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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 29276

FusionGeneSummary for PTCH1_IPPK

check button Fusion gene summary
Fusion gene informationFusion gene name: PTCH1_IPPK
Fusion gene ID: 29276
HgeneTgene
Gene symbol

PTCH1

IPPK

Gene ID

5727

64768

Gene namepatched 1inositol-pentakisphosphate 2-kinase
SynonymsBCNS|NBCCS|PTC|PTC1|PTCHC9orf12|INSP5K2|IP5K|IPK1|bA476B13.1
Cytomap

9q22.32

9q22.31

Type of geneprotein-codingprotein-coding
Descriptionprotein patched homolog 1inositol-pentakisphosphate 2-kinaseIPK1 homologbA476B13.1 (novel protein)inositol 1,3,4,5,6-pentakisphosphate 2-kinaseins(1,3,4,5,6)P5 2-kinaseinsP5 2-kinase
Modification date2018052320180523
UniProtAcc

Q13635

Q9H8X2

Ensembl transtripts involved in fusion geneENST00000331920, ENST00000418258, 
ENST00000421141, ENST00000437951, 
ENST00000430669, ENST00000429896, 
ENST00000375274, ENST00000548379, 
ENST00000468211, 		ENST00000287996, 
ENST00000486841, ENST00000375522, 
Fusion gene scores* DoF score5 X 5 X 3=754 X 4 X 4=64
# samples 54
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTCH1 [Title/Abstract] AND IPPK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTCH1

GO:0010875

positive regulation of cholesterol efflux

21931618

HgenePTCH1

GO:0072659

protein localization to plasma membrane

11278759

TgeneIPPK

GO:0052746

inositol phosphorylation

12084730


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A1KZ-01APTCH1chr9

98268689

-IPPKchr9

95381847

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000331920ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000331920ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000331920ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-3CDSENST00000418258ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-5UTRENST00000418258ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-5UTRENST00000418258ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-3CDSENST00000421141ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-5UTRENST00000421141ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-5UTRENST00000421141ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
In-frameENST00000437951ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000437951ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000437951ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
Frame-shiftENST00000430669ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000430669ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000430669ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-3CDSENST00000429896ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-5UTRENST00000429896ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
5UTR-5UTRENST00000429896ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
In-frameENST00000375274ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000375274ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000375274ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
intron-3CDSENST00000548379ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
intron-5UTRENST00000548379ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
intron-5UTRENST00000548379ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-
Frame-shiftENST00000468211ENST00000287996PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000468211ENST00000486841PTCH1chr9

98268689

-IPPKchr9

95381847

-
5CDS-5UTRENST00000468211ENST00000375522PTCH1chr9

98268689

-IPPKchr9

95381847

-

Top

FusionProtFeatures for PTCH1_IPPK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTCH1

Q13635

IPPK

Q9H8X2

Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to formIns(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in manyprocesses such as mRNA export, non-homologous end-joining,endocytosis, ion channel regulation. It also protects cells fromTNF-alpha-induced apoptosis. {ECO:0000269|PubMed:12084730,ECO:0000269|PubMed:15967797}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-22414_311312534Compositional biasNote=Gly-rich
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-22414_311301526Compositional biasNote=Gly-rich
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-22314_31651382Compositional biasNote=Gly-rich
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-22414_31652468Compositional biasNote=Gly-rich
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-2514_3165184Compositional biasNote=Gly-rich
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241_1001312534Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241_1001301526Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224101_1211312534TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224101_1211301526TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-22414_31-202461Compositional biasNote=Gly-rich
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-22414_31-202513Compositional biasNote=Gly-rich
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-22414_31-202093Compositional biasNote=Gly-rich
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224438_5981312534DomainSSD
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224438_5981301526DomainSSD
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224438_598-202461DomainSSD
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224438_598-202513DomainSSD
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224438_598-202093DomainSSD
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223438_598651382DomainSSD
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224438_598652468DomainSSD
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25438_59865184DomainSSD
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241049_10551312534Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241077_10831312534Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241105_11211312534Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241142_11541312534Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241176_14471312534Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224122_4361312534Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224458_4721312534Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224494_5011312534Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224523_5471312534Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224569_5771312534Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224599_7481312534Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224770_10271312534Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241049_10551301526Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241077_10831301526Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241105_11211301526Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241142_11541301526Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241176_14471301526Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224122_4361301526Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224458_4721301526Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224494_5011301526Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224523_5471301526Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224569_5771301526Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224599_7481301526Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224770_10271301526Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241049_1055-202461Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241077_1083-202461Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241105_1121-202461Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241142_1154-202461Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241176_1447-202461Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224122_436-202461Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241_100-202461Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224458_472-202461Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224494_501-202461Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224523_547-202461Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224569_577-202461Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224599_748-202461Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224770_1027-202461Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241049_1055-202513Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241077_1083-202513Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241105_1121-202513Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241142_1154-202513Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241176_1447-202513Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224122_436-202513Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241_100-202513Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224458_472-202513Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224494_501-202513Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224523_547-202513Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224569_577-202513Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224599_748-202513Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224770_1027-202513Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241049_1055-202093Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241077_1083-202093Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241105_1121-202093Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241142_1154-202093Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241176_1447-202093Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224122_436-202093Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241_100-202093Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224458_472-202093Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224494_501-202093Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224523_547-202093Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224569_577-202093Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224599_748-202093Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224770_1027-202093Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231049_1055651382Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231077_1083651382Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231105_1121651382Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231142_1154651382Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231176_1447651382Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223122_436651382Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231_100651382Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223458_472651382Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223494_501651382Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223523_547651382Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223569_577651382Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223599_748651382Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223770_1027651382Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241049_1055652468Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241077_1083652468Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241105_1121652468Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241142_1154652468Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241176_1447652468Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224122_436652468Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241_100652468Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224458_472652468Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224494_501652468Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224523_547652468Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224569_577652468Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224599_748652468Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224770_1027652468Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251049_105565184Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251077_108365184Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251105_112165184Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251142_115465184Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251176_144765184Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25122_43665184Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251_10065184Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25458_47265184Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25494_50165184Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25523_54765184Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25569_57765184Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25599_74865184Topological domainCytoplasmic
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25770_102765184Topological domainExtracellular
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241028_10481312534TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241056_10761312534TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241084_11041312534TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241122_11411312534TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-2241155_11751312534TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224437_4571312534TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224473_4931312534TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224502_5221312534TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224548_5681312534TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224578_5981312534TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000331920-224749_7691312534TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241028_10481301526TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241056_10761301526TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241084_11041301526TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241122_11411301526TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-2241155_11751301526TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224437_4571301526TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224473_4931301526TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224502_5221301526TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224548_5681301526TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224578_5981301526TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000375274-224749_7691301526TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224101_121-202461TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241028_1048-202461TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241056_1076-202461TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241084_1104-202461TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241122_1141-202461TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-2241155_1175-202461TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224437_457-202461TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224473_493-202461TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224502_522-202461TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224548_568-202461TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224578_598-202461TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000418258-224749_769-202461TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224101_121-202513TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241028_1048-202513TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241056_1076-202513TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241084_1104-202513TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241122_1141-202513TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-2241155_1175-202513TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224437_457-202513TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224473_493-202513TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224502_522-202513TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224548_568-202513TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224578_598-202513TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000421141-224749_769-202513TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224101_121-202093TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241028_1048-202093TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241056_1076-202093TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241084_1104-202093TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241122_1141-202093TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-2241155_1175-202093TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224437_457-202093TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224473_493-202093TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224502_522-202093TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224548_568-202093TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224578_598-202093TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000429896-224749_769-202093TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223101_121651382TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231028_1048651382TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231056_1076651382TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231084_1104651382TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231122_1141651382TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-2231155_1175651382TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223437_457651382TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223473_493651382TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223502_522651382TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223548_568651382TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223578_598651382TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000430669-223749_769651382TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224101_121652468TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241028_1048652468TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241056_1076652468TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241084_1104652468TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241122_1141652468TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-2241155_1175652468TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224437_457652468TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224473_493652468TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224502_522652468TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224548_568652468TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224578_598652468TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000437951-224749_769652468TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25101_12165184TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251028_104865184TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251056_107665184TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251084_110465184TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251122_114165184TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-251155_117565184TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25437_45765184TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25473_49365184TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25502_52265184TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25548_56865184TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25578_59865184TransmembraneHelical
HgenePTCH1chr9:98268689chr9:95381847ENST00000468211-25749_76965184TransmembraneHelical
TgeneIPPKchr9:98268689chr9:95381847ENST00000287996-1013136_140390492MotifNote=EXKPK motif


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FusionGeneSequence for PTCH1_IPPK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PTCH1_ENST00000331920_chr9_98268689_-_IPPK_ENST00000287996_chr9_95381847_-_233aa
MASAGNAAEPQDRGGGGSGCIGAPGRPAGGGRRRRTGGLRRAAAPDRDYLHRPSYCDAAFALEQISKGKATGRKAPLWLRAKFQRLLFKL
GCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEGAAVPRRHDCQGLLHHDCTVSLSAGCQLXSKACRPFIEVQVCLFRVCAG

>In-frame_PTCH1_ENST00000437951_chr9_98268689_-_IPPK_ENST00000287996_chr9_95381847_-_167aa
MGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEGAAVPRRHDCQGLLHHDCTVSLSAG

>In-frame_PTCH1_ENST00000375274_chr9_98268689_-_IPPK_ENST00000287996_chr9_95381847_-_232aa
MELLNRNRLVIVSPRCTPPKASGGPARRGFYTFRSFCKDGGGGEEEEENGGEEKDDRGDKETRSDKGKATGRKAPLWLRAKFQRLLFKLG
CYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEGAAVPRRHDCQGLLHHDCTVSLSAGCQLXSKACRPFIEVQVCLFRVCAGP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PTCH1_ENST00000331920_chr9_98268689_-_IPPK_ENST00000287996_chr9_95381847_-_700nt
ATGGCCTCGGCTGGTAACGCCGCCGAGCCCCAGGACCGCGGCGGCGGCGGCAGCGGCTGTATCGGTGCCCCGGGACGGCCGGCTGGAGGC
GGGAGGCGCAGACGGACGGGGGGGCTGCGCCGTGCTGCCGCGCCGGACCGGGACTATCTGCACCGGCCCAGCTACTGCGACGCCGCCTTC
GCTCTGGAGCAGATTTCCAAGGGGAAGGCTACTGGCCGGAAAGCGCCGCTGTGGCTGAGAGCGAAGTTTCAGAGACTCTTATTTAAACTG
GGTTGTTACATTCAAAAAAACTGCGGCAAGTTCTTGGTTGTGGGCCTCCTCATATTTGGGGCCTTCGCGGTGGGATTAAAAGCAGCGAAC
CTCGAGACCAACGTGGAGGAGCTGTGGGTGGAAGGTGCAGCAGTACCGCGTCGCCATGACTGCCAAGGACTGCTCCATCATGATTGCACT
GTCTCCCTGTCTGCAGGATGCCAGCTCTGATCAAAGGCCTGTCGTCCCTTCATCGAGGTCCAGGTTTGCCTTTTCCGTGTCTGTGCTGGA
CCTTGACCTCAAGCCCTACGAGAGCATTCCCCATCAGTATAAACTGGACGGCAAGATCGTCAACTATTATTCAAAGACTGTACGTGCCAA

>In-frame_PTCH1_ENST00000437951_chr9_98268689_-_IPPK_ENST00000287996_chr9_95381847_-_502nt
ATGGGGAAGGCTACTGGCCGGAAAGCGCCGCTGTGGCTGAGAGCGAAGTTTCAGAGACTCTTATTTAAACTGGGTTGTTACATTCAAAAA
AACTGCGGCAAGTTCTTGGTTGTGGGCCTCCTCATATTTGGGGCCTTCGCGGTGGGATTAAAAGCAGCGAACCTCGAGACCAACGTGGAG
GAGCTGTGGGTGGAAGGTGCAGCAGTACCGCGTCGCCATGACTGCCAAGGACTGCTCCATCATGATTGCACTGTCTCCCTGTCTGCAGGA
TGCCAGCTCTGATCAAAGGCCTGTCGTCCCTTCATCGAGGTCCAGGTTTGCCTTTTCCGTGTCTGTGCTGGACCTTGACCTCAAGCCCTA
CGAGAGCATTCCCCATCAGTATAAACTGGACGGCAAGATCGTCAACTATTATTCAAAGACTGTACGTGCCAAAGACAACGCCGTGATGTC

>In-frame_PTCH1_ENST00000375274_chr9_98268689_-_IPPK_ENST00000287996_chr9_95381847_-_697nt
ATGGAACTGCTTAATAGAAACAGGCTTGTAATTGTGAGTCCGCGCTGCACTCCGCCGAAAGCCTCCGGCGGCCCAGCGCGCCGGGGTTTT
TACACTTTCCGTTCCTTTTGTAAAGACGGAGGAGGAGGAGAAGAAGAAGAAGAAAACGGAGGAGAAGAAAAAGACGACAGGGGAGACAAA
GAGACCCGCAGCGACAAGGGGAAGGCTACTGGCCGGAAAGCGCCGCTGTGGCTGAGAGCGAAGTTTCAGAGACTCTTATTTAAACTGGGT
TGTTACATTCAAAAAAACTGCGGCAAGTTCTTGGTTGTGGGCCTCCTCATATTTGGGGCCTTCGCGGTGGGATTAAAAGCAGCGAACCTC
GAGACCAACGTGGAGGAGCTGTGGGTGGAAGGTGCAGCAGTACCGCGTCGCCATGACTGCCAAGGACTGCTCCATCATGATTGCACTGTC
TCCCTGTCTGCAGGATGCCAGCTCTGATCAAAGGCCTGTCGTCCCTTCATCGAGGTCCAGGTTTGCCTTTTCCGTGTCTGTGCTGGACCT
TGACCTCAAGCCCTACGAGAGCATTCCCCATCAGTATAAACTGGACGGCAAGATCGTCAACTATTATTCAAAGACTGTACGTGCCAAAGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_PTCH1_ENST00000331920_chr9_98268689_-_IPPK_ENST00000287996_chr9_95381847_-_3648nt
GAACTGGATGTGGGCAGCGGCGGCCGCAGAGACCTCGGGACCCCCGCGCAATGTGGCAATGGAAGGCGCAGGGTCTGACTCCCCGGCAGC
GGCCGCGGCCGCAGCGGCAGCAGCGCCCGCCGTGTGAGCAGCAGCAGCGGCTGGTCTGTCAACCGGAGCCCGAGCCCGAGCAGCCTGCGG
CCAGCAGCGTCCTCGCAAGCCGAGCGCCCAGGCGCGCCAGGAGCCCGCAGCAGCGGCAGCAGCGCGCCGGGCCGCCCGGGAAGCCTCCGT
CCCCGCGGCGGCGGCGGCGGCGGCGGCAACATGGCCTCGGCTGGTAACGCCGCCGAGCCCCAGGACCGCGGCGGCGGCGGCAGCGGCTGT
ATCGGTGCCCCGGGACGGCCGGCTGGAGGCGGGAGGCGCAGACGGACGGGGGGGCTGCGCCGTGCTGCCGCGCCGGACCGGGACTATCTG
CACCGGCCCAGCTACTGCGACGCCGCCTTCGCTCTGGAGCAGATTTCCAAGGGGAAGGCTACTGGCCGGAAAGCGCCGCTGTGGCTGAGA
GCGAAGTTTCAGAGACTCTTATTTAAACTGGGTTGTTACATTCAAAAAAACTGCGGCAAGTTCTTGGTTGTGGGCCTCCTCATATTTGGG
GCCTTCGCGGTGGGATTAAAAGCAGCGAACCTCGAGACCAACGTGGAGGAGCTGTGGGTGGAAGGTGCAGCAGTACCGCGTCGCCATGAC
TGCCAAGGACTGCTCCATCATGATTGCACTGTCTCCCTGTCTGCAGGATGCCAGCTCTGATCAAAGGCCTGTCGTCCCTTCATCGAGGTC
CAGGTTTGCCTTTTCCGTGTCTGTGCTGGACCTTGACCTCAAGCCCTACGAGAGCATTCCCCATCAGTATAAACTGGACGGCAAGATCGT
CAACTATTATTCAAAGACTGTACGTGCCAAAGACAACGCCGTGATGTCGACTCGGTTCAAGGAAAGCGAAGATTGCACATTAGTTCTCCA
CAAGGTCTAACTCTTTCCCTGCAGTGTCTTTGAAACTTGAACATAATGTGAAGGCTGAATGATAGAGATATTTTCTGTTGTGTTGGGTGA
CCTTTGGTTGTGAATGTTTTTGCTTTTAACCCCTTTTGAGGTGGGATTGCCTCTTGGAGACATGGAATTGAAGAGCACTAGAAACAACTT
CCTGGACAAGGAATGTAGGAAGTGAGTGCTGTGTCCCAGGAAGCTGCTCACACTCTTAAAATGGAAGTGTCCGTTAAGCCCTGGGAAGAC
GTTCTGGATAGTTCTTCTTTCCCAACCAGGGCTCATGTCTGATTCTCTAATGCGAAAAGCCTTATTCTAAGACCCAAGGTTTGGATCTGC
TACCACCAGACTCCTAACATAGAAAACTTGAATTGTCACATACATTTTACAGTTTGGACTTTTAAGAAAACATGGATACTACTGGAACTT
CCCCCAGCTGAGTTACATGGTCACTTTTTCAGTGCAAGCCACATATCAACACAGGTTTTTAGGTGGTTCCCTGCTGCACAGCGTGACCTC
GTGGTCGCGCAGATGCCGATTCTGAGCAGTGTAGACTCAGGGTCCCTGTGGAGGTGCTGAAGCCCACAGTTCCACACAGGGCAGCAGGGA
GCGCAAGGCTCAGGTCAGGATGGACACCACTCATGCGAGCATTGACCTTTTTTTTTTTGCTTTACAATTTAATCTTTCACATGAGGGGGA
GATGAGCTGTTCTTTCCCACTAAAAATTGCTGCTGTAGAAGTTGGAGGTGGAGCTGTGACTGGCTGAGCTGCTGTGGCCGGGCTGGGCAG
TGTGCCCCAACAGCTCAGTGCTTTCCTGACACTCCAGTGTCTGGGGTGGTTGAGGAGCGAGTTCTCTCTTCCTCCCAGACCAAGTTCCTC
CCTCGGGTTTGCCTTGAGACGTGTTGCGTTTTTGGGCCCCGTGGCCTCTCCCTGTTAGGCTGCCACAGGCCCTGCTTCTGGAAGGTGAAC
AGCTCCTGGCTGCTGCCGAGAGGGTTCTCGTTGGGGTCACCAAAGTGTGCCCGGCTGCTATGAAAAACGTTGGGAATCTTGGTTTCAGTT
TTTTATTCTATGCTAGGTTGTACAGACTTATTTATATCATCGTTTTGAGGGACTAATGGAGGCTTATTGTAACATATAATATTAGTGAAA
CCATGGAATTATATGAAAATGATACATGAGAAATAAGGAAACTATTTTGCTGATTGTAAATTTTTGTGGGAAATTTTGTGATAACTTGAG
AATTATACTTGTTTGAATCAAGGCAACTCTTCTAGAATTTATTGTTCAATTCTGTCATATTTACTTCTAATTCTACTCTCAGAGGTGCAA
AAAGATACTTATCTAACTGGACACTTTTACTGTTTTCTTCTCACTTCCAATGACACCGTCTCATACACACGGGTCCTGTGTGCTGGGATG
GGGGCTTTGGTGAAGTGCACGGAGCTCACGGACAAGCCGCAGGCTCTGGGAAGCGTGGAGGTAGTGGCCGTTGAGTACTGTCTTGACCCA
AGGGAGTTCACTGTTGCTGGGCTGGGGCTGGGGCAGCCTGGTTTGGGATGATTTTGCCCATTGTCACGGTGTGTGGAGGATGCTGGGTCC
TGGGTTCAAGTGCACATGTGAGGGAACCCCAGTCCGTGGGAAGGTGGGCTGGGCTCCCTAGGTCCTTCAGGGCTGCAAGAGTTATTGCCT
AGCACAGGGCCCAGACAGGGCTGGACTAGACACGATGAAAACAGCCTGTATTTGAGGGAGAAGAGAAAACAGATGGAGACCCCCACTCTG
TCTGGTCTTGGCTCCCACCAGCCCGGGCTGTGAGGAGCCCCTGAGCCGCGGGTGCCACTGCTGTGGATGCGTTTCTGGCCCGTCTTGGAA
ACTGCTGCTGCTGCGTAGTCATGACGGCCCTGACTGGTTTGAGACAACACGCGTTCACAGATCTTAACAATGCTAAATGGGCGACTGATG
AGGTCACGGTTCTTAAGGCACATCCGGGACGATCGATATAGCACTTAGGCTATGCAGGGGGGTCTTTCTTTCATAAAGGACCTCATTCCT
TGCGTCCCAGCCCAGGAACAGTGCTGTCTTTGCTGTCTTAGGCCATTCTTGTTATTAAGCTGACAGCTTCACTTTCTTGTGGAAGACCAA
GAACAGCATGAGGACTTGCTGAGACTGCCTCACGGTGCCACCATGCGGACCGGGGGGAGGCAGGGAGTGAGGGTGTGGCTCCCCTGGGCT
ACTAAGGACAGTTTAAAGATGAGGCGCCATAGGCATCCGTCTCCAGAGCCCCCAGGAGGCAGGAACCAGGATAAGGGTGGCTTCTCCCAG
CTGAGTAATGTGGCCACCATGTCCAAGGTGGACTCGGTGTGAGGCTGCAGTGGGTGGGGGATGGATCCTCCCCACACATCTGAGGACACA
CAACCACTTGGTACATTTTCTCAGATGTTAAGCTTATTTTTATAAACCACATTGTACGTGTCACTTTTATTTGGCATTTTATACTTAACT
AGTTGTATTTATTTTTCATGTCATGAGAGTTTCCATATAATGTGCCATAACTGCATAGACAGCACGTCTTCAGGGTGTGGTTTCTAAGCA

>In-frame_PTCH1_ENST00000437951_chr9_98268689_-_IPPK_ENST00000287996_chr9_95381847_-_3644nt
ACCCAGGAGGGCTGTGCTGATAGCACGTTCCTCGAGTTTACTTTGCTTTCCTTGAGTTTATTGTAAAGGGGTAAAGTTTTCGGATCCGTC
ACGTGACCCTGACAGGTCCTGCCTATGGCGCGGCAGACCACCCACGCCGAGGGCCATGGAACTGCTTAATAGAAACAGGCTTGTAATTGT
GAGTCCGCGCTGCACTCCGCCGAAAGCCTCCGGCGGCCCAGCGCGCCGGGGTTTTTACACTTTCCGTTCCTTTTGTAAAGACGGAGGAGG
AGGAGAAGAAGAAGAAGAAAACGGAGGAGAAGAAAAAGACGACAGGGGAGACAAAGAGACCCGCAGCGACAAGGCAAGGGGGAGACGAGG
GAAGACTGGGAGAAGACGGAGGAGCGGAGGACGAGGAAAGGGGGGCCAGGGAAAAAAAAGGAATTGATGTGAAATCCAAGCCCAGCGTCC
GCGCCATCGGCACCCGCGCTCCGAGCAGGGGTTGACGGCCGGCTATGGGGAAGGCTACTGGCCGGAAAGCGCCGCTGTGGCTGAGAGCGA
AGTTTCAGAGACTCTTATTTAAACTGGGTTGTTACATTCAAAAAAACTGCGGCAAGTTCTTGGTTGTGGGCCTCCTCATATTTGGGGCCT
TCGCGGTGGGATTAAAAGCAGCGAACCTCGAGACCAACGTGGAGGAGCTGTGGGTGGAAGGTGCAGCAGTACCGCGTCGCCATGACTGCC
AAGGACTGCTCCATCATGATTGCACTGTCTCCCTGTCTGCAGGATGCCAGCTCTGATCAAAGGCCTGTCGTCCCTTCATCGAGGTCCAGG
TTTGCCTTTTCCGTGTCTGTGCTGGACCTTGACCTCAAGCCCTACGAGAGCATTCCCCATCAGTATAAACTGGACGGCAAGATCGTCAAC
TATTATTCAAAGACTGTACGTGCCAAAGACAACGCCGTGATGTCGACTCGGTTCAAGGAAAGCGAAGATTGCACATTAGTTCTCCACAAG
GTCTAACTCTTTCCCTGCAGTGTCTTTGAAACTTGAACATAATGTGAAGGCTGAATGATAGAGATATTTTCTGTTGTGTTGGGTGACCTT
TGGTTGTGAATGTTTTTGCTTTTAACCCCTTTTGAGGTGGGATTGCCTCTTGGAGACATGGAATTGAAGAGCACTAGAAACAACTTCCTG
GACAAGGAATGTAGGAAGTGAGTGCTGTGTCCCAGGAAGCTGCTCACACTCTTAAAATGGAAGTGTCCGTTAAGCCCTGGGAAGACGTTC
TGGATAGTTCTTCTTTCCCAACCAGGGCTCATGTCTGATTCTCTAATGCGAAAAGCCTTATTCTAAGACCCAAGGTTTGGATCTGCTACC
ACCAGACTCCTAACATAGAAAACTTGAATTGTCACATACATTTTACAGTTTGGACTTTTAAGAAAACATGGATACTACTGGAACTTCCCC
CAGCTGAGTTACATGGTCACTTTTTCAGTGCAAGCCACATATCAACACAGGTTTTTAGGTGGTTCCCTGCTGCACAGCGTGACCTCGTGG
TCGCGCAGATGCCGATTCTGAGCAGTGTAGACTCAGGGTCCCTGTGGAGGTGCTGAAGCCCACAGTTCCACACAGGGCAGCAGGGAGCGC
AAGGCTCAGGTCAGGATGGACACCACTCATGCGAGCATTGACCTTTTTTTTTTTGCTTTACAATTTAATCTTTCACATGAGGGGGAGATG
AGCTGTTCTTTCCCACTAAAAATTGCTGCTGTAGAAGTTGGAGGTGGAGCTGTGACTGGCTGAGCTGCTGTGGCCGGGCTGGGCAGTGTG
CCCCAACAGCTCAGTGCTTTCCTGACACTCCAGTGTCTGGGGTGGTTGAGGAGCGAGTTCTCTCTTCCTCCCAGACCAAGTTCCTCCCTC
GGGTTTGCCTTGAGACGTGTTGCGTTTTTGGGCCCCGTGGCCTCTCCCTGTTAGGCTGCCACAGGCCCTGCTTCTGGAAGGTGAACAGCT
CCTGGCTGCTGCCGAGAGGGTTCTCGTTGGGGTCACCAAAGTGTGCCCGGCTGCTATGAAAAACGTTGGGAATCTTGGTTTCAGTTTTTT
ATTCTATGCTAGGTTGTACAGACTTATTTATATCATCGTTTTGAGGGACTAATGGAGGCTTATTGTAACATATAATATTAGTGAAACCAT
GGAATTATATGAAAATGATACATGAGAAATAAGGAAACTATTTTGCTGATTGTAAATTTTTGTGGGAAATTTTGTGATAACTTGAGAATT
ATACTTGTTTGAATCAAGGCAACTCTTCTAGAATTTATTGTTCAATTCTGTCATATTTACTTCTAATTCTACTCTCAGAGGTGCAAAAAG
ATACTTATCTAACTGGACACTTTTACTGTTTTCTTCTCACTTCCAATGACACCGTCTCATACACACGGGTCCTGTGTGCTGGGATGGGGG
CTTTGGTGAAGTGCACGGAGCTCACGGACAAGCCGCAGGCTCTGGGAAGCGTGGAGGTAGTGGCCGTTGAGTACTGTCTTGACCCAAGGG
AGTTCACTGTTGCTGGGCTGGGGCTGGGGCAGCCTGGTTTGGGATGATTTTGCCCATTGTCACGGTGTGTGGAGGATGCTGGGTCCTGGG
TTCAAGTGCACATGTGAGGGAACCCCAGTCCGTGGGAAGGTGGGCTGGGCTCCCTAGGTCCTTCAGGGCTGCAAGAGTTATTGCCTAGCA
CAGGGCCCAGACAGGGCTGGACTAGACACGATGAAAACAGCCTGTATTTGAGGGAGAAGAGAAAACAGATGGAGACCCCCACTCTGTCTG
GTCTTGGCTCCCACCAGCCCGGGCTGTGAGGAGCCCCTGAGCCGCGGGTGCCACTGCTGTGGATGCGTTTCTGGCCCGTCTTGGAAACTG
CTGCTGCTGCGTAGTCATGACGGCCCTGACTGGTTTGAGACAACACGCGTTCACAGATCTTAACAATGCTAAATGGGCGACTGATGAGGT
CACGGTTCTTAAGGCACATCCGGGACGATCGATATAGCACTTAGGCTATGCAGGGGGGTCTTTCTTTCATAAAGGACCTCATTCCTTGCG
TCCCAGCCCAGGAACAGTGCTGTCTTTGCTGTCTTAGGCCATTCTTGTTATTAAGCTGACAGCTTCACTTTCTTGTGGAAGACCAAGAAC
AGCATGAGGACTTGCTGAGACTGCCTCACGGTGCCACCATGCGGACCGGGGGGAGGCAGGGAGTGAGGGTGTGGCTCCCCTGGGCTACTA
AGGACAGTTTAAAGATGAGGCGCCATAGGCATCCGTCTCCAGAGCCCCCAGGAGGCAGGAACCAGGATAAGGGTGGCTTCTCCCAGCTGA
GTAATGTGGCCACCATGTCCAAGGTGGACTCGGTGTGAGGCTGCAGTGGGTGGGGGATGGATCCTCCCCACACATCTGAGGACACACAAC
CACTTGGTACATTTTCTCAGATGTTAAGCTTATTTTTATAAACCACATTGTACGTGTCACTTTTATTTGGCATTTTATACTTAACTAGTT
GTATTTATTTTTCATGTCATGAGAGTTTCCATATAATGTGCCATAACTGCATAGACAGCACGTCTTCAGGGTGTGGTTTCTAAGCAGAAA

>In-frame_PTCH1_ENST00000375274_chr9_98268689_-_IPPK_ENST00000287996_chr9_95381847_-_3490nt
ACCCAGGAGGGCTGTGCTGATAGCACGTTCCTCGAGTTTACTTTGCTTTCCTTGAGTTTATTGTAAAGGGGTAAAGTTTTCGGATCCGTC
ACGTGACCCTGACAGGTCCTGCCTATGGCGCGGCAGACCACCCACGCCGAGGGCCATGGAACTGCTTAATAGAAACAGGCTTGTAATTGT
GAGTCCGCGCTGCACTCCGCCGAAAGCCTCCGGCGGCCCAGCGCGCCGGGGTTTTTACACTTTCCGTTCCTTTTGTAAAGACGGAGGAGG
AGGAGAAGAAGAAGAAGAAAACGGAGGAGAAGAAAAAGACGACAGGGGAGACAAAGAGACCCGCAGCGACAAGGGGAAGGCTACTGGCCG
GAAAGCGCCGCTGTGGCTGAGAGCGAAGTTTCAGAGACTCTTATTTAAACTGGGTTGTTACATTCAAAAAAACTGCGGCAAGTTCTTGGT
TGTGGGCCTCCTCATATTTGGGGCCTTCGCGGTGGGATTAAAAGCAGCGAACCTCGAGACCAACGTGGAGGAGCTGTGGGTGGAAGGTGC
AGCAGTACCGCGTCGCCATGACTGCCAAGGACTGCTCCATCATGATTGCACTGTCTCCCTGTCTGCAGGATGCCAGCTCTGATCAAAGGC
CTGTCGTCCCTTCATCGAGGTCCAGGTTTGCCTTTTCCGTGTCTGTGCTGGACCTTGACCTCAAGCCCTACGAGAGCATTCCCCATCAGT
ATAAACTGGACGGCAAGATCGTCAACTATTATTCAAAGACTGTACGTGCCAAAGACAACGCCGTGATGTCGACTCGGTTCAAGGAAAGCG
AAGATTGCACATTAGTTCTCCACAAGGTCTAACTCTTTCCCTGCAGTGTCTTTGAAACTTGAACATAATGTGAAGGCTGAATGATAGAGA
TATTTTCTGTTGTGTTGGGTGACCTTTGGTTGTGAATGTTTTTGCTTTTAACCCCTTTTGAGGTGGGATTGCCTCTTGGAGACATGGAAT
TGAAGAGCACTAGAAACAACTTCCTGGACAAGGAATGTAGGAAGTGAGTGCTGTGTCCCAGGAAGCTGCTCACACTCTTAAAATGGAAGT
GTCCGTTAAGCCCTGGGAAGACGTTCTGGATAGTTCTTCTTTCCCAACCAGGGCTCATGTCTGATTCTCTAATGCGAAAAGCCTTATTCT
AAGACCCAAGGTTTGGATCTGCTACCACCAGACTCCTAACATAGAAAACTTGAATTGTCACATACATTTTACAGTTTGGACTTTTAAGAA
AACATGGATACTACTGGAACTTCCCCCAGCTGAGTTACATGGTCACTTTTTCAGTGCAAGCCACATATCAACACAGGTTTTTAGGTGGTT
CCCTGCTGCACAGCGTGACCTCGTGGTCGCGCAGATGCCGATTCTGAGCAGTGTAGACTCAGGGTCCCTGTGGAGGTGCTGAAGCCCACA
GTTCCACACAGGGCAGCAGGGAGCGCAAGGCTCAGGTCAGGATGGACACCACTCATGCGAGCATTGACCTTTTTTTTTTTGCTTTACAAT
TTAATCTTTCACATGAGGGGGAGATGAGCTGTTCTTTCCCACTAAAAATTGCTGCTGTAGAAGTTGGAGGTGGAGCTGTGACTGGCTGAG
CTGCTGTGGCCGGGCTGGGCAGTGTGCCCCAACAGCTCAGTGCTTTCCTGACACTCCAGTGTCTGGGGTGGTTGAGGAGCGAGTTCTCTC
TTCCTCCCAGACCAAGTTCCTCCCTCGGGTTTGCCTTGAGACGTGTTGCGTTTTTGGGCCCCGTGGCCTCTCCCTGTTAGGCTGCCACAG
GCCCTGCTTCTGGAAGGTGAACAGCTCCTGGCTGCTGCCGAGAGGGTTCTCGTTGGGGTCACCAAAGTGTGCCCGGCTGCTATGAAAAAC
GTTGGGAATCTTGGTTTCAGTTTTTTATTCTATGCTAGGTTGTACAGACTTATTTATATCATCGTTTTGAGGGACTAATGGAGGCTTATT
GTAACATATAATATTAGTGAAACCATGGAATTATATGAAAATGATACATGAGAAATAAGGAAACTATTTTGCTGATTGTAAATTTTTGTG
GGAAATTTTGTGATAACTTGAGAATTATACTTGTTTGAATCAAGGCAACTCTTCTAGAATTTATTGTTCAATTCTGTCATATTTACTTCT
AATTCTACTCTCAGAGGTGCAAAAAGATACTTATCTAACTGGACACTTTTACTGTTTTCTTCTCACTTCCAATGACACCGTCTCATACAC
ACGGGTCCTGTGTGCTGGGATGGGGGCTTTGGTGAAGTGCACGGAGCTCACGGACAAGCCGCAGGCTCTGGGAAGCGTGGAGGTAGTGGC
CGTTGAGTACTGTCTTGACCCAAGGGAGTTCACTGTTGCTGGGCTGGGGCTGGGGCAGCCTGGTTTGGGATGATTTTGCCCATTGTCACG
GTGTGTGGAGGATGCTGGGTCCTGGGTTCAAGTGCACATGTGAGGGAACCCCAGTCCGTGGGAAGGTGGGCTGGGCTCCCTAGGTCCTTC
AGGGCTGCAAGAGTTATTGCCTAGCACAGGGCCCAGACAGGGCTGGACTAGACACGATGAAAACAGCCTGTATTTGAGGGAGAAGAGAAA
ACAGATGGAGACCCCCACTCTGTCTGGTCTTGGCTCCCACCAGCCCGGGCTGTGAGGAGCCCCTGAGCCGCGGGTGCCACTGCTGTGGAT
GCGTTTCTGGCCCGTCTTGGAAACTGCTGCTGCTGCGTAGTCATGACGGCCCTGACTGGTTTGAGACAACACGCGTTCACAGATCTTAAC
AATGCTAAATGGGCGACTGATGAGGTCACGGTTCTTAAGGCACATCCGGGACGATCGATATAGCACTTAGGCTATGCAGGGGGGTCTTTC
TTTCATAAAGGACCTCATTCCTTGCGTCCCAGCCCAGGAACAGTGCTGTCTTTGCTGTCTTAGGCCATTCTTGTTATTAAGCTGACAGCT
TCACTTTCTTGTGGAAGACCAAGAACAGCATGAGGACTTGCTGAGACTGCCTCACGGTGCCACCATGCGGACCGGGGGGAGGCAGGGAGT
GAGGGTGTGGCTCCCCTGGGCTACTAAGGACAGTTTAAAGATGAGGCGCCATAGGCATCCGTCTCCAGAGCCCCCAGGAGGCAGGAACCA
GGATAAGGGTGGCTTCTCCCAGCTGAGTAATGTGGCCACCATGTCCAAGGTGGACTCGGTGTGAGGCTGCAGTGGGTGGGGGATGGATCC
TCCCCACACATCTGAGGACACACAACCACTTGGTACATTTTCTCAGATGTTAAGCTTATTTTTATAAACCACATTGTACGTGTCACTTTT
ATTTGGCATTTTATACTTAACTAGTTGTATTTATTTTTCATGTCATGAGAGTTTCCATATAATGTGCCATAACTGCATAGACAGCACGTC


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FusionGenePPI for PTCH1_IPPK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTCH1SMO, CAV1, ITCH, WWP2, NEDD4, NEDD4L, SMURF1, SMURF2, WWP1, CASP9, FHL2, CNTNAP3, B4GALT7, CACNA2D2, IMPAD1, SEMA6A, PLXNA1, TMEM132A, PAM, HLA-C, HLA-A, HSPA5, TMEM160, PLXNB2, NDST2, TPST2, CNNM4, CNNM1, POMGNT2, CHST14, SPPL2B, EXT1, ADAM17, ENPP1, DDX19B, TTC17, MUCL1, COCH, ASPH, TMEM131, EGFR, MOXD1, UGT8, ITGA7, HS6ST2, SLIT2, POMT2, B4GALT1, SULF2, ATF6B, CHST12, MAN2A1, ARSK, ITGA6, NETO2, CCPG1, ST3GAL6, CHSY1, CACNA2D1, UGT3A2, MGAT5, B4GALT3, PXYLP1, GCNT1, COL18A1, DHFRL1, TXNDC15, SEMA4F, B3GALTL, FUT11, TOR1AIP1, ABCA2, ST8SIA4, RNF130, ITGA8, ST3GAL4, ST6GALNAC3, ITGA4, CHPF, ENDOG, TMEM2, LRFN3, GALNT7, TGFBR3, MGAT1, PDF, KIAA1161, YAP1, GALNT18, CHST3, BTN2A1, NPTX1, ITGAV, ABHD14A, CCNB1IPPKCDK12, LPAR1, TYRO3, ENPP4, SELT, SLC9A1, SC5D, CERS4, CERS5, ATP2B3, TMEM87B, GPR50, CPLX4, ZDHHC17, ATP9A, ARL6IP1, ZDHHC18, COLEC12, ATP2B4, TESC, GPR137, GPRC5B, TMEM186, SNX13, LEMD3, CD97, SNX14, NDUFAF1, ECSIT, ADCY6, GOLGA5, FAM134C, CKAP4, SCAP, C4orf32, RTN2, FZD8, TMEM11, TMEM87A, RMND1, STX4, SERINC1, TMEM161B, ND2, CXCR4, CERS6, LMBR1, NDC1, STX8, MPZL1, SLC30A5, SLC7A3, TMEM223, REEP6, ZDHHC9, YIPF4, KIAA1715, FAM20B, SMAD5, FITM2, EXTL2, ARL10, OCIAD1, C10orf35, CSGALNACT2, EXTL3, PIGW, ITPR2, MBOAT7, GPRC5C, ACP2, VEZT, MRS2, STXBP3, MFSD8, PTPLB, GP1BB, KTN1, LPCAT3, LGALS3, VAMP3, GOLGB1, CD47, LRRC8A, PCDH19, KDSR, DAGLB, TSPAN15, GPR89A, TMEM63B, LPHN3, ARV1, LCLAT1, ZDHHC13, ACAD9, CERS2, GPR108, TTYH3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTCH1_IPPK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTCH1_IPPK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTCH1C0004779Basal Cell Nevus Syndrome13CTD_human;ORPHANET;UNIPROT
HgenePTCH1C0007117Basal cell carcinoma3CTD_human;HPO
HgenePTCH1C0025149Medulloblastoma3CTD_human;HPO
HgenePTCH1C1835820HOLOPROSENCEPHALY 73CTD_human;UNIPROT
HgenePTCH1C0376634Craniofacial Abnormalities2CTD_human
HgenePTCH1C0006118Brain Neoplasms1CTD_human
HgenePTCH1C0008924Cleft Lip1CTD_human;HPO
HgenePTCH1C0008925Cleft Palate1CTD_human;HPO
HgenePTCH1C0019693HIV Infections1CTD_human
HgenePTCH1C0030297Pancreatic Neoplasm1CTD_human
HgenePTCH1C0035412Rhabdomyosarcoma1CTD_human
HgenePTCH1C0037286Skin Neoplasms1CTD_human
HgenePTCH1C0206663Neuroectodermal Tumor, Primitive1CTD_human