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Fusion gene ID: 29328 |
FusionGeneSummary for PTGFRN_NOTCH2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PTGFRN_NOTCH2 | Fusion gene ID: 29328 | Hgene | Tgene | Gene symbol | PTGFRN | NOTCH2 | Gene ID | 5738 | 4853 |
Gene name | prostaglandin F2 receptor inhibitor | notch 2 | |
Synonyms | CD315|CD9P-1|EWI-F|FPRP|SMAP-6 | AGS2|HJCYS|hN2 | |
Cytomap | 1p13.1 | 1p12 | |
Type of gene | protein-coding | protein-coding | |
Description | prostaglandin F2 receptor negative regulatorCD9 partner 1glu-Trp-Ile EWI motif-containing protein Fprostaglandin F2-alpha receptor regulatory proteinprostaglandin F2-alpha receptor-associated protein | neurogenic locus notch homolog protein 2Notch homolog 2 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9P2B2 | Q04721 | |
Ensembl transtripts involved in fusion gene | ENST00000393203, ENST00000496699, | ENST00000256646, ENST00000602566, ENST00000493703, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 9 X 7 X 3=189 |
# samples | 4 | 9 | |
** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/189*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PTGFRN [Title/Abstract] AND NOTCH2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | NOTCH2 | GO:0007050 | cell cycle arrest | 11306509 |
Tgene | NOTCH2 | GO:0007219 | Notch signaling pathway | 11306509|25985737 |
Tgene | NOTCH2 | GO:0010629 | negative regulation of gene expression | 11306509 |
Tgene | NOTCH2 | GO:0045967 | negative regulation of growth rate | 11306509 |
Tgene | NOTCH2 | GO:0046579 | positive regulation of Ras protein signal transduction | 11306509 |
Tgene | NOTCH2 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 11306509 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-C8-A12L-01A | PTGFRN | chr1 | 117492194 | + | NOTCH2 | chr1 | 120512367 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000393203 | ENST00000256646 | PTGFRN | chr1 | 117492194 | + | NOTCH2 | chr1 | 120512367 | - |
5CDS-intron | ENST00000393203 | ENST00000602566 | PTGFRN | chr1 | 117492194 | + | NOTCH2 | chr1 | 120512367 | - |
5CDS-intron | ENST00000393203 | ENST00000493703 | PTGFRN | chr1 | 117492194 | + | NOTCH2 | chr1 | 120512367 | - |
intron-3CDS | ENST00000496699 | ENST00000256646 | PTGFRN | chr1 | 117492194 | + | NOTCH2 | chr1 | 120512367 | - |
intron-intron | ENST00000496699 | ENST00000602566 | PTGFRN | chr1 | 117492194 | + | NOTCH2 | chr1 | 120512367 | - |
intron-intron | ENST00000496699 | ENST00000493703 | PTGFRN | chr1 | 117492194 | + | NOTCH2 | chr1 | 120512367 | - |
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FusionProtFeatures for PTGFRN_NOTCH2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PTGFRN | NOTCH2 |
Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptornumber rather than the affinity constant. Functional coupling withthe prostaglandin F2-alpha receptor seems to occur (Bysimilarity). {ECO:0000250}. | Functions as a receptor for membrane-bound ligandsJagged1, Jagged2 and Delta1 to regulate cell-fate determination.Upon ligand activation through the released notch intracellulardomain (NICD) it forms a transcriptional activator complex withRBPJ/RBPSUH and activates genes of the enhancer of split locus.Affects the implementation of differentiation, proliferation andapoptotic programs (By similarity). Involved in bone remodelingand homeostasis. In collaboration with RELA/p65 enhances NFATc1promoter activity and positively regulates RANKL-inducedosteoclast differentiation (PubMed:29149593). Positively regulatesself-renewal of liver cancer cells (PubMed:25985737).{ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985,ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737,ECO:0000269|PubMed:29149593}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PTGFRN | chr1:117492194 | chr1:120512367 | ENST00000393203 | + | 4 | 9 | 149_268 | 404 | 880 | Domain | Note=Ig-like C2-type 2 |
Hgene | PTGFRN | chr1:117492194 | chr1:120512367 | ENST00000393203 | + | 4 | 9 | 26_129 | 404 | 880 | Domain | Note=Ig-like C2-type 1 |
Hgene | PTGFRN | chr1:117492194 | chr1:120512367 | ENST00000393203 | + | 4 | 9 | 276_394 | 404 | 880 | Domain | Note=Ig-like C2-type 3 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1645_1648 | 291 | 2472 | Compositional bias | Note=Poly-Ala |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1994_1997 | 291 | 2472 | Compositional bias | Note=Poly-Leu |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 2426_2429 | 291 | 2472 | Compositional bias | Note=Poly-Ser |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1025_1061 | 291 | 2472 | Domain | EGF-like 27%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1063_1099 | 291 | 2472 | Domain | EGF-like 28 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1101_1147 | 291 | 2472 | Domain | EGF-like 29 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1149_1185 | 291 | 2472 | Domain | EGF-like 30%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1187_1223 | 291 | 2472 | Domain | EGF-like 31%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1225_1262 | 291 | 2472 | Domain | EGF-like 32%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1264_1302 | 291 | 2472 | Domain | EGF-like 33 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1304_1343 | 291 | 2472 | Domain | EGF-like 34 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1374_1412 | 291 | 2472 | Domain | EGF-like 35 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 298_336 | 291 | 2472 | Domain | EGF-like 8%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 338_374 | 291 | 2472 | Domain | EGF-like 9%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 375_413 | 291 | 2472 | Domain | EGF-like 10 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 415_454 | 291 | 2472 | Domain | EGF-like 11%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 456_492 | 291 | 2472 | Domain | EGF-like 12%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 494_530 | 291 | 2472 | Domain | EGF-like 13%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 532_568 | 291 | 2472 | Domain | EGF-like 14%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 570_605 | 291 | 2472 | Domain | EGF-like 15%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 607_643 | 291 | 2472 | Domain | EGF-like 16%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 645_680 | 291 | 2472 | Domain | EGF-like 17%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 682_718 | 291 | 2472 | Domain | EGF-like 18%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 720_755 | 291 | 2472 | Domain | EGF-like 19 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 757_793 | 291 | 2472 | Domain | EGF-like 20%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 795_831 | 291 | 2472 | Domain | EGF-like 21%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 833_871 | 291 | 2472 | Domain | EGF-like 22 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 873_909 | 291 | 2472 | Domain | EGF-like 23%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 911_947 | 291 | 2472 | Domain | EGF-like 24%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 949_985 | 291 | 2472 | Domain | EGF-like 25%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 987_1023 | 291 | 2472 | Domain | EGF-like 26%3B calcium-binding |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1425_1677 | 291 | 2472 | Region | Note=Negative regulatory region (NRR) |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1425_1465 | 291 | 2472 | Repeat | Note=LNR 1 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1466_1502 | 291 | 2472 | Repeat | Note=LNR 2 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1503_1544 | 291 | 2472 | Repeat | Note=LNR 3 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1827_1871 | 291 | 2472 | Repeat | Note=ANK 1 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1876_1905 | 291 | 2472 | Repeat | Note=ANK 2 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1909_1939 | 291 | 2472 | Repeat | Note=ANK 3 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1943_1972 | 291 | 2472 | Repeat | Note=ANK 4 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1976_2005 | 291 | 2472 | Repeat | Note=ANK 5 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 2009_2038 | 291 | 2472 | Repeat | Note=ANK 6 |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1699_2471 | 291 | 2472 | Topological domain | Cytoplasmic |
Tgene | >NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 1678_1698 | 291 | 2472 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >PTGFRN | chr1:117492194 | chr1:120512367 | ENST00000393203 | + | 4 | 9 | 406_536 | 404 | 880 | Domain | Note=Ig-like C2-type 4 |
Hgene | >PTGFRN | chr1:117492194 | chr1:120512367 | ENST00000393203 | + | 4 | 9 | 544_662 | 404 | 880 | Domain | Note=Ig-like C2-type 5 |
Hgene | >PTGFRN | chr1:117492194 | chr1:120512367 | ENST00000393203 | + | 4 | 9 | 688_813 | 404 | 880 | Domain | Note=Ig-like C2-type 6 |
Hgene | >PTGFRN | chr1:117492194 | chr1:120512367 | ENST00000393203 | + | 4 | 9 | 424_427 | 404 | 880 | Motif | Note=Endoplasmic reticulum retention signal |
Hgene | >PTGFRN | chr1:117492194 | chr1:120512367 | ENST00000393203 | + | 4 | 9 | 703_705 | 404 | 880 | Motif | Cell attachment site |
Hgene | >PTGFRN | chr1:117492194 | chr1:120512367 | ENST00000393203 | + | 4 | 9 | 26_832 | 404 | 880 | Topological domain | Extracellular |
Hgene | >PTGFRN | chr1:117492194 | chr1:120512367 | ENST00000393203 | + | 4 | 9 | 854_879 | 404 | 880 | Topological domain | Cytoplasmic |
Hgene | >PTGFRN | chr1:117492194 | chr1:120512367 | ENST00000393203 | + | 4 | 9 | 833_853 | 404 | 880 | Transmembrane | Helical |
Tgene | NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 105_143 | 291 | 2472 | Domain | EGF-like 3 |
Tgene | NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 144_180 | 291 | 2472 | Domain | EGF-like 4 |
Tgene | NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 182_219 | 291 | 2472 | Domain | EGF-like 5%3B calcium-binding |
Tgene | NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 221_258 | 291 | 2472 | Domain | EGF-like 6 |
Tgene | NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 260_296 | 291 | 2472 | Domain | EGF-like 7%3B calcium-binding |
Tgene | NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 26_63 | 291 | 2472 | Domain | EGF-like 1 |
Tgene | NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 64_102 | 291 | 2472 | Domain | EGF-like 2 |
Tgene | NOTCH2 | chr1:117492194 | chr1:120512367 | ENST00000256646 | - | 4 | 34 | 26_1677 | 291 | 2472 | Topological domain | Extracellular |
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FusionGeneSequence for PTGFRN_NOTCH2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_PTGFRN_ENST00000393203_chr1_117492194_+_NOTCH2_ENST00000256646_chr1_120512367_-_2585aa MGRLASRPLLLALLSLALCRGRVVRVPTATLVRVVGTELVIPCNVSDYDGPSEQNFDWSFSSLGSSFVELASTWEVGFPAQLYQERLQRG EILLRRTANDAVELHIKNVQPSDQGHYKCSTPSTDATVQGNYEDTVQVKVLADSLHVGPSARPPPSLSLREGEPFELRCTAASASPLHTH LALLWEVHRGPARRSVLALTHEGRFHPGLGYEQRYHSGDVRLDTVGSDAYRLSVSRALSADQGSYRCIVSEWIAEQGNWQEIQEKAVEVA TVVIQPSVLRAAVPKNVSVAEGKELDLTCNITTDRADDVRPEVTWSFSRMPDSTLPGSRVLARLDRDSLVHSSPHVALSHVDARSYHLLV RDVSKENSGYYYCHVSLWAPGHNRSWHKVAEAVSSPAGVGVTWLGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSE NIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPC EHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQ CLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQ IDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATC INGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGF KGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDEC ISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDY VNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTG KNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCE EQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLN GGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPD GFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAP PSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFECQGNSKTCKYDK YCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDARSFLRALGTLLHTNLRIKRDSQGELMVYPYYGEKS AAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASHAIQGTLSYPLVSVVSESLTPERTQLLYLLAVAVV IILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQVSEANLIGTGTSEHWVDDEGPQPKKVKAEDEALL SEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIITDLVYQGA SLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVE GMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPR DVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKSRRPSAKSTMPTSLPNLAKEAKDAKGSRRKKSLSE KVQLSESSVTLSPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGASTVLPSVSQLLSH HHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIAPQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQ PAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASSNAAERTPSHSGH |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_PTGFRN_ENST00000393203_chr1_117492194_+_NOTCH2_ENST00000256646_chr1_120512367_-_7755nt ATGGGGCGCCTGGCCTCGAGGCCGCTGCTGCTGGCGCTCCTGTCGTTGGCTCTTTGCCGAGGGCGTGTGGTGAGAGTCCCCACAGCGACC CTGGTTCGAGTGGTGGGCACTGAGCTGGTCATCCCCTGCAACGTCAGTGACTATGATGGCCCCAGCGAGCAAAACTTTGACTGGAGCTTC TCATCTTTGGGGAGCAGCTTTGTGGAGCTTGCAAGCACCTGGGAGGTGGGGTTCCCAGCCCAGCTGTACCAGGAGCGGCTGCAGAGGGGC GAGATCCTGTTAAGGCGGACTGCCAACGACGCCGTGGAGCTCCACATAAAGAACGTCCAGCCTTCAGACCAAGGCCACTACAAATGTTCA ACCCCCAGCACAGATGCCACTGTCCAGGGAAACTATGAGGACACAGTGCAGGTTAAAGTGCTGGCCGACTCCCTGCACGTGGGCCCCAGC GCGCGGCCCCCGCCGAGCCTGAGCCTGCGGGAGGGGGAGCCCTTCGAGCTGCGCTGCACCGCCGCCTCCGCCTCGCCGCTGCACACGCAC CTGGCGCTGCTGTGGGAGGTGCACCGCGGCCCGGCCAGGCGGAGCGTCCTCGCCCTGACCCACGAGGGCAGGTTCCACCCGGGCCTGGGG TACGAGCAGCGCTACCACAGTGGGGACGTGCGCCTCGACACCGTGGGCAGCGACGCCTACCGCCTCTCAGTGTCCCGGGCTCTGTCTGCC GACCAGGGCTCCTACAGGTGTATCGTCAGCGAGTGGATCGCCGAGCAGGGCAACTGGCAGGAAATCCAAGAAAAGGCCGTGGAAGTTGCC ACCGTGGTGATCCAGCCATCAGTTCTGCGAGCAGCTGTGCCCAAGAATGTGTCTGTGGCTGAAGGAAAGGAACTGGACCTGACCTGTAAC ATCACAACAGACCGAGCCGATGACGTCCGGCCCGAGGTGACGTGGTCCTTCAGCAGGATGCCTGACAGCACCCTACCTGGCTCCCGCGTG TTGGCGCGGCTTGACCGTGATTCCCTGGTGCACAGCTCGCCTCATGTTGCTTTGAGTCATGTGGATGCACGCTCCTACCATTTACTGGTT CGGGATGTTAGCAAAGAAAACTCTGGCTACTATTACTGCCACGTGTCCCTGTGGGCACCCGGACACAACAGGAGCTGGCACAAAGTGGCA GAGGCCGTGTCTTCCCCAGCTGGTGTGGGTGTGACCTGGCTAGGACAGTTCTGCACAGAGGATGTGGATGAATGCCTGCTGCAGCCCAAT GCCTGTCAAAATGGGGGCACCTGTGCCAACCGCAATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGGAGTGGAGATGACTGCAGTGAG AACATTGATGATTGTGCCTTCGCCTCCTGTACTCCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTCTCTTGCATGTGCCCAGAGGGG AAGGCAGGTCTCCTGTGTCATCTGGATGATGCATGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGTGACACCAACCCCCTAAATGGG CAATATATTTGCACCTGCCCACAAGGCTACAAAGGGGCTGACTGCACAGAAGATGTGGATGAATGTGCCATGGCCAATAGCAATCCTTGT GAGCATGCAGGAAAATGTGTGAACACGGATGGCGCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGACCTCGTTGTGAGATGGACATC AATGAGTGCCATTCAGACCCCTGCCAGAATGATGCTACCTGTCTGGATAAGATTGGAGGCTTCACATGTCTGTGCATGCCAGGTTTCAAA GGTGTGCATTGTGAATTAGAAATAAATGAATGTCAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTGGATAAAGTCAATCGTTTCCAG TGCCTGTGTCCTCCTGGTTTCACTGGGCCAGTTTGCCAGATTGATATTGATGACTGTTCCAGTACTCCGTGTCTGAATGGGGCAAAGTGT ATCGATCACCCGAATGGCTATGAATGCCAGTGTGCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAACATTGACAACTGTGACCCCGAT CCTTGCCACCATGGTCAGTGTCAGGATGGTATTGATTCCTACACCTGCATCTGCAATCCCGGGTACATGGGCGCCATCTGCAGTGACCAG ATTGATGAATGTTACAGCAGCCCTTGCCTGAACGATGGTCGCTGCATTGACCTGGTCAATGGCTACCAGTGCAACTGCCAGCCAGGCACG TCAGGGGTTAATTGTGAAATTAATTTTGATGACTGTGCAAGTAACCCTTGTATCCATGGAATCTGTATGGATGGCATTAATCGCTACAGT TGTGTCTGCTCACCAGGATTCACAGGGCAGAGATGTAACATTGACATTGATGAGTGTGCCTCCAATCCCTGTCGCAAGGGTGCAACATGT ATCAACGGTGTGAATGGTTTCCGCTGTATATGCCCCGAGGGACCCCATCACCCCAGCTGCTACTCACAGGTGAACGAATGCCTGAGCAAT CCCTGCATCCATGGAAACTGTACTGGAGGTCTCAGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTTGGCATCAACTGTGAAGTGGAC AAAAATGAATGCCTTTCGAATCCATGCCAGAATGGAGGAACTTGTGACAATCTGGTGAATGGATACAGGTGTACTTGCAAGAAGGGCTTT AAAGGCTATAACTGCCAGGTGAATATTGATGAATGTGCCTCAAATCCATGCCTGAACCAAGGAACCTGCTTTGATGACATAAGTGGCTAC ACTTGCCACTGTGTGCTGCCATACACAGGCAAGAATTGTCAGACAGTATTGGCTCCCTGTTCCCCAAACCCTTGTGAGAATGCTGCTGTT TGCAAAGAGTCACCAAATTTTGAGAGTTATACTTGCTTGTGTGCTCCTGGCTGGCAAGGTCAGCGGTGTACCATTGACATTGACGAGTGT ATCTCCAAGCCCTGCATGAACCATGGTCTCTGCCATAACACCCAGGGCAGCTACATGTGTGAATGTCCACCAGGCTTCAGTGGTATGGAC TGTGAGGAGGACATTGATGACTGCCTTGCCAATCCTTGCCAGAATGGAGGTTCCTGTATGGATGGAGTGAATACTTTCTCCTGCCTCTGC CTTCCGGGTTTCACTGGGGATAAGTGCCAGACAGACATGAATGAGTGTCTGAGTGAACCCTGTAAGAATGGAGGGACCTGCTCTGACTAC GTCAACAGTTACACTTGCAAGTGCCAGGCAGGATTTGATGGAGTCCATTGTGAGAACAACATCAATGAGTGCACTGAGAGCTCCTGTTTC AATGGTGGCACATGTGTTGATGGGATTAACTCCTTCTCTTGCTTGTGCCCTGTGGGTTTCACTGGATCCTTCTGCCTCCATGAGATCAAT GAATGCAGCTCTCATCCATGCCTGAATGAGGGAACGTGTGTTGATGGCCTGGGTACCTACCGCTGCAGCTGCCCCCTGGGCTACACTGGG AAAAACTGTCAGACCCTGGTGAATCTCTGCAGTCGGTCTCCATGTAAAAACAAAGGTACTTGCGTTCAGAAAAAAGCAGAGTCCCAGTGC CTATGTCCATCTGGATGGGCTGGTGCCTATTGTGACGTGCCCAATGTCTCTTGTGACATAGCAGCCTCCAGGAGAGGTGTGCTTGTTGAA CACTTGTGCCAGCACTCAGGTGTCTGCATCAATGCTGGCAACACGCATTACTGTCAGTGCCCCCTGGGCTATACTGGGAGCTACTGTGAG GAGCAACTCGATGAGTGTGCGTCCAACCCCTGCCAGCACGGGGCAACATGCAGTGACTTCATTGGTGGATACAGATGCGAGTGTGTCCCA GGCTATCAGGGTGTCAACTGTGAGTATGAAGTGGATGAGTGCCAGAATCAGCCCTGCCAGAATGGAGGCACCTGTATTGACCTTGTGAAC CATTTCAAGTGCTCTTGCCCACCAGGCACTCGGGGCCTACTCTGTGAAGAGAACATTGATGACTGTGCCCGGGGTCCCCATTGCCTTAAT GGTGGTCAGTGCATGGATAGGATTGGAGGCTACAGTTGTCGCTGCTTGCCTGGCTTTGCTGGGGAGCGTTGTGAGGGAGACATCAACGAG TGCCTCTCCAACCCCTGCAGCTCTGAGGGCAGCCTGGACTGTATACAGCTCACCAATGACTACCTGTGTGTTTGCCGTAGTGCCTTTACT GGCCGGCACTGTGAAACCTTCGTCGATGTGTGTCCCCAGATGCCCTGCCTGAATGGAGGGACTTGTGCTGTGGCCAGTAACATGCCTGAT GGTTTCATTTGCCGTTGTCCCCCGGGATTTTCCGGGGCAAGGTGCCAGAGCAGCTGTGGACAAGTGAAATGTAGGAAGGGGGAGCAGTGT GTGCACACCGCCTCTGGACCCCGCTGCTTCTGCCCCAGTCCCCGGGACTGCGAGTCAGGCTGTGCCAGTAGCCCCTGCCAGCACGGGGGC AGCTGCCACCCTCAGCGCCAGCCTCCTTATTACTCCTGCCAGTGTGCCCCACCATTCTCGGGTAGCCGCTGTGAACTCTACACGGCACCC CCCAGCACCCCTCCTGCCACCTGTCTGAGCCAGTATTGTGCCGACAAAGCTCGGGATGGCGTCTGTGATGAGGCCTGCAACAGCCATGCC TGCCAGTGGGATGGGGGTGACTGTTCTCTCACCATGGAGAACCCCTGGGCCAACTGCTCCTCCCCACTTCCCTGCTGGGATTATATCAAC AACCAGTGTGATGAGCTGTGCAACACGGTCGAGTGCCTGTTTGACAACTTTGAATGCCAGGGGAACAGCAAGACATGCAAGTATGACAAA TACTGTGCAGACCACTTCAAAGACAACCACTGTGACCAGGGGTGCAACAGTGAGGAGTGTGGTTGGGATGGGCTGGACTGTGCTGCTGAC CAACCTGAGAACCTGGCAGAAGGTACCCTGGTTATTGTGGTATTGATGCCACCTGAACAACTGCTCCAGGATGCTCGCAGCTTCTTGCGG GCACTGGGTACCCTGCTCCACACCAACCTGCGCATTAAGCGGGACTCCCAGGGGGAACTCATGGTGTACCCCTATTATGGTGAGAAGTCA GCTGCTATGAAGAAACAGAGGATGACACGCAGATCCCTTCCTGGTGAACAAGAACAGGAGGTGGCTGGCTCTAAAGTCTTTCTGGAAATT GACAACCGCCAGTGTGTTCAAGACTCAGACCACTGCTTCAAGAACACGGATGCAGCAGCAGCTCTCCTGGCCTCTCACGCCATACAGGGG ACCCTGTCATACCCTCTTGTGTCTGTCGTCAGTGAATCCCTGACTCCAGAACGCACTCAGCTCCTCTATCTCCTTGCTGTTGCTGTTGTC ATCATTCTGTTTATTATTCTGCTGGGGGTAATCATGGCAAAACGAAAGCGTAAGCATGGCTCTCTCTGGCTGCCTGAAGGTTTCACTCTT CGCCGAGATGCAAGCAATCACAAGCGTCGTGAGCCAGTGGGACAGGATGCTGTGGGGCTGAAAAATCTCTCAGTGCAAGTCTCAGAAGCT AACCTAATTGGTACTGGAACAAGTGAACACTGGGTCGATGATGAAGGGCCCCAGCCAAAGAAAGTAAAGGCTGAAGATGAGGCCTTACTC TCAGAAGAAGATGACCCCATTGATCGACGGCCATGGACACAGCAGCACCTTGAAGCTGCAGACATCCGTAGGACACCATCGCTGGCTCTC ACCCCTCCTCAGGCAGAGCAGGAGGTGGATGTGTTAGATGTGAATGTCCGTGGCCCAGATGGCTGCACCCCATTGATGTTGGCTTCTCTC CGAGGAGGCAGCTCAGATTTGAGTGATGAAGATGAAGATGCAGAGGACTCTTCTGCTAACATCATCACAGACTTGGTCTACCAGGGTGCC AGCCTCCAGGCCCAGACAGACCGGACTGGTGAGATGGCCCTGCACCTTGCAGCCCGCTACTCACGGGCTGATGCTGCCAAGCGTCTCCTG GATGCAGGTGCAGATGCCAATGCCCAGGACAACATGGGCCGCTGTCCACTCCATGCTGCAGTGGCAGCTGATGCCCAAGGTGTCTTCCAG ATTCTGATTCGCAACCGAGTAACTGATCTAGATGCCAGGATGAATGATGGTACTACACCCCTGATCCTGGCTGCCCGCCTGGCTGTGGAG GGAATGGTGGCAGAACTGATCAACTGCCAAGCGGATGTGAATGCAGTGGATGACCATGGAAAATCTGCTCTTCACTGGGCAGCTGCTGTC AATAATGTGGAGGCAACTCTTTTGTTGTTGAAAAATGGGGCCAACCGAGACATGCAGGACAACAAGGAAGAGACACCTCTGTTTCTTGCT GCCCGGGAGGGGAGCTATGAAGCAGCCAAGATCCTGTTAGACCATTTTGCCAATCGAGACATCACAGACCATATGGATCGTCTTCCCCGG GATGTGGCTCGGGATCGCATGCACCATGACATTGTGCGCCTTCTGGATGAATACAATGTGACCCCAAGCCCTCCAGGCACCGTGTTGACT TCTGCTCTCTCACCTGTCATCTGTGGGCCCAACAGATCTTTCCTCAGCCTGAAGCACACCCCAATGGGCAAGAAGTCTAGACGGCCCAGT GCCAAGAGTACCATGCCTACTAGCCTCCCTAACCTTGCCAAGGAGGCAAAGGATGCCAAGGGTAGTAGGAGGAAGAAGTCTCTGAGTGAG AAGGTCCAACTGTCTGAGAGTTCAGTAACTTTATCCCCTGTTGATTCCCTAGAATCTCCTCACACGTATGTTTCCGACACCACATCCTCT CCAATGATTACATCCCCTGGGATCTTACAGGCCTCACCCAACCCTATGTTGGCCACTGCCGCCCCTCCTGCCCCAGTCCATGCCCAGCAT GCACTATCTTTTTCTAACCTTCATGAAATGCAGCCTTTGGCACATGGGGCCAGCACTGTGCTTCCCTCAGTGAGCCAGTTGCTATCCCAC CACCACATTGTGTCTCCAGGCAGTGGCAGTGCTGGAAGCTTGAGTAGGCTCCATCCAGTCCCAGTCCCAGCAGATTGGATGAACCGCATG GAGGTGAATGAGACCCAGTACAATGAGATGTTTGGTATGGTCCTGGCTCCAGCTGAGGGCACCCATCCTGGCATAGCTCCCCAGAGCAGG CCACCTGAAGGGAAGCACATAACCACCCCTCGGGAGCCCTTGCCCCCCATTGTGACTTTCCAGCTCATCCCTAAAGGCAGTATTGCCCAA CCAGCGGGGGCTCCCCAGCCTCAGTCCACCTGCCCTCCAGCTGTTGCGGGCCCCCTGCCCACCATGTACCAGATTCCAGAAATGGCCCGT TTGCCCAGTGTGGCTTTCCCCACTGCCATGATGCCCCAGCAGGACGGGCAGGTAGCTCAGACCATTCTCCCAGCCTATCATCCTTTCCCA GCCTCTGTGGGCAAGTACCCCACACCCCCTTCACAGCACAGTTATGCTTCCTCAAATGCTGCTGAGCGAACACCCAGTCACAGTGGTCAC CTCCAGGGTGAGCATCCCTACCTGACACCATCCCCAGAGTCTCCTGACCAGTGGTCAAGTTCATCACCCCACTCTGCTTCTGACTGGTCA GATGTGACCACCAGCCCTACCCCTGGGGGTGCTGGAGGAGGTCAGCGGGGACCTGGGACACACATGTCTGAGCCACCACACAACAACATG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_PTGFRN_ENST00000393203_chr1_117492194_+_NOTCH2_ENST00000256646_chr1_120512367_-_11655nt GATTTATCGGCTCGCGAGGAGAGCGGAGCAGGCGCGCGGCCCAGGCGGAGGAGCGCCGACTCTGGAGCAGCCGGAGCTGGAAGAGGAGGA GGAGGAGAGGCGGCGGGGAAGGAGGAGGAGGGGGAGAGTCGCTCCCGCCGGGCGAGCATGGGGCGCCTGGCCTCGAGGCCGCTGCTGCTG GCGCTCCTGTCGTTGGCTCTTTGCCGAGGGCGTGTGGTGAGAGTCCCCACAGCGACCCTGGTTCGAGTGGTGGGCACTGAGCTGGTCATC CCCTGCAACGTCAGTGACTATGATGGCCCCAGCGAGCAAAACTTTGACTGGAGCTTCTCATCTTTGGGGAGCAGCTTTGTGGAGCTTGCA AGCACCTGGGAGGTGGGGTTCCCAGCCCAGCTGTACCAGGAGCGGCTGCAGAGGGGCGAGATCCTGTTAAGGCGGACTGCCAACGACGCC GTGGAGCTCCACATAAAGAACGTCCAGCCTTCAGACCAAGGCCACTACAAATGTTCAACCCCCAGCACAGATGCCACTGTCCAGGGAAAC TATGAGGACACAGTGCAGGTTAAAGTGCTGGCCGACTCCCTGCACGTGGGCCCCAGCGCGCGGCCCCCGCCGAGCCTGAGCCTGCGGGAG GGGGAGCCCTTCGAGCTGCGCTGCACCGCCGCCTCCGCCTCGCCGCTGCACACGCACCTGGCGCTGCTGTGGGAGGTGCACCGCGGCCCG GCCAGGCGGAGCGTCCTCGCCCTGACCCACGAGGGCAGGTTCCACCCGGGCCTGGGGTACGAGCAGCGCTACCACAGTGGGGACGTGCGC CTCGACACCGTGGGCAGCGACGCCTACCGCCTCTCAGTGTCCCGGGCTCTGTCTGCCGACCAGGGCTCCTACAGGTGTATCGTCAGCGAG TGGATCGCCGAGCAGGGCAACTGGCAGGAAATCCAAGAAAAGGCCGTGGAAGTTGCCACCGTGGTGATCCAGCCATCAGTTCTGCGAGCA GCTGTGCCCAAGAATGTGTCTGTGGCTGAAGGAAAGGAACTGGACCTGACCTGTAACATCACAACAGACCGAGCCGATGACGTCCGGCCC GAGGTGACGTGGTCCTTCAGCAGGATGCCTGACAGCACCCTACCTGGCTCCCGCGTGTTGGCGCGGCTTGACCGTGATTCCCTGGTGCAC AGCTCGCCTCATGTTGCTTTGAGTCATGTGGATGCACGCTCCTACCATTTACTGGTTCGGGATGTTAGCAAAGAAAACTCTGGCTACTAT TACTGCCACGTGTCCCTGTGGGCACCCGGACACAACAGGAGCTGGCACAAAGTGGCAGAGGCCGTGTCTTCCCCAGCTGGTGTGGGTGTG ACCTGGCTAGGACAGTTCTGCACAGAGGATGTGGATGAATGCCTGCTGCAGCCCAATGCCTGTCAAAATGGGGGCACCTGTGCCAACCGC AATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGGAGTGGAGATGACTGCAGTGAGAACATTGATGATTGTGCCTTCGCCTCCTGTACT CCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTCTCTTGCATGTGCCCAGAGGGGAAGGCAGGTCTCCTGTGTCATCTGGATGATGCA TGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGTGACACCAACCCCCTAAATGGGCAATATATTTGCACCTGCCCACAAGGCTACAAA GGGGCTGACTGCACAGAAGATGTGGATGAATGTGCCATGGCCAATAGCAATCCTTGTGAGCATGCAGGAAAATGTGTGAACACGGATGGC GCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGACCTCGTTGTGAGATGGACATCAATGAGTGCCATTCAGACCCCTGCCAGAATGAT GCTACCTGTCTGGATAAGATTGGAGGCTTCACATGTCTGTGCATGCCAGGTTTCAAAGGTGTGCATTGTGAATTAGAAATAAATGAATGT CAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTGGATAAAGTCAATCGTTTCCAGTGCCTGTGTCCTCCTGGTTTCACTGGGCCAGTT TGCCAGATTGATATTGATGACTGTTCCAGTACTCCGTGTCTGAATGGGGCAAAGTGTATCGATCACCCGAATGGCTATGAATGCCAGTGT GCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAACATTGACAACTGTGACCCCGATCCTTGCCACCATGGTCAGTGTCAGGATGGTATT GATTCCTACACCTGCATCTGCAATCCCGGGTACATGGGCGCCATCTGCAGTGACCAGATTGATGAATGTTACAGCAGCCCTTGCCTGAAC GATGGTCGCTGCATTGACCTGGTCAATGGCTACCAGTGCAACTGCCAGCCAGGCACGTCAGGGGTTAATTGTGAAATTAATTTTGATGAC TGTGCAAGTAACCCTTGTATCCATGGAATCTGTATGGATGGCATTAATCGCTACAGTTGTGTCTGCTCACCAGGATTCACAGGGCAGAGA TGTAACATTGACATTGATGAGTGTGCCTCCAATCCCTGTCGCAAGGGTGCAACATGTATCAACGGTGTGAATGGTTTCCGCTGTATATGC CCCGAGGGACCCCATCACCCCAGCTGCTACTCACAGGTGAACGAATGCCTGAGCAATCCCTGCATCCATGGAAACTGTACTGGAGGTCTC AGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTTGGCATCAACTGTGAAGTGGACAAAAATGAATGCCTTTCGAATCCATGCCAGAAT GGAGGAACTTGTGACAATCTGGTGAATGGATACAGGTGTACTTGCAAGAAGGGCTTTAAAGGCTATAACTGCCAGGTGAATATTGATGAA TGTGCCTCAAATCCATGCCTGAACCAAGGAACCTGCTTTGATGACATAAGTGGCTACACTTGCCACTGTGTGCTGCCATACACAGGCAAG AATTGTCAGACAGTATTGGCTCCCTGTTCCCCAAACCCTTGTGAGAATGCTGCTGTTTGCAAAGAGTCACCAAATTTTGAGAGTTATACT TGCTTGTGTGCTCCTGGCTGGCAAGGTCAGCGGTGTACCATTGACATTGACGAGTGTATCTCCAAGCCCTGCATGAACCATGGTCTCTGC CATAACACCCAGGGCAGCTACATGTGTGAATGTCCACCAGGCTTCAGTGGTATGGACTGTGAGGAGGACATTGATGACTGCCTTGCCAAT CCTTGCCAGAATGGAGGTTCCTGTATGGATGGAGTGAATACTTTCTCCTGCCTCTGCCTTCCGGGTTTCACTGGGGATAAGTGCCAGACA GACATGAATGAGTGTCTGAGTGAACCCTGTAAGAATGGAGGGACCTGCTCTGACTACGTCAACAGTTACACTTGCAAGTGCCAGGCAGGA TTTGATGGAGTCCATTGTGAGAACAACATCAATGAGTGCACTGAGAGCTCCTGTTTCAATGGTGGCACATGTGTTGATGGGATTAACTCC TTCTCTTGCTTGTGCCCTGTGGGTTTCACTGGATCCTTCTGCCTCCATGAGATCAATGAATGCAGCTCTCATCCATGCCTGAATGAGGGA ACGTGTGTTGATGGCCTGGGTACCTACCGCTGCAGCTGCCCCCTGGGCTACACTGGGAAAAACTGTCAGACCCTGGTGAATCTCTGCAGT CGGTCTCCATGTAAAAACAAAGGTACTTGCGTTCAGAAAAAAGCAGAGTCCCAGTGCCTATGTCCATCTGGATGGGCTGGTGCCTATTGT GACGTGCCCAATGTCTCTTGTGACATAGCAGCCTCCAGGAGAGGTGTGCTTGTTGAACACTTGTGCCAGCACTCAGGTGTCTGCATCAAT GCTGGCAACACGCATTACTGTCAGTGCCCCCTGGGCTATACTGGGAGCTACTGTGAGGAGCAACTCGATGAGTGTGCGTCCAACCCCTGC CAGCACGGGGCAACATGCAGTGACTTCATTGGTGGATACAGATGCGAGTGTGTCCCAGGCTATCAGGGTGTCAACTGTGAGTATGAAGTG GATGAGTGCCAGAATCAGCCCTGCCAGAATGGAGGCACCTGTATTGACCTTGTGAACCATTTCAAGTGCTCTTGCCCACCAGGCACTCGG GGCCTACTCTGTGAAGAGAACATTGATGACTGTGCCCGGGGTCCCCATTGCCTTAATGGTGGTCAGTGCATGGATAGGATTGGAGGCTAC AGTTGTCGCTGCTTGCCTGGCTTTGCTGGGGAGCGTTGTGAGGGAGACATCAACGAGTGCCTCTCCAACCCCTGCAGCTCTGAGGGCAGC CTGGACTGTATACAGCTCACCAATGACTACCTGTGTGTTTGCCGTAGTGCCTTTACTGGCCGGCACTGTGAAACCTTCGTCGATGTGTGT CCCCAGATGCCCTGCCTGAATGGAGGGACTTGTGCTGTGGCCAGTAACATGCCTGATGGTTTCATTTGCCGTTGTCCCCCGGGATTTTCC GGGGCAAGGTGCCAGAGCAGCTGTGGACAAGTGAAATGTAGGAAGGGGGAGCAGTGTGTGCACACCGCCTCTGGACCCCGCTGCTTCTGC CCCAGTCCCCGGGACTGCGAGTCAGGCTGTGCCAGTAGCCCCTGCCAGCACGGGGGCAGCTGCCACCCTCAGCGCCAGCCTCCTTATTAC TCCTGCCAGTGTGCCCCACCATTCTCGGGTAGCCGCTGTGAACTCTACACGGCACCCCCCAGCACCCCTCCTGCCACCTGTCTGAGCCAG TATTGTGCCGACAAAGCTCGGGATGGCGTCTGTGATGAGGCCTGCAACAGCCATGCCTGCCAGTGGGATGGGGGTGACTGTTCTCTCACC ATGGAGAACCCCTGGGCCAACTGCTCCTCCCCACTTCCCTGCTGGGATTATATCAACAACCAGTGTGATGAGCTGTGCAACACGGTCGAG TGCCTGTTTGACAACTTTGAATGCCAGGGGAACAGCAAGACATGCAAGTATGACAAATACTGTGCAGACCACTTCAAAGACAACCACTGT GACCAGGGGTGCAACAGTGAGGAGTGTGGTTGGGATGGGCTGGACTGTGCTGCTGACCAACCTGAGAACCTGGCAGAAGGTACCCTGGTT ATTGTGGTATTGATGCCACCTGAACAACTGCTCCAGGATGCTCGCAGCTTCTTGCGGGCACTGGGTACCCTGCTCCACACCAACCTGCGC ATTAAGCGGGACTCCCAGGGGGAACTCATGGTGTACCCCTATTATGGTGAGAAGTCAGCTGCTATGAAGAAACAGAGGATGACACGCAGA TCCCTTCCTGGTGAACAAGAACAGGAGGTGGCTGGCTCTAAAGTCTTTCTGGAAATTGACAACCGCCAGTGTGTTCAAGACTCAGACCAC TGCTTCAAGAACACGGATGCAGCAGCAGCTCTCCTGGCCTCTCACGCCATACAGGGGACCCTGTCATACCCTCTTGTGTCTGTCGTCAGT GAATCCCTGACTCCAGAACGCACTCAGCTCCTCTATCTCCTTGCTGTTGCTGTTGTCATCATTCTGTTTATTATTCTGCTGGGGGTAATC ATGGCAAAACGAAAGCGTAAGCATGGCTCTCTCTGGCTGCCTGAAGGTTTCACTCTTCGCCGAGATGCAAGCAATCACAAGCGTCGTGAG CCAGTGGGACAGGATGCTGTGGGGCTGAAAAATCTCTCAGTGCAAGTCTCAGAAGCTAACCTAATTGGTACTGGAACAAGTGAACACTGG GTCGATGATGAAGGGCCCCAGCCAAAGAAAGTAAAGGCTGAAGATGAGGCCTTACTCTCAGAAGAAGATGACCCCATTGATCGACGGCCA TGGACACAGCAGCACCTTGAAGCTGCAGACATCCGTAGGACACCATCGCTGGCTCTCACCCCTCCTCAGGCAGAGCAGGAGGTGGATGTG TTAGATGTGAATGTCCGTGGCCCAGATGGCTGCACCCCATTGATGTTGGCTTCTCTCCGAGGAGGCAGCTCAGATTTGAGTGATGAAGAT GAAGATGCAGAGGACTCTTCTGCTAACATCATCACAGACTTGGTCTACCAGGGTGCCAGCCTCCAGGCCCAGACAGACCGGACTGGTGAG ATGGCCCTGCACCTTGCAGCCCGCTACTCACGGGCTGATGCTGCCAAGCGTCTCCTGGATGCAGGTGCAGATGCCAATGCCCAGGACAAC ATGGGCCGCTGTCCACTCCATGCTGCAGTGGCAGCTGATGCCCAAGGTGTCTTCCAGATTCTGATTCGCAACCGAGTAACTGATCTAGAT GCCAGGATGAATGATGGTACTACACCCCTGATCCTGGCTGCCCGCCTGGCTGTGGAGGGAATGGTGGCAGAACTGATCAACTGCCAAGCG GATGTGAATGCAGTGGATGACCATGGAAAATCTGCTCTTCACTGGGCAGCTGCTGTCAATAATGTGGAGGCAACTCTTTTGTTGTTGAAA AATGGGGCCAACCGAGACATGCAGGACAACAAGGAAGAGACACCTCTGTTTCTTGCTGCCCGGGAGGGGAGCTATGAAGCAGCCAAGATC CTGTTAGACCATTTTGCCAATCGAGACATCACAGACCATATGGATCGTCTTCCCCGGGATGTGGCTCGGGATCGCATGCACCATGACATT GTGCGCCTTCTGGATGAATACAATGTGACCCCAAGCCCTCCAGGCACCGTGTTGACTTCTGCTCTCTCACCTGTCATCTGTGGGCCCAAC AGATCTTTCCTCAGCCTGAAGCACACCCCAATGGGCAAGAAGTCTAGACGGCCCAGTGCCAAGAGTACCATGCCTACTAGCCTCCCTAAC CTTGCCAAGGAGGCAAAGGATGCCAAGGGTAGTAGGAGGAAGAAGTCTCTGAGTGAGAAGGTCCAACTGTCTGAGAGTTCAGTAACTTTA TCCCCTGTTGATTCCCTAGAATCTCCTCACACGTATGTTTCCGACACCACATCCTCTCCAATGATTACATCCCCTGGGATCTTACAGGCC TCACCCAACCCTATGTTGGCCACTGCCGCCCCTCCTGCCCCAGTCCATGCCCAGCATGCACTATCTTTTTCTAACCTTCATGAAATGCAG CCTTTGGCACATGGGGCCAGCACTGTGCTTCCCTCAGTGAGCCAGTTGCTATCCCACCACCACATTGTGTCTCCAGGCAGTGGCAGTGCT GGAAGCTTGAGTAGGCTCCATCCAGTCCCAGTCCCAGCAGATTGGATGAACCGCATGGAGGTGAATGAGACCCAGTACAATGAGATGTTT GGTATGGTCCTGGCTCCAGCTGAGGGCACCCATCCTGGCATAGCTCCCCAGAGCAGGCCACCTGAAGGGAAGCACATAACCACCCCTCGG GAGCCCTTGCCCCCCATTGTGACTTTCCAGCTCATCCCTAAAGGCAGTATTGCCCAACCAGCGGGGGCTCCCCAGCCTCAGTCCACCTGC CCTCCAGCTGTTGCGGGCCCCCTGCCCACCATGTACCAGATTCCAGAAATGGCCCGTTTGCCCAGTGTGGCTTTCCCCACTGCCATGATG CCCCAGCAGGACGGGCAGGTAGCTCAGACCATTCTCCCAGCCTATCATCCTTTCCCAGCCTCTGTGGGCAAGTACCCCACACCCCCTTCA CAGCACAGTTATGCTTCCTCAAATGCTGCTGAGCGAACACCCAGTCACAGTGGTCACCTCCAGGGTGAGCATCCCTACCTGACACCATCC CCAGAGTCTCCTGACCAGTGGTCAAGTTCATCACCCCACTCTGCTTCTGACTGGTCAGATGTGACCACCAGCCCTACCCCTGGGGGTGCT GGAGGAGGTCAGCGGGGACCTGGGACACACATGTCTGAGCCACCACACAACAACATGCAGGTTTATGCGTGAGAGAGTCCACCTCCAGTG TAGAGACATAACTGACTTTTGTAAATGCTGCTGAGGAACAAATGAAGGTCATCCGGGAGAGAAATGAAGAAATCTCTGGAGCCAGCTTCT AGAGGTAGGAAAGAGAAGATGTTCTTATTCAGATAATGCAAGAGAAGCAATTCGTCAGTTTCACTGGGTATCTGCAAGGCTTATTGATTA TTCTAATCTAATAAGACAAGTTTGTGGAAATGCAAGATGAATACAAGCCTTGGGTCCATGTTTACTCTCTTCTATTTGGAGAATAAGATG GATGCTTATTGAAGCCCAGACATTCTTGCAGCTTGGACTGCATTTTAAGCCCTGCAGGCTTCTGCCATATCCATGAGAAGATTCTACACT AGCGTCCTGTTGGGAATTATGCCCTGGAATTCTGCCTGAATTGACCTACGCATCTCCTCCTCCTTGGACATTCTTTTGTCTTCATTTGGT GCTTTTGGTTTTGCACCTCTCCGTGATTGTAGCCCTACCAGCATGTTATAGGGCAAGACCTTTGTGCTTTTGATCATTCTGGCCCATGAA AGCAACTTTGGTCTCCTTTCCCCTCCTGTCTTCCCGGTATCCCTTGGAGTCTCACAAGGTTTACTTTGGTATGGTTCTCAGCACAAACCT TTCAAGTATGTTGTTTCTTTGGAAAATGGACATACTGTATTGTGTTCTCCTGCATATATCATTCCTGGAGAGAGAAGGGGAGAAGAATAC TTTTCTTCAACAAATTTTGGGGGCAGGAGATCCCTTCAAGAGGCTGCACCTTAATTTTTCTTGTCTGTGTGCAGGTCTTCATATAAACTT TACCAGGAAGAAGGGTGTGAGTTTGTTGTTTTTCTGTGTATGGGCCTGGTCAGTGTAAAGTTTTATCCTTGATAGTCTAGTTACTATGAC CCTCCCCACTTTTTTAAAACCAGAAAAAGGTTTGGAATGTTGGAATGACCAAGAGACAAGTTAACTCGTGCAAGAGCCAGTTACCCACCC ACAGGTCCCCCTACTTCCTGCCAAGCATTCCATTGACTGCCTGTATGGAACACATTTGTCCCAGATCTGAGCATTCTAGGCCTGTTTCAC TCACTCACCCAGCATATGAAACTAGTCTTAACTGTTGAGCCTTTCCTTTCATATCCACAGAAGACACTGTCTCAAATGTTGTACCCTTGC CATTTAGGACTGAACTTTCCTTAGCCCAAGGGACCCAGTGACAGTTGTCTTCCGTTTGTCAGATGATCAGTCTCTACTGATTATCTTGCT GCTTAAAGGCCTGCTCACCAATCTTTCTTTCACACCGTGTGGTCCGTGTTACTGGTATACCCAGTATGTTCTCACTGAAGACATGGACTT TATATGTTCAAGTGCAGGAATTGGAAAGTTGGACTTGTTTTCTATGATCCAAAACAGCCCTATAAGAAGGTTGGAAAAGGAGGAACTATA TAGCAGCCTTTGCTATTTTCTGCTACCATTTCTTTTCCTCTGAAGCGGCCATGACATTCCCTTTGGCAACTAACGTAGAAACTCAACAGA ACATTTTCCTTTCCTAGAGTCACCTTTTAGATGATAATGGACAACTATAGACTTGCTCATTGTTCAGACTGATTGCCCCTCACCTGAATC CACTCTCTGTATTCATGCTCTTGGCAATTTCTTTGACTTTCTTTTAAGGGCAGAAGCATTTTAGTTAATTGTAGATAAAGAATAGTTTTC TTCCTCTTCTCCTTGGGCCAGTTAATAATTGGTCCATGGCTACACTGCAACTTCCGTCCAGTGCTGTGATGCCCATGACACCTGCAAAAT AAGTTCTGCCTGGGCATTTTGTAGATATTAACAGGTGAATTCCCGACTCTTTTGGTTTGAATGACAGTTCTCATTCCTTCTATGGCTGCA AGTATGCATCAGTGCTTCCCACTTACCTGATTTGTCTGTCGGTGGCCCCATATGGAAACCCTGCGTGTCTGTTGGCATAATAGTTTACAA ATGGTTTTTTCAGTCCTATCCAAATTTATTGAACCAACAAAAATAATTACTTCTGCCCTGAGATAAGCAGATTAAGTTTGTTCATTCTCT GCTTTATTCTCTCCATGTGGCAACATTCTGTCAGCCTCTTTCATAGTGTGCAAACATTTTATCATTCTAAATGGTGACTCTCTGCCCTTG GACCCATTTATTATTCACAGATGGGGAGAACCTATCTGCATGGACCTCTGTGGACCACAGCGTACCTGCCCCTTTCTGCCCTCCTGCTCC AGCCCCACTTCTGAAAGTATCAGCTACTGATCCAGCCACTGGATATTTTATATCCTCCCTTTTCCTTAAGCACAATGTCAGACCAAATTG CTTGTTTCTTTTTCTTGGACTACTTTAATTTGGATCCTTTGGGTTTGGAGAAAGGGAATGTGAAAGCTGTCATTACAGACAACAGGTTTC AGTGATGAGGAGGACAACACTGCCTTTCAAACTTTTTACTGATCTCTTAGATTTTAAGAACTCTTGAATTGTGTGGTATCTAATAAAAGG GAAGGTAAGATGGATAATCACTTTCTCATTTGGGTTCTGAATTGGAGACTCAGTTTTTATGAGACACATCTTTTATGCCATGTATAGATC CTCCCCTGCTATTTTTGGTTTATTTTTATTGTTATAAATGCTTTCTTTCTTTGACTCCTCTTCTGCCTGCCTTTGGGGATAGGTTTTTTT GTTTGTTTATTTGCTTCCTCTGTTTTGTTTTAAGCATCATTTTCTTATGTGAGGTGGGGAAGGGAAAGGTATGAGGGAAAGAGAGTCTGA GAATTAAAATATTTTAGTATAAGCAATTGGCTGTGATGCTCAAATCCATTGCATCCTCTTATTGAATTTGCCAATTTGTAATTTTTGCAT AATAAAGAACCAAAGGTGTAATGTTTTGTTGAGAGGTGGTTTAGGGATTTTGGCCCTAACCAATACATTGAATGTATGATGACTATTTGG GAGGACACATTTATGTACCCAGAGGCCCCCACTAATAAGTGGTACTATGGTTACTTCCTTGTGTACATTTCTCTTAAAAGTGATATTATA TCTGTTTGTATGAGAAACCCAGTAACCAATAAAATGACCGCATATTCCTGACTAAACGTAGTAAGGAAAATGCACACTTTGTTTTTACTT TTCCGTTTCATTCTAAAGGTAGTTAAGATGAAATTTATATGAAAGCATTTTTATCACAAAATAAAAAAGGTTTGCCAAGCTCAGTGGTGT TGTATTTTTTATTTTCCAATACTGCATCCATGGCCTGGCAGTGTTACCTCATGATGTCATAATTTGCTGAGAGAGCAAATTTTCTTTTCT TTCTGAATCCCACAAAGCCTAGCACCAAACTTCTTTTTTTCTTCCTTTAATTAGATCATAAATAAATGATCCTGGGGAAAAAGCATCTGT CAAATAGGAAACATCACAAAACTGAGCACTCTTCTGTGCACTAGCCATAGCTGGTGACAAACAGATGGTTGCTCAGGGACAAGGTGCCTT CCAATGGAAATGCGAAGTAGTTGCTATAGCAAGAATTGGGAACTGGGATATAAGTCATAATATTAATTATGCTGTTATGTAAATGATTGG TTTGTAACATTCCTTAAGTGAAATTTGTGTAGAACTTAATATACAGGATTATAAAATAATATTTTGTGTATAAATTTGTTATAAGTTCAC |
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FusionGenePPI for PTGFRN_NOTCH2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PTGFRN | CD151, CD81, CD9, CD63, CD82, FBXO6, RPL6, LGALS3, LGALS8, LGALS9, A4GALT, ATP1B4, BTNL8, SIAE, TSPAN2, SCGB1D1, ST8SIA4 | NOTCH2 | CNTN1, GSK3B, JAG1, DLL1, RBPJ, MAML1, JAG2, CRKL, MYOC, SPEN, NDUFV2, NDUFV1, SEC24C, PCMT1, PSMB1, TJP1, SIN3A, PLAUR, NOTCH1, SMAD1, EGFL7, ANKRD28, LATS2, ASB14, ANKRD44, RABGGTB, ZFP41, EEF2, MLLT4, ATP2A2, CDC42, MSN, RDX, PDIA6, CST6, EPSTI1, FAM84B, IL13RA2, IL24, ITIH5, KLK5, MTA3, PSMC3IP, ST14, TMEM17, FBXL17, CDH1, VASN, LRRIQ1, AGRP |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTGFRN_NOTCH2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PTGFRN_NOTCH2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | NOTCH2 | C0917715 | Hajdu-Cheney Syndrome | 2 | CTD_human;ORPHANET |
Tgene | NOTCH2 | C0004114 | Astrocytoma | 1 | CTD_human |
Tgene | NOTCH2 | C0007873 | Uterine Cervical Neoplasm | 1 | CTD_human |
Tgene | NOTCH2 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Tgene | NOTCH2 | C0017636 | Glioblastoma | 1 | CTD_human |
Tgene | NOTCH2 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | NOTCH2 | C0206663 | Neuroectodermal Tumor, Primitive | 1 | CTD_human |
Tgene | NOTCH2 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Tgene | NOTCH2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | NOTCH2 | C1857761 | Alagille Syndrome 2 | 1 | ORPHANET;UNIPROT |