nt
ATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCC
CAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCC

>In-frame_PTK7_ENST00000471863_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_252nt
ATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCC
CAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_PTK7_ENST00000230419_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_2788nt
GGCGGGGCTTGGCGGCGGCGGCGGCGGCGCGCGGGGACTCGGAGGTACTGGGCGCGCGCGGCTCCGGCTCGGGACGCCTCGGGACGCCTC
GGGGTCGGGCTCCGGCTGCGGCTGCTGCTGCGGCGCCCGCGCTCCGGTGCGCTCCGCCTCCTGTGCCCGCCGCGGAGCGCAGTCTGCGCG
CCCGCCGTGCGCCCTCAGCTCCTTTTCCTGAGCCCGCCGCGATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGC
TCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCCCAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAG
CAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCCGGGAGCAGCAGCAACCTCACCGAGCTACAGGTGGTGAACCTGGACACCG
CCCACAGCACCAAGAGTGAATGATCCGCCCGCCGCCCTGGACAGATGGCCCAAGGGATGGCACCACTTATTTATTGTTGCCTTTTCACGT
TTTCTTTACACACACGTTGACGGGCCGCAGGAGGGAGGCGGGGAGGAGGAACGGGCAGCCACAGGACTGAGCCCTCTCACTCCAGCCAAA
GAAATGGGCCTGCCTGCCTCCACCCGTCCTCCCTCAGCCTCCCCTTCTTCCCGCCCCACCTCCCATTTCTGTTGCTGGAGGGGCTGTCCT
CCTTCCTGGGACCCCCTCGCCAGCTTGGCTCGATGTTTGCCATGAGTATTAGCTTACCCAATGGGACCGTGCCCCACCTCCCCACACACA
GGCCTTCTGTGGGGCTGGGCACCGTGTCCTCCTCTGAGGAAGCAGTTGGGGCCCTCTTGCCAGCCTCCTTGCTGACCCCAGGTCAGCCCT
GTGTCTGTCACAGGCTGGGTCAAAAGAGCCCTGGCTCTGCCCCTCAGGGGGCCAGCTGGGGAGATGGGGGCTTCTTCCTCACACTGCTGT
CCTCTCCCCCTTCAGCTCCTGAGTAGCTGGGCCTGTGCACTGGGCAGGTTCCTGGGGCCGCCTGCCCTGCCTTGCCGCTCCCCTTGGACC
TCCAGGGGCTCCTGGGTTGGAGGGAACCACCAGCGTTCCCTTCTCCCCCTTGTCTTCCCCCCTCTCCTCCCAGCTGCTTTACTTAAAGTT
GATTTTGAACTTTTTATTTGAGGAGACGAAGTGAAAACAAATCTATAAATATATATTTTTAAAATATTTAACTTTTTTTTATGGCGTTTT
TCTCGTCCCCCTCCCTGCCCAAACTCCCCTTCCCTGGGGAGCCCTCAGGCTCCCCAGAACTGGCTGGGCCCCTGGGGACAGAGCCACCCC
ATGAGCTCGGGGTCCACCAGTGTGTGGGGGAGATTCTGGGTTTGCCCAGTCCTGGGTTGTTTCCAGGAGAAAGCCGGGGGAGGGGCCCTC
AGGCCATTCCCCAACGGGGTGGGGAGGGTGACCCACAGCTCTGGGCCTCTTTTTGCCCTTTAGGGCTGTTGCTAGGGAGAGGGAAGAGGG
AGACCAAATGTCGGGGTTGGGGTGGGAGGGCGTCAGGCAGAGGCAACTGACTTCATTTGTGCCACACGCATGGGCATTGCAGCCTTGCGC
TGTCCCAGGCATGCAGCTGCCTGGGGCCCAAGTTGCAGTGAGCAGGGTGGGGTCTGGGAGGGGGTGAGAGGCAGGAATGGGGGTCAGAAG
AAGTGGGAGCAGCTTCTTGGGCTGAGTGCAGCCAAAGGGGAGCCAGAAATGGGCAGTTCTCCCAGGGAGTGAGCAGCTACTGTAACTTTT
TTAAATTAAGACAAAAAGCCTTGAAGAAAATGACTTTATTTTTCTAAGTGTAACCTCAGTATTTATGTAATTTGTACAGGGGCCATGCCC
CACCCCCCTCCTCCCCCTTTGGGGTAGACCTTGAGGGTGGGCCAGCATAGGGGGGAGGGTCTTTTACCCTGTGTCAGAGCCTACCTTCAC
CACCTATATCCAGAAGGGGAGCTTTTTCAGAAACAGGGCAGCAGTGGGGTGAAATTTTCTTAACCCCTAAGACTGCCTTCAGTAGGAACA
AGCTGGCTTCTGTGATTAGGTGAAGGGATGGGGGAAGATTTTATGCACAGCCTAGTTATCAAGGGGATGATTTGCCGACATGTTTGAGAA
CCCCCTAACCTCTAACCCTCATTGCTGTCTTGCCCCAGTTTGGGGTGCCAAGATGGAAGTCACCTTTCTGGGCTTTCTCCTGGAGATAGC
TGGGGCTTATGGGTGGCTTTCAAGGCTGGGGCATGGCAAATCAGGGGCCAGAGAGCAGGGGAGCTTGGGACTCAGGTCTGTAACTGCCCA
GCCCCTTTTCTCTGCTCTTGTTTCACTCCACCATCACTCACTCACTCCCCACTCCCCCACCCATGGGGAGGAGACCTTTGATGAATTCTT
CCTCTCCTTCCCACAAAAGACAGACCCAGTGAGTGAATCAGGCAAAGTGCTTATAATGTGTGTTGTGTGAGCGTGGCCTTGGGAGGACAT
GCGTGTGTCAGGGATGAGTTGAGGTGATATTTTTATGTGCAGCGACCCTTGGTGTTTCCCTTCCTCGGTGGCTCTGGGGTATGTGTGTGT
GGGTGTGTGCGCCTGAGTGAGTGTGTGTGCTTGAATGTGAGTGTGTATGTCAGTGGTTTCTACTTCCCCTGGGATGCTGACCCAGGAATA

>In-frame_PTK7_ENST00000230419_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_709nt
GGCGGGGCTTGGCGGCGGCGGCGGCGGCGCGCGGGGACTCGGAGGTACTGGGCGCGCGCGGCTCCGGCTCGGGACGCCTCGGGACGCCTC
GGGGTCGGGCTCCGGCTGCGGCTGCTGCTGCGGCGCCCGCGCTCCGGTGCGCTCCGCCTCCTGTGCCCGCCGCGGAGCGCAGTCTGCGCG
CCCGCCGTGCGCCCTCAGCTCCTTTTCCTGAGCCCGCCGCGATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGC
TCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCCCAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAG
CAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCCGGGAGCAGCAGCAACCTCACCGAGCTACAGGTGGTGAACCTGGACACCG
CCCACAGCACCAAGAGTGAATGATCCGCCCGCCGCCCTGGACAGATGGCCCAAGGGATGGCACCACTTATTTATTGTTGCCTTTTCACGT
TTTCTTTACACACACGTTGACGGGCCGCAGGAGGGAGGCGGGGAGGAGGAACGGGCAGCCACAGGACTGAGCCCTCTCACTCCAGCCAAA

>In-frame_PTK7_ENST00000349241_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_2714nt
CGCCTCGGGACGCCTCGGGGTCGGGCTCCGGCTGCGGCTGCTGCTGCGGCGCCCGCGCTCCGGTGCGCTCCGCCTCCTGTGCCCGCCGCG
GAGCGCAGTCTGCGCGCCCGCCGTGCGCCCTCAGCTCCTTTTCCTGAGCCCGCCGCGATGGGAGCTGCGCGGGGATCCCCGGCCAGACCC
CGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCCCAGGTGTTCCTGACAGCATCATCTGGGACAGTG
CAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCCGGGAGCAGCAGCAACCTCACCGAGCTACAGGTG
GTGAACCTGGACACCGCCCACAGCACCAAGAGTGAATGATCCGCCCGCCGCCCTGGACAGATGGCCCAAGGGATGGCACCACTTATTTAT
TGTTGCCTTTTCACGTTTTCTTTACACACACGTTGACGGGCCGCAGGAGGGAGGCGGGGAGGAGGAACGGGCAGCCACAGGACTGAGCCC
TCTCACTCCAGCCAAAGAAATGGGCCTGCCTGCCTCCACCCGTCCTCCCTCAGCCTCCCCTTCTTCCCGCCCCACCTCCCATTTCTGTTG
CTGGAGGGGCTGTCCTCCTTCCTGGGACCCCCTCGCCAGCTTGGCTCGATGTTTGCCATGAGTATTAGCTTACCCAATGGGACCGTGCCC
CACCTCCCCACACACAGGCCTTCTGTGGGGCTGGGCACCGTGTCCTCCTCTGAGGAAGCAGTTGGGGCCCTCTTGCCAGCCTCCTTGCTG
ACCCCAGGTCAGCCCTGTGTCTGTCACAGGCTGGGTCAAAAGAGCCCTGGCTCTGCCCCTCAGGGGGCCAGCTGGGGAGATGGGGGCTTC
TTCCTCACACTGCTGTCCTCTCCCCCTTCAGCTCCTGAGTAGCTGGGCCTGTGCACTGGGCAGGTTCCTGGGGCCGCCTGCCCTGCCTTG
CCGCTCCCCTTGGACCTCCAGGGGCTCCTGGGTTGGAGGGAACCACCAGCGTTCCCTTCTCCCCCTTGTCTTCCCCCCTCTCCTCCCAGC
TGCTTTACTTAAAGTTGATTTTGAACTTTTTATTTGAGGAGACGAAGTGAAAACAAATCTATAAATATATATTTTTAAAATATTTAACTT
TTTTTTATGGCGTTTTTCTCGTCCCCCTCCCTGCCCAAACTCCCCTTCCCTGGGGAGCCCTCAGGCTCCCCAGAACTGGCTGGGCCCCTG
GGGACAGAGCCACCCCATGAGCTCGGGGTCCACCAGTGTGTGGGGGAGATTCTGGGTTTGCCCAGTCCTGGGTTGTTTCCAGGAGAAAGC
CGGGGGAGGGGCCCTCAGGCCATTCCCCAACGGGGTGGGGAGGGTGACCCACAGCTCTGGGCCTCTTTTTGCCCTTTAGGGCTGTTGCTA
GGGAGAGGGAAGAGGGAGACCAAATGTCGGGGTTGGGGTGGGAGGGCGTCAGGCAGAGGCAACTGACTTCATTTGTGCCACACGCATGGG
CATTGCAGCCTTGCGCTGTCCCAGGCATGCAGCTGCCTGGGGCCCAAGTTGCAGTGAGCAGGGTGGGGTCTGGGAGGGGGTGAGAGGCAG
GAATGGGGGTCAGAAGAAGTGGGAGCAGCTTCTTGGGCTGAGTGCAGCCAAAGGGGAGCCAGAAATGGGCAGTTCTCCCAGGGAGTGAGC
AGCTACTGTAACTTTTTTAAATTAAGACAAAAAGCCTTGAAGAAAATGACTTTATTTTTCTAAGTGTAACCTCAGTATTTATGTAATTTG
TACAGGGGCCATGCCCCACCCCCCTCCTCCCCCTTTGGGGTAGACCTTGAGGGTGGGCCAGCATAGGGGGGAGGGTCTTTTACCCTGTGT
CAGAGCCTACCTTCACCACCTATATCCAGAAGGGGAGCTTTTTCAGAAACAGGGCAGCAGTGGGGTGAAATTTTCTTAACCCCTAAGACT
GCCTTCAGTAGGAACAAGCTGGCTTCTGTGATTAGGTGAAGGGATGGGGGAAGATTTTATGCACAGCCTAGTTATCAAGGGGATGATTTG
CCGACATGTTTGAGAACCCCCTAACCTCTAACCCTCATTGCTGTCTTGCCCCAGTTTGGGGTGCCAAGATGGAAGTCACCTTTCTGGGCT
TTCTCCTGGAGATAGCTGGGGCTTATGGGTGGCTTTCAAGGCTGGGGCATGGCAAATCAGGGGCCAGAGAGCAGGGGAGCTTGGGACTCA
GGTCTGTAACTGCCCAGCCCCTTTTCTCTGCTCTTGTTTCACTCCACCATCACTCACTCACTCCCCACTCCCCCACCCATGGGGAGGAGA
CCTTTGATGAATTCTTCCTCTCCTTCCCACAAAAGACAGACCCAGTGAGTGAATCAGGCAAAGTGCTTATAATGTGTGTTGTGTGAGCGT
GGCCTTGGGAGGACATGCGTGTGTCAGGGATGAGTTGAGGTGATATTTTTATGTGCAGCGACCCTTGGTGTTTCCCTTCCTCGGTGGCTC
TGGGGTATGTGTGTGTGGGTGTGTGCGCCTGAGTGAGTGTGTGTGCTTGAATGTGAGTGTGTATGTCAGTGGTTTCTACTTCCCCTGGGA
TGCTGACCCAGGAATAGTGGACATGGTCACAGTCCTATGTACAGAGCTTTCTTTTGTATTAAAAAAAAATACTCTTTCAATAAATGTATC

>In-frame_PTK7_ENST00000349241_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_635nt
CGCCTCGGGACGCCTCGGGGTCGGGCTCCGGCTGCGGCTGCTGCTGCGGCGCCCGCGCTCCGGTGCGCTCCGCCTCCTGTGCCCGCCGCG
GAGCGCAGTCTGCGCGCCCGCCGTGCGCCCTCAGCTCCTTTTCCTGAGCCCGCCGCGATGGGAGCTGCGCGGGGATCCCCGGCCAGACCC
CGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCCCAGGTGTTCCTGACAGCATCATCTGGGACAGTG
CAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCCGGGAGCAGCAGCAACCTCACCGAGCTACAGGTG
GTGAACCTGGACACCGCCCACAGCACCAAGAGTGAATGATCCGCCCGCCGCCCTGGACAGATGGCCCAAGGGATGGCACCACTTATTTAT
TGTTGCCTTTTCACGTTTTCTTTACACACACGTTGACGGGCCGCAGGAGGGAGGCGGGGAGGAGGAACGGGCAGCCACAGGACTGAGCCC
TCTCACTCCAGCCAAAGAAATGGGCCTGCCTGCCTCCACCCGTCCTCCCTCAGCCTCCCCTTCTTCCCGCCCCACCTCCCATTTCTGTTG

>In-frame_PTK7_ENST00000345201_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_2714nt
CGCCTCGGGACGCCTCGGGGTCGGGCTCCGGCTGCGGCTGCTGCTGCGGCGCCCGCGCTCCGGTGCGCTCCGCCTCCTGTGCCCGCCGCG
GAGCGCAGTCTGCGCGCCCGCCGTGCGCCCTCAGCTCCTTTTCCTGAGCCCGCCGCGATGGGAGCTGCGCGGGGATCCCCGGCCAGACCC
CGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCCCAGGTGTTCCTGACAGCATCATCTGGGACAGTG
CAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCCGGGAGCAGCAGCAACCTCACCGAGCTACAGGTG
GTGAACCTGGACACCGCCCACAGCACCAAGAGTGAATGATCCGCCCGCCGCCCTGGACAGATGGCCCAAGGGATGGCACCACTTATTTAT
TGTTGCCTTTTCACGTTTTCTTTACACACACGTTGACGGGCCGCAGGAGGGAGGCGGGGAGGAGGAACGGGCAGCCACAGGACTGAGCCC
TCTCACTCCAGCCAAAGAAATGGGCCTGCCTGCCTCCACCCGTCCTCCCTCAGCCTCCCCTTCTTCCCGCCCCACCTCCCATTTCTGTTG
CTGGAGGGGCTGTCCTCCTTCCTGGGACCCCCTCGCCAGCTTGGCTCGATGTTTGCCATGAGTATTAGCTTACCCAATGGGACCGTGCCC
CACCTCCCCACACACAGGCCTTCTGTGGGGCTGGGCACCGTGTCCTCCTCTGAGGAAGCAGTTGGGGCCCTCTTGCCAGCCTCCTTGCTG
ACCCCAGGTCAGCCCTGTGTCTGTCACAGGCTGGGTCAAAAGAGCCCTGGCTCTGCCCCTCAGGGGGCCAGCTGGGGAGATGGGGGCTTC
TTCCTCACACTGCTGTCCTCTCCCCCTTCAGCTCCTGAGTAGCTGGGCCTGTGCACTGGGCAGGTTCCTGGGGCCGCCTGCCCTGCCTTG
CCGCTCCCCTTGGACCTCCAGGGGCTCCTGGGTTGGAGGGAACCACCAGCGTTCCCTTCTCCCCCTTGTCTTCCCCCCTCTCCTCCCAGC
TGCTTTACTTAAAGTTGATTTTGAACTTTTTATTTGAGGAGACGAAGTGAAAACAAATCTATAAATATATATTTTTAAAATATTTAACTT
TTTTTTATGGCGTTTTTCTCGTCCCCCTCCCTGCCCAAACTCCCCTTCCCTGGGGAGCCCTCAGGCTCCCCAGAACTGGCTGGGCCCCTG
GGGACAGAGCCACCCCATGAGCTCGGGGTCCACCAGTGTGTGGGGGAGATTCTGGGTTTGCCCAGTCCTGGGTTGTTTCCAGGAGAAAGC
CGGGGGAGGGGCCCTCAGGCCATTCCCCAACGGGGTGGGGAGGGTGACCCACAGCTCTGGGCCTCTTTTTGCCCTTTAGGGCTGTTGCTA
GGGAGAGGGAAGAGGGAGACCAAATGTCGGGGTTGGGGTGGGAGGGCGTCAGGCAGAGGCAACTGACTTCATTTGTGCCACACGCATGGG
CATTGCAGCCTTGCGCTGTCCCAGGCATGCAGCTGCCTGGGGCCCAAGTTGCAGTGAGCAGGGTGGGGTCTGGGAGGGGGTGAGAGGCAG
GAATGGGGGTCAGAAGAAGTGGGAGCAGCTTCTTGGGCTGAGTGCAGCCAAAGGGGAGCCAGAAATGGGCAGTTCTCCCAGGGAGTGAGC
AGCTACTGTAACTTTTTTAAATTAAGACAAAAAGCCTTGAAGAAAATGACTTTATTTTTCTAAGTGTAACCTCAGTATTTATGTAATTTG
TACAGGGGCCATGCCCCACCCCCCTCCTCCCCCTTTGGGGTAGACCTTGAGGGTGGGCCAGCATAGGGGGGAGGGTCTTTTACCCTGTGT
CAGAGCCTACCTTCACCACCTATATCCAGAAGGGGAGCTTTTTCAGAAACAGGGCAGCAGTGGGGTGAAATTTTCTTAACCCCTAAGACT
GCCTTCAGTAGGAACAAGCTGGCTTCTGTGATTAGGTGAAGGGATGGGGGAAGATTTTATGCACAGCCTAGTTATCAAGGGGATGATTTG
CCGACATGTTTGAGAACCCCCTAACCTCTAACCCTCATTGCTGTCTTGCCCCAGTTTGGGGTGCCAAGATGGAAGTCACCTTTCTGGGCT
TTCTCCTGGAGATAGCTGGGGCTTATGGGTGGCTTTCAAGGCTGGGGCATGGCAAATCAGGGGCCAGAGAGCAGGGGAGCTTGGGACTCA
GGTCTGTAACTGCCCAGCCCCTTTTCTCTGCTCTTGTTTCACTCCACCATCACTCACTCACTCCCCACTCCCCCACCCATGGGGAGGAGA
CCTTTGATGAATTCTTCCTCTCCTTCCCACAAAAGACAGACCCAGTGAGTGAATCAGGCAAAGTGCTTATAATGTGTGTTGTGTGAGCGT
GGCCTTGGGAGGACATGCGTGTGTCAGGGATGAGTTGAGGTGATATTTTTATGTGCAGCGACCCTTGGTGTTTCCCTTCCTCGGTGGCTC
TGGGGTATGTGTGTGTGGGTGTGTGCGCCTGAGTGAGTGTGTGTGCTTGAATGTGAGTGTGTATGTCAGTGGTTTCTACTTCCCCTGGGA
TGCTGACCCAGGAATAGTGGACATGGTCACAGTCCTATGTACAGAGCTTTCTTTTGTATTAAAAAAAAATACTCTTTCAATAAATGTATC

>In-frame_PTK7_ENST00000345201_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_635nt
CGCCTCGGGACGCCTCGGGGTCGGGCTCCGGCTGCGGCTGCTGCTGCGGCGCCCGCGCTCCGGTGCGCTCCGCCTCCTGTGCCCGCCGCG
GAGCGCAGTCTGCGCGCCCGCCGTGCGCCCTCAGCTCCTTTTCCTGAGCCCGCCGCGATGGGAGCTGCGCGGGGATCCCCGGCCAGACCC
CGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCCCAGGTGTTCCTGACAGCATCATCTGGGACAGTG
CAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCCGGGAGCAGCAGCAACCTCACCGAGCTACAGGTG
GTGAACCTGGACACCGCCCACAGCACCAAGAGTGAATGATCCGCCCGCCGCCCTGGACAGATGGCCCAAGGGATGGCACCACTTATTTAT
TGTTGCCTTTTCACGTTTTCTTTACACACACGTTGACGGGCCGCAGGAGGGAGGCGGGGAGGAGGAACGGGCAGCCACAGGACTGAGCCC
TCTCACTCCAGCCAAAGAAATGGGCCTGCCTGCCTCCACCCGTCCTCCCTCAGCCTCCCCTTCTTCCCGCCCCACCTCCCATTTCTGTTG

>In-frame_PTK7_ENST00000352931_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_2714nt
CGCCTCGGGACGCCTCGGGGTCGGGCTCCGGCTGCGGCTGCTGCTGCGGCGCCCGCGCTCCGGTGCGCTCCGCCTCCTGTGCCCGCCGCG
GAGCGCAGTCTGCGCGCCCGCCGTGCGCCCTCAGCTCCTTTTCCTGAGCCCGCCGCGATGGGAGCTGCGCGGGGATCCCCGGCCAGACCC
CGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCCCAGGTGTTCCTGACAGCATCATCTGGGACAGTG
CAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCCGGGAGCAGCAGCAACCTCACCGAGCTACAGGTG
GTGAACCTGGACACCGCCCACAGCACCAAGAGTGAATGATCCGCCCGCCGCCCTGGACAGATGGCCCAAGGGATGGCACCACTTATTTAT
TGTTGCCTTTTCACGTTTTCTTTACACACACGTTGACGGGCCGCAGGAGGGAGGCGGGGAGGAGGAACGGGCAGCCACAGGACTGAGCCC
TCTCACTCCAGCCAAAGAAATGGGCCTGCCTGCCTCCACCCGTCCTCCCTCAGCCTCCCCTTCTTCCCGCCCCACCTCCCATTTCTGTTG
CTGGAGGGGCTGTCCTCCTTCCTGGGACCCCCTCGCCAGCTTGGCTCGATGTTTGCCATGAGTATTAGCTTACCCAATGGGACCGTGCCC
CACCTCCCCACACACAGGCCTTCTGTGGGGCTGGGCACCGTGTCCTCCTCTGAGGAAGCAGTTGGGGCCCTCTTGCCAGCCTCCTTGCTG
ACCCCAGGTCAGCCCTGTGTCTGTCACAGGCTGGGTCAAAAGAGCCCTGGCTCTGCCCCTCAGGGGGCCAGCTGGGGAGATGGGGGCTTC
TTCCTCACACTGCTGTCCTCTCCCCCTTCAGCTCCTGAGTAGCTGGGCCTGTGCACTGGGCAGGTTCCTGGGGCCGCCTGCCCTGCCTTG
CCGCTCCCCTTGGACCTCCAGGGGCTCCTGGGTTGGAGGGAACCACCAGCGTTCCCTTCTCCCCCTTGTCTTCCCCCCTCTCCTCCCAGC
TGCTTTACTTAAAGTTGATTTTGAACTTTTTATTTGAGGAGACGAAGTGAAAACAAATCTATAAATATATATTTTTAAAATATTTAACTT
TTTTTTATGGCGTTTTTCTCGTCCCCCTCCCTGCCCAAACTCCCCTTCCCTGGGGAGCCCTCAGGCTCCCCAGAACTGGCTGGGCCCCTG
GGGACAGAGCCACCCCATGAGCTCGGGGTCCACCAGTGTGTGGGGGAGATTCTGGGTTTGCCCAGTCCTGGGTTGTTTCCAGGAGAAAGC
CGGGGGAGGGGCCCTCAGGCCATTCCCCAACGGGGTGGGGAGGGTGACCCACAGCTCTGGGCCTCTTTTTGCCCTTTAGGGCTGTTGCTA
GGGAGAGGGAAGAGGGAGACCAAATGTCGGGGTTGGGGTGGGAGGGCGTCAGGCAGAGGCAACTGACTTCATTTGTGCCACACGCATGGG
CATTGCAGCCTTGCGCTGTCCCAGGCATGCAGCTGCCTGGGGCCCAAGTTGCAGTGAGCAGGGTGGGGTCTGGGAGGGGGTGAGAGGCAG
GAATGGGGGTCAGAAGAAGTGGGAGCAGCTTCTTGGGCTGAGTGCAGCCAAAGGGGAGCCAGAAATGGGCAGTTCTCCCAGGGAGTGAGC
AGCTACTGTAACTTTTTTAAATTAAGACAAAAAGCCTTGAAGAAAATGACTTTATTTTTCTAAGTGTAACCTCAGTATTTATGTAATTTG
TACAGGGGCCATGCCCCACCCCCCTCCTCCCCCTTTGGGGTAGACCTTGAGGGTGGGCCAGCATAGGGGGGAGGGTCTTTTACCCTGTGT
CAGAGCCTACCTTCACCACCTATATCCAGAAGGGGAGCTTTTTCAGAAACAGGGCAGCAGTGGGGTGAAATTTTCTTAACCCCTAAGACT
GCCTTCAGTAGGAACAAGCTGGCTTCTGTGATTAGGTGAAGGGATGGGGGAAGATTTTATGCACAGCCTAGTTATCAAGGGGATGATTTG
CCGACATGTTTGAGAACCCCCTAACCTCTAACCCTCATTGCTGTCTTGCCCCAGTTTGGGGTGCCAAGATGGAAGTCACCTTTCTGGGCT
TTCTCCTGGAGATAGCTGGGGCTTATGGGTGGCTTTCAAGGCTGGGGCATGGCAAATCAGGGGCCAGAGAGCAGGGGAGCTTGGGACTCA
GGTCTGTAACTGCCCAGCCCCTTTTCTCTGCTCTTGTTTCACTCCACCATCACTCACTCACTCCCCACTCCCCCACCCATGGGGAGGAGA
CCTTTGATGAATTCTTCCTCTCCTTCCCACAAAAGACAGACCCAGTGAGTGAATCAGGCAAAGTGCTTATAATGTGTGTTGTGTGAGCGT
GGCCTTGGGAGGACATGCGTGTGTCAGGGATGAGTTGAGGTGATATTTTTATGTGCAGCGACCCTTGGTGTTTCCCTTCCTCGGTGGCTC
TGGGGTATGTGTGTGTGGGTGTGTGCGCCTGAGTGAGTGTGTGTGCTTGAATGTGAGTGTGTATGTCAGTGGTTTCTACTTCCCCTGGGA
TGCTGACCCAGGAATAGTGGACATGGTCACAGTCCTATGTACAGAGCTTTCTTTTGTATTAAAAAAAAATACTCTTTCAATAAATGTATC

>In-frame_PTK7_ENST00000352931_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_635nt
CGCCTCGGGACGCCTCGGGGTCGGGCTCCGGCTGCGGCTGCTGCTGCGGCGCCCGCGCTCCGGTGCGCTCCGCCTCCTGTGCCCGCCGCG
GAGCGCAGTCTGCGCGCCCGCCGTGCGCCCTCAGCTCCTTTTCCTGAGCCCGCCGCGATGGGAGCTGCGCGGGGATCCCCGGCCAGACCC
CGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCCCAGGTGTTCCTGACAGCATCATCTGGGACAGTG
CAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCCGGGAGCAGCAGCAACCTCACCGAGCTACAGGTG
GTGAACCTGGACACCGCCCACAGCACCAAGAGTGAATGATCCGCCCGCCGCCCTGGACAGATGGCCCAAGGGATGGCACCACTTATTTAT
TGTTGCCTTTTCACGTTTTCTTTACACACACGTTGACGGGCCGCAGGAGGGAGGCGGGGAGGAGGAACGGGCAGCCACAGGACTGAGCCC
TCTCACTCCAGCCAAAGAAATGGGCCTGCCTGCCTCCACCCGTCCTCCCTCAGCCTCCCCTTCTTCCCGCCCCACCTCCCATTTCTGTTG

>In-frame_PTK7_ENST00000476760_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_2749nt
CGGAGGTACTGGGCGCGCGCGGCTCCGGCTCGGGACGCCTCGGGACGCCTCGGGGTCGGGCTCCGGCTGCGGCTGCTGCTGCGGCGCCCG
CGCTCCGGTGCGCTCCGCCTCCTGTGCCCGCCGCGGAGCGCAGTCTGCGCGCCCGCCGTGCGCCCTCAGCTCCTTTTCCTGAGCCCGCCG
CGATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCC
CCCAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGG
CCGGGAGCAGCAGCAACCTCACCGAGCTACAGGTGGTGAACCTGGACACCGCCCACAGCACCAAGAGTGAATGATCCGCCCGCCGCCCTG
GACAGATGGCCCAAGGGATGGCACCACTTATTTATTGTTGCCTTTTCACGTTTTCTTTACACACACGTTGACGGGCCGCAGGAGGGAGGC
GGGGAGGAGGAACGGGCAGCCACAGGACTGAGCCCTCTCACTCCAGCCAAAGAAATGGGCCTGCCTGCCTCCACCCGTCCTCCCTCAGCC
TCCCCTTCTTCCCGCCCCACCTCCCATTTCTGTTGCTGGAGGGGCTGTCCTCCTTCCTGGGACCCCCTCGCCAGCTTGGCTCGATGTTTG
CCATGAGTATTAGCTTACCCAATGGGACCGTGCCCCACCTCCCCACACACAGGCCTTCTGTGGGGCTGGGCACCGTGTCCTCCTCTGAGG
AAGCAGTTGGGGCCCTCTTGCCAGCCTCCTTGCTGACCCCAGGTCAGCCCTGTGTCTGTCACAGGCTGGGTCAAAAGAGCCCTGGCTCTG
CCCCTCAGGGGGCCAGCTGGGGAGATGGGGGCTTCTTCCTCACACTGCTGTCCTCTCCCCCTTCAGCTCCTGAGTAGCTGGGCCTGTGCA
CTGGGCAGGTTCCTGGGGCCGCCTGCCCTGCCTTGCCGCTCCCCTTGGACCTCCAGGGGCTCCTGGGTTGGAGGGAACCACCAGCGTTCC
CTTCTCCCCCTTGTCTTCCCCCCTCTCCTCCCAGCTGCTTTACTTAAAGTTGATTTTGAACTTTTTATTTGAGGAGACGAAGTGAAAACA
AATCTATAAATATATATTTTTAAAATATTTAACTTTTTTTTATGGCGTTTTTCTCGTCCCCCTCCCTGCCCAAACTCCCCTTCCCTGGGG
AGCCCTCAGGCTCCCCAGAACTGGCTGGGCCCCTGGGGACAGAGCCACCCCATGAGCTCGGGGTCCACCAGTGTGTGGGGGAGATTCTGG
GTTTGCCCAGTCCTGGGTTGTTTCCAGGAGAAAGCCGGGGGAGGGGCCCTCAGGCCATTCCCCAACGGGGTGGGGAGGGTGACCCACAGC
TCTGGGCCTCTTTTTGCCCTTTAGGGCTGTTGCTAGGGAGAGGGAAGAGGGAGACCAAATGTCGGGGTTGGGGTGGGAGGGCGTCAGGCA
GAGGCAACTGACTTCATTTGTGCCACACGCATGGGCATTGCAGCCTTGCGCTGTCCCAGGCATGCAGCTGCCTGGGGCCCAAGTTGCAGT
GAGCAGGGTGGGGTCTGGGAGGGGGTGAGAGGCAGGAATGGGGGTCAGAAGAAGTGGGAGCAGCTTCTTGGGCTGAGTGCAGCCAAAGGG
GAGCCAGAAATGGGCAGTTCTCCCAGGGAGTGAGCAGCTACTGTAACTTTTTTAAATTAAGACAAAAAGCCTTGAAGAAAATGACTTTAT
TTTTCTAAGTGTAACCTCAGTATTTATGTAATTTGTACAGGGGCCATGCCCCACCCCCCTCCTCCCCCTTTGGGGTAGACCTTGAGGGTG
GGCCAGCATAGGGGGGAGGGTCTTTTACCCTGTGTCAGAGCCTACCTTCACCACCTATATCCAGAAGGGGAGCTTTTTCAGAAACAGGGC
AGCAGTGGGGTGAAATTTTCTTAACCCCTAAGACTGCCTTCAGTAGGAACAAGCTGGCTTCTGTGATTAGGTGAAGGGATGGGGGAAGAT
TTTATGCACAGCCTAGTTATCAAGGGGATGATTTGCCGACATGTTTGAGAACCCCCTAACCTCTAACCCTCATTGCTGTCTTGCCCCAGT
TTGGGGTGCCAAGATGGAAGTCACCTTTCTGGGCTTTCTCCTGGAGATAGCTGGGGCTTATGGGTGGCTTTCAAGGCTGGGGCATGGCAA
ATCAGGGGCCAGAGAGCAGGGGAGCTTGGGACTCAGGTCTGTAACTGCCCAGCCCCTTTTCTCTGCTCTTGTTTCACTCCACCATCACTC
ACTCACTCCCCACTCCCCCACCCATGGGGAGGAGACCTTTGATGAATTCTTCCTCTCCTTCCCACAAAAGACAGACCCAGTGAGTGAATC
AGGCAAAGTGCTTATAATGTGTGTTGTGTGAGCGTGGCCTTGGGAGGACATGCGTGTGTCAGGGATGAGTTGAGGTGATATTTTTATGTG
CAGCGACCCTTGGTGTTTCCCTTCCTCGGTGGCTCTGGGGTATGTGTGTGTGGGTGTGTGCGCCTGAGTGAGTGTGTGTGCTTGAATGTG
AGTGTGTATGTCAGTGGTTTCTACTTCCCCTGGGATGCTGACCCAGGAATAGTGGACATGGTCACAGTCCTATGTACAGAGCTTTCTTTT

>In-frame_PTK7_ENST00000476760_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_670nt
CGGAGGTACTGGGCGCGCGCGGCTCCGGCTCGGGACGCCTCGGGACGCCTCGGGGTCGGGCTCCGGCTGCGGCTGCTGCTGCGGCGCCCG
CGCTCCGGTGCGCTCCGCCTCCTGTGCCCGCCGCGGAGCGCAGTCTGCGCGCCCGCCGTGCGCCCTCAGCTCCTTTTCCTGAGCCCGCCG
CGATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCC
CCCAGGTGTTCCTGACAGCATCATCTGGGACAGTGCAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGG
CCGGGAGCAGCAGCAACCTCACCGAGCTACAGGTGGTGAACCTGGACACCGCCCACAGCACCAAGAGTGAATGATCCGCCCGCCGCCCTG
GACAGATGGCCCAAGGGATGGCACCACTTATTTATTGTTGCCTTTTCACGTTTTCTTTACACACACGTTGACGGGCCGCAGGAGGGAGGC
GGGGAGGAGGAACGGGCAGCCACAGGACTGAGCCCTCTCACTCCAGCCAAAGAAATGGGCCTGCCTGCCTCCACCCGTCCTCCCTCAGCC

>In-frame_PTK7_ENST00000471863_chr6_43044305_+_SRF_ENST00000265354_chr6_43146544_+_2717nt
GGACGCCTCGGGACGCCTCGGGGTCGGGCTCCGGCTGCGGCTGCTGCTGCGGCGCCCGCGCTCCGGTGCGCTCCGCCTCCTGTGCCCGCC
GCGGAGCGCAGTCTGCGCGCCCGCCGTGCGCCCTCAGCTCCTTTTCCTGAGCCCGCCGCGATGGGAGCTGCGCGGGGATCCCCGGCCAGA
CCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCCCAGGTGTTCCTGACAGCATCATCTGGGACA
GTGCAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCCGGGAGCAGCAGCAACCTCACCGAGCTACAG
GTGGTGAACCTGGACACCGCCCACAGCACCAAGAGTGAATGATCCGCCCGCCGCCCTGGACAGATGGCCCAAGGGATGGCACCACTTATT
TATTGTTGCCTTTTCACGTTTTCTTTACACACACGTTGACGGGCCGCAGGAGGGAGGCGGGGAGGAGGAACGGGCAGCCACAGGACTGAG
CCCTCTCACTCCAGCCAAAGAAATGGGCCTGCCTGCCTCCACCCGTCCTCCCTCAGCCTCCCCTTCTTCCCGCCCCACCTCCCATTTCTG
TTGCTGGAGGGGCTGTCCTCCTTCCTGGGACCCCCTCGCCAGCTTGGCTCGATGTTTGCCATGAGTATTAGCTTACCCAATGGGACCGTG
CCCCACCTCCCCACACACAGGCCTTCTGTGGGGCTGGGCACCGTGTCCTCCTCTGAGGAAGCAGTTGGGGCCCTCTTGCCAGCCTCCTTG
CTGACCCCAGGTCAGCCCTGTGTCTGTCACAGGCTGGGTCAAAAGAGCCCTGGCTCTGCCCCTCAGGGGGCCAGCTGGGGAGATGGGGGC
TTCTTCCTCACACTGCTGTCCTCTCCCCCTTCAGCTCCTGAGTAGCTGGGCCTGTGCACTGGGCAGGTTCCTGGGGCCGCCTGCCCTGCC
TTGCCGCTCCCCTTGGACCTCCAGGGGCTCCTGGGTTGGAGGGAACCACCAGCGTTCCCTTCTCCCCCTTGTCTTCCCCCCTCTCCTCCC
AGCTGCTTTACTTAAAGTTGATTTTGAACTTTTTATTTGAGGAGACGAAGTGAAAACAAATCTATAAATATATATTTTTAAAATATTTAA
CTTTTTTTTATGGCGTTTTTCTCGTCCCCCTCCCTGCCCAAACTCCCCTTCCCTGGGGAGCCCTCAGGCTCCCCAGAACTGGCTGGGCCC
CTGGGGACAGAGCCACCCCATGAGCTCGGGGTCCACCAGTGTGTGGGGGAGATTCTGGGTTTGCCCAGTCCTGGGTTGTTTCCAGGAGAA
AGCCGGGGGAGGGGCCCTCAGGCCATTCCCCAACGGGGTGGGGAGGGTGACCCACAGCTCTGGGCCTCTTTTTGCCCTTTAGGGCTGTTG
CTAGGGAGAGGGAAGAGGGAGACCAAATGTCGGGGTTGGGGTGGGAGGGCGTCAGGCAGAGGCAACTGACTTCATTTGTGCCACACGCAT
GGGCATTGCAGCCTTGCGCTGTCCCAGGCATGCAGCTGCCTGGGGCCCAAGTTGCAGTGAGCAGGGTGGGGTCTGGGAGGGGGTGAGAGG
CAGGAATGGGGGTCAGAAGAAGTGGGAGCAGCTTCTTGGGCTGAGTGCAGCCAAAGGGGAGCCAGAAATGGGCAGTTCTCCCAGGGAGTG
AGCAGCTACTGTAACTTTTTTAAATTAAGACAAAAAGCCTTGAAGAAAATGACTTTATTTTTCTAAGTGTAACCTCAGTATTTATGTAAT
TTGTACAGGGGCCATGCCCCACCCCCCTCCTCCCCCTTTGGGGTAGACCTTGAGGGTGGGCCAGCATAGGGGGGAGGGTCTTTTACCCTG
TGTCAGAGCCTACCTTCACCACCTATATCCAGAAGGGGAGCTTTTTCAGAAACAGGGCAGCAGTGGGGTGAAATTTTCTTAACCCCTAAG
ACTGCCTTCAGTAGGAACAAGCTGGCTTCTGTGATTAGGTGAAGGGATGGGGGAAGATTTTATGCACAGCCTAGTTATCAAGGGGATGAT
TTGCCGACATGTTTGAGAACCCCCTAACCTCTAACCCTCATTGCTGTCTTGCCCCAGTTTGGGGTGCCAAGATGGAAGTCACCTTTCTGG
GCTTTCTCCTGGAGATAGCTGGGGCTTATGGGTGGCTTTCAAGGCTGGGGCATGGCAAATCAGGGGCCAGAGAGCAGGGGAGCTTGGGAC
TCAGGTCTGTAACTGCCCAGCCCCTTTTCTCTGCTCTTGTTTCACTCCACCATCACTCACTCACTCCCCACTCCCCCACCCATGGGGAGG
AGACCTTTGATGAATTCTTCCTCTCCTTCCCACAAAAGACAGACCCAGTGAGTGAATCAGGCAAAGTGCTTATAATGTGTGTTGTGTGAG
CGTGGCCTTGGGAGGACATGCGTGTGTCAGGGATGAGTTGAGGTGATATTTTTATGTGCAGCGACCCTTGGTGTTTCCCTTCCTCGGTGG
CTCTGGGGTATGTGTGTGTGGGTGTGTGCGCCTGAGTGAGTGTGTGTGCTTGAATGTGAGTGTGTATGTCAGTGGTTTCTACTTCCCCTG
GGATGCTGACCCAGGAATAGTGGACATGGTCACAGTCCTATGTACAGAGCTTTCTTTTGTATTAAAAAAAAATACTCTTTCAATAAATGT

>In-frame_PTK7_ENST00000471863_chr6_43044305_+_SRF_ENST00000457278_chr6_43146544_+_638nt
GGACGCCTCGGGACGCCTCGGGGTCGGGCTCCGGCTGCGGCTGCTGCTGCGGCGCCCGCGCTCCGGTGCGCTCCGCCTCCTGTGCCCGCC
GCGGAGCGCAGTCTGCGCGCCCGCCGTGCGCCCTCAGCTCCTTTTCCTGAGCCCGCCGCGATGGGAGCTGCGCGGGGATCCCCGGCCAGA
CCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTGGCGTCCCCCAGGTGTTCCTGACAGCATCATCTGGGACA
GTGCAGATCCCTGTTTCAGCAGTTCAGCTCCACCAGATGGCTGTGATAGGGCAGCAGGCCGGGAGCAGCAGCAACCTCACCGAGCTACAG
GTGGTGAACCTGGACACCGCCCACAGCACCAAGAGTGAATGATCCGCCCGCCGCCCTGGACAGATGGCCCAAGGGATGGCACCACTTATT
TATTGTTGCCTTTTCACGTTTTCTTTACACACACGTTGACGGGCCGCAGGAGGGAGGCGGGGAGGAGGAACGGGCAGCCACAGGACTGAG
CCCTCTCACTCCAGCCAAAGAAATGGGCCTGCCTGCCTCCACCCGTCCTCCCTCAGCCTCCCCTTCTTCCCGCCCCACCTCCCATTTCTG


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FusionGenePPI for PTK7_SRF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTK7RYK, TSHR, CEACAM21, ATP1B4, BTNL8, NTRK1, PPM1G, CLNK, TMEM17, PPP3CA, PPP3CB, PPM1A, PPM1B, PPM1F, PPM1K, ILKAP, CTDSP2, PTPRR, PTPN6, PTPN7, PTPN11, PTPN12, DUSP10, DUSP14, DUSP15, DUSP18, DUSP19, DUSP21, DUSP26, DUPD1, STYX, CDC14A, PTEN, TPTE, TPTE2, MTMR1, MTMR6, MTMR9, MTMR10SRFNCOA6, MYOCD, MKL1, MKL2, PML, CREBBP, SSRP1, RXRG, GATA4, REL, RELA, NFYA, GTF2F1, NKX3-1, MYOG, FLI1, ELK1, TEAD1, SP1, NCOR2, GTF2I, ELK4, CD63, ATF6, CEBPB, SMARCA4, HDAC3, SMAD7, EPC1, HDAC4, KAT5, PELP1, CSNK2A1, SRF, KDM6A, TRIM63, UBE2I, SHBG, PRKDC, NFKB1, SRFBP1, ALDH3A1, CIRBP, ZIC3, FHL1, FHL2, TRIP4, NCOA1, RARA, RXRA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePTK7chr6:43044305chr6:43146544ENST00000230419+120794_1070261071CTNNB1
HgenePTK7chr6:43044305chr6:43146544ENST00000345201+119794_1070261031CTNNB1
HgenePTK7chr6:43044305chr6:43146544ENST00000349241+117794_107026941CTNNB1
HgenePTK7chr6:43044305chr6:43146544ENST00000352931+119794_1070261015CTNNB1
HgenePTK7chr6:43044305chr6:43146544ENST00000481273+120794_1070-241079CTNNB1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTK7_SRF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTK7_SRF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSRFC0015923Fetal Alcohol Syndrome2PSYGENET
TgeneSRFC2985290Fetal Alcohol Spectrum Disorders2PSYGENET
TgeneSRFC0019693HIV Infections1CTD_human