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Fusion gene ID: 29219 |
FusionGeneSummary for PSME2_RPS20 |
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Fusion gene information | Fusion gene name: PSME2_RPS20 | Fusion gene ID: 29219 | Hgene | Tgene | Gene symbol | PSME2 | RPS20 | Gene ID | 5721 | 6224 |
Gene name | proteasome activator subunit 2 | ribosomal protein S20 | |
Synonyms | PA28B|PA28beta|REGbeta | S20|uS10 | |
Cytomap | 14q12 | 8q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | proteasome activator complex subunit 211S regulator complex beta subunit11S regulator complex subunit betaMCP activator, 31-kD subunitREG-betaactivator of multicatalytic protease subunit 2cell migration-inducing protein 22proteasome (prosome, macro | 40S ribosomal protein S20small ribosomal subunit protein uS10 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UL46 | P60866 | |
Ensembl transtripts involved in fusion gene | ENST00000560410, ENST00000216802, ENST00000471700, | ENST00000519807, ENST00000009589, ENST00000524349, ENST00000520490, ENST00000520627, ENST00000521262, ENST00000523936, ENST00000519606, ENST00000518875, | |
Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 2 X 2 X 1=4 |
# samples | 7 | 2 | |
** MAII score | log2(7/16*10)=2.12928301694497 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: PSME2 [Title/Abstract] AND RPS20 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF205135 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000560410 | ENST00000519807 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000560410 | ENST00000009589 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000560410 | ENST00000524349 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-intron | ENST00000560410 | ENST00000520490 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000560410 | ENST00000520627 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000560410 | ENST00000521262 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-intron | ENST00000560410 | ENST00000523936 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000560410 | ENST00000519606 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000560410 | ENST00000518875 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000216802 | ENST00000519807 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000216802 | ENST00000009589 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000216802 | ENST00000524349 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-intron | ENST00000216802 | ENST00000520490 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000216802 | ENST00000520627 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000216802 | ENST00000521262 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-intron | ENST00000216802 | ENST00000523936 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000216802 | ENST00000519606 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000216802 | ENST00000518875 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000471700 | ENST00000519807 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000471700 | ENST00000009589 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000471700 | ENST00000524349 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-intron | ENST00000471700 | ENST00000520490 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000471700 | ENST00000520627 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000471700 | ENST00000521262 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-intron | ENST00000471700 | ENST00000523936 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000471700 | ENST00000519606 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
intron-5UTR | ENST00000471700 | ENST00000518875 | PSME2 | chr14 | 24615814 | + | RPS20 | chr8 | 56987051 | - |
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FusionProtFeatures for PSME2_RPS20 |
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Hgene | Tgene |
PSME2 | RPS20 |
Implicated in immunoproteasome assembly and required forefficient antigen processing. The PA28 activator complex enhancesthe generation of class I binding peptides by altering thecleavage pattern of the proteasome. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PSME2_RPS20 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PSME2_RPS20 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PSME2_RPS20 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PSME2_RPS20 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PSME2 | C0019693 | HIV Infections | 1 | CTD_human |
Hgene | PSME2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | PSME2 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |