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Fusion gene ID: 2908 |
FusionGeneSummary for ASAP1_TRAPPC9 |
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Fusion gene information | Fusion gene name: ASAP1_TRAPPC9 | Fusion gene ID: 2908 | Hgene | Tgene | Gene symbol | ASAP1 | TRAPPC9 | Gene ID | 50807 | 83696 |
Gene name | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | trafficking protein particle complex 9 | |
Synonyms | AMAP1|CENTB4|DDEF1|PAG2|PAP|ZG14P | IBP|IKBKBBP|MRT13|NIBP|T1|TRS120 | |
Cytomap | 8q24.21-q24.22 | 8q24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating proteinADP-ribosyl | trafficking protein particle complex subunit 9IKK2 binding proteinNIK and IKK-beta binding proteinNIK- and IKBKB-binding proteinTRAPP 120 kDa subunittularik gene 1 protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9ULH1 | Q96Q05 | |
Ensembl transtripts involved in fusion gene | ENST00000357668, ENST00000518721, ENST00000520625, | ENST00000389327, ENST00000389328, ENST00000438773, ENST00000522504, | |
Fusion gene scores | * DoF score | 20 X 11 X 10=2200 | 12 X 10 X 7=840 |
# samples | 22 | 14 | |
** MAII score | log2(22/2200*10)=-3.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/840*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ASAP1 [Title/Abstract] AND TRAPPC9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-A6YX-01A | ASAP1 | chr8 | 131226802 | - | TRAPPC9 | chr8 | 140743471 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000357668 | ENST00000389327 | ASAP1 | chr8 | 131226802 | - | TRAPPC9 | chr8 | 140743471 | - |
Frame-shift | ENST00000357668 | ENST00000389328 | ASAP1 | chr8 | 131226802 | - | TRAPPC9 | chr8 | 140743471 | - |
Frame-shift | ENST00000357668 | ENST00000438773 | ASAP1 | chr8 | 131226802 | - | TRAPPC9 | chr8 | 140743471 | - |
5CDS-5UTR | ENST00000357668 | ENST00000522504 | ASAP1 | chr8 | 131226802 | - | TRAPPC9 | chr8 | 140743471 | - |
Frame-shift | ENST00000518721 | ENST00000389327 | ASAP1 | chr8 | 131226802 | - | TRAPPC9 | chr8 | 140743471 | - |
In-frame | ENST00000518721 | ENST00000389328 | ASAP1 | chr8 | 131226802 | - | TRAPPC9 | chr8 | 140743471 | - |
Frame-shift | ENST00000518721 | ENST00000438773 | ASAP1 | chr8 | 131226802 | - | TRAPPC9 | chr8 | 140743471 | - |
5CDS-5UTR | ENST00000518721 | ENST00000522504 | ASAP1 | chr8 | 131226802 | - | TRAPPC9 | chr8 | 140743471 | - |
intron-3CDS | ENST00000520625 | ENST00000389327 | ASAP1 | chr8 | 131226802 | - | TRAPPC9 | chr8 | 140743471 | - |
intron-3CDS | ENST00000520625 | ENST00000389328 | ASAP1 | chr8 | 131226802 | - | TRAPPC9 | chr8 | 140743471 | - |
intron-3CDS | ENST00000520625 | ENST00000438773 | ASAP1 | chr8 | 131226802 | - | TRAPPC9 | chr8 | 140743471 | - |
intron-5UTR | ENST00000520625 | ENST00000522504 | ASAP1 | chr8 | 131226802 | - | TRAPPC9 | chr8 | 140743471 | - |
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FusionProtFeatures for ASAP1_TRAPPC9 |
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Hgene | Tgene |
ASAP1 | TRAPPC9 |
Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADPribosylation factor 1) and ARF5 and a lesser activity towardsARF6. May coordinate membrane trafficking with cell growth oractin cytoskeleton remodeling by binding to both SRC and PIP2. Mayfunction as a signal transduction protein involved in thedifferentiation of fibroblasts into adipocytes and possibly othercell types (By similarity). Plays a role in ciliogenesis.{ECO:0000250, ECO:0000269|PubMed:20393563}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ASAP1_TRAPPC9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_ASAP1_ENST00000518721_chr8_131226802_-_TRAPPC9_ENST00000389328_chr8_140743471_-_191aa MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQ NEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLVQPSGQSACLGALLFLYTGDFFLHIRFHEDSTSKELPPSWFCLPS |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_ASAP1_ENST00000518721_chr8_131226802_-_TRAPPC9_ENST00000389328_chr8_140743471_-_573nt ATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGAGATTCACTATGGAATCGGATGCCGGACCAGATCTCTGTCTCGGAGTTC ATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCCAGCTTCACCACGCGGCTGCACAACTGCAGGAACACCGTCACGCTGCTG GAGGAGGCTCTAGACCAAGATAGAACAGCCCTTCAGAAAGTGAAGAAGTCTGTAAAAGCAATATATAATTCTGGTCAAGATCATGTACAA AATGAAGAAAACTATGCACAAGTTCTTGATAAGTTTGGGAGTAATTTTTTAAGTCGAGACAACCCCGACCTTGGCACCGCGTTTGTCAAG TTTTCTACTCTTACAAAGGAACTGTCCACACTGCTGAAAAATCTGGTGCAGCCGTCCGGCCAGTCGGCCTGCCTCGGGGCCCTCCTCTTC CTCTACACGGGAGACTTCTTCCTCCACATCCGGTTCCACGAGGACAGCACCAGCAAGGAGCTGCCACCCTCTTGGTTCTGCCTGCCCAGT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_ASAP1_ENST00000518721_chr8_131226802_-_TRAPPC9_ENST00000389328_chr8_140743471_-_1519nt CCCTTCCTGCGCCGCGCTCGGCTCCCGCGCCTCGCCTGGCCTGGCCGCTGCCGCGGGCGAGCACTGTGCGCTGGGCAGCCCCGGGCCCGC GCCTCCCGCCCAGCCGGCGCTTCCCGGTCGCAGTTCGCTTTCCCACCCGAGAGCCGCGAGCGCCCGGCCGAACCCGCGATGGAATAATGC CCAGCGGCCCGCCAGGTCCCGGTCGTTTTCTGATGTGACGGCTGAGACATGAGATCTTCAGCCTCCAGGCTCTCCAGTTTTTCGTCGAGA GATTCACTATGGAATCGGATGCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCC AGCTTCACCACGCGGCTGCACAACTGCAGGAACACCGTCACGCTGCTGGAGGAGGCTCTAGACCAAGATAGAACAGCCCTTCAGAAAGTG AAGAAGTCTGTAAAAGCAATATATAATTCTGGTCAAGATCATGTACAAAATGAAGAAAACTATGCACAAGTTCTTGATAAGTTTGGGAGT AATTTTTTAAGTCGAGACAACCCCGACCTTGGCACCGCGTTTGTCAAGTTTTCTACTCTTACAAAGGAACTGTCCACACTGCTGAAAAAT CTGGTGCAGCCGTCCGGCCAGTCGGCCTGCCTCGGGGCCCTCCTCTTCCTCTACACGGGAGACTTCTTCCTCCACATCCGGTTCCACGAG GACAGCACCAGCAAGGAGCTGCCACCCTCTTGGTTCTGCCTGCCCAGTGTGCACGTGTGTGCCCTGGAGGCGCAGGCCTGAGCCCGCCTA CTTCCGTCCCTCTTTCTGCAGGGCCAGAGGTGACCCTGCCTGGCCTCCCACACCCCCTGCAATGAGCAAGGCCTTCACTGCAGCCCCATC TCCTCCTCCTCCCCCAGACCCCTCCCAGCCCTCTCCTCCTGTTCCTCCTGTAGCATCTTTGCTGGGCTACGCAGAAGCCCCGGACATGGC AGCCCCACCCCATGCCACGCCCCTTCCTACACTGTTCCCTGGACCATACACAGGCTGAAGCAGAGGAAATCCCAAAGCGGGTGCCCATCC AGCCCAGGTCCCAGGATCCCTGCACCCATTTCTGTGACCTGGGGCCCCAGCCGTGCTGTGCTGCTCATCCCAGCAGAGGGACCTCCCTCG TCCAGCGACTTCCCTTTGGCCATAGAAAGAAATGGTGAGCATGAGACTGGGCACAGCCTGAGGGCGTGGGCAGCTTCCCACCCTCCCTGG GCCTTGGAATCCCCCAAGGCTGGTTTTCTTCCTGGAGACCCCCATGGGCAACTTGGCAGGAGAGATGGTGCCGTAGGAGGTCGTGGATGG TTGATGCCAAGAGAGGCCCTCCACCCGTGGTGGGCAAATGTCCAGGCCTGGGCTGGCAGCCCAGGGCTGTTTCTGGGTGCTCCCTGGCCC |
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FusionGenePPI for ASAP1_TRAPPC9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ASAP1 | SRC, CRK, PXN, PACSIN1, PACSIN2, PACSIN3, TRIP10, FCHSD1, GRB2, ARF6, ELAVL1, SH3KBP1, CBL, CBLB, ARAP3, CTTN, PTK2, LRRK1, NCK2, NTRK1, RAB11FIP3, RAB11FIP1, RAB11FIP2, CDH1, PTPN12, ASAP3, TRIM25, ARF1 | TRAPPC9 | IKBKB, TRAPPC2, TRAPPC2L, TRAPPC3L, TRAPPC4, TRAPPC8, TRAPPC10, TRAPPC12, NOTCH1, AMOTL2, MOV10, NXF1, ODF3L2, SULT1A2, CNN2, BCL2L14, RUFY4, CABS1, ACAA1, CRYAB, NTRK1, APP, TRAPPC5, KANK4, TRAPPC1, STMN4, GATA2, GLB1, GRAMD1B, RAB30, BTBD1, KCTD3, LGALS3BP, TBC1D14, FAM19A3, CRTAC1, TRAPPC3, RAB3IP, TMEM102, MB21D2, PDLIM7, RAB3IL1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ASAP1_TRAPPC9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ASAP1_TRAPPC9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ASAP1 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Hgene | ASAP1 | C0041327 | Tuberculosis, Pulmonary | 1 | CTD_human |