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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2926

FusionGeneSummary for ASB5_MGP

check button Fusion gene summary
Fusion gene informationFusion gene name: ASB5_MGP
Fusion gene ID: 2926
HgeneTgene
Gene symbol

ASB5

MGP

Gene ID

140458

4256

Gene nameankyrin repeat and SOCS box containing 5matrix Gla protein
SynonymsASB-5GIG36|MGLAP|NTI
Cytomap

4q34.2

12p12.3

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat and SOCS box protein 5SOCS box protein ASB-5matrix Gla proteincell growth-inhibiting gene 36 protein
Modification date2018052320180527
UniProtAcc

Q8WWX0

P08493

Ensembl transtripts involved in fusion geneENST00000296525, ENST00000512254, 
ENST00000511879, 
ENST00000539261, 
ENST00000228938, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 7 X 2=140
# samples 118
** MAII scorelog2(1/1*10)=3.32192809488736log2(18/140*10)=0.362570079384708
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ASB5 [Title/Abstract] AND MGP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP317842ASB5chr4

177136628

-MGPchr12

15035177

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000296525ENST00000539261ASB5chr4

177136628

-MGPchr12

15035177

-
intron-3CDSENST00000296525ENST00000228938ASB5chr4

177136628

-MGPchr12

15035177

-
intron-3CDSENST00000512254ENST00000539261ASB5chr4

177136628

-MGPchr12

15035177

-
intron-3CDSENST00000512254ENST00000228938ASB5chr4

177136628

-MGPchr12

15035177

-
intron-3CDSENST00000511879ENST00000539261ASB5chr4

177136628

-MGPchr12

15035177

-
intron-3CDSENST00000511879ENST00000228938ASB5chr4

177136628

-MGPchr12

15035177

-

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FusionProtFeatures for ASB5_MGP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASB5

Q8WWX0

MGP

P08493

May be a substrate-recognition component of a SCF-likeECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligasecomplex which mediates the ubiquitination and subsequentproteasomal degradation of target proteins. May play a role in theinitiation of arteriogenesis (By similarity). {ECO:0000250}. Associates with the organic matrix of bone andcartilage. Thought to act as an inhibitor of bone formation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ASB5_MGP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ASB5_MGP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ASB5_MGP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMGPP08493DB01373CalciumMatrix Gla proteinsmall moleculeapproved|nutraceutical

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RelatedDiseases for ASB5_MGP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMGPC0024667Animal Mammary Neoplasms2CTD_human
TgeneMGPC0024668Mammary Neoplasms, Experimental2CTD_human
TgeneMGPC0000786Spontaneous abortion1CTD_human;HPO
TgeneMGPC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneMGPC0041948Uremia1CTD_human
TgeneMGPC0042345Varicosity1CTD_human
TgeneMGPC0342649Vascular calcification1CTD_human
TgeneMGPC1855607Keutel syndrome1CTD_human;ORPHANET