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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29108

FusionGeneSummary for PSMA3_ACTR10

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMA3_ACTR10
Fusion gene ID: 29108
HgeneTgene
Gene symbol

PSMA3

ACTR10

Gene ID

5684

55860

Gene nameproteasome subunit alpha 3actin related protein 10 homolog
SynonymsHC8|PSC3ACTR11|Arp10|Arp11|HARP11
Cytomap

14q23.1

14q23.1

Type of geneprotein-codingprotein-coding
Descriptionproteasome subunit alpha type-3macropain subunit C8multicatalytic endopeptidase complex subunit C8proteasome (prosome, macropain) subunit, alpha type, 3proteasome component C8proteasome subunit C8testicular secretory protein Li 43actin-related protein 10actin-related protein 11
Modification date2018052320180522
UniProtAcc

P25788

Q9NZ32

Ensembl transtripts involved in fusion geneENST00000216455, ENST00000412908, 
ENST00000557508, ENST00000554456, 
ENST00000254286, 
Fusion gene scores* DoF score3 X 5 X 4=602 X 3 X 4=24
# samples 54
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PSMA3 [Title/Abstract] AND ACTR10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-VR-A8Q7-01APSMA3chr14

58734238

+ACTR10chr14

58669573

+
TCGARVLIHCTCGA-BC-A216-01APSMA3chr14

58714550

+ACTR10chr14

58697117

+
TCGARVPAADTCGA-IB-AAUP-01APSMA3chr14

58718960

+ACTR10chr14

58701088

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000216455ENST00000254286PSMA3chr14

58734238

+ACTR10chr14

58669573

+
In-frameENST00000412908ENST00000254286PSMA3chr14

58734238

+ACTR10chr14

58669573

+
In-frameENST00000557508ENST00000254286PSMA3chr14

58734238

+ACTR10chr14

58669573

+
intron-3CDSENST00000554456ENST00000254286PSMA3chr14

58734238

+ACTR10chr14

58669573

+
In-frameENST00000216455ENST00000254286PSMA3chr14

58714550

+ACTR10chr14

58697117

+
In-frameENST00000412908ENST00000254286PSMA3chr14

58714550

+ACTR10chr14

58697117

+
intron-3CDSENST00000557508ENST00000254286PSMA3chr14

58714550

+ACTR10chr14

58697117

+
intron-3CDSENST00000554456ENST00000254286PSMA3chr14

58714550

+ACTR10chr14

58697117

+
Frame-shitENST00000216455ENST00000254286PSMA3chr14

58718960

+ACTR10chr14

58701088

+
Frame-shitENST00000412908ENST00000254286PSMA3chr14

58718960

+ACTR10chr14

58701088

+
Frame-shitENST00000557508ENST00000254286PSMA3chr14

58718960

+ACTR10chr14

58701088

+
intron-3CDSENST00000554456ENST00000254286PSMA3chr14

58718960

+ACTR10chr14

58701088

+

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FusionProtFeatures for PSMA3_ACTR10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSMA3

P25788

ACTR10

Q9NZ32

Component of the 20S core proteasome complex involved inthe proteolytic degradation of most intracellular proteins. Thiscomplex plays numerous essential roles within the cell byassociating with different regulatory particles. Associated withtwo 19S regulatory particles, forms the 26S proteasome and thusparticipates in the ATP-dependent degradation of ubiquitinatedproteins. The 26S proteasome plays a key role in the maintenanceof protein homeostasis by removing misfolded or damaged proteinsthat could impair cellular functions, and by removing proteinswhose functions are no longer required. Associated with the PA200or PA28, the 20S proteasome mediates ubiquitin-independent proteindegradation. This type of proteolysis is required in severalpathways including spermatogenesis (20S-PA200 complex) orgeneration of a subset of MHC class I-presented antigenic peptides(20S-PA28 complex). Binds to the C-terminus of CDKN1A and therebymediates its degradation. Negatively regulates the membranetrafficking of the cell-surface thromboxane A2 receptor (TBXA2R)isoform 2. {ECO:0000269|PubMed:11350925,ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466,ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PSMA3_ACTR10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PSMA3_ACTR10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PSMA3PRRC2A, PSMD13, SNRPB, STX11, SNRPF, PSMA6, PSMA1, PLK1, EGR1, CDKN1A, CRYAB, TRIB3, PSMD14, SLX1B, IKBKG, UBC, MYC, PSMC3, USP5, WDR48, USP14, PAF1, HDAC2, TBL1XR1, RBBP5, ENO1, WDR5, NCL, SF3A3, PUF60, EFTUD2, CPSF2, TARDBP, HNRNPF, HNRNPLL, HNRNPA2B1, HNRNPC, KHSRP, NONO, PTBP1, DDX1, DDX5, SRRT, CALR, P4HB, HSPA9, HSPD1, HSPA8, HSPA1L, HSP90AB1, HSP90AA1, DNAJA1, CCT2, ACTB, ACTN2, ACTN4, TUBA1B, TUBB2A, PRPF19, XRCC6, XRCC5, RUVBL1, HSPA5, ATP5B, ALDOA, AHSG, CKB, GAPDH, MDH2, MCM3, MCM6, PPM1F, PSMC4, RAD23B, GTF2B, HNRNPA1, PCBP2, IREB2, EEF1A1, EEF2, WARS, GARS, KARS, HSP90B1, HSPA2, CCT8, CCT4, CCT3, CCT6A, STIP1, TPI1, HADHB, PGAM1, SERPINA3, PKM, PGK1, LDHA, DLAT, MTHFD1, CTPS1, LONP1, GANAB, ASAH1, DONSON, ALB, TF, SERPINB3, PSMD1, PSMA7, PSMA2, NCOA3, CFTR, RAD23A, PSMA4, PSMB5, SERPINE1, AURKB, PSMA5, HHEX, FKBP8, PSMC1, STUB1, NEDD8, YWHAQ, MDM2, USP7, CUL1, UCHL5, POMP, PSMB10, SACS, BAG1, ATN1, GFI1B, PRNP, RERE, PSMB9, PSMB1, PSMB2, PSMB3, PSMB4, PSMB6, PSMB7, PSMD6, PSMC2, PSMC5, PSMD2, PSMD3, PSMD11, PSMC6, PSMD8, PSMB8, PSMD7, PSME2, PSME1, PSMA8, VCAM1, CSNK2A1, IQCB1, NOS2, ITGA4, PARK2, BAG3, PML, DVL1, BTRC, FRAT1, TCF7L2, LBP, NUMBL, XRN2, SRPK2, FBXO6, HOXA2, AP3M1, SART3, IQCE, KIF1A, STX1A, TBX6, SNAI2, HUWE1, ATP6V0C, CDK6, CST2, CYBA, GATA2, GATA3, NPBWR2, KRAS, LASP1, LETM1, CTAGE5, NPPB, PSMA3, RAB3IL1, SNRPC, STX4, SF1, APLN, SERF2, STX6, BTN2A2, SLMO1, DMC1, LPHN1, RAD54L2, RBFOX2, FBXO7, PTPN23, GORASP2, CCDC69, SH3KBP1, PRR13, VPS37C, CCL28, DMRT3, SLC22A23, RBM42, C14orf159, FBXL18, PRR3, FAM103A1, YPEL3, KIRREL2, MUM1, URB1-AS1, RFT1, CTBP1-AS2, C1orf105, CRB3, OSR2, SLAIN1, TBC1D16, NEU4, SPATA8, LOC149950, FAM218A, ZNF366, PWWP2B, ZNF385C, PATL1, TINCR, KIRREL3-AS3, FAM171A2, LINC00908, RUSC1-AS1, RTP5, KRTAP8-1, KRTAP19-5, KRTAP26-1, C9orf106, C1QTNF9B-AS1, AMFR, SYVN1, BUB1B, HSPB1, AMBRA1, ELP6, EXOSC4, EXOSC6, NELFE, ADRM1, CLIC4, EXOSC5, MCM5, PSMD12, PSMD4, PSMD5, PSME4, UBA2, XPOT, PSME3, PSMG2, VCP, NTRK1, PTTG1, EGFR, CYLD, TRIM25, CCND2ACTR10DCTN4, ACTR1A, ACTR1B, DCTN2, DCTN3, LMNB1, RABEP1, NAGK, CSPP1, ORC6, C9orf24, CAPZA2, GPS2, CA10, LOC554223, DCTN1, KIF11, MYO19, DUSP13, DCTN6, KLHL2, DEFB127, UQCRH, RIC8A, PDGFD, MIS18A, C16orf45, RPS19BP1, C1orf106, RHOC, MAPK8IP3, NEXN, CCDC120, NGEF, BCL7C, ACTBL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PSMA3_ACTR10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PSMA3_ACTR10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource