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Fusion gene ID: 29267 |
FusionGeneSummary for PTBP1_UBE3C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTBP1_UBE3C | Fusion gene ID: 29267 | Hgene | Tgene | Gene symbol | PTBP1 | UBE3C | Gene ID | 5725 | 9690 |
| Gene name | polypyrimidine tract binding protein 1 | ubiquitin protein ligase E3C | |
| Synonyms | HNRNP-I|HNRNPI|HNRPI|PTB|PTB-1|PTB-T|PTB2|PTB3|PTB4|pPTB | HECTH2 | |
| Cytomap | 19p13.3 | 7q36.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | polypyrimidine tract-binding protein 157 kDa RNA-binding protein PPTB-1RNA-binding proteinheterogeneous nuclear ribonucleoprotein Iheterogeneous nuclear ribonucleoprotein polypeptide IhnRNP Ipolypyrimidine tract binding protein (heterogeneous nuclea | ubiquitin-protein ligase E3CHECT-type ubiquitin transferase E3Cubiquitin-protein isopeptide ligase (E3) | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P26599 | Q15386 | |
| Ensembl transtripts involved in fusion gene | ENST00000356948, ENST00000350092, ENST00000349038, ENST00000394601, | ENST00000348165, ENST00000389103, | |
| Fusion gene scores | * DoF score | 7 X 7 X 6=294 | 6 X 6 X 3=108 |
| # samples | 8 | 6 | |
| ** MAII score | log2(8/294*10)=-1.877744249949 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PTBP1 [Title/Abstract] AND UBE3C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PTBP1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 16260624|21518792 |
| Hgene | PTBP1 | GO:0033119 | negative regulation of RNA splicing | 18335065 |
| Hgene | PTBP1 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome | 15009664 |
| Hgene | PTBP1 | GO:0051148 | negative regulation of muscle cell differentiation | 21518792 |
| Tgene | UBE3C | GO:0000209 | protein polyubiquitination | 11278995 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-KK-A6E1-01A | PTBP1 | chr19 | 803636 | + | UBE3C | chr7 | 157009561 | + |
| TCGA | LD | PRAD | TCGA-KK-A6E1-01A | PTBP1 | chr19 | 804438 | + | UBE3C | chr7 | 157009561 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000356948 | ENST00000348165 | PTBP1 | chr19 | 803636 | + | UBE3C | chr7 | 157009561 | + |
| 5CDS-intron | ENST00000356948 | ENST00000389103 | PTBP1 | chr19 | 803636 | + | UBE3C | chr7 | 157009561 | + |
| intron-3CDS | ENST00000350092 | ENST00000348165 | PTBP1 | chr19 | 803636 | + | UBE3C | chr7 | 157009561 | + |
| intron-intron | ENST00000350092 | ENST00000389103 | PTBP1 | chr19 | 803636 | + | UBE3C | chr7 | 157009561 | + |
| Frame-shift | ENST00000349038 | ENST00000348165 | PTBP1 | chr19 | 803636 | + | UBE3C | chr7 | 157009561 | + |
| 5CDS-intron | ENST00000349038 | ENST00000389103 | PTBP1 | chr19 | 803636 | + | UBE3C | chr7 | 157009561 | + |
| Frame-shift | ENST00000394601 | ENST00000348165 | PTBP1 | chr19 | 803636 | + | UBE3C | chr7 | 157009561 | + |
| 5CDS-intron | ENST00000394601 | ENST00000389103 | PTBP1 | chr19 | 803636 | + | UBE3C | chr7 | 157009561 | + |
| In-frame | ENST00000356948 | ENST00000348165 | PTBP1 | chr19 | 804438 | + | UBE3C | chr7 | 157009561 | + |
| 5CDS-intron | ENST00000356948 | ENST00000389103 | PTBP1 | chr19 | 804438 | + | UBE3C | chr7 | 157009561 | + |
| intron-3CDS | ENST00000350092 | ENST00000348165 | PTBP1 | chr19 | 804438 | + | UBE3C | chr7 | 157009561 | + |
| intron-intron | ENST00000350092 | ENST00000389103 | PTBP1 | chr19 | 804438 | + | UBE3C | chr7 | 157009561 | + |
| In-frame | ENST00000349038 | ENST00000348165 | PTBP1 | chr19 | 804438 | + | UBE3C | chr7 | 157009561 | + |
| 5CDS-intron | ENST00000349038 | ENST00000389103 | PTBP1 | chr19 | 804438 | + | UBE3C | chr7 | 157009561 | + |
| In-frame | ENST00000394601 | ENST00000348165 | PTBP1 | chr19 | 804438 | + | UBE3C | chr7 | 157009561 | + |
| 5CDS-intron | ENST00000394601 | ENST00000389103 | PTBP1 | chr19 | 804438 | + | UBE3C | chr7 | 157009561 | + |
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FusionProtFeatures for PTBP1_UBE3C |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PTBP1 | UBE3C |
| Plays a role in pre-mRNA splicing and in the regulationof alternative splicing events. Activates exon skipping of its ownpre-mRNA during muscle cell differentiation. Binds to thepolypyrimidine tract of introns. May promote RNA looping whenbound to two separate polypyrimidine tracts in the same pre-mRNA.May promote the binding of U2 snRNP to pre-mRNA. Cooperates withRAVER1 to modulate switching between mutually exclusive exonsduring maturation of the TPM1 pre-mRNA. Represses the splicing ofMAPT/Tau exon 10 (PubMed:15009664). In case of infection bypicornaviruses, binds to the viral internal ribosome entry site(IRES) and stimulates the IRES-mediated translation(PubMed:21518806). {ECO:0000269|PubMed:11003644,ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:16179478,ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:21518792,ECO:0000269|PubMed:21518806}. | E3 ubiquitin-protein ligase that accepts ubiquitin fromthe E2 ubiquitin-conjugating enzyme UBE2D1 in the form of athioester and then directly transfers the ubiquitin to targetedsubstrates. Can assemble unanchored poly-ubiquitin chains ineither 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Haspreference for 'Lys-48' linkages. It can target itself forubiquitination in vitro and may promote its own degradation invivo. {ECO:0000269|PubMed:11278995, ECO:0000269|PubMed:12692129,ECO:0000269|PubMed:16341092, ECO:0000269|PubMed:16601690}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PTBP1 | chr19:804438 | chr7:157009561 | ENST00000349038 | + | 5 | 14 | 59_143 | 145 | 532 | Domain | RRM 1 |
| Hgene | PTBP1 | chr19:804438 | chr7:157009561 | ENST00000356948 | + | 5 | 15 | 59_143 | 145 | 558 | Domain | RRM 1 |
| Hgene | PTBP1 | chr19:804438 | chr7:157009561 | ENST00000394601 | + | 5 | 15 | 59_143 | 145 | 551 | Domain | RRM 1 |
| Tgene | >UBE3C | chr19:804438 | chr7:157009561 | ENST00000348165 | + | 12 | 23 | 744_1083 | 603 | 1084 | Domain | HECT |
| Tgene | >UBE3C | chr19:804438 | chr7:157009561 | ENST00000389103 | + | 0 | 9 | 45_74 | -26 | 405 | Domain | IQ |
| Tgene | >UBE3C | chr19:804438 | chr7:157009561 | ENST00000389103 | + | 0 | 9 | 744_1083 | -26 | 405 | Domain | HECT |
| Tgene | >UBE3C | chr19:804438 | chr7:157009561 | ENST00000389103 | + | 0 | 9 | 1_60 | -26 | 405 | Region | Note=Cis-determinant of acceptor ubiquitin-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PTBP1 | chr19:804438 | chr7:157009561 | ENST00000349038 | + | 5 | 14 | 316_323 | 145 | 532 | Compositional bias | Note=Poly-Ala |
| Hgene | >PTBP1 | chr19:804438 | chr7:157009561 | ENST00000356948 | + | 5 | 15 | 316_323 | 145 | 558 | Compositional bias | Note=Poly-Ala |
| Hgene | >PTBP1 | chr19:804438 | chr7:157009561 | ENST00000394601 | + | 5 | 15 | 316_323 | 145 | 551 | Compositional bias | Note=Poly-Ala |
| Hgene | >PTBP1 | chr19:804438 | chr7:157009561 | ENST00000349038 | + | 5 | 14 | 184_260 | 145 | 532 | Domain | RRM 2 |
| Hgene | >PTBP1 | chr19:804438 | chr7:157009561 | ENST00000349038 | + | 5 | 14 | 337_411 | 145 | 532 | Domain | RRM 3 |
| Hgene | >PTBP1 | chr19:804438 | chr7:157009561 | ENST00000349038 | + | 5 | 14 | 454_529 | 145 | 532 | Domain | RRM 4 |
| Hgene | >PTBP1 | chr19:804438 | chr7:157009561 | ENST00000356948 | + | 5 | 15 | 184_260 | 145 | 558 | Domain | RRM 2 |
| Hgene | >PTBP1 | chr19:804438 | chr7:157009561 | ENST00000356948 | + | 5 | 15 | 337_411 | 145 | 558 | Domain | RRM 3 |
| Hgene | >PTBP1 | chr19:804438 | chr7:157009561 | ENST00000356948 | + | 5 | 15 | 454_529 | 145 | 558 | Domain | RRM 4 |
| Hgene | >PTBP1 | chr19:804438 | chr7:157009561 | ENST00000394601 | + | 5 | 15 | 184_260 | 145 | 551 | Domain | RRM 2 |
| Hgene | >PTBP1 | chr19:804438 | chr7:157009561 | ENST00000394601 | + | 5 | 15 | 337_411 | 145 | 551 | Domain | RRM 3 |
| Hgene | >PTBP1 | chr19:804438 | chr7:157009561 | ENST00000394601 | + | 5 | 15 | 454_529 | 145 | 551 | Domain | RRM 4 |
| Tgene | UBE3C | chr19:804438 | chr7:157009561 | ENST00000348165 | + | 12 | 23 | 45_74 | 603 | 1084 | Domain | IQ |
| Tgene | UBE3C | chr19:804438 | chr7:157009561 | ENST00000348165 | + | 12 | 23 | 1_60 | 603 | 1084 | Region | Note=Cis-determinant of acceptor ubiquitin-binding |
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FusionGeneSequence for PTBP1_UBE3C |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PTBP1_ENST00000356948_chr19_804438_+_UBE3C_ENST00000348165_chr7_157009561_+_626aa MDGIVPDIAVGTKRGSDELFSTCVTNGPFIMSSNSASAANGNDSKKFKGDSRSAGVPSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLM LKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKTDSSPNQAVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADK VTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIR RNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHY YFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKD IPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWR >In-frame_PTBP1_ENST00000349038_chr19_804438_+_UBE3C_ENST00000348165_chr7_157009561_+_626aa MDGIVPDIAVGTKRGSDELFSTCVTNGPFIMSSNSASAANGNDSKKFKGDSRSAGVPSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLM LKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKTDSSPNQAVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADK VTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIR RNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHY YFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKD IPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWR >In-frame_PTBP1_ENST00000394601_chr19_804438_+_UBE3C_ENST00000348165_chr7_157009561_+_626aa MDGIVPDIAVGTKRGSDELFSTCVTNGPFIMSSNSASAANGNDSKKFKGDSRSAGVPSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLM LKGKNQAFIEMNTEEAANTMVNYYTSVTPVLRGQPIYIQFSNHKELKTDSSPNQAVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADK VTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIR RNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHY YFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKD IPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PTBP1_ENST00000356948_chr19_804438_+_UBE3C_ENST00000348165_chr7_157009561_+_1878nt ATGGACGGCATTGTCCCAGATATAGCCGTTGGTACAAAGCGGGGATCTGACGAGCTTTTCTCTACTTGTGTCACTAACGGACCGTTTATC ATGAGCAGCAACTCGGCTTCTGCAGCAAACGGAAATGACAGCAAGAAGTTCAAAGGTGACAGCCGAAGTGCAGGCGTCCCCTCTAGAGTG ATCCACATCCGGAAGCTCCCCATCGACGTCACGGAGGGGGAAGTCATCTCCCTGGGGCTGCCCTTTGGGAAGGTCACCAACCTCCTGATG CTGAAGGGGAAAAACCAGGCCTTCATCGAGATGAACACGGAGGAGGCTGCCAACACCATGGTGAACTACTACACCTCGGTGACCCCTGTG CTGCGCGGCCAGCCCATCTACATCCAGTTCTCCAACCACAAGGAGCTGAAGACCGACAGCTCTCCCAACCAGGCGGTTATCACCAATCTA GTGAAAATGTTGAAGTCCAGAGACACGAGGAGAAATTTTTGTCCTCCAAACCACTGGCTGTCAGAACAAGAAGATATTAAAGCAGATAAG GTCACTCAGCTCTATGTGCCAGCATCCAGACATGTGTGGAGGTTCCGGCGGATGGGGAGGATAGGCCCGCTGCAGTCCACCCTGGACGTG GGTTTGGAGTCCCCGCCGCTGTCTGTGTCTGAGGAAAGACAGCTTGCTGTCCTGACAGAGTTGCCTTTTGTGGTTCCATTTGAGGAACGA GTAAAGATCTTTCAGAGGTTGATTTATGCAGATAAGCAAGAAGTTCAAGGAGATGGTCCATTTCTGGATGGAATTAATGTCACAATAAGA AGAAATTACATTTATGAAGATGCTTATGACAAACTTTCTCCAGAAAATGAGCCTGATTTGAAAAAGCGGATCCGTGTGCACTTGCTCAAT GCCCATGGCCTGGATGAAGCTGGCATTGATGGTGGTGGTATTTTCAGAGAGTTTTTAAATGAACTACTGAAGTCAGGATTTAACCCCAAC CAGGGGTTCTTTAAGACTACTAATGAAGGGCTTCTGTACCCCAACCCGGCTGCTCAGATGCTTGTGGGAGATTCTTTTGCCAGACATTAC TACTTCCTAGGCAGAATGCTTGGAAAGGCTCTCTATGAGAACATGCTGGTGGAGCTGCCCTTTGCAGGCTTCTTTCTTTCCAAGTTGCTT GGAACCAGTGCCGACGTGGACATTCACCACCTCGCCTCCCTAGACCCTGAGGTGTATAAGAATTTGCTCTTTCTGAAGAGCTACGAAGAC GATGTGGAGGAGCTTGGGCTGAACTTCACTGTGGTGAACAATGACCTGGGAGAGGCGCAGGTAGTTGAACTAAAATTCGGTGGGAAAGAC ATCCCTGTCACCAGCGCCAACCGGATTGCGTACATCCACTTGGTGGCAGACTACAGGCTGAACAGGCAGATCCGCCAGCACTGCCTGGCT TTCCGCCAGGGCCTTGCCAATGTCGTCAGCCTCGAGTGGCTCCGAATGTTTGATCAGCAAGAAATTCAGGTATTAATTTCTGGTGCACAA GTTCCCATAAGCCTAGAGGACCTAAAATCCTTTACAAACTATTCAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGA GTTGTGGAAGGGTTCACTGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAG TTGTATCCCGCATTTTGTATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCC >In-frame_PTBP1_ENST00000349038_chr19_804438_+_UBE3C_ENST00000348165_chr7_157009561_+_1878nt ATGGACGGCATTGTCCCAGATATAGCCGTTGGTACAAAGCGGGGATCTGACGAGCTTTTCTCTACTTGTGTCACTAACGGACCGTTTATC ATGAGCAGCAACTCGGCTTCTGCAGCAAACGGAAATGACAGCAAGAAGTTCAAAGGTGACAGCCGAAGTGCAGGCGTCCCCTCTAGAGTG ATCCACATCCGGAAGCTCCCCATCGACGTCACGGAGGGGGAAGTCATCTCCCTGGGGCTGCCCTTTGGGAAGGTCACCAACCTCCTGATG CTGAAGGGGAAAAACCAGGCCTTCATCGAGATGAACACGGAGGAGGCTGCCAACACCATGGTGAACTACTACACCTCGGTGACCCCTGTG CTGCGCGGCCAGCCCATCTACATCCAGTTCTCCAACCACAAGGAGCTGAAGACCGACAGCTCTCCCAACCAGGCGGTTATCACCAATCTA GTGAAAATGTTGAAGTCCAGAGACACGAGGAGAAATTTTTGTCCTCCAAACCACTGGCTGTCAGAACAAGAAGATATTAAAGCAGATAAG GTCACTCAGCTCTATGTGCCAGCATCCAGACATGTGTGGAGGTTCCGGCGGATGGGGAGGATAGGCCCGCTGCAGTCCACCCTGGACGTG GGTTTGGAGTCCCCGCCGCTGTCTGTGTCTGAGGAAAGACAGCTTGCTGTCCTGACAGAGTTGCCTTTTGTGGTTCCATTTGAGGAACGA GTAAAGATCTTTCAGAGGTTGATTTATGCAGATAAGCAAGAAGTTCAAGGAGATGGTCCATTTCTGGATGGAATTAATGTCACAATAAGA AGAAATTACATTTATGAAGATGCTTATGACAAACTTTCTCCAGAAAATGAGCCTGATTTGAAAAAGCGGATCCGTGTGCACTTGCTCAAT GCCCATGGCCTGGATGAAGCTGGCATTGATGGTGGTGGTATTTTCAGAGAGTTTTTAAATGAACTACTGAAGTCAGGATTTAACCCCAAC CAGGGGTTCTTTAAGACTACTAATGAAGGGCTTCTGTACCCCAACCCGGCTGCTCAGATGCTTGTGGGAGATTCTTTTGCCAGACATTAC TACTTCCTAGGCAGAATGCTTGGAAAGGCTCTCTATGAGAACATGCTGGTGGAGCTGCCCTTTGCAGGCTTCTTTCTTTCCAAGTTGCTT GGAACCAGTGCCGACGTGGACATTCACCACCTCGCCTCCCTAGACCCTGAGGTGTATAAGAATTTGCTCTTTCTGAAGAGCTACGAAGAC GATGTGGAGGAGCTTGGGCTGAACTTCACTGTGGTGAACAATGACCTGGGAGAGGCGCAGGTAGTTGAACTAAAATTCGGTGGGAAAGAC ATCCCTGTCACCAGCGCCAACCGGATTGCGTACATCCACTTGGTGGCAGACTACAGGCTGAACAGGCAGATCCGCCAGCACTGCCTGGCT TTCCGCCAGGGCCTTGCCAATGTCGTCAGCCTCGAGTGGCTCCGAATGTTTGATCAGCAAGAAATTCAGGTATTAATTTCTGGTGCACAA GTTCCCATAAGCCTAGAGGACCTAAAATCCTTTACAAACTATTCAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGA GTTGTGGAAGGGTTCACTGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAG TTGTATCCCGCATTTTGTATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCC >In-frame_PTBP1_ENST00000394601_chr19_804438_+_UBE3C_ENST00000348165_chr7_157009561_+_1878nt ATGGACGGCATTGTCCCAGATATAGCCGTTGGTACAAAGCGGGGATCTGACGAGCTTTTCTCTACTTGTGTCACTAACGGACCGTTTATC ATGAGCAGCAACTCGGCTTCTGCAGCAAACGGAAATGACAGCAAGAAGTTCAAAGGTGACAGCCGAAGTGCAGGCGTCCCCTCTAGAGTG ATCCACATCCGGAAGCTCCCCATCGACGTCACGGAGGGGGAAGTCATCTCCCTGGGGCTGCCCTTTGGGAAGGTCACCAACCTCCTGATG CTGAAGGGGAAAAACCAGGCCTTCATCGAGATGAACACGGAGGAGGCTGCCAACACCATGGTGAACTACTACACCTCGGTGACCCCTGTG CTGCGCGGCCAGCCCATCTACATCCAGTTCTCCAACCACAAGGAGCTGAAGACCGACAGCTCTCCCAACCAGGCGGTTATCACCAATCTA GTGAAAATGTTGAAGTCCAGAGACACGAGGAGAAATTTTTGTCCTCCAAACCACTGGCTGTCAGAACAAGAAGATATTAAAGCAGATAAG GTCACTCAGCTCTATGTGCCAGCATCCAGACATGTGTGGAGGTTCCGGCGGATGGGGAGGATAGGCCCGCTGCAGTCCACCCTGGACGTG GGTTTGGAGTCCCCGCCGCTGTCTGTGTCTGAGGAAAGACAGCTTGCTGTCCTGACAGAGTTGCCTTTTGTGGTTCCATTTGAGGAACGA GTAAAGATCTTTCAGAGGTTGATTTATGCAGATAAGCAAGAAGTTCAAGGAGATGGTCCATTTCTGGATGGAATTAATGTCACAATAAGA AGAAATTACATTTATGAAGATGCTTATGACAAACTTTCTCCAGAAAATGAGCCTGATTTGAAAAAGCGGATCCGTGTGCACTTGCTCAAT GCCCATGGCCTGGATGAAGCTGGCATTGATGGTGGTGGTATTTTCAGAGAGTTTTTAAATGAACTACTGAAGTCAGGATTTAACCCCAAC CAGGGGTTCTTTAAGACTACTAATGAAGGGCTTCTGTACCCCAACCCGGCTGCTCAGATGCTTGTGGGAGATTCTTTTGCCAGACATTAC TACTTCCTAGGCAGAATGCTTGGAAAGGCTCTCTATGAGAACATGCTGGTGGAGCTGCCCTTTGCAGGCTTCTTTCTTTCCAAGTTGCTT GGAACCAGTGCCGACGTGGACATTCACCACCTCGCCTCCCTAGACCCTGAGGTGTATAAGAATTTGCTCTTTCTGAAGAGCTACGAAGAC GATGTGGAGGAGCTTGGGCTGAACTTCACTGTGGTGAACAATGACCTGGGAGAGGCGCAGGTAGTTGAACTAAAATTCGGTGGGAAAGAC ATCCCTGTCACCAGCGCCAACCGGATTGCGTACATCCACTTGGTGGCAGACTACAGGCTGAACAGGCAGATCCGCCAGCACTGCCTGGCT TTCCGCCAGGGCCTTGCCAATGTCGTCAGCCTCGAGTGGCTCCGAATGTTTGATCAGCAAGAAATTCAGGTATTAATTTCTGGTGCACAA GTTCCCATAAGCCTAGAGGACCTAAAATCCTTTACAAACTATTCAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGA GTTGTGGAAGGGTTCACTGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAG TTGTATCCCGCATTTTGTATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PTBP1_ENST00000356948_chr19_804438_+_UBE3C_ENST00000348165_chr7_157009561_+_3918nt GGGCAAAGCACGCTTCCCGCCGCCTGACTCGCCACGTACCCACTCTCAAGATGGCGTCTCCCGCAAAGCCACGCGCCAGCTGACTGGCTC AGACGCCGTCACGTGATCCCATTTTCTCCCCCTCCCCCGACTACACAAGCCGTTTCCGCCTTCGGCCTTGAGGAATAACCGCCTCCCCCA ATAGGCGCCTGCGATTTCTCTGGGTCCCGCCCCCGGGCGGCCTTCTGGCCAGTGGGAGGTGCTGGCGGGGGCCCGCGGGGCTCTCCCCGC CCCCTGGCTGCAGCGGGAGCCAATGGGCAGCGCGCGCGGGGGACGTGTGCGGGCGTCTCCGCCATTTTGTGAGTCTATAACTCGGAGCCG TTGGGTCGGTTCCTGCTATTCCGGCGCCTCCACTCCGTCCCCCGCGGGTCTGCTCTGTGTGCCATGGACGGCATTGTCCCAGATATAGCC GTTGGTACAAAGCGGGGATCTGACGAGCTTTTCTCTACTTGTGTCACTAACGGACCGTTTATCATGAGCAGCAACTCGGCTTCTGCAGCA AACGGAAATGACAGCAAGAAGTTCAAAGGTGACAGCCGAAGTGCAGGCGTCCCCTCTAGAGTGATCCACATCCGGAAGCTCCCCATCGAC GTCACGGAGGGGGAAGTCATCTCCCTGGGGCTGCCCTTTGGGAAGGTCACCAACCTCCTGATGCTGAAGGGGAAAAACCAGGCCTTCATC GAGATGAACACGGAGGAGGCTGCCAACACCATGGTGAACTACTACACCTCGGTGACCCCTGTGCTGCGCGGCCAGCCCATCTACATCCAG TTCTCCAACCACAAGGAGCTGAAGACCGACAGCTCTCCCAACCAGGCGGTTATCACCAATCTAGTGAAAATGTTGAAGTCCAGAGACACG AGGAGAAATTTTTGTCCTCCAAACCACTGGCTGTCAGAACAAGAAGATATTAAAGCAGATAAGGTCACTCAGCTCTATGTGCCAGCATCC AGACATGTGTGGAGGTTCCGGCGGATGGGGAGGATAGGCCCGCTGCAGTCCACCCTGGACGTGGGTTTGGAGTCCCCGCCGCTGTCTGTG TCTGAGGAAAGACAGCTTGCTGTCCTGACAGAGTTGCCTTTTGTGGTTCCATTTGAGGAACGAGTAAAGATCTTTCAGAGGTTGATTTAT GCAGATAAGCAAGAAGTTCAAGGAGATGGTCCATTTCTGGATGGAATTAATGTCACAATAAGAAGAAATTACATTTATGAAGATGCTTAT GACAAACTTTCTCCAGAAAATGAGCCTGATTTGAAAAAGCGGATCCGTGTGCACTTGCTCAATGCCCATGGCCTGGATGAAGCTGGCATT GATGGTGGTGGTATTTTCAGAGAGTTTTTAAATGAACTACTGAAGTCAGGATTTAACCCCAACCAGGGGTTCTTTAAGACTACTAATGAA GGGCTTCTGTACCCCAACCCGGCTGCTCAGATGCTTGTGGGAGATTCTTTTGCCAGACATTACTACTTCCTAGGCAGAATGCTTGGAAAG GCTCTCTATGAGAACATGCTGGTGGAGCTGCCCTTTGCAGGCTTCTTTCTTTCCAAGTTGCTTGGAACCAGTGCCGACGTGGACATTCAC CACCTCGCCTCCCTAGACCCTGAGGTGTATAAGAATTTGCTCTTTCTGAAGAGCTACGAAGACGATGTGGAGGAGCTTGGGCTGAACTTC ACTGTGGTGAACAATGACCTGGGAGAGGCGCAGGTAGTTGAACTAAAATTCGGTGGGAAAGACATCCCTGTCACCAGCGCCAACCGGATT GCGTACATCCACTTGGTGGCAGACTACAGGCTGAACAGGCAGATCCGCCAGCACTGCCTGGCTTTCCGCCAGGGCCTTGCCAATGTCGTC AGCCTCGAGTGGCTCCGAATGTTTGATCAGCAAGAAATTCAGGTATTAATTTCTGGTGCACAAGTTCCCATAAGCCTAGAGGACCTAAAA TCCTTTACAAACTATTCAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTGGAAGGGTTCACTGATGAAGAA AAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTATCCCGCATTTTGTATTCACAAC GGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTCTATGACGAGACACTTTTGCGA AGTAAACTTCTCTATGCGATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGATGCTGGGGTCAGACCCCTACAGAGAACCAGTGC TTCCTTCGTCAGCAGCGCCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAGGCTCTCCTAAGCTCCTTCTTTCATTCTGCCAT TCCTCCCTCCCTTCCTTTTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGATGGACATTGCTTTTCAAATAACTTAAAATAACA CGTTATGTGCCATGTGGCTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCTCAGTGAAATTAACCAAAGATG AAGCTTTGGCTTTGCTGGTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGGGCTGCACAGGCGGCAGAGATA CAGGGTCTGAGGGCTGAGACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCATTATTAAAACTGAAGGCATTTT TTTTTTCTGCTGCCTTTCCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGTGCTTTTTAAGCCATTTCCCCA AATGGGACTAGCATGCTTGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATACTGTCTGTGGATGTGAGGTGGGGACTTCA TTCATTGTCCTATTTCTATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGGAGGGTCTGCCAAGCTACTGCAACATCTG TCACCCACTATACCCAGTTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTGTTTGAACCAAAGTGGCGGCTGCATCTTTGTCC CGATGCTAGCCGTGCCGGTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCTTCCTGGATATTTGGGGGTGAC TCGCCATGCTTGGCACCCTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCACATCCAGGGAAGAGGAGTGTCG GTAGTTCTTGCAGTAGGCACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAGAAAGCGTTTCAAAGCGTCAGC TGTGGGAGCAGAGTGACCCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTATGTCTCGTATTTTACTGTCACT GGAGGCTCTGTGGGCTGTCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGAATGACACTTTTAAGACAATGA ACATTATCAAAACAAAATGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGCTATTTGTAGTCTTGATATACAGAAATAAA ATAATTAGGGTTGGTCTTTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTTATTAGTTAATTTGTATATTTTATTAGTATTTT GGAAATAGCATATCTGAGACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTTTCTCAGCTATTCTGAGCTTATTTATTTATTTG >In-frame_PTBP1_ENST00000349038_chr19_804438_+_UBE3C_ENST00000348165_chr7_157009561_+_3568nt CTCGGAGCCGTTGGGTCGGTTCCTGCTATTCCGGCGCCTCCACTCCGTCCCCCGCGGGTCTGCTCTGTGTGCCATGGACGGCATTGTCCC AGATATAGCCGTTGGTACAAAGCGGGGATCTGACGAGCTTTTCTCTACTTGTGTCACTAACGGACCGTTTATCATGAGCAGCAACTCGGC TTCTGCAGCAAACGGAAATGACAGCAAGAAGTTCAAAGGTGACAGCCGAAGTGCAGGCGTCCCCTCTAGAGTGATCCACATCCGGAAGCT CCCCATCGACGTCACGGAGGGGGAAGTCATCTCCCTGGGGCTGCCCTTTGGGAAGGTCACCAACCTCCTGATGCTGAAGGGGAAAAACCA GGCCTTCATCGAGATGAACACGGAGGAGGCTGCCAACACCATGGTGAACTACTACACCTCGGTGACCCCTGTGCTGCGCGGCCAGCCCAT CTACATCCAGTTCTCCAACCACAAGGAGCTGAAGACCGACAGCTCTCCCAACCAGGCGGTTATCACCAATCTAGTGAAAATGTTGAAGTC CAGAGACACGAGGAGAAATTTTTGTCCTCCAAACCACTGGCTGTCAGAACAAGAAGATATTAAAGCAGATAAGGTCACTCAGCTCTATGT GCCAGCATCCAGACATGTGTGGAGGTTCCGGCGGATGGGGAGGATAGGCCCGCTGCAGTCCACCCTGGACGTGGGTTTGGAGTCCCCGCC GCTGTCTGTGTCTGAGGAAAGACAGCTTGCTGTCCTGACAGAGTTGCCTTTTGTGGTTCCATTTGAGGAACGAGTAAAGATCTTTCAGAG GTTGATTTATGCAGATAAGCAAGAAGTTCAAGGAGATGGTCCATTTCTGGATGGAATTAATGTCACAATAAGAAGAAATTACATTTATGA AGATGCTTATGACAAACTTTCTCCAGAAAATGAGCCTGATTTGAAAAAGCGGATCCGTGTGCACTTGCTCAATGCCCATGGCCTGGATGA AGCTGGCATTGATGGTGGTGGTATTTTCAGAGAGTTTTTAAATGAACTACTGAAGTCAGGATTTAACCCCAACCAGGGGTTCTTTAAGAC TACTAATGAAGGGCTTCTGTACCCCAACCCGGCTGCTCAGATGCTTGTGGGAGATTCTTTTGCCAGACATTACTACTTCCTAGGCAGAAT GCTTGGAAAGGCTCTCTATGAGAACATGCTGGTGGAGCTGCCCTTTGCAGGCTTCTTTCTTTCCAAGTTGCTTGGAACCAGTGCCGACGT GGACATTCACCACCTCGCCTCCCTAGACCCTGAGGTGTATAAGAATTTGCTCTTTCTGAAGAGCTACGAAGACGATGTGGAGGAGCTTGG GCTGAACTTCACTGTGGTGAACAATGACCTGGGAGAGGCGCAGGTAGTTGAACTAAAATTCGGTGGGAAAGACATCCCTGTCACCAGCGC CAACCGGATTGCGTACATCCACTTGGTGGCAGACTACAGGCTGAACAGGCAGATCCGCCAGCACTGCCTGGCTTTCCGCCAGGGCCTTGC CAATGTCGTCAGCCTCGAGTGGCTCCGAATGTTTGATCAGCAAGAAATTCAGGTATTAATTTCTGGTGCACAAGTTCCCATAAGCCTAGA GGACCTAAAATCCTTTACAAACTATTCAGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTGGAAGGGTTCAC TGATGAAGAAAAGCGCAAACTGCTGAAGTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTATCCCGCATTTTG TATTCACAACGGAGGCTCCGACCTTGAGCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTCTATGACGAGAC ACTTTTGCGAAGTAAACTTCTCTATGCGATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGATGCTGGGGTCAGACCCCTACAGA GAACCAGTGCTTCCTTCGTCAGCAGCGCCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAGGCTCTCCTAAGCTCCTTCTTTC ATTCTGCCATTCCTCCCTCCCTTCCTTTTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGATGGACATTGCTTTTCAAATAACT TAAAATAACACGTTATGTGCCATGTGGCTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCTCAGTGAAATTA ACCAAAGATGAAGCTTTGGCTTTGCTGGTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGGGCTGCACAGGC GGCAGAGATACAGGGTCTGAGGGCTGAGACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCATTATTAAAACTG AAGGCATTTTTTTTTTCTGCTGCCTTTCCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGTGCTTTTTAAGC CATTTCCCCAAATGGGACTAGCATGCTTGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATACTGTCTGTGGATGTGAGGT GGGGACTTCATTCATTGTCCTATTTCTATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGGAGGGTCTGCCAAGCTACT GCAACATCTGTCACCCACTATACCCAGTTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTGTTTGAACCAAAGTGGCGGCTGC ATCTTTGTCCCGATGCTAGCCGTGCCGGTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCTTCCTGGATATT TGGGGGTGACTCGCCATGCTTGGCACCCTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCACATCCAGGGAAG AGGAGTGTCGGTAGTTCTTGCAGTAGGCACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAGAAAGCGTTTCA AAGCGTCAGCTGTGGGAGCAGAGTGACCCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTATGTCTCGTATTT TACTGTCACTGGAGGCTCTGTGGGCTGTCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGAATGACACTTTT AAGACAATGAACATTATCAAAACAAAATGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGCTATTTGTAGTCTTGATATA CAGAAATAAAATAATTAGGGTTGGTCTTTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTTATTAGTTAATTTGTATATTTTA TTAGTATTTTGGAAATAGCATATCTGAGACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTTTCTCAGCTATTCTGAGCTTATT >In-frame_PTBP1_ENST00000394601_chr19_804438_+_UBE3C_ENST00000348165_chr7_157009561_+_3541nt ATTCCGGCGCCTCCACTCCGTCCCCCGCGGGTCTGCTCTGTGTGCCATGGACGGCATTGTCCCAGATATAGCCGTTGGTACAAAGCGGGG ATCTGACGAGCTTTTCTCTACTTGTGTCACTAACGGACCGTTTATCATGAGCAGCAACTCGGCTTCTGCAGCAAACGGAAATGACAGCAA GAAGTTCAAAGGTGACAGCCGAAGTGCAGGCGTCCCCTCTAGAGTGATCCACATCCGGAAGCTCCCCATCGACGTCACGGAGGGGGAAGT CATCTCCCTGGGGCTGCCCTTTGGGAAGGTCACCAACCTCCTGATGCTGAAGGGGAAAAACCAGGCCTTCATCGAGATGAACACGGAGGA GGCTGCCAACACCATGGTGAACTACTACACCTCGGTGACCCCTGTGCTGCGCGGCCAGCCCATCTACATCCAGTTCTCCAACCACAAGGA GCTGAAGACCGACAGCTCTCCCAACCAGGCGGTTATCACCAATCTAGTGAAAATGTTGAAGTCCAGAGACACGAGGAGAAATTTTTGTCC TCCAAACCACTGGCTGTCAGAACAAGAAGATATTAAAGCAGATAAGGTCACTCAGCTCTATGTGCCAGCATCCAGACATGTGTGGAGGTT CCGGCGGATGGGGAGGATAGGCCCGCTGCAGTCCACCCTGGACGTGGGTTTGGAGTCCCCGCCGCTGTCTGTGTCTGAGGAAAGACAGCT TGCTGTCCTGACAGAGTTGCCTTTTGTGGTTCCATTTGAGGAACGAGTAAAGATCTTTCAGAGGTTGATTTATGCAGATAAGCAAGAAGT TCAAGGAGATGGTCCATTTCTGGATGGAATTAATGTCACAATAAGAAGAAATTACATTTATGAAGATGCTTATGACAAACTTTCTCCAGA AAATGAGCCTGATTTGAAAAAGCGGATCCGTGTGCACTTGCTCAATGCCCATGGCCTGGATGAAGCTGGCATTGATGGTGGTGGTATTTT CAGAGAGTTTTTAAATGAACTACTGAAGTCAGGATTTAACCCCAACCAGGGGTTCTTTAAGACTACTAATGAAGGGCTTCTGTACCCCAA CCCGGCTGCTCAGATGCTTGTGGGAGATTCTTTTGCCAGACATTACTACTTCCTAGGCAGAATGCTTGGAAAGGCTCTCTATGAGAACAT GCTGGTGGAGCTGCCCTTTGCAGGCTTCTTTCTTTCCAAGTTGCTTGGAACCAGTGCCGACGTGGACATTCACCACCTCGCCTCCCTAGA CCCTGAGGTGTATAAGAATTTGCTCTTTCTGAAGAGCTACGAAGACGATGTGGAGGAGCTTGGGCTGAACTTCACTGTGGTGAACAATGA CCTGGGAGAGGCGCAGGTAGTTGAACTAAAATTCGGTGGGAAAGACATCCCTGTCACCAGCGCCAACCGGATTGCGTACATCCACTTGGT GGCAGACTACAGGCTGAACAGGCAGATCCGCCAGCACTGCCTGGCTTTCCGCCAGGGCCTTGCCAATGTCGTCAGCCTCGAGTGGCTCCG AATGTTTGATCAGCAAGAAATTCAGGTATTAATTTCTGGTGCACAAGTTCCCATAAGCCTAGAGGACCTAAAATCCTTTACAAACTATTC AGGAGGCTATTCTGCAGACCATCCTGTTATTAAGGTCTTCTGGAGAGTTGTGGAAGGGTTCACTGATGAAGAAAAGCGCAAACTGCTGAA GTTTGTAACAAGCTGCTCTCGACCCCCTCTCTTGGGGTTTAAGGAGTTGTATCCCGCATTTTGTATTCACAACGGAGGCTCCGACCTTGA GCGGCTCCCCACAGCCAGCACCTGCATGAACCTGCTGAAGCTCCCCGAGTTCTATGACGAGACACTTTTGCGAAGTAAACTTCTCTATGC GATTGAATGTGCCGCTGGCTTTGAGCTGAGCTGAAGCTGATGCTGGGGTCAGACCCCTACAGAGAACCAGTGCTTCCTTCGTCAGCAGCG CCTCCCCAGACCCACGAGGATACTCACACTGCACGCCTGAGGCTCTCCTAAGCTCCTTCTTTCATTCTGCCATTCCTCCCTCCCTTCCTT TTTTAAATGATTTTTATTACGGTGTGGTCACTTATTTAGATGGACATTGCTTTTCAAATAACTTAAAATAACACGTTATGTGCCATGTGG CTACTTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCTCAGTGAAATTAACCAAAGATGAAGCTTTGGCTTTGCTG GTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGGGCTGCACAGGCGGCAGAGATACAGGGTCTGAGGGCTGA GACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCATTATTAAAACTGAAGGCATTTTTTTTTTCTGCTGCCTTT CCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGTGCTTTTTAAGCCATTTCCCCAAATGGGACTAGCATGCT TGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATACTGTCTGTGGATGTGAGGTGGGGACTTCATTCATTGTCCTATTTCT ATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGAGGTGGAGGAGGAGGGTCTGCCAAGCTACTGCAACATCTGTCACCCACTATACCCAG TTACTTGGGGGAGGACAGACACTGTGGTGTCATTAAAGTTGTTTGAACCAAAGTGGCGGCTGCATCTTTGTCCCGATGCTAGCCGTGCCG GTCTCCCATCATCCGCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCTTCCTGGATATTTGGGGGTGACTCGCCATGCTTGGCACC CTCTGCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCACATCCAGGGAAGAGGAGTGTCGGTAGTTCTTGCAGTAGG CACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAGAAAGCGTTTCAAAGCGTCAGCTGTGGGAGCAGAGTGAC CCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTATGTCTCGTATTTTACTGTCACTGGAGGCTCTGTGGGCTG TCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGAATGACACTTTTAAGACAATGAACATTATCAAAACAAAA TGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGCTATTTGTAGTCTTGATATACAGAAATAAAATAATTAGGGTTGGTCT TTTTTATTTTAGGTTGTTTTATGTTGAATGTTCTATATCTTATTAGTTAATTTGTATATTTTATTAGTATTTTGGAAATAGCATATCTGA GACTGAAGAGAAATTGACAATTCACTTATTTGTGGTTTTTTTCTCAGCTATTCTGAGCTTATTTATTTATTTGTATGTTCTAATGGCTAA |
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FusionGenePPI for PTBP1_UBE3C |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PTBP1 | HNRNPL, CALCOCO2, SNRPA, PTBP1, SFPQ, PCBP2, HNRNPK, SAP25, SRRM1, UBC, HDAC5, PSMA3, SMARCAD1, ARRB2, HNRNPA1, ISG15, CUL3, CUL5, CDK2, CUL1, COPS5, CAND1, PCBP1, PCBP3, QKI, FBXO6, NPM1, APP, HNRNPU, HNRNPA2B1, SRSF5, HNRNPA3, HNRNPD, NCL, HNRNPA0, HNRNPDL, HTATSF1, RPS7, RPL36, TMEM177, PNPT1, RAB1A, NOTCH1, RORA, FN1, VCAM1, RBM10, ELAVL1, HNRNPAB, RBFOX2, NOS2, IL7R, ITGA4, HMGA1, HMGA2, SRPK2, TARDBP, APBB1, AIMP1, IQGAP1, RPSA, ABCF1, AIMP2, NELFB, YBX3, DIMT1, EIF2B2, EIF4G1, EPRS, FAU, G3BP1, ILF2, QARS, RPS27, YBX1, SPTAN1, RPA3, RPA2, RPA1, LGR4, NONO, MOV10, NXF1, MDM2, HIST3H3, CUL7, OBSL1, CCDC8, SUZ12, EED, RNF2, BMI1, MARK4, ACAT1, AMIGO2, ATP5A1, ATP5B, ATP5C1, CANX, CCNH, CHEK1, DDX17, FUS, HSD17B10, HSPA5, HSPB1, PDHA1, PDHB, HSPA9, PHB2, RAB2A, RANGAP1, SAR1A, SLC3A2, STOML2, TIMM13, TOMM70A, TUFM, NTRK1, SCARNA22, MATR3, CRY1, MCM2, CDC5L, U2AF2, CYLD, COX15, DLD, DNM1L, TRIM25, BRCA1, YAP1 | UBE3C | PSMD2, PSMC5, PSMD6, CAND2, MYC, RAD21, ELAVL1, UBC, PSMA2, UBE3C, UBE2D1, UBE2L3, APP, THOC2, RBM15, THOC7, WDR74, KDM1A, PHKA2, CPEB4, USP13, UTRN, ECT2, MTA2, TLK1, EEF2K, PANK4, WDR92, SHFM1, PSMD14, GOLGA2, UBE2D2, EFNB2, VSIG4, SCN2B, NTRK1, ANXA7, UBE2D3, ESR1, CCNB1, FAF2, FAM3C, KIAA1467, TRIM25, MTA1, PCBP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTBP1_UBE3C |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PTBP1_UBE3C |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PTBP1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | PTBP1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | UBE3C | C3495559 | Juvenile arthritis | 1 | CTD_human |
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