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Fusion gene ID: 29215 |
FusionGeneSummary for PSME1_AP1G2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PSME1_AP1G2 | Fusion gene ID: 29215 | Hgene | Tgene | Gene symbol | PSME1 | AP1G2 | Gene ID | 5720 | 8906 |
Gene name | proteasome activator subunit 1 | adaptor related protein complex 1 subunit gamma 2 | |
Synonyms | HEL-S-129m|IFI5111|PA28A|PA28alpha|REGalpha | G2AD | |
Cytomap | 14q12 | 14q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | proteasome activator complex subunit 111S regulator complex subunit alpha29-kD MCP activator subunitIGUP I-5111activator of multicatalytic protease subunit 1epididymis secretory sperm binding protein Li 129minterferon gamma up-regulated I-5111 prote | AP-1 complex subunit gamma-like 2adaptor related protein complex 1 gamma 2 subunitclathrin-associated/assembly/adaptor protein, large, gamma-2gamma2-adaptin | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q06323 | O75843 | |
Ensembl transtripts involved in fusion gene | ENST00000206451, ENST00000559123, ENST00000382708, ENST00000561435, ENST00000470718, | ENST00000308724, ENST00000397120, ENST00000556277, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 14 X 4 X 8=448 |
# samples | 2 | 14 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(14/448*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PSME1 [Title/Abstract] AND AP1G2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | KIRP | TCGA-A4-7287-01A | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000206451 | ENST00000308724 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
5CDS-intron | ENST00000206451 | ENST00000397120 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
5CDS-intron | ENST00000206451 | ENST00000556277 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
intron-3CDS | ENST00000559123 | ENST00000308724 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
intron-intron | ENST00000559123 | ENST00000397120 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
intron-intron | ENST00000559123 | ENST00000556277 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
Frame-shift | ENST00000382708 | ENST00000308724 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
5CDS-intron | ENST00000382708 | ENST00000397120 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
5CDS-intron | ENST00000382708 | ENST00000556277 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
In-frame | ENST00000561435 | ENST00000308724 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
5CDS-intron | ENST00000561435 | ENST00000397120 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
5CDS-intron | ENST00000561435 | ENST00000556277 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
intron-3CDS | ENST00000470718 | ENST00000308724 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
intron-intron | ENST00000470718 | ENST00000397120 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
intron-intron | ENST00000470718 | ENST00000556277 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
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FusionProtFeatures for PSME1_AP1G2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PSME1 | AP1G2 |
Implicated in immunoproteasome assembly and required forefficient antigen processing. The PA28 activator complex enhancesthe generation of class I binding peptides by altering thecleavage pattern of the proteasome. | May function in protein sorting in late endosomes ormultivesucular bodies (MVBs). {ECO:0000269|PubMed:9733768}. (Microbial infection) Involved in MVB-assistedmaturation of hepatitis B virus (HBV).{ECO:0000269|PubMed:16867982, ECO:0000269|PubMed:17553870}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PSME1_AP1G2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_PSME1_ENST00000561435_chr14_24608175_+_AP1G2_ENST00000308724_chr14_24037279_-_303aa MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAPLDIPVPDPVKEKEKEERKKQQEKEDKDEKK KGEDEDKGPPCGPVNCNEKIVVLLQRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYVRRLCYMTSSXRTSRSSRSPGEKQREXSIESPLSHSVMSTAETFLLF |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_PSME1_ENST00000561435_chr14_24608175_+_AP1G2_ENST00000308724_chr14_24037279_-_909nt ATGGCCATGCTCAGGGTCCAGCCCGAGGCCCAAGCCAAGGTGGATGTGTTTCGTGAAGACCTCTGTACCAAGACAGAGAACCTGCTCGGG AGCTATTTCCCCAAGAAGATTTCTGAGCTGGATGCATTTTTAAAGGAGCCAGCTCTCAATGAAGCCAACTTGAGCAATCTGAAGGCCCCA TTGGACATCCCAGTGCCTGATCCAGTCAAGGAGAAAGAGAAAGAGGAGCGGAAGAAACAGCAGGAGAAGGAAGACAAGGATGAAAAGAAG AAGGGGGAGGATGAAGACAAAGGTCCTCCCTGTGGCCCAGTGAACTGCAATGAAAAGATCGTGGTCCTTCTGCAGCGCTTGAAGCCTGAG ATCAAGGATGTCATTGAGCAGCTCAACCTGGTCACCACCTGGTTGCAGCTGCAGATACCTCGGATTGAGGATGGTAACAATTTTGGAGTG GCTGTCCAGGAGAAGGTGTTTGAGCTGATGACCAGCCTCCACACCAAGCTAGAAGGCTTCCACACTCAAATCTCTAAGTATTTCTCTGAG CGTGGTGATGCAGTGACTAAAGCAGCCAAGCAGCCCCATGTGGGTGATTATCGGCAGCTGGTGCACGAGCTGGATGAGGCAGAGTACCGG GACATCCGGCTGATGGTCATGGAGATCCGCAATGCTTATGTGAGGAGGCTGTGTTATATGACATCATCCTGAAGAACTTCGAGAAGCTCA AGAAGCCCAGGGGAGAAACAAAGGGAATGATCTATTGAGAGCCCTCTCTCCCATTCTGTGATGAGTACAGCAGAGACCTTCCTGCTTTTT ACTGGGGACTCCAGATTTTCCCCAAACTTGCTTCTGTTGAGATTTTTCCCTCACCTTGCCTCTCAGGCACAATAAATATAGTTATACCAC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_PSME1_ENST00000561435_chr14_24608175_+_AP1G2_ENST00000308724_chr14_24037279_-_4243nt CACTCCTTGTGCGGCGCTAGGCCCCCCGTCCCGGTCATGGCCATGCTCAGGGTCCAGCCCGAGGCCCAAGCCAAGGTGGATGTGTTTCGT GAAGACCTCTGTACCAAGACAGAGAACCTGCTCGGGAGCTATTTCCCCAAGAAGATTTCTGAGCTGGATGCATTTTTAAAGGAGCCAGCT CTCAATGAAGCCAACTTGAGCAATCTGAAGGCCCCATTGGACATCCCAGTGCCTGATCCAGTCAAGGAGAAAGAGAAAGAGGAGCGGAAG AAACAGCAGGAGAAGGAAGACAAGGATGAAAAGAAGAAGGGGGAGGATGAAGACAAAGGTCCTCCCTGTGGCCCAGTGAACTGCAATGAA AAGATCGTGGTCCTTCTGCAGCGCTTGAAGCCTGAGATCAAGGATGTCATTGAGCAGCTCAACCTGGTCACCACCTGGTTGCAGCTGCAG ATACCTCGGATTGAGGATGGTAACAATTTTGGAGTGGCTGTCCAGGAGAAGGTGTTTGAGCTGATGACCAGCCTCCACACCAAGCTAGAA GGCTTCCACACTCAAATCTCTAAGTATTTCTCTGAGCGTGGTGATGCAGTGACTAAAGCAGCCAAGCAGCCCCATGTGGGTGATTATCGG CAGCTGGTGCACGAGCTGGATGAGGCAGAGTACCGGGACATCCGGCTGATGGTCATGGAGATCCGCAATGCTTATGTGAGGAGGCTGTGT TATATGACATCATCCTGAAGAACTTCGAGAAGCTCAAGAAGCCCAGGGGAGAAACAAAGGGAATGATCTATTGAGAGCCCTCTCTCCCAT TCTGTGATGAGTACAGCAGAGACCTTCCTGCTTTTTACTGGGGACTCCAGATTTTCCCCAAACTTGCTTCTGTTGAGATTTTTCCCTCAC CTTGCCTCTCAGGCACAATAAATATAGTTATACCACTGCCCATCAAAAAAAAATATATTAATAAAAAAGTTCAAAAAAGGGGGGGGATTG TCATCTCCTTTGGGGTGCGATGGCTTCAAATCCAAACTGAGGCTCTCCGGGTGGTAAGGATGTGCGAGGAGGCCTCTTGAAGAACTCCAG GCCTATCATGCTGTCTCTCCGCTAAAGCCTGAGGCCCGAGGTCAGAGGATTCAGGAAGGCTCTGCAGTCGGCCCAGGAGGGCGGGGTCCC GTGGTGGAGGCGGGGAGAGGGAAGGACCGCACGGAGCACCAACCCCTGCTCGGCCCCGTACCAGGAAGCGCTGGGGGGCAGAGGAGCGGA GTTGAGGCAGAAGCCAGGTGAGGCTGGAGTCCTGGGGTAGGCAGGCTGTCGCTGCCGCTGCCGCTGCCTGAGATGGAAATCGGGGGAGGA AGCTCGCGGAAGAAACAGCGGAGGGTCGTGGAAAAAAAAGCAATGGCTGAGCTAGGGATGGGGTACCAGGTAGGGGGAGGAAACGGTAGA GAGAAATAGGTGGGGCTCCCGCGCATGCTCAATAGGAAGGGGCGCCGGTGGGGTGCGGACGCATGCGTAGTGGGCTTCTCGGGCGGTGGG GTGGGCGCGGAATTTGGAGACCCACTTCGGGAAAGGTAAAATGCGGGCGCAATTTTAGGGTACCTGTGGGACCCGGGCTCTTAGGGTCTT GACACAGGACGGGCCTGGGCCGAAAGCCCAGGCACGCCCGACCAGAGAGTGTTTCTCCACTCCCGGACTCTGCCAGTCAGGATGGTGGTG CCTTCGCTGAAGCTTCAGGACCTCATCGAAGAGATTCGCGGGGCCAAGACTCAGGCCCAGGAGCGGGAGGTGATCCAAAAGGAGTGTGCC CACATCCGGGCCTCCTTCCGCGACGGGGACCCAGTGCACAGGCACCGGCAGCTGGCCAAACTGCTCTACGTCCACATGTTGGGCTACCCC GCCCACTTTGGACAGATGGAGTGCCTGAAACTGATCGCCTCCTCCAGATTCACAGACAAGAGGGTGGGCTACCTGGGGGCCATGCTTCTA TTGGATGAGAGGCACGATGCCCACCTGCTCATTACCAACAGCATCAAGAATGACCTGAGCCAGGGGATTCAGCCAGTACAAGGCCTGGCC TTGTGCACTTTGAGCACCATGGGCTCTGCTGAGATGTGCCGAGACCTGGCCCCAGAGGTGGAGAAACTGCTCCTGCAGCCCAGTCCCTAC GTGCGCAAGAAGGCTATTCTGACTGCAGTGCACATGATCCGGAAGGTCCCTGAACTCTCCAGTGTCTTCCTCCCACCCTGTGCCCAACTG CTTCATGAGCGTCACCATGGCATCCTGCTGGGCACCATCACGCTGATCACGGAGCTCTGCGAACGAAGCCCTGCAGCCCTCAGGCACTTC CGAAAGGTGGTACCCCAGCTGGTACACATCCTCCGGACTCTGGTGACAATGGGATACTCCACAGAACACAGCATATCTGGAGTCAGCGAC CCCTTCCTGCAGGTCCAGATACTTCGTCTGCTTCGGATCCTGGGCCGGAACCACGAGGAGAGCAGTGAGACCATGAATGACTTGCTGGCC CAGGTGGCCACTAACACGGACACCAGCCGAAATGCCGGAAATGCGGTCCTGTTTGAGACAGTACTCACCATCATGGATATCCGCTCTGCA GCTGGCCTACGGGTTCTAGCTGTCAACATTCTTGGTCGCTTCCTACTCAACAGTGACAGGAACATTAGGTATGTAGCCCTGACATCACTG CTTCGACTGGTGCAGTCTGATCACAGTGCTGTGCAGCGGCATCGGCCCACTGTGGTGGAATGTCTACGGGAAACTGATGCCTCCCTCAGC CGGAGAGCCCTGGAACTAAGCCTGGCTCTGGTAAATAGCTCCAATGTGCGAGCCATGATGCAAGAGCTGCAGGCCTTTCTGGAGTCCTGC CCTCCTGACCTACGGGCTGACTGTGCCTCAGGCATCCTGCTGGCTGCAGAGAGGTTTGCTCCAACCAAACGCTGGCACATAGACACCATC CTGCATGTGCTGACAACGGCGGGCACCCATGTGCGGGATGATGCAGTGGCCAACCTGACCCAGCTGATTGGGGGGGCCCAGGAGCTACAT GCCTACTCTGTGCGCCGCCTCTACAATGCCCTGGCAGAAGACATTTCCCAGCAACCACTGGTGCAGGTGGCAGCCTGGTGCATTGGGGAG TATGGGGACCTCCTGCTGGCAGGGAACTGCGAGGAGATTGAGCCCCTTCAGGTGGACGAAGAGGAAGTGCTGGCATTGCTGGAAAAGGTG CTGCAGTCCCACATGTCCCTGCCAGCCACTCGAGGATATGCCCTCACAGCCCTCATGAAGCTCAGCACTCGCCTCTGTGGGGACAACAAC CGCATCCGCCAGGTGGTGTCCATCTACGGGAGCTGCTTGGACGTGGAGCTGCAGCAGCGGGCTGTGGAGTATGACACACTCTTCCGGAAA TACGACCACATGAGGGCTGCCATCCTGGAAAAAATGCCTCTTGTGGAGCGAGATGGCCCTCAGGCTGATGAGGAAGCAAAGGAAAGCAAA GAAGCAGCCCAGCTTTCAGAAGCAGCCCCAGTGCCCACAGAGCCCCAGGCCTCACAGCTCCTGGATCTGCTAGATCTCCTGGATGGGGCT TCTGGGGATGTCCAGCATCCTCCCCATCTGGACCCCTCCCCAGGAGGTGCCCTGGTACACCTGCTTGACCTTCCCTGTGTACCTCCACCC CCAGCTCCCATCCCAGATCTCAAAGTGTTTGAGCGTGAGGGAGTACAGCTGAATCTGTCTTTCATTCGACCCCCTGAAAACCCTGCTTTG CTGTTAATCACCATCACTGCCACCAACTTCTCAGAGGGTGATGTCACCCATTTCATCTGCCAGGCTGCTGTGCCCAAGAGTCTCCAGCTG CAGCTGCAGGCCCCCAGTGGGAACACAGTTCCAGCTCGGGGTGGCCTTCCTATCACCCAGCTCTTCAGAATCCTCAATCCTAACAAGGCC CCCCTGCGGCTAAAGCTGCGCCTCACCTACGACCACTTTCACCAGTCGGTGCAGGAGATCTTTGAGGTGAACAACTTGCCTGTGGAATCG TGGCAGTAACTGTCTCCACTCACAGCCTGAAATTCTCCTGTGTCCCAAACCCCAGGGGGCCCCAGCAGCTTCGAACCTACACCTGAGGGC TACCAGCAGGTGGCGCTCTGGCTTTGCACTGCAAAAACTGGGGACCAGCCCCCTTCTCCCACAAATAAAGCCCAATAAAGCCTGAGAAGT |
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FusionGenePPI for PSME1_AP1G2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PSME1 | PSME2, EMD, USP22, PFDN1, PSME1, VCL, VIM, CHD3, EIF6, TUBB4B, ATP1B1, RPP14, AIMP2, TK1, CDC37, SMN1, SETDB1, PIK3R3, PSMA1, PSMC5, PSMA6, PSMC1, PSMA2, TUBG1, GRB2, PSMB6, PSMB9, PSMA4, PSMD6, PSMB7, PSMB8, PSMB10, APP, PSMB1, PSMB2, PSMC4, PSMA3, PSMD1, PSMC2, PSMB3, PSMA7, PSMD12, RBBP6, UBL7, OXCT1, PSRC1, USP5, PHPT1, PRDX3, CSE1L, PARVB, NUBP2, PARK2, BAG3, KIF5B, PSMD14, ADRM1, SHFM1, NAA10, HUWE1, CTRL, PSMB4, DDX19B, RNF26, CYP1A1, GARS, PAK2, SCLT1, MCM2, U2AF2, FBXO7, PPP1CC, CDK15, GPX7, GJB4, PSMG2 | AP1G2 | AP1S1, AP1S2, XRN1, SYNRG, NEDD4, ATXN1L, EGFR, KDM1A, PRMT6, CENPK, SYNE4, AAGAB, AP1M2, AP2M1, IST1, RABEP1, XPO1, RBM14-RBM4, THBS2, IL27RA, TMX3, ZYG11B, ATG2B, ZNF318, RBM3 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PSME1_AP1G2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PSME1_AP1G2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PSME1 | C0019693 | HIV Infections | 1 | CTD_human |
Hgene | PSME1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | PSME1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | PSME1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |