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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29159

FusionGeneSummary for PSMC5_PSD3

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMC5_PSD3
Fusion gene ID: 29159
HgeneTgene
Gene symbol

PSMC5

PSD3

Gene ID

5705

23362

Gene nameproteasome 26S subunit, ATPase 5pleckstrin and Sec7 domain containing 3
SynonymsS8|SUG-1|SUG1|TBP10|TRIP1|p45|p45/SUGEFA6D|EFA6R|HCA67
Cytomap

17q23.3

8p22

Type of geneprotein-codingprotein-coding
Description26S proteasome regulatory subunit 826S protease regulatory subunit 826S proteasome AAA-ATPase subunit RPT6MSUG1 proteinTat-binding protein homolog 10proteasome (prosome, macropain) 26S subunit, ATPase, 5proteasome 26S ATPase subunit 5proteasome subPH and SEC7 domain-containing protein 3ADP-ribosylation factor guanine nucleotide factor 6epididymis tissue protein Li 20mPexchange factor for ADP-ribosylation factor guanine nucleotide factor 6exchange factor for ADP-ribosylation factor guanine nucle
Modification date2018052320180523
UniProtAcc

P62195

Q9NYI0

Ensembl transtripts involved in fusion geneENST00000310144, ENST00000582420, 
ENST00000580864, ENST00000375812, 
ENST00000581882, 		ENST00000327040, 
ENST00000440756, ENST00000286485, 
ENST00000428502, ENST00000523619, 
ENST00000520789, 
Fusion gene scores* DoF score7 X 8 X 1=564 X 4 X 2=32
# samples 84
** MAII scorelog2(8/56*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PSMC5 [Title/Abstract] AND PSD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePSMC5

GO:0006357

regulation of transcription by RNA polymerase II

7870181

HgenePSMC5

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

12110588


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CK725100PSMC5chr17

61909127

-PSD3chr8

18725438

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000310144ENST00000327040PSMC5chr17

61909127

-PSD3chr8

18725438

+
Frame-shiftENST00000310144ENST00000440756PSMC5chr17

61909127

-PSD3chr8

18725438

+
5CDS-intronENST00000310144ENST00000286485PSMC5chr17

61909127

-PSD3chr8

18725438

+
5CDS-intronENST00000310144ENST00000428502PSMC5chr17

61909127

-PSD3chr8

18725438

+
5CDS-intronENST00000310144ENST00000523619PSMC5chr17

61909127

-PSD3chr8

18725438

+
5CDS-intronENST00000310144ENST00000520789PSMC5chr17

61909127

-PSD3chr8

18725438

+
intron-3CDSENST00000582420ENST00000327040PSMC5chr17

61909127

-PSD3chr8

18725438

+
intron-3CDSENST00000582420ENST00000440756PSMC5chr17

61909127

-PSD3chr8

18725438

+
intron-intronENST00000582420ENST00000286485PSMC5chr17

61909127

-PSD3chr8

18725438

+
intron-intronENST00000582420ENST00000428502PSMC5chr17

61909127

-PSD3chr8

18725438

+
intron-intronENST00000582420ENST00000523619PSMC5chr17

61909127

-PSD3chr8

18725438

+
intron-intronENST00000582420ENST00000520789PSMC5chr17

61909127

-PSD3chr8

18725438

+
Frame-shiftENST00000580864ENST00000327040PSMC5chr17

61909127

-PSD3chr8

18725438

+
Frame-shiftENST00000580864ENST00000440756PSMC5chr17

61909127

-PSD3chr8

18725438

+
5CDS-intronENST00000580864ENST00000286485PSMC5chr17

61909127

-PSD3chr8

18725438

+
5CDS-intronENST00000580864ENST00000428502PSMC5chr17

61909127

-PSD3chr8

18725438

+
5CDS-intronENST00000580864ENST00000523619PSMC5chr17

61909127

-PSD3chr8

18725438

+
5CDS-intronENST00000580864ENST00000520789PSMC5chr17

61909127

-PSD3chr8

18725438

+
Frame-shiftENST00000375812ENST00000327040PSMC5chr17

61909127

-PSD3chr8

18725438

+
Frame-shiftENST00000375812ENST00000440756PSMC5chr17

61909127

-PSD3chr8

18725438

+
5CDS-intronENST00000375812ENST00000286485PSMC5chr17

61909127

-PSD3chr8

18725438

+
5CDS-intronENST00000375812ENST00000428502PSMC5chr17

61909127

-PSD3chr8

18725438

+
5CDS-intronENST00000375812ENST00000523619PSMC5chr17

61909127

-PSD3chr8

18725438

+
5CDS-intronENST00000375812ENST00000520789PSMC5chr17

61909127

-PSD3chr8

18725438

+
Frame-shiftENST00000581882ENST00000327040PSMC5chr17

61909127

-PSD3chr8

18725438

+
Frame-shiftENST00000581882ENST00000440756PSMC5chr17

61909127

-PSD3chr8

18725438

+
5CDS-intronENST00000581882ENST00000286485PSMC5chr17

61909127

-PSD3chr8

18725438

+
5CDS-intronENST00000581882ENST00000428502PSMC5chr17

61909127

-PSD3chr8

18725438

+
5CDS-intronENST00000581882ENST00000523619PSMC5chr17

61909127

-PSD3chr8

18725438

+
5CDS-intronENST00000581882ENST00000520789PSMC5chr17

61909127

-PSD3chr8

18725438

+

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FusionProtFeatures for PSMC5_PSD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSMC5

P62195

PSD3

Q9NYI0

Component of the 26S proteasome, a multiprotein complexinvolved in the ATP-dependent degradation of ubiquitinatedproteins. This complex plays a key role in the maintenance ofprotein homeostasis by removing misfolded or damaged proteins,which could impair cellular functions, and by removing proteinswhose functions are no longer required. Therefore, the proteasomeparticipates in numerous cellular processes, including cell cycleprogression, apoptosis, or DNA damage repair. PSMC5 belongs to theheterohexameric ring of AAA (ATPases associated with diversecellular activities) proteins that unfolds ubiquitinated targetproteins that are concurrently translocated into a proteolyticchamber and degraded into peptides. {ECO:0000269|PubMed:1317798}. Guanine nucleotide exchange factor for ARF6.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PSMC5_PSD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PSMC5_PSD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PSMC5_PSD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PSMC5_PSD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePSMC5C0019693HIV Infections1CTD_human
HgenePSMC5C0038325Stevens-Johnson Syndrome1CTD_human
TgenePSD3C0017638Glioma1CTD_human
TgenePSD3C0036341Schizophrenia1PSYGENET
TgenePSD3C0236733Amphetamine-Related Disorders1CTD_human