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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29220

FusionGeneSummary for PSME2_SNAP91

check button Fusion gene summary
Fusion gene informationFusion gene name: PSME2_SNAP91
Fusion gene ID: 29220
HgeneTgene
Gene symbol

PSME2

SNAP91

Gene ID

5721

9892

Gene nameproteasome activator subunit 2synaptosome associated protein 91
SynonymsPA28B|PA28beta|REGbetaAP180|CALM
Cytomap

14q12

6q14.2

Type of geneprotein-codingprotein-coding
Descriptionproteasome activator complex subunit 211S regulator complex beta subunit11S regulator complex subunit betaMCP activator, 31-kD subunitREG-betaactivator of multicatalytic protease subunit 2cell migration-inducing protein 22proteasome (prosome, macroclathrin coat assembly protein AP18091 kDa synaptosomal-associated proteinassembly protein, 180kDaclathrin coat-associated protein AP180phosphoprotein F1-20synaptosomal-associated protein, 91kDa homologsynaptosome associated protein 91kDa
Modification date2018052320180529
UniProtAcc

Q9UL46

O60641

Ensembl transtripts involved in fusion geneENST00000560410, ENST00000216802, 
ENST00000471700, 		ENST00000521485, 
ENST00000369694, ENST00000195649, 
ENST00000439399, ENST00000428679, 
ENST00000437520, ENST00000521743, 
ENST00000520302, ENST00000520213, 
ENST00000519133, 
Fusion gene scores* DoF score4 X 4 X 1=162 X 2 X 3=12
# samples 73
** MAII scorelog2(7/16*10)=2.12928301694497
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PSME2 [Title/Abstract] AND SNAP91 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF884903PSME2chr14

24614339

-SNAP91chr6

84312558

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000560410ENST00000521485PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000560410ENST00000369694PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000560410ENST00000195649PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000560410ENST00000439399PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000560410ENST00000428679PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000560410ENST00000437520PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000560410ENST00000521743PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000560410ENST00000520302PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000560410ENST00000520213PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000560410ENST00000519133PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000216802ENST00000521485PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000216802ENST00000369694PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000216802ENST00000195649PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000216802ENST00000439399PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000216802ENST00000428679PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000216802ENST00000437520PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000216802ENST00000521743PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000216802ENST00000520302PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000216802ENST00000520213PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000216802ENST00000519133PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000471700ENST00000521485PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000471700ENST00000369694PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000471700ENST00000195649PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000471700ENST00000439399PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000471700ENST00000428679PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000471700ENST00000437520PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000471700ENST00000521743PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000471700ENST00000520302PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000471700ENST00000520213PSME2chr14

24614339

-SNAP91chr6

84312558

+
intron-intronENST00000471700ENST00000519133PSME2chr14

24614339

-SNAP91chr6

84312558

+

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FusionProtFeatures for PSME2_SNAP91


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSME2

Q9UL46

SNAP91

O60641

Implicated in immunoproteasome assembly and required forefficient antigen processing. The PA28 activator complex enhancesthe generation of class I binding peptides by altering thecleavage pattern of the proteasome. Adaptins are components of the adapter complexes whichlink clathrin to receptors in coated vesicles. Clathrin-associatedprotein complexes are believed to interact with the cytoplasmictails of membrane proteins, leading to their selection andconcentration. Binding of AP180 to clathrin triskelia inducestheir assembly into 60-70 nm coats (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PSME2_SNAP91


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PSME2_SNAP91


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PSME2_SNAP91


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PSME2_SNAP91


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePSME2C0019693HIV Infections1CTD_human
HgenePSME2C0023893Liver Cirrhosis, Experimental1CTD_human
HgenePSME2C0279626Squamous cell carcinoma of esophagus1CTD_human