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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29336

FusionGeneSummary for PTGS1_SYNPO2

check button Fusion gene summary
Fusion gene informationFusion gene name: PTGS1_SYNPO2
Fusion gene ID: 29336
HgeneTgene
Gene symbol

PTGS1

SYNPO2

Gene ID

5742

171024

Gene nameprostaglandin-endoperoxide synthase 1synaptopodin 2
SynonymsCOX1|COX3|PCOX1|PES-1|PGG/HS|PGHS-1|PGHS1|PHS1|PTGHS-
Cytomap

9q33.2

4q26

Type of geneprotein-codingprotein-coding
Descriptionprostaglandin G/H synthase 1PGH synthase 1cyclooxygenase-1prostaglandin H2 synthase 1prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)synaptopodin-2genethonin-2myopodin
Modification date2018051920180523
UniProtAcc

P23219

Q9UMS6

Ensembl transtripts involved in fusion geneENST00000540753, ENST00000223423, 
ENST00000362012, ENST00000373698, 
ENST00000307142, ENST00000448416, 
ENST00000429713, ENST00000434046, 
Fusion gene scores* DoF score3 X 3 X 1=97 X 6 X 3=126
# samples 38
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTGS1 [Title/Abstract] AND SYNPO2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTGS1

GO:0019371

cyclooxygenase pathway

1380156


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI972452PTGS1chr9

125155415

-SYNPO2chr4

119952493

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000540753ENST00000307142PTGS1chr9

125155415

-SYNPO2chr4

119952493

-
intron-intronENST00000540753ENST00000448416PTGS1chr9

125155415

-SYNPO2chr4

119952493

-
intron-intronENST00000540753ENST00000429713PTGS1chr9

125155415

-SYNPO2chr4

119952493

-
intron-intronENST00000540753ENST00000434046PTGS1chr9

125155415

-SYNPO2chr4

119952493

-
3UTR-3CDSENST00000223423ENST00000307142PTGS1chr9

125155415

-SYNPO2chr4

119952493

-
3UTR-intronENST00000223423ENST00000448416PTGS1chr9

125155415

-SYNPO2chr4

119952493

-
3UTR-intronENST00000223423ENST00000429713PTGS1chr9

125155415

-SYNPO2chr4

119952493

-
3UTR-intronENST00000223423ENST00000434046PTGS1chr9

125155415

-SYNPO2chr4

119952493

-
3UTR-3CDSENST00000362012ENST00000307142PTGS1chr9

125155415

-SYNPO2chr4

119952493

-
3UTR-intronENST00000362012ENST00000448416PTGS1chr9

125155415

-SYNPO2chr4

119952493

-
3UTR-intronENST00000362012ENST00000429713PTGS1chr9

125155415

-SYNPO2chr4

119952493

-
3UTR-intronENST00000362012ENST00000434046PTGS1chr9

125155415

-SYNPO2chr4

119952493

-
intron-3CDSENST00000373698ENST00000307142PTGS1chr9

125155415

-SYNPO2chr4

119952493

-
intron-intronENST00000373698ENST00000448416PTGS1chr9

125155415

-SYNPO2chr4

119952493

-
intron-intronENST00000373698ENST00000429713PTGS1chr9

125155415

-SYNPO2chr4

119952493

-
intron-intronENST00000373698ENST00000434046PTGS1chr9

125155415

-SYNPO2chr4

119952493

-

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FusionProtFeatures for PTGS1_SYNPO2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTGS1

P23219

SYNPO2

Q9UMS6

Has an actin-binding and actin-bundling activity. Caninduce the formation of F-actin networks in an isoform-specificmanner (PubMed:24005909, PubMed:23225103). At the sarcomeric Zlines is proposed to act as adapter protein that links nascentmyofibers to the sarcolemma via ZYX and may play a role in earlyassembly and stabilization of the Z lines. Involved inautophagosome formation. May play a role in chaperone-assistedselective autophagy (CASA) involved in Z lines maintenance instriated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering andfusion complex providing autophagosome membranes (By similarity).Involved in regulation of cell migration (PubMed:22915763,PubMed:25883213). May be a tumor suppressor (PubMed:16885336).{ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8,ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103,ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213,ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}. Isoform 1: Involved in regulation of cell migration. Caninduce formation of thick, irregular actin bundles in the cellbody. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}. Isoform 2: Involved in regulation of cell migration. Caninduce long, well-organized actin bundles frequently orientated inparallel along the long axis of the cell showing characteristicsof contractile ventral stress fibers.{ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}. Isoform 3: Involved in regulation of cell migration. Caninduce an amorphous actin meshwork throughout the cell bodycontaining a mixture of long and short, randomly organized thickand thin actin bundles. {ECO:0000269|PubMed:22915763,ECO:0000269|PubMed:24005909}. Isoform 4: Can induce long, well-organized actin bundlesfrequently orientated in parallel along the long axis of the cellshowing characteristics of contractile ventral stress fibers.{ECO:0000269|PubMed:24005909}. Isoform 5: Involved in regulation of cell migration inpart dependent on the Rho-ROCK cascade; can promote formation ofnascent focal adhesions, actin bundles at the leading cell edgeand lamellipodia (PubMed:22915763, PubMed:25883213). Can induceformation of thick, irregular actin bundles in the cell body; theinduced actin network is associated with enhanced cell migrationin vitro. {ECO:0000269|PubMed:22915763,ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTGS1_SYNPO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTGS1_SYNPO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTGS1_SYNPO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePTGS1P23219DB00244MesalazineProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00316AcetaminophenProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00461NabumetoneProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00465KetorolacProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00469TenoxicamProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00500TolmetinProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00573FenoprofenProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00784Mefenamic acidProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00795SulfasalazineProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00963BromfenacProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00991OxaprozinProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB01050IbuprofenProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB01399SalsalateProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB01600Tiaprofenic acidProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB04552Niflumic AcidProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB13783AcemetacinProstaglandin G/H synthase 1small moleculeapproved|experimental|investigational
HgenePTGS1P23219DB00328IndomethacinProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB00350MinoxidilProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB00554PiroxicamProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB00605SulindacProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB00712FlurbiprofenProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB00861DiflunisalProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB01014BalsalazideProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB01283LumiracoxibProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB01435AntipyrineProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB06725LornoxicamProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB06736AceclofenacProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB06802NepafenacProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB08814TriflusalProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB09213DexibuprofenProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB09214DexketoprofenProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB09216Tolfenamic AcidProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB09288PropacetamolProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB00711DiethylcarbamazineProstaglandin G/H synthase 1small moleculeapproved|investigational|vet_approved
HgenePTGS1P23219DB00749EtodolacProstaglandin G/H synthase 1small moleculeapproved|investigational|vet_approved
HgenePTGS1P23219DB00936Salicylic acidProstaglandin G/H synthase 1small moleculeapproved|investigational|vet_approved
HgenePTGS1P23219DB04817MetamizoleProstaglandin G/H synthase 1small moleculeapproved|investigational|withdrawn
HgenePTGS1P23219DB00586DiclofenacProstaglandin G/H synthase 1small moleculeapproved|vet_approved
HgenePTGS1P23219DB00788NaproxenProstaglandin G/H synthase 1small moleculeapproved|vet_approved
HgenePTGS1P23219DB00812PhenylbutazoneProstaglandin G/H synthase 1small moleculeapproved|vet_approved
HgenePTGS1P23219DB00814MeloxicamProstaglandin G/H synthase 1small moleculeapproved|vet_approved
HgenePTGS1P23219DB00939Meclofenamic acidProstaglandin G/H synthase 1small moleculeapproved|vet_approved
HgenePTGS1P23219DB00945Acetylsalicylic acidProstaglandin G/H synthase 1small moleculeapproved|vet_approved
HgenePTGS1P23219DB01009KetoprofenProstaglandin G/H synthase 1small moleculeapproved|vet_approved
HgenePTGS1P23219DB00870SuprofenProstaglandin G/H synthase 1small moleculeapproved|withdrawn

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RelatedDiseases for PTGS1_SYNPO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTGS1C0021846Intestinal Polyps2CTD_human
HgenePTGS1C0038358Gastric ulcer2CTD_human
HgenePTGS1C0013182Drug Allergy1CTD_human
HgenePTGS1C0014859Esophageal Neoplasms1CTD_human
HgenePTGS1C0016382Flushing1CTD_human
HgenePTGS1C0018801Heart failure1CTD_human
HgenePTGS1C0020429Hyperalgesia1CTD_human
HgenePTGS1C0022661Kidney Failure, Chronic1CTD_human
HgenePTGS1C0023893Liver Cirrhosis, Experimental1CTD_human
HgenePTGS1C0029927Ovarian Cysts1CTD_human
HgenePTGS1C0035126Reperfusion Injury1CTD_human
HgenePTGS1C0036341Schizophrenia1PSYGENET
HgenePTGS1C0037316Sleep Deprivation1CTD_human
HgenePTGS1C0085129Bronchial Hyperreactivity1CTD_human
HgenePTGS1C0264423Asthma, Occupational1CTD_human
HgenePTGS1C1458155Mammary Neoplasms1CTD_human
TgeneSYNPO2C0677886Epithelial ovarian cancer1CTD_human