	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 29077

FusionGeneSummary for PSD3_SNRPN

Fusion gene summary

Fusion gene information	Fusion gene name: PSD3_SNRPN
	Fusion gene ID: 29077
		Hgene	Tgene
	Gene symbol	PSD3	SNRPN
	Gene ID	23362	6638
	Gene name	pleckstrin and Sec7 domain containing 3	small nuclear ribonucleoprotein polypeptide N
	Synonyms	EFA6D\|EFA6R\|HCA67	HCERN3\|PWCR\|RT-LI\|SM-D\|SMN\|SNRNP-N\|SNURF-SNRPN\|sm-N
	Cytomap	8p22	15q11.2
	Type of gene	protein-coding	protein-coding
	Description	PH and SEC7 domain-containing protein 3ADP-ribosylation factor guanine nucleotide factor 6epididymis tissue protein Li 20mPexchange factor for ADP-ribosylation factor guanine nucleotide factor 6exchange factor for ADP-ribosylation factor guanine nucle	small nuclear ribonucleoprotein-associated protein NSM protein Nsm protein Dtissue-specific splicing protein
	Modification date	20180523	20180523
	UniProtAcc	Q9NYI0	P63162
	Ensembl transtripts involved in fusion gene	ENST00000327040, ENST00000440756, ENST00000286485, ENST00000428502, ENST00000523619, ENST00000520789,	ENST00000400098, ENST00000400100, ENST00000400097, ENST00000553597, ENST00000390687, ENST00000346403, ENST00000554227, ENST00000577565, ENST00000444203,
Fusion gene scores	* DoF score	8 X 7 X 6=336	7 X 10 X 2=140
	# samples	8	11
	** MAII score	log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/140*10)=-0.347923303420307 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PSD3 [Title/Abstract] AND SNRPN [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AW894859	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000327040	ENST00000400098	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000327040	ENST00000400100	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000327040	ENST00000400097	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000327040	ENST00000553597	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000327040	ENST00000390687	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000327040	ENST00000346403	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000327040	ENST00000554227	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000327040	ENST00000577565	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000327040	ENST00000444203	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000440756	ENST00000400098	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000440756	ENST00000400100	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000440756	ENST00000400097	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000440756	ENST00000553597	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000440756	ENST00000390687	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000440756	ENST00000346403	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000440756	ENST00000554227	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000440756	ENST00000577565	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000440756	ENST00000444203	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000286485	ENST00000400098	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000286485	ENST00000400100	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000286485	ENST00000400097	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000286485	ENST00000553597	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000286485	ENST00000390687	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000286485	ENST00000346403	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000286485	ENST00000554227	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000286485	ENST00000577565	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000286485	ENST00000444203	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000428502	ENST00000400098	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000428502	ENST00000400100	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000428502	ENST00000400097	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000428502	ENST00000553597	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000428502	ENST00000390687	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000428502	ENST00000346403	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000428502	ENST00000554227	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000428502	ENST00000577565	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000428502	ENST00000444203	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000523619	ENST00000400098	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000523619	ENST00000400100	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000523619	ENST00000400097	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000523619	ENST00000553597	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000523619	ENST00000390687	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000523619	ENST00000346403	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000523619	ENST00000554227	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000523619	ENST00000577565	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000523619	ENST00000444203	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000520789	ENST00000400098	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000520789	ENST00000400100	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000520789	ENST00000400097	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000520789	ENST00000553597	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000520789	ENST00000390687	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000520789	ENST00000346403	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000520789	ENST00000554227	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000520789	ENST00000577565	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+
intron-intron	ENST00000520789	ENST00000444203	PSD3	chr8	18533584	+	SNRPN	chr15	25248001	+

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FusionProtFeatures for PSD3_SNRPN

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PSD3 Q9NYI0	SNRPN P63162
Guanine nucleotide exchange factor for ARF6.{ECO:0000250}.	May be involved in tissue-specific alternative RNAprocessing events.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for PSD3_SNRPN

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PSD3_SNRPN

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for PSD3_SNRPN

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for PSD3_SNRPN

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PSD3	C0017638	Glioma	1	CTD_human
Hgene	PSD3	C0036341	Schizophrenia	1	PSYGENET
Hgene	PSD3	C0236733	Amphetamine-Related Disorders	1	CTD_human

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Fusion gene ID: 29077

FusionGeneSummary for PSD3_SNRPN

FusionProtFeatures for PSD3_SNRPN

FusionGeneSequence for PSD3_SNRPN

FusionGenePPI for PSD3_SNRPN

RelatedDrugs for PSD3_SNRPN

RelatedDiseases for PSD3_SNRPN