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Fusion gene ID: 29216 |
FusionGeneSummary for PSME1_IQCE |
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Fusion gene information | Fusion gene name: PSME1_IQCE | Fusion gene ID: 29216 | Hgene | Tgene | Gene symbol | PSME1 | IQCE | Gene ID | 5720 | 23288 |
Gene name | proteasome activator subunit 1 | IQ motif containing E | |
Synonyms | HEL-S-129m|IFI5111|PA28A|PA28alpha|REGalpha | 1700028P05Rik|PAPA7 | |
Cytomap | 14q12 | 7p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | proteasome activator complex subunit 111S regulator complex subunit alpha29-kD MCP activator subunitIGUP I-5111activator of multicatalytic protease subunit 1epididymis secretory sperm binding protein Li 129minterferon gamma up-regulated I-5111 prote | IQ domain-containing protein E | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q06323 | Q6IPM2 | |
Ensembl transtripts involved in fusion gene | ENST00000206451, ENST00000559123, ENST00000382708, ENST00000561435, ENST00000470718, | ENST00000404984, ENST00000402050, ENST00000438376, ENST00000325979, ENST00000497572, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 12 X 3 X 9=324 |
# samples | 2 | 12 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(12/324*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PSME1 [Title/Abstract] AND IQCE [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM990679 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000206451 | ENST00000404984 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000206451 | ENST00000402050 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000206451 | ENST00000438376 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000206451 | ENST00000325979 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000206451 | ENST00000497572 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000559123 | ENST00000404984 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000559123 | ENST00000402050 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000559123 | ENST00000438376 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000559123 | ENST00000325979 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000559123 | ENST00000497572 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000382708 | ENST00000404984 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000382708 | ENST00000402050 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000382708 | ENST00000438376 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000382708 | ENST00000325979 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000382708 | ENST00000497572 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000561435 | ENST00000404984 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000561435 | ENST00000402050 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000561435 | ENST00000438376 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000561435 | ENST00000325979 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000561435 | ENST00000497572 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000470718 | ENST00000404984 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000470718 | ENST00000402050 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000470718 | ENST00000438376 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000470718 | ENST00000325979 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
intron-intron | ENST00000470718 | ENST00000497572 | PSME1 | chr14 | 24607403 | - | IQCE | chr7 | 2647130 | + |
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FusionProtFeatures for PSME1_IQCE |
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Hgene | Tgene |
PSME1 | IQCE |
Implicated in immunoproteasome assembly and required forefficient antigen processing. The PA28 activator complex enhancesthe generation of class I binding peptides by altering thecleavage pattern of the proteasome. | Component of the EvC complex that positively regulatesciliary Hedgehog (Hh) signaling. {ECO:0000250|UniProtKB:Q6PCQ0}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PSME1_IQCE |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PSME1_IQCE |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PSME1_IQCE |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PSME1_IQCE |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PSME1 | C0019693 | HIV Infections | 1 | CTD_human |
Hgene | PSME1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | PSME1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | PSME1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |