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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2908

FusionGeneSummary for ASAP1_TRAPPC9

check button Fusion gene summary
Fusion gene informationFusion gene name: ASAP1_TRAPPC9
Fusion gene ID: 2908
HgeneTgene
Gene symbol

ASAP1

TRAPPC9

Gene ID

50807

83696

Gene nameArfGAP with SH3 domain, ankyrin repeat and PH domain 1trafficking protein particle complex 9
SynonymsAMAP1|CENTB4|DDEF1|PAG2|PAP|ZG14PIBP|IKBKBBP|MRT13|NIBP|T1|TRS120
Cytomap

8q24.21-q24.22

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating proteinADP-ribosyltrafficking protein particle complex subunit 9IKK2 binding proteinNIK and IKK-beta binding proteinNIK- and IKBKB-binding proteinTRAPP 120 kDa subunittularik gene 1 protein
Modification date2018052320180523
UniProtAcc

Q9ULH1

Q96Q05

Ensembl transtripts involved in fusion geneENST00000357668, ENST00000518721, 
ENST00000520625, 
ENST00000389327, 
ENST00000389328, ENST00000438773, 
ENST00000522504, 
Fusion gene scores* DoF score20 X 11 X 10=220012 X 10 X 7=840
# samples 2214
** MAII scorelog2(22/2200*10)=-3.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/840*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASAP1 [Title/Abstract] AND TRAPPC9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A6YX-01AASAP1chr8

131226802

-TRAPPC9chr8

140743471

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000357668ENST00000389327ASAP1chr8

131226802

-TRAPPC9chr8

140743471

-
Frame-shitENST00000357668ENST00000389328ASAP1chr8

131226802

-TRAPPC9chr8

140743471

-
Frame-shitENST00000357668ENST00000438773ASAP1chr8

131226802

-TRAPPC9chr8

140743471

-
5CDS-5UTRENST00000357668ENST00000522504ASAP1chr8

131226802

-TRAPPC9chr8

140743471

-
Frame-shitENST00000518721ENST00000389327ASAP1chr8

131226802

-TRAPPC9chr8

140743471

-
In-frameENST00000518721ENST00000389328ASAP1chr8

131226802

-TRAPPC9chr8

140743471

-
Frame-shitENST00000518721ENST00000438773ASAP1chr8

131226802

-TRAPPC9chr8

140743471

-
5CDS-5UTRENST00000518721ENST00000522504ASAP1chr8

131226802

-TRAPPC9chr8

140743471

-
intron-3CDSENST00000520625ENST00000389327ASAP1chr8

131226802

-TRAPPC9chr8

140743471

-
intron-3CDSENST00000520625ENST00000389328ASAP1chr8

131226802

-TRAPPC9chr8

140743471

-
intron-3CDSENST00000520625ENST00000438773ASAP1chr8

131226802

-TRAPPC9chr8

140743471

-
intron-5UTRENST00000520625ENST00000522504ASAP1chr8

131226802

-TRAPPC9chr8

140743471

-

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FusionProtFeatures for ASAP1_TRAPPC9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASAP1

Q9ULH1

TRAPPC9

Q96Q05

Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADPribosylation factor 1) and ARF5 and a lesser activity towardsARF6. May coordinate membrane trafficking with cell growth oractin cytoskeleton remodeling by binding to both SRC and PIP2. Mayfunction as a signal transduction protein involved in thedifferentiation of fibroblasts into adipocytes and possibly othercell types (By similarity). Plays a role in ciliogenesis.{ECO:0000250, ECO:0000269|PubMed:20393563}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ASAP1_TRAPPC9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ASAP1_ENST00000518721_chr8_131226802_-_TRAPPC9_ENST00000389328_chr8_140743471_-_191aa
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQ
NEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLVQPSGQSACLGALLFLYTGDFFLHIRFHEDSTSKELPPSWFCLPS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ASAP1_ENST00000518721_chr8_131226802_-_TRAPPC9_ENST00000389328_chr8_140743471_-_573nt
ATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGAGATTCACTATGGAATCGGATGCCGGACCAGATCTCTGTCTCGGAGTTC
ATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCCAGCTTCACCACGCGGCTGCACAACTGCAGGAACACCGTCACGCTGCTG
GAGGAGGCTCTAGACCAAGATAGAACAGCCCTTCAGAAAGTGAAGAAGTCTGTAAAAGCAATATATAATTCTGGTCAAGATCATGTACAA
AATGAAGAAAACTATGCACAAGTTCTTGATAAGTTTGGGAGTAATTTTTTAAGTCGAGACAACCCCGACCTTGGCACCGCGTTTGTCAAG
TTTTCTACTCTTACAAAGGAACTGTCCACACTGCTGAAAAATCTGGTGCAGCCGTCCGGCCAGTCGGCCTGCCTCGGGGCCCTCCTCTTC
CTCTACACGGGAGACTTCTTCCTCCACATCCGGTTCCACGAGGACAGCACCAGCAAGGAGCTGCCACCCTCTTGGTTCTGCCTGCCCAGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ASAP1_ENST00000518721_chr8_131226802_-_TRAPPC9_ENST00000389328_chr8_140743471_-_1519nt
CCCTTCCTGCGCCGCGCTCGGCTCCCGCGCCTCGCCTGGCCTGGCCGCTGCCGCGGGCGAGCACTGTGCGCTGGGCAGCCCCGGGCCCGC
GCCTCCCGCCCAGCCGGCGCTTCCCGGTCGCAGTTCGCTTTCCCACCCGAGAGCCGCGAGCGCCCGGCCGAACCCGCGATGGAATAATGC
CCAGCGGCCCGCCAGGTCCCGGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGA
GATTCACTATGGAATCGGATGCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCC
AGCTTCACCACGCGGCTGCACAACTGCAGGAACACCGTCACGCTGCTGGAGGAGGCTCTAGACCAAGATAGAACAGCCCTTCAGAAAGTG
AAGAAGTCTGTAAAAGCAATATATAATTCTGGTCAAGATCATGTACAAAATGAAGAAAACTATGCACAAGTTCTTGATAAGTTTGGGAGT
AATTTTTTAAGTCGAGACAACCCCGACCTTGGCACCGCGTTTGTCAAGTTTTCTACTCTTACAAAGGAACTGTCCACACTGCTGAAAAAT
CTGGTGCAGCCGTCCGGCCAGTCGGCCTGCCTCGGGGCCCTCCTCTTCCTCTACACGGGAGACTTCTTCCTCCACATCCGGTTCCACGAG
GACAGCACCAGCAAGGAGCTGCCACCCTCTTGGTTCTGCCTGCCCAGTGTGCACGTGTGTGCCCTGGAGGCGCAGGCCTGAGCCCGCCTA
CTTCCGTCCCTCTTTCTGCAGGGCCAGAGGTGACCCTGCCTGGCCTCCCACACCCCCTGCAATGAGCAAGGCCTTCACTGCAGCCCCATC
TCCTCCTCCTCCCCCAGACCCCTCCCAGCCCTCTCCTCCTGTTCCTCCTGTAGCATCTTTGCTGGGCTACGCAGAAGCCCCGGACATGGC
AGCCCCACCCCATGCCACGCCCCTTCCTACACTGTTCCCTGGACCATACACAGGCTGAAGCAGAGGAAATCCCAAAGCGGGTGCCCATCC
AGCCCAGGTCCCAGGATCCCTGCACCCATTTCTGTGACCTGGGGCCCCAGCCGTGCTGTGCTGCTCATCCCAGCAGAGGGACCTCCCTCG
TCCAGCGACTTCCCTTTGGCCATAGAAAGAAATGGTGAGCATGAGACTGGGCACAGCCTGAGGGCGTGGGCAGCTTCCCACCCTCCCTGG
GCCTTGGAATCCCCCAAGGCTGGTTTTCTTCCTGGAGACCCCCATGGGCAACTTGGCAGGAGAGATGGTGCCGTAGGAGGTCGTGGATGG
TTGATGCCAAGAGAGGCCCTCCACCCGTGGTGGGCAAATGTCCAGGCCTGGGCTGGCAGCCCAGGGCTGTTTCTGGGTGCTCCCTGGCCC


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FusionGenePPI for ASAP1_TRAPPC9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ASAP1SRC, CRK, PXN, PACSIN1, PACSIN2, PACSIN3, TRIP10, FCHSD1, GRB2, ARF6, ELAVL1, SH3KBP1, CBL, CBLB, ARAP3, CTTN, PTK2, LRRK1, NCK2, NTRK1, RAB11FIP3, RAB11FIP1, RAB11FIP2, CDH1, PTPN12, ASAP3, TRIM25, ARF1TRAPPC9IKBKB, TRAPPC2, TRAPPC2L, TRAPPC3L, TRAPPC4, TRAPPC8, TRAPPC10, TRAPPC12, NOTCH1, AMOTL2, MOV10, NXF1, ODF3L2, SULT1A2, CNN2, BCL2L14, RUFY4, CABS1, ACAA1, CRYAB, NTRK1, APP, TRAPPC5, KANK4, TRAPPC1, STMN4, GATA2, GLB1, GRAMD1B, RAB30, BTBD1, KCTD3, LGALS3BP, TBC1D14, FAM19A3, CRTAC1, TRAPPC3, RAB3IP, TMEM102, MB21D2, PDLIM7, RAB3IL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ASAP1_TRAPPC9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ASAP1_TRAPPC9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASAP1C0005695Bladder Neoplasm1CTD_human
HgeneASAP1C0041327Tuberculosis, Pulmonary1CTD_human