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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29113

FusionGeneSummary for PSMA5_USF1

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMA5_USF1
Fusion gene ID: 29113
HgeneTgene
Gene symbol

PSMA5

USF1

Gene ID

5686

7391

Gene nameproteasome subunit alpha 5upstream transcription factor 1
SynonymsPSC5|ZETAFCHL|FCHL1|HYPLIP1|MLTF|MLTFI|UEF|bHLHb11
Cytomap

1p13.3

1q23.3

Type of geneprotein-codingprotein-coding
Descriptionproteasome subunit alpha type-5epididymis tissue sperm binding protein Li 11nmacropain subunit zetamacropain zeta chainmulticatalytic endopeptidase complex zeta chainproteasome (prosome, macropain) subunit, alpha type, 5proteasome alpha 5 subunitprupstream stimulatory factor 1class B basic helix-loop-helix protein 11major late transcription factor 1
Modification date2018052320180522
UniProtAcc

P28066

P22415

Ensembl transtripts involved in fusion geneENST00000271308, ENST00000538610, 
ENST00000490870, 
ENST00000368020, 
ENST00000368021, ENST00000435396, 
ENST00000368019, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 6 X 2=48
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PSMA5 [Title/Abstract] AND USF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUSF1

GO:0006366

transcription by RNA polymerase II

2249772

TgeneUSF1

GO:0019086

late viral transcription

2249772

TgeneUSF1

GO:0032869

cellular response to insulin stimulus

19303849


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP284679PSMA5chr1

109954767

-USF1chr1

161015686

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000271308ENST00000368020PSMA5chr1

109954767

-USF1chr1

161015686

-
intron-5UTRENST00000271308ENST00000368021PSMA5chr1

109954767

-USF1chr1

161015686

-
intron-5UTRENST00000271308ENST00000435396PSMA5chr1

109954767

-USF1chr1

161015686

-
intron-intronENST00000271308ENST00000368019PSMA5chr1

109954767

-USF1chr1

161015686

-
intron-intronENST00000538610ENST00000368020PSMA5chr1

109954767

-USF1chr1

161015686

-
intron-5UTRENST00000538610ENST00000368021PSMA5chr1

109954767

-USF1chr1

161015686

-
intron-5UTRENST00000538610ENST00000435396PSMA5chr1

109954767

-USF1chr1

161015686

-
intron-intronENST00000538610ENST00000368019PSMA5chr1

109954767

-USF1chr1

161015686

-
intron-intronENST00000490870ENST00000368020PSMA5chr1

109954767

-USF1chr1

161015686

-
intron-5UTRENST00000490870ENST00000368021PSMA5chr1

109954767

-USF1chr1

161015686

-
intron-5UTRENST00000490870ENST00000435396PSMA5chr1

109954767

-USF1chr1

161015686

-
intron-intronENST00000490870ENST00000368019PSMA5chr1

109954767

-USF1chr1

161015686

-

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FusionProtFeatures for PSMA5_USF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSMA5

P28066

USF1

P22415

Component of the 20S core proteasome complex involved inthe proteolytic degradation of most intracellular proteins. Thiscomplex plays numerous essential roles within the cell byassociating with different regulatory particles. Associated withtwo 19S regulatory particles, forms the 26S proteasome and thusparticipates in the ATP-dependent degradation of ubiquitinatedproteins. The 26S proteasome plays a key role in the maintenanceof protein homeostasis by removing misfolded or damaged proteinsthat could impair cellular functions, and by removing proteinswhose functions are no longer required. Associated with the PA200or PA28, the 20S proteasome mediates ubiquitin-independent proteindegradation. This type of proteolysis is required in severalpathways including spermatogenesis (20S-PA200 complex) orgeneration of a subset of MHC class I-presented antigenic peptides(20S-PA28 complex). {ECO:0000269|PubMed:15244466,ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}. Transcription factor that binds to a symmetrical DNAsequence (E-boxes) (5'-CACGTG-3') that is found in a variety ofviral and cellular promoters.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PSMA5_USF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PSMA5_USF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PSMA5_USF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PSMA5_USF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePSMA5C0015695Fatty Liver1CTD_human
HgenePSMA5C0019693HIV Infections1CTD_human
HgenePSMA5C0029456Osteoporosis1CTD_human