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Fusion gene ID: 29215 |
FusionGeneSummary for PSME1_AP1G2 |
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Fusion gene information | Fusion gene name: PSME1_AP1G2 | Fusion gene ID: 29215 | Hgene | Tgene | Gene symbol | PSME1 | AP1G2 | Gene ID | 5720 | 8906 |
Gene name | proteasome activator subunit 1 | adaptor related protein complex 1 subunit gamma 2 | |
Synonyms | HEL-S-129m|IFI5111|PA28A|PA28alpha|REGalpha | G2AD | |
Cytomap | 14q12 | 14q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | proteasome activator complex subunit 111S regulator complex subunit alpha29-kD MCP activator subunitIGUP I-5111activator of multicatalytic protease subunit 1epididymis secretory sperm binding protein Li 129minterferon gamma up-regulated I-5111 prote | AP-1 complex subunit gamma-like 2adaptor related protein complex 1 gamma 2 subunitclathrin-associated/assembly/adaptor protein, large, gamma-2gamma2-adaptin | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q06323 | O75843 | |
Ensembl transtripts involved in fusion gene | ENST00000206451, ENST00000559123, ENST00000382708, ENST00000561435, ENST00000470718, | ENST00000308724, ENST00000397120, ENST00000556277, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 14 X 4 X 8=448 |
# samples | 2 | 14 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(14/448*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PSME1 [Title/Abstract] AND AP1G2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | KIRP | TCGA-A4-7287-01A | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000206451 | ENST00000308724 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
5CDS-intron | ENST00000206451 | ENST00000397120 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
5CDS-intron | ENST00000206451 | ENST00000556277 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
intron-3CDS | ENST00000559123 | ENST00000308724 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
intron-intron | ENST00000559123 | ENST00000397120 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
intron-intron | ENST00000559123 | ENST00000556277 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
Frame-shift | ENST00000382708 | ENST00000308724 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
5CDS-intron | ENST00000382708 | ENST00000397120 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
5CDS-intron | ENST00000382708 | ENST00000556277 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
In-frame | ENST00000561435 | ENST00000308724 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
5CDS-intron | ENST00000561435 | ENST00000397120 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
5CDS-intron | ENST00000561435 | ENST00000556277 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
intron-3CDS | ENST00000470718 | ENST00000308724 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
intron-intron | ENST00000470718 | ENST00000397120 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
intron-intron | ENST00000470718 | ENST00000556277 | PSME1 | chr14 | 24608175 | + | AP1G2 | chr14 | 24037279 | - |
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FusionProtFeatures for PSME1_AP1G2 |
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Hgene | Tgene |
PSME1 | AP1G2 |
Implicated in immunoproteasome assembly and required forefficient antigen processing. The PA28 activator complex enhancesthe generation of class I binding peptides by altering thecleavage pattern of the proteasome. | May function in protein sorting in late endosomes ormultivesucular bodies (MVBs). {ECO:0000269|PubMed:9733768}. (Microbial infection) Involved in MVB-assistedmaturation of hepatitis B virus (HBV).{ECO:0000269|PubMed:16867982, ECO:0000269|PubMed:17553870}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PSME1_AP1G2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_PSME1_ENST00000561435_chr14_24608175_+_AP1G2_ENST00000308724_chr14_24037279_-_303aa MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAPLDIPVPDPVKEKEKEERKKQQEKEDKDEKK KGEDEDKGPPCGPVNCNEKIVVLLQRLKPEIKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYVRRLCYMTSSXRTSRSSRSPGEKQREXSIESPLSHSVMSTAETFLLF |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_PSME1_ENST00000561435_chr14_24608175_+_AP1G2_ENST00000308724_chr14_24037279_-_909nt ATGGCCATGCTCAGGGTCCAGCCCGAGGCCCAAGCCAAGGTGGATGTGTTTCGTGAAGACCTCTGTACCAAGACAGAGAACCTGCTCGGG AGCTATTTCCCCAAGAAGATTTCTGAGCTGGATGCATTTTTAAAGGAGCCAGCTCTCAATGAAGCCAACTTGAGCAATCTGAAGGCCCCA TTGGACATCCCAGTGCCTGATCCAGTCAAGGAGAAAGAGAAAGAGGAGCGGAAGAAACAGCAGGAGAAGGAAGACAAGGATGAAAAGAAG AAGGGGGAGGATGAAGACAAAGGTCCTCCCTGTGGCCCAGTGAACTGCAATGAAAAGATCGTGGTCCTTCTGCAGCGCTTGAAGCCTGAG ATCAAGGATGTCATTGAGCAGCTCAACCTGGTCACCACCTGGTTGCAGCTGCAGATACCTCGGATTGAGGATGGTAACAATTTTGGAGTG GCTGTCCAGGAGAAGGTGTTTGAGCTGATGACCAGCCTCCACACCAAGCTAGAAGGCTTCCACACTCAAATCTCTAAGTATTTCTCTGAG CGTGGTGATGCAGTGACTAAAGCAGCCAAGCAGCCCCATGTGGGTGATTATCGGCAGCTGGTGCACGAGCTGGATGAGGCAGAGTACCGG GACATCCGGCTGATGGTCATGGAGATCCGCAATGCTTATGTGAGGAGGCTGTGTTATATGACATCATCCTGAAGAACTTCGAGAAGCTCA AGAAGCCCAGGGGAGAAACAAAGGGAATGATCTATTGAGAGCCCTCTCTCCCATTCTGTGATGAGTACAGCAGAGACCTTCCTGCTTTTT ACTGGGGACTCCAGATTTTCCCCAAACTTGCTTCTGTTGAGATTTTTCCCTCACCTTGCCTCTCAGGCACAATAAATATAGTTATACCAC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_PSME1_ENST00000561435_chr14_24608175_+_AP1G2_ENST00000308724_chr14_24037279_-_4243nt CACTCCTTGTGCGGCGCTAGGCCCCCCGTCCCGGTCATGGCCATGCTCAGGGTCCAGCCCGAGGCCCAAGCCAAGGTGGATGTGTTTCGT GAAGACCTCTGTACCAAGACAGAGAACCTGCTCGGGAGCTATTTCCCCAAGAAGATTTCTGAGCTGGATGCATTTTTAAAGGAGCCAGCT CTCAATGAAGCCAACTTGAGCAATCTGAAGGCCCCATTGGACATCCCAGTGCCTGATCCAGTCAAGGAGAAAGAGAAAGAGGAGCGGAAG AAACAGCAGGAGAAGGAAGACAAGGATGAAAAGAAGAAGGGGGAGGATGAAGACAAAGGTCCTCCCTGTGGCCCAGTGAACTGCAATGAA AAGATCGTGGTCCTTCTGCAGCGCTTGAAGCCTGAGATCAAGGATGTCATTGAGCAGCTCAACCTGGTCACCACCTGGTTGCAGCTGCAG ATACCTCGGATTGAGGATGGTAACAATTTTGGAGTGGCTGTCCAGGAGAAGGTGTTTGAGCTGATGACCAGCCTCCACACCAAGCTAGAA GGCTTCCACACTCAAATCTCTAAGTATTTCTCTGAGCGTGGTGATGCAGTGACTAAAGCAGCCAAGCAGCCCCATGTGGGTGATTATCGG CAGCTGGTGCACGAGCTGGATGAGGCAGAGTACCGGGACATCCGGCTGATGGTCATGGAGATCCGCAATGCTTATGTGAGGAGGCTGTGT TATATGACATCATCCTGAAGAACTTCGAGAAGCTCAAGAAGCCCAGGGGAGAAACAAAGGGAATGATCTATTGAGAGCCCTCTCTCCCAT TCTGTGATGAGTACAGCAGAGACCTTCCTGCTTTTTACTGGGGACTCCAGATTTTCCCCAAACTTGCTTCTGTTGAGATTTTTCCCTCAC CTTGCCTCTCAGGCACAATAAATATAGTTATACCACTGCCCATCAAAAAAAAATATATTAATAAAAAAGTTCAAAAAAGGGGGGGGATTG TCATCTCCTTTGGGGTGCGATGGCTTCAAATCCAAACTGAGGCTCTCCGGGTGGTAAGGATGTGCGAGGAGGCCTCTTGAAGAACTCCAG GCCTATCATGCTGTCTCTCCGCTAAAGCCTGAGGCCCGAGGTCAGAGGATTCAGGAAGGCTCTGCAGTCGGCCCAGGAGGGCGGGGTCCC GTGGTGGAGGCGGGGAGAGGGAAGGACCGCACGGAGCACCAACCCCTGCTCGGCCCCGTACCAGGAAGCGCTGGGGGGCAGAGGAGCGGA GTTGAGGCAGAAGCCAGGTGAGGCTGGAGTCCTGGGGTAGGCAGGCTGTCGCTGCCGCTGCCGCTGCCTGAGATGGAAATCGGGGGAGGA AGCTCGCGGAAGAAACAGCGGAGGGTCGTGGAAAAAAAAGCAATGGCTGAGCTAGGGATGGGGTACCAGGTAGGGGGAGGAAACGGTAGA GAGAAATAGGTGGGGCTCCCGCGCATGCTCAATAGGAAGGGGCGCCGGTGGGGTGCGGACGCATGCGTAGTGGGCTTCTCGGGCGGTGGG GTGGGCGCGGAATTTGGAGACCCACTTCGGGAAAGGTAAAATGCGGGCGCAATTTTAGGGTACCTGTGGGACCCGGGCTCTTAGGGTCTT GACACAGGACGGGCCTGGGCCGAAAGCCCAGGCACGCCCGACCAGAGAGTGTTTCTCCACTCCCGGACTCTGCCAGTCAGGATGGTGGTG CCTTCGCTGAAGCTTCAGGACCTCATCGAAGAGATTCGCGGGGCCAAGACTCAGGCCCAGGAGCGGGAGGTGATCCAAAAGGAGTGTGCC CACATCCGGGCCTCCTTCCGCGACGGGGACCCAGTGCACAGGCACCGGCAGCTGGCCAAACTGCTCTACGTCCACATGTTGGGCTACCCC GCCCACTTTGGACAGATGGAGTGCCTGAAACTGATCGCCTCCTCCAGATTCACAGACAAGAGGGTGGGCTACCTGGGGGCCATGCTTCTA TTGGATGAGAGGCACGATGCCCACCTGCTCATTACCAACAGCATCAAGAATGACCTGAGCCAGGGGATTCAGCCAGTACAAGGCCTGGCC TTGTGCACTTTGAGCACCATGGGCTCTGCTGAGATGTGCCGAGACCTGGCCCCAGAGGTGGAGAAACTGCTCCTGCAGCCCAGTCCCTAC GTGCGCAAGAAGGCTATTCTGACTGCAGTGCACATGATCCGGAAGGTCCCTGAACTCTCCAGTGTCTTCCTCCCACCCTGTGCCCAACTG CTTCATGAGCGTCACCATGGCATCCTGCTGGGCACCATCACGCTGATCACGGAGCTCTGCGAACGAAGCCCTGCAGCCCTCAGGCACTTC CGAAAGGTGGTACCCCAGCTGGTACACATCCTCCGGACTCTGGTGACAATGGGATACTCCACAGAACACAGCATATCTGGAGTCAGCGAC CCCTTCCTGCAGGTCCAGATACTTCGTCTGCTTCGGATCCTGGGCCGGAACCACGAGGAGAGCAGTGAGACCATGAATGACTTGCTGGCC CAGGTGGCCACTAACACGGACACCAGCCGAAATGCCGGAAATGCGGTCCTGTTTGAGACAGTACTCACCATCATGGATATCCGCTCTGCA GCTGGCCTACGGGTTCTAGCTGTCAACATTCTTGGTCGCTTCCTACTCAACAGTGACAGGAACATTAGGTATGTAGCCCTGACATCACTG CTTCGACTGGTGCAGTCTGATCACAGTGCTGTGCAGCGGCATCGGCCCACTGTGGTGGAATGTCTACGGGAAACTGATGCCTCCCTCAGC CGGAGAGCCCTGGAACTAAGCCTGGCTCTGGTAAATAGCTCCAATGTGCGAGCCATGATGCAAGAGCTGCAGGCCTTTCTGGAGTCCTGC CCTCCTGACCTACGGGCTGACTGTGCCTCAGGCATCCTGCTGGCTGCAGAGAGGTTTGCTCCAACCAAACGCTGGCACATAGACACCATC CTGCATGTGCTGACAACGGCGGGCACCCATGTGCGGGATGATGCAGTGGCCAACCTGACCCAGCTGATTGGGGGGGCCCAGGAGCTACAT GCCTACTCTGTGCGCCGCCTCTACAATGCCCTGGCAGAAGACATTTCCCAGCAACCACTGGTGCAGGTGGCAGCCTGGTGCATTGGGGAG TATGGGGACCTCCTGCTGGCAGGGAACTGCGAGGAGATTGAGCCCCTTCAGGTGGACGAAGAGGAAGTGCTGGCATTGCTGGAAAAGGTG CTGCAGTCCCACATGTCCCTGCCAGCCACTCGAGGATATGCCCTCACAGCCCTCATGAAGCTCAGCACTCGCCTCTGTGGGGACAACAAC CGCATCCGCCAGGTGGTGTCCATCTACGGGAGCTGCTTGGACGTGGAGCTGCAGCAGCGGGCTGTGGAGTATGACACACTCTTCCGGAAA TACGACCACATGAGGGCTGCCATCCTGGAAAAAATGCCTCTTGTGGAGCGAGATGGCCCTCAGGCTGATGAGGAAGCAAAGGAAAGCAAA GAAGCAGCCCAGCTTTCAGAAGCAGCCCCAGTGCCCACAGAGCCCCAGGCCTCACAGCTCCTGGATCTGCTAGATCTCCTGGATGGGGCT TCTGGGGATGTCCAGCATCCTCCCCATCTGGACCCCTCCCCAGGAGGTGCCCTGGTACACCTGCTTGACCTTCCCTGTGTACCTCCACCC CCAGCTCCCATCCCAGATCTCAAAGTGTTTGAGCGTGAGGGAGTACAGCTGAATCTGTCTTTCATTCGACCCCCTGAAAACCCTGCTTTG CTGTTAATCACCATCACTGCCACCAACTTCTCAGAGGGTGATGTCACCCATTTCATCTGCCAGGCTGCTGTGCCCAAGAGTCTCCAGCTG CAGCTGCAGGCCCCCAGTGGGAACACAGTTCCAGCTCGGGGTGGCCTTCCTATCACCCAGCTCTTCAGAATCCTCAATCCTAACAAGGCC CCCCTGCGGCTAAAGCTGCGCCTCACCTACGACCACTTTCACCAGTCGGTGCAGGAGATCTTTGAGGTGAACAACTTGCCTGTGGAATCG TGGCAGTAACTGTCTCCACTCACAGCCTGAAATTCTCCTGTGTCCCAAACCCCAGGGGGCCCCAGCAGCTTCGAACCTACACCTGAGGGC TACCAGCAGGTGGCGCTCTGGCTTTGCACTGCAAAAACTGGGGACCAGCCCCCTTCTCCCACAAATAAAGCCCAATAAAGCCTGAGAAGT |
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FusionGenePPI for PSME1_AP1G2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PSME1 | PSME2, EMD, USP22, PFDN1, PSME1, VCL, VIM, CHD3, EIF6, TUBB4B, ATP1B1, RPP14, AIMP2, TK1, CDC37, SMN1, SETDB1, PIK3R3, PSMA1, PSMC5, PSMA6, PSMC1, PSMA2, TUBG1, GRB2, PSMB6, PSMB9, PSMA4, PSMD6, PSMB7, PSMB8, PSMB10, APP, PSMB1, PSMB2, PSMC4, PSMA3, PSMD1, PSMC2, PSMB3, PSMA7, PSMD12, RBBP6, UBL7, OXCT1, PSRC1, USP5, PHPT1, PRDX3, CSE1L, PARVB, NUBP2, PARK2, BAG3, KIF5B, PSMD14, ADRM1, SHFM1, NAA10, HUWE1, CTRL, PSMB4, DDX19B, RNF26, CYP1A1, GARS, PAK2, SCLT1, MCM2, U2AF2, FBXO7, PPP1CC, CDK15, GPX7, GJB4, PSMG2 | AP1G2 | AP1S1, AP1S2, XRN1, SYNRG, NEDD4, ATXN1L, EGFR, KDM1A, PRMT6, CENPK, SYNE4, AAGAB, AP1M2, AP2M1, IST1, RABEP1, XPO1, RBM14-RBM4, THBS2, IL27RA, TMX3, ZYG11B, ATG2B, ZNF318, RBM3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PSME1_AP1G2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PSME1_AP1G2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PSME1 | C0019693 | HIV Infections | 1 | CTD_human |
Hgene | PSME1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | PSME1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | PSME1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |