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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29216

FusionGeneSummary for PSME1_IQCE

check button Fusion gene summary
Fusion gene informationFusion gene name: PSME1_IQCE
Fusion gene ID: 29216
HgeneTgene
Gene symbol

PSME1

IQCE

Gene ID

5720

23288

Gene nameproteasome activator subunit 1IQ motif containing E
SynonymsHEL-S-129m|IFI5111|PA28A|PA28alpha|REGalpha1700028P05Rik|PAPA7
Cytomap

14q12

7p22.3

Type of geneprotein-codingprotein-coding
Descriptionproteasome activator complex subunit 111S regulator complex subunit alpha29-kD MCP activator subunitIGUP I-5111activator of multicatalytic protease subunit 1epididymis secretory sperm binding protein Li 129minterferon gamma up-regulated I-5111 proteIQ domain-containing protein E
Modification date2018052320180519
UniProtAcc

Q06323

Q6IPM2

Ensembl transtripts involved in fusion geneENST00000206451, ENST00000559123, 
ENST00000382708, ENST00000561435, 
ENST00000470718, 		ENST00000404984, 
ENST00000402050, ENST00000438376, 
ENST00000325979, ENST00000497572, 
Fusion gene scores* DoF score2 X 2 X 2=812 X 3 X 9=324
# samples 212
** MAII scorelog2(2/8*10)=1.32192809488736log2(12/324*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PSME1 [Title/Abstract] AND IQCE [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM990679PSME1chr14

24607403

-IQCEchr7

2647130

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000206451ENST00000404984PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000206451ENST00000402050PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000206451ENST00000438376PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000206451ENST00000325979PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000206451ENST00000497572PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000559123ENST00000404984PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000559123ENST00000402050PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000559123ENST00000438376PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000559123ENST00000325979PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000559123ENST00000497572PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000382708ENST00000404984PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000382708ENST00000402050PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000382708ENST00000438376PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000382708ENST00000325979PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000382708ENST00000497572PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000561435ENST00000404984PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000561435ENST00000402050PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000561435ENST00000438376PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000561435ENST00000325979PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000561435ENST00000497572PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000470718ENST00000404984PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000470718ENST00000402050PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000470718ENST00000438376PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000470718ENST00000325979PSME1chr14

24607403

-IQCEchr7

2647130

+
intron-intronENST00000470718ENST00000497572PSME1chr14

24607403

-IQCEchr7

2647130

+

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FusionProtFeatures for PSME1_IQCE


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSME1

Q06323

IQCE

Q6IPM2

Implicated in immunoproteasome assembly and required forefficient antigen processing. The PA28 activator complex enhancesthe generation of class I binding peptides by altering thecleavage pattern of the proteasome. Component of the EvC complex that positively regulatesciliary Hedgehog (Hh) signaling. {ECO:0000250|UniProtKB:Q6PCQ0}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PSME1_IQCE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PSME1_IQCE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PSME1_IQCE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PSME1_IQCE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePSME1C0019693HIV Infections1CTD_human
HgenePSME1C0024667Animal Mammary Neoplasms1CTD_human
HgenePSME1C0024668Mammary Neoplasms, Experimental1CTD_human
HgenePSME1C0279626Squamous cell carcinoma of esophagus1CTD_human