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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29206

FusionGeneSummary for PSMD5_PSMD5

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMD5_PSMD5
Fusion gene ID: 29206
HgeneTgene
Gene symbol

PSMD5

PSMD5

Gene ID

5711

5711

Gene nameproteasome 26S subunit, non-ATPase 5proteasome 26S subunit, non-ATPase 5
SynonymsS5BS5B
Cytomap

9q33.2

9q33.2

Type of geneprotein-codingprotein-coding
Description26S proteasome non-ATPase regulatory subunit 526S protease subunit S5 basic26S proteasome subunit S5Bproteasome (prosome, macropain) 26S subunit, non-ATPase, 526S proteasome non-ATPase regulatory subunit 526S protease subunit S5 basic26S proteasome subunit S5Bproteasome (prosome, macropain) 26S subunit, non-ATPase, 5
Modification date2018052320180523
UniProtAcc

Q16401

Q16401

Ensembl transtripts involved in fusion geneENST00000210313, ENST00000373904, 
ENST00000604848, 		ENST00000210313, 
ENST00000373904, ENST00000604848, 
Fusion gene scores* DoF score2 X 3 X 2=122 X 3 X 2=12
# samples 33
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PSMD5 [Title/Abstract] AND PSMD5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI005318PSMD5chr9

123579560

+PSMD5chr9

123579355

-
ChiTaRS3.1BU607444PSMD5chr9

123578802

+PSMD5chr9

123579138

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000210313ENST00000210313PSMD5chr9

123579560

+PSMD5chr9

123579355

-
intron-intronENST00000210313ENST00000373904PSMD5chr9

123579560

+PSMD5chr9

123579355

-
intron-intronENST00000210313ENST00000604848PSMD5chr9

123579560

+PSMD5chr9

123579355

-
intron-3UTRENST00000373904ENST00000210313PSMD5chr9

123579560

+PSMD5chr9

123579355

-
intron-intronENST00000373904ENST00000373904PSMD5chr9

123579560

+PSMD5chr9

123579355

-
intron-intronENST00000373904ENST00000604848PSMD5chr9

123579560

+PSMD5chr9

123579355

-
intron-3UTRENST00000604848ENST00000210313PSMD5chr9

123579560

+PSMD5chr9

123579355

-
intron-intronENST00000604848ENST00000373904PSMD5chr9

123579560

+PSMD5chr9

123579355

-
intron-intronENST00000604848ENST00000604848PSMD5chr9

123579560

+PSMD5chr9

123579355

-
intron-3UTRENST00000210313ENST00000210313PSMD5chr9

123578802

+PSMD5chr9

123579138

-
intron-intronENST00000210313ENST00000373904PSMD5chr9

123578802

+PSMD5chr9

123579138

-
intron-intronENST00000210313ENST00000604848PSMD5chr9

123578802

+PSMD5chr9

123579138

-
intron-3UTRENST00000373904ENST00000210313PSMD5chr9

123578802

+PSMD5chr9

123579138

-
intron-intronENST00000373904ENST00000373904PSMD5chr9

123578802

+PSMD5chr9

123579138

-
intron-intronENST00000373904ENST00000604848PSMD5chr9

123578802

+PSMD5chr9

123579138

-
intron-3UTRENST00000604848ENST00000210313PSMD5chr9

123578802

+PSMD5chr9

123579138

-
intron-intronENST00000604848ENST00000373904PSMD5chr9

123578802

+PSMD5chr9

123579138

-
intron-intronENST00000604848ENST00000604848PSMD5chr9

123578802

+PSMD5chr9

123579138

-

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FusionProtFeatures for PSMD5_PSMD5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSMD5

Q16401

PSMD5

Q16401

Acts as a chaperone during the assembly of the 26Sproteasome, specifically of the base subcomplex of the PA700/19Sregulatory complex (RC). In the initial step of the basesubcomplex assembly is part of an intermediatePSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with aPSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5.{ECO:0000269|PubMed:19412159, ECO:0000269|PubMed:19490896}. Acts as a chaperone during the assembly of the 26Sproteasome, specifically of the base subcomplex of the PA700/19Sregulatory complex (RC). In the initial step of the basesubcomplex assembly is part of an intermediatePSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with aPSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5.{ECO:0000269|PubMed:19412159, ECO:0000269|PubMed:19490896}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PSMD5_PSMD5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PSMD5_PSMD5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PSMD5_PSMD5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PSMD5_PSMD5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource