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Fusion gene ID: 29165 |
FusionGeneSummary for PSMD11_CDK12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PSMD11_CDK12 | Fusion gene ID: 29165 | Hgene | Tgene | Gene symbol | PSMD11 | CDK12 | Gene ID | 5717 | 51755 |
| Gene name | proteasome 26S subunit, non-ATPase 11 | cyclin dependent kinase 12 | |
| Synonyms | Rpn6|S9|p44.5 | CRK7|CRKR|CRKRS | |
| Cytomap | 17q11.2 | 17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 26S proteasome non-ATPase regulatory subunit 1126S proteasome regulatory subunit 926S proteasome regulatory subunit RPN626S proteasome regulatory subunit S926S proteasome regulatory subunit p44.5proteasome (prosome, macropain) 26S subunit, non-ATPase | cyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O00231 | Q9NYV4 | |
| Ensembl transtripts involved in fusion gene | ENST00000261712, ENST00000457654, | ENST00000430627, ENST00000447079, ENST00000559545, | |
| Fusion gene scores | * DoF score | 10 X 5 X 6=300 | 27 X 15 X 12=4860 |
| # samples | 11 | 31 | |
| ** MAII score | log2(11/300*10)=-1.44745897697122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(31/4860*10)=-3.97061619321891 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PSMD11 [Title/Abstract] AND CDK12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CDK12 | GO:0046777 | protein autophosphorylation | 11683387 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A8-A08S-01A | PSMD11 | chr17 | 30774064 | + | CDK12 | chr17 | 37707291 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000261712 | ENST00000430627 | PSMD11 | chr17 | 30774064 | + | CDK12 | chr17 | 37707291 | + |
| 5CDS-intron | ENST00000261712 | ENST00000447079 | PSMD11 | chr17 | 30774064 | + | CDK12 | chr17 | 37707291 | + |
| 5CDS-3UTR | ENST00000261712 | ENST00000559545 | PSMD11 | chr17 | 30774064 | + | CDK12 | chr17 | 37707291 | + |
| 5CDS-intron | ENST00000457654 | ENST00000430627 | PSMD11 | chr17 | 30774064 | + | CDK12 | chr17 | 37707291 | + |
| 5CDS-intron | ENST00000457654 | ENST00000447079 | PSMD11 | chr17 | 30774064 | + | CDK12 | chr17 | 37707291 | + |
| 5CDS-3UTR | ENST00000457654 | ENST00000559545 | PSMD11 | chr17 | 30774064 | + | CDK12 | chr17 | 37707291 | + |
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FusionProtFeatures for PSMD11_CDK12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PSMD11 | CDK12 |
| Component of the 26S proteasome, a multiprotein complexinvolved in the ATP-dependent degradation of ubiquitinatedproteins. This complex plays a key role in the maintenance ofprotein homeostasis by removing misfolded or damaged proteins,which could impair cellular functions, and by removing proteinswhose functions are no longer required. Therefore, the proteasomeparticipates in numerous cellular processes, including cell cycleprogression, apoptosis, or DNA damage repair. In the complex,PSMD11 is required for proteasome assembly. Plays a key role inincreased proteasome activity in embryonic stem cells (ESCs): itshigh expression in ESCs promotes enhanced assembly of the 26Sproteasome, followed by higher proteasome activity.{ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:22972301}. | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II(POLR2A), thereby acting as a key regulator of transcriptionelongation. Regulates the expression of genes involved in DNArepair and is required for the maintenance of genomic stability.Preferentially phosphorylates 'Ser-5' in CTD repeats that arealready phosphorylated at 'Ser-7', but can also phosphorylate'Ser-2'. Required for RNA splicing, possibly by phosphorylatingSRSF1/SF2. Involved in regulation of MAP kinase activity, possiblyleading to affect the response to estrogen inhibitors.{ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820,ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619,ECO:0000269|PubMed:24662513}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PSMD11_CDK12 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PSMD11_CDK12 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PSMD11 | PSMD13, PSMD10, PSMD6, PAAF1, PSMC4, GDF9, CCSER2, CCDC90B, IGSF21, PTPRK, COPS6, HAP1, SETDB1, ZHX1, MED31, EEF1G, GAPDH, PTN, LRIF1, TLE1, TP53, TUBB2A, UNC119, ZBTB16, BRD7, CRMP1, RBM48, EEF1A1, PSMD14, PSMD7, UCHL5, USP14, USP15, USP20, SLX1B, NFKB2, UBC, HDAC5, INSIG2, SHFM1, RAD23A, PRKAB2, PRKAA2, PRKAA1, FKBP8, FBXO25, PSMA2, CDK2, USP4, GRK5, GRB2, APP, PSMC5, PSMC6, PSMC1, PSMC3, PSMC2, PSMD12, PSMD1, PSMD2, PSMD3, PSMD8, PSMD4, PSMA5, PSMA7, PSMB1, PSMA6, PSMA3, PSMB7, PSMA1, PSMB2, PSMB3, PSMB5, PSMA4, PSMB4, PSME3, PUS1, LRRK2, FN1, VCAM1, NOS2, SMAD3, SMAD4, SMAD2, SMAD1, SMAD5, CFTR, PARK2, PRMT6, RNF11, ADRM1, KIAA0368, KCMF1, RPS15A, RPS21, RPS8, ASB11, HUWE1, CUL7, CCDC74B, CCDC92, PSMB9, COPS3, COX5A, DCTN1, DNAJA2, MCFD2, MTCH1, NHP2L1, NLRP9, POLE, PSMB6, PSMB8, DNAJA1, DNAJA4, IKBKAP, PSMD5, PSMD9, NTRK1, HERC2, FAN1, RNF168, SUCO, CRY1, CRY2, PRKACA, MID2, SNW1, CDC5L, RC3H1, DERL1, UBLCP1, KDELR1, ODF1, ATG9A, ZFYVE27, NALCN, SLCO6A1, SLC17A2, TMC7, CYLD, DLD, HSD17B10, SOD1, BRCA1 | CDK12 | MGMT, SRRM2, RBM39, ELAVL1, MYC, PRPF4, CDK13, CCNK, TRIM24, IPPK, VPS51, ZNF606, TCEB3, BARD1, PAXIP1, PRPF40A, EWSR1, CDK20, CDK9, PIN1, RPL14, ACAA1, MAP4K4, SCAF4, SUPT16H, SRPK2, CLK1, BCLAF1, RNPS1, SNW1, PCGF1, CDX1, RPL37A, RRS1, ZNF2, FGF8, RPS14, WEE1, LASP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PSMD11_CDK12 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PSMD11_CDK12 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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