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Fusion gene ID: 29218 |
FusionGeneSummary for PSME2_RAB10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PSME2_RAB10 | Fusion gene ID: 29218 | Hgene | Tgene | Gene symbol | PSME2 | RAB10 | Gene ID | 5721 | 10890 |
| Gene name | proteasome activator subunit 2 | RAB10, member RAS oncogene family | |
| Synonyms | PA28B|PA28beta|REGbeta | - | |
| Cytomap | 14q12 | 2p23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | proteasome activator complex subunit 211S regulator complex beta subunit11S regulator complex subunit betaMCP activator, 31-kD subunitREG-betaactivator of multicatalytic protease subunit 2cell migration-inducing protein 22proteasome (prosome, macro | ras-related protein Rab-10GTP-binding protein RAB10ras-related GTP-binding protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UL46 | P61026 | |
| Ensembl transtripts involved in fusion gene | ENST00000560410, ENST00000216802, ENST00000471700, | ENST00000264710, ENST00000462003, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 5 X 5 X 3=75 |
| # samples | 7 | 7 | |
| ** MAII score | log2(7/16*10)=2.12928301694497 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/75*10)=-0.0995356735509144 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PSME2 [Title/Abstract] AND RAB10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW997232 | PSME2 | chr14 | 24615821 | + | RAB10 | chr2 | 26298901 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000560410 | ENST00000264710 | PSME2 | chr14 | 24615821 | + | RAB10 | chr2 | 26298901 | - |
| intron-intron | ENST00000560410 | ENST00000462003 | PSME2 | chr14 | 24615821 | + | RAB10 | chr2 | 26298901 | - |
| intron-intron | ENST00000216802 | ENST00000264710 | PSME2 | chr14 | 24615821 | + | RAB10 | chr2 | 26298901 | - |
| intron-intron | ENST00000216802 | ENST00000462003 | PSME2 | chr14 | 24615821 | + | RAB10 | chr2 | 26298901 | - |
| intron-intron | ENST00000471700 | ENST00000264710 | PSME2 | chr14 | 24615821 | + | RAB10 | chr2 | 26298901 | - |
| intron-intron | ENST00000471700 | ENST00000462003 | PSME2 | chr14 | 24615821 | + | RAB10 | chr2 | 26298901 | - |
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FusionProtFeatures for PSME2_RAB10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PSME2 | RAB10 |
| Implicated in immunoproteasome assembly and required forefficient antigen processing. The PA28 activator complex enhancesthe generation of class I binding peptides by altering thecleavage pattern of the proteasome. | The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cyclebetween an inactive GDP-bound form and an active GTP-bound formthat is able to recruit to membranes different set of downstreameffectors directly responsible for vesicle formation, movement,tethering and fusion (By similarity). That Rab is mainly involvedin the biosynthetic transport of proteins from the Golgi to theplasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucosetransporter-enriched vesicles delivery to the plasma membrane. Inparallel, it regulates the transport of TLR4, a toll-like receptorto the plasma membrane and therefore may be important for innateimmune response. Plays also a specific role in asymmetric proteintransport to the plasma membrane within the polarized neuron andepithelial cells. In neurons, it is involved in axonogenesisthrough regulation of vesicular membrane trafficking toward theaxonal plasma membrane while in epithelial cells, it regulatestransport from the Golgi to the basolateral membrane. Moreover,may play a role in the basolateral recycling pathway and inphagosome maturation. According to PubMed:23263280, may play arole in endoplasmic reticulum dynamics and morphology controllingtubulation along microtubules and tubules fusion. {ECO:0000250,ECO:0000269|PubMed:16641372, ECO:0000269|PubMed:21248164,ECO:0000269|PubMed:23263280}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PSME2_RAB10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PSME2_RAB10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PSME2_RAB10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PSME2_RAB10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PSME2 | C0019693 | HIV Infections | 1 | CTD_human |
| Hgene | PSME2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | PSME2 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
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