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Fusion gene ID: 29230 |
FusionGeneSummary for PSMG2_OSBPL1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PSMG2_OSBPL1A | Fusion gene ID: 29230 | Hgene | Tgene | Gene symbol | PSMG2 | OSBPL1A | Gene ID | 56984 | 114876 |
| Gene name | proteasome assembly chaperone 2 | oxysterol binding protein like 1A | |
| Synonyms | CLAST3|HCCA3|HsT1707|MDS003|PAC2|TNFSF5IP1 | ORP-1|ORP1|OSBPL1B | |
| Cytomap | 18p11.21 | 18q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | proteasome assembly chaperone 2CD40 ligand-activated specific transcript 3HDCMC29PHSPC260PAC-2hepatocellular carcinoma susceptibility proteinhepatocellular carcinoma-susceptibility protein 3likely ortholog of mouse CD40 ligand-activated specific tr | oxysterol-binding protein-related protein 1OSBP-related protein 1oxysterol binding protein-like 1Boxysterol-binding protein-related protein 1 variant 1oxysterol-binding protein-related protein 1 variant 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q969U7 | Q9BXW6 | |
| Ensembl transtripts involved in fusion gene | ENST00000585331, ENST00000317615, ENST00000590217, ENST00000589405, | ENST00000319481, ENST00000399443, ENST00000357041, ENST00000399441, ENST00000582618, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 11 X 9 X 9=891 |
| # samples | 5 | 12 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/891*10)=-2.8923910259134 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PSMG2 [Title/Abstract] AND OSBPL1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PSMG2 | GO:0043248 | proteasome assembly | 16251969 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-L5-A8NE-01A | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000585331 | ENST00000319481 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| intron-intron | ENST00000585331 | ENST00000399443 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| intron-intron | ENST00000585331 | ENST00000357041 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| intron-intron | ENST00000585331 | ENST00000399441 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| intron-intron | ENST00000585331 | ENST00000582618 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| Frame-shift | ENST00000317615 | ENST00000319481 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| 5CDS-intron | ENST00000317615 | ENST00000399443 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| 5CDS-intron | ENST00000317615 | ENST00000357041 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| 5CDS-intron | ENST00000317615 | ENST00000399441 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| 5CDS-intron | ENST00000317615 | ENST00000582618 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| Frame-shift | ENST00000590217 | ENST00000319481 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| 5CDS-intron | ENST00000590217 | ENST00000399443 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| 5CDS-intron | ENST00000590217 | ENST00000357041 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| 5CDS-intron | ENST00000590217 | ENST00000399441 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| 5CDS-intron | ENST00000590217 | ENST00000582618 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| intron-3CDS | ENST00000589405 | ENST00000319481 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| intron-intron | ENST00000589405 | ENST00000399443 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| intron-intron | ENST00000589405 | ENST00000357041 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| intron-intron | ENST00000589405 | ENST00000399441 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
| intron-intron | ENST00000589405 | ENST00000582618 | PSMG2 | chr18 | 12703163 | + | OSBPL1A | chr18 | 21914294 | - |
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FusionProtFeatures for PSMG2_OSBPL1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PSMG2 | OSBPL1A |
| Chaperone protein which promotes assembly of the 20Sproteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2heterodimer binds to the PSMA5 and PSMA7 proteasome subunits,promotes assembly of the proteasome alpha subunits into theheteroheptameric alpha ring and prevents alpha ring dimerization.{ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}. | Binds phospholipids; exhibits strong binding tophosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on lateendosomes/lysosomes and alters functional properties of lateendocytic compartments via its interaction with RAB7A(PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol(PubMed:17428193). {ECO:0000250, ECO:0000269|PubMed:16176980,ECO:0000269|PubMed:17428193}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PSMG2_OSBPL1A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PSMG2_OSBPL1A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PSMG2 | SLC35F6, PSMA2, PSMA4, POMP, PSMG1, THOP1, FN1, PSMA6, PSMG3, SHFM1, KRT31, TCF4, NOTCH2NL, PSMA1, PSMB4, FBXO7, PSMB7, PSMA5, PSMG4, PSMF1, PSMB9, WDR83, FOXR2, CA10, C16orf70, FARSA, PAFAH1B2, PSMD13, CCDC22, PSMA3, PSMB3, PSMB5, PSMB6, PSMC3, PSMC5, PSMD7, WARS, PSMB2, PSMB1, NRIP3, SPATA8, XAGE3, SOST, A1CF, LINGO1, PSME1 | OSBPL1A | BCL6, NPM1, BIN3, HEXIM1, C9orf41, VAPB, POLG2, KIFAP3, TSC22D2, VAPA, HIF1AN, DMD, CTNNA3, ZNF331, BSPRY, PRPF31, TRIM25, BAALC |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PSMG2_OSBPL1A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PSMG2_OSBPL1A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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