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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29334

FusionGeneSummary for PTGS1_GNAS

check button Fusion gene summary
Fusion gene informationFusion gene name: PTGS1_GNAS
Fusion gene ID: 29334
HgeneTgene
Gene symbol

PTGS1

GNAS

Gene ID

5742

2778

Gene nameprostaglandin-endoperoxide synthase 1GNAS complex locus
SynonymsCOX1|COX3|PCOX1|PES-1|PGG/HS|PGHS-1|PGHS1|PHS1|PTGHSAHO|C20orf45|GNAS1|GPSA|GSA|GSP|NESP|PITA3|POH|SCG6|SgVI
Cytomap

9q33.2

20q13.32

Type of geneprotein-codingprotein-coding
Descriptionprostaglandin G/H synthase 1PGH synthase 1cyclooxygenase-1prostaglandin H2 synthase 1prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)protein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha
Modification date2018051920180523
UniProtAcc

P23219

Q5JWF2

Ensembl transtripts involved in fusion geneENST00000540753, ENST00000223423, 
ENST00000362012, ENST00000373698, 
ENST00000313949, ENST00000371098, 
ENST00000371075, ENST00000371100, 
ENST00000371099, ENST00000371102, 
ENST00000464624, ENST00000306120, 
ENST00000371095, ENST00000371085, 
ENST00000354359, ENST00000265620, 
ENST00000306090, ENST00000371081, 
Fusion gene scores* DoF score3 X 3 X 1=933 X 25 X 8=6600
# samples 335
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(35/6600*10)=-4.23703919730085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTGS1 [Title/Abstract] AND GNAS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTGS1

GO:0019371

cyclooxygenase pathway

1380156


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA773408PTGS1chr9

125155344

+GNASchr20

57470930

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000540753ENST00000313949PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000540753ENST00000371098PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000540753ENST00000371075PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000540753ENST00000371100PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000540753ENST00000371099PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000540753ENST00000371102PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000540753ENST00000464624PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000540753ENST00000306120PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000540753ENST00000371095PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000540753ENST00000371085PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000540753ENST00000354359PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000540753ENST00000265620PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000540753ENST00000306090PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000540753ENST00000371081PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000223423ENST00000313949PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000223423ENST00000371098PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000223423ENST00000371075PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000223423ENST00000371100PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000223423ENST00000371099PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000223423ENST00000371102PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000223423ENST00000464624PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000223423ENST00000306120PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000223423ENST00000371095PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000223423ENST00000371085PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000223423ENST00000354359PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000223423ENST00000265620PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000223423ENST00000306090PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000223423ENST00000371081PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000362012ENST00000313949PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000362012ENST00000371098PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000362012ENST00000371075PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000362012ENST00000371100PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000362012ENST00000371099PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000362012ENST00000371102PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000362012ENST00000464624PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000362012ENST00000306120PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000362012ENST00000371095PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000362012ENST00000371085PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000362012ENST00000354359PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000362012ENST00000265620PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000362012ENST00000306090PTGS1chr9

125155344

+GNASchr20

57470930

+
3UTR-intronENST00000362012ENST00000371081PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000373698ENST00000313949PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000373698ENST00000371098PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000373698ENST00000371075PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000373698ENST00000371100PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000373698ENST00000371099PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000373698ENST00000371102PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000373698ENST00000464624PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000373698ENST00000306120PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000373698ENST00000371095PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000373698ENST00000371085PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000373698ENST00000354359PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000373698ENST00000265620PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000373698ENST00000306090PTGS1chr9

125155344

+GNASchr20

57470930

+
intron-intronENST00000373698ENST00000371081PTGS1chr9

125155344

+GNASchr20

57470930

+

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FusionProtFeatures for PTGS1_GNAS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTGS1

P23219

GNAS

Q5JWF2

Guanine nucleotide-binding proteins (G proteins)function as transducers in numerous signaling pathways controlledby G protein-coupled receptors (GPCRs). Signaling involves theactivation of adenylyl cyclases, resulting in increased levels ofthe signaling molecule cAMP. GNAS functions downstream of severalGPCRs, including beta-adrenergic receptors. XLas isoforms interactwith the same set of receptors as GNAS isoforms (By similarity).{ECO:0000250|UniProtKB:Q6R0H7}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTGS1_GNAS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTGS1_GNAS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTGS1_GNAS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePTGS1P23219DB00244MesalazineProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00316AcetaminophenProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00461NabumetoneProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00465KetorolacProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00469TenoxicamProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00500TolmetinProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00573FenoprofenProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00784Mefenamic acidProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00795SulfasalazineProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00963BromfenacProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB00991OxaprozinProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB01050IbuprofenProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB01399SalsalateProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB01600Tiaprofenic acidProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB04552Niflumic AcidProstaglandin G/H synthase 1small moleculeapproved
HgenePTGS1P23219DB13783AcemetacinProstaglandin G/H synthase 1small moleculeapproved|experimental|investigational
HgenePTGS1P23219DB00328IndomethacinProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB00350MinoxidilProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB00554PiroxicamProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB00605SulindacProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB00712FlurbiprofenProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB00861DiflunisalProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB01014BalsalazideProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB01283LumiracoxibProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB01435AntipyrineProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB06725LornoxicamProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB06736AceclofenacProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB06802NepafenacProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB08814TriflusalProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB09213DexibuprofenProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB09214DexketoprofenProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB09216Tolfenamic AcidProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB09288PropacetamolProstaglandin G/H synthase 1small moleculeapproved|investigational
HgenePTGS1P23219DB00711DiethylcarbamazineProstaglandin G/H synthase 1small moleculeapproved|investigational|vet_approved
HgenePTGS1P23219DB00749EtodolacProstaglandin G/H synthase 1small moleculeapproved|investigational|vet_approved
HgenePTGS1P23219DB00936Salicylic acidProstaglandin G/H synthase 1small moleculeapproved|investigational|vet_approved
HgenePTGS1P23219DB04817MetamizoleProstaglandin G/H synthase 1small moleculeapproved|investigational|withdrawn
HgenePTGS1P23219DB00586DiclofenacProstaglandin G/H synthase 1small moleculeapproved|vet_approved
HgenePTGS1P23219DB00788NaproxenProstaglandin G/H synthase 1small moleculeapproved|vet_approved
HgenePTGS1P23219DB00812PhenylbutazoneProstaglandin G/H synthase 1small moleculeapproved|vet_approved
HgenePTGS1P23219DB00814MeloxicamProstaglandin G/H synthase 1small moleculeapproved|vet_approved
HgenePTGS1P23219DB00939Meclofenamic acidProstaglandin G/H synthase 1small moleculeapproved|vet_approved
HgenePTGS1P23219DB00945Acetylsalicylic acidProstaglandin G/H synthase 1small moleculeapproved|vet_approved
HgenePTGS1P23219DB01009KetoprofenProstaglandin G/H synthase 1small moleculeapproved|vet_approved
HgenePTGS1P23219DB00870SuprofenProstaglandin G/H synthase 1small moleculeapproved|withdrawn

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RelatedDiseases for PTGS1_GNAS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTGS1C0021846Intestinal Polyps2CTD_human
HgenePTGS1C0038358Gastric ulcer2CTD_human
HgenePTGS1C0013182Drug Allergy1CTD_human
HgenePTGS1C0014859Esophageal Neoplasms1CTD_human
HgenePTGS1C0016382Flushing1CTD_human
HgenePTGS1C0018801Heart failure1CTD_human
HgenePTGS1C0020429Hyperalgesia1CTD_human
HgenePTGS1C0022661Kidney Failure, Chronic1CTD_human
HgenePTGS1C0023893Liver Cirrhosis, Experimental1CTD_human
HgenePTGS1C0029927Ovarian Cysts1CTD_human
HgenePTGS1C0035126Reperfusion Injury1CTD_human
HgenePTGS1C0036341Schizophrenia1PSYGENET
HgenePTGS1C0037316Sleep Deprivation1CTD_human
HgenePTGS1C0085129Bronchial Hyperreactivity1CTD_human
HgenePTGS1C0264423Asthma, Occupational1CTD_human
HgenePTGS1C1458155Mammary Neoplasms1CTD_human
TgeneGNASC3494506Pseudohypoparathyroidism, Type Ia13CTD_human;ORPHANET;UNIPROT
TgeneGNASC0242292McCune-Albright Syndrome5ORPHANET;UNIPROT
TgeneGNASC2931404Albright's hereditary osteodystrophy4CTD_human
TgeneGNASC0016065Polyostotic fibrous dysplasia3CTD_human;HPO;ORPHANET
TgeneGNASC0033806Pseudohypoparathyroidism3CTD_human;HPO
TgeneGNASC1857451Acth-Independent Macronodular Adrenal Hyperplasia3ORPHANET;UNIPROT
TgeneGNASC0014130Endocrine System Diseases2CTD_human
TgeneGNASC0034013Precocious Puberty2CTD_human;HPO
TgeneGNASC0221263Cafe-au-Lait Spots2CTD_human
TgeneGNASC0001206Acromegaly1CTD_human;HPO
TgeneGNASC0001624Adrenal Gland Neoplasms1CTD_human
TgeneGNASC0011573Endogenous depression1PSYGENET
TgeneGNASC0019087Hemorrhagic Disorders1CTD_human
TgeneGNASC0020538Hypertensive disease1CTD_human;HPO
TgeneGNASC0021655Insulin Resistance1CTD_human
TgeneGNASC0023897Liver Diseases, Parasitic1CTD_human
TgeneGNASC0027819Neuroblastoma1CTD_human
TgeneGNASC0028754Obesity1CTD_human;HPO
TgeneGNASC0029396Heterotopic Ossification1CTD_human;HPO
TgeneGNASC0032460Polycystic Ovary Syndrome1CTD_human
TgeneGNASC0033835Pseudopseudohypoparathyroidism1CTD_human;ORPHANET
TgeneGNASC0035204Respiration Disorders1CTD_human
TgeneGNASC0036341Schizophrenia1PSYGENET
TgeneGNASC0038587Substance Withdrawal Syndrome1CTD_human
TgeneGNASC0039231Tachycardia1CTD_human
TgeneGNASC0206698Cholangiocarcinoma1CTD_human
TgeneGNASC0221357Brachydactyly1CTD_human;HPO
TgeneGNASC0242184Hypoxia1CTD_human
TgeneGNASC0242216Biliary calculi1CTD_human
TgeneGNASC0334041Osteoma cutis1CTD_human;ORPHANET;UNIPROT
TgeneGNASC0346302Growth Hormone-Secreting Pituitary Adenoma1CTD_human
TgeneGNASC2932715Pseudohypoparathyroidism Type 1B1CTD_human;ORPHANET
TgeneGNASC2932716Pseudohypoparathyroidism Type 1C1ORPHANET;UNIPROT
TgeneGNASC3714756Intellectual Disability1CTD_human;HPO